JPH03190809A - Skin external preparation - Google Patents

Abstract

PURPOSE:To obtain a skin external preparation having preventing and improving effects on chapped skin, excellently alleviating effects especially on inflammation by an activator and on exasperation of excessive turnover, stably mixable even by an alcohol-based prescription, containing a specific plant extract. CONSTITUTION:The above-mentioned skin preparation containing an extract of Aucuba japonica Thunb., Firmiana platanifolia Schott et Endl., AMERICATSUGA, Pyrola japonica Klenze, Curecuma Longa L., Aristolochia kaempferi Willd., OSHUSAISHIN, Pulsatilla cernua Spreng., Xanthium strmarium L., Patrinia scabiosaefolia LinK., Metaplexis japonica Makino, Typha latifolia L., Pinellia termatu Breit., Cassia mimosoides L., KYONOGIKU, Ajuga decumbens Thunb., Paulounia tomentosa Steudel, Chelidonium majus L., Kadsura japonica Dunal, Cymbidium virescens Lindl., Hypericium perforatum L., Geum japonicum Thunb., Taraxacum platycarpum Kahlst., Ligularia tussilaginea Makino, eggplant, NAHAKONOKASO, Nandina domestica Thunb., Euonymus alata Sieb., leek, Welsh onion, Cirsium japonicum DC., Allium grayi Regel, Nelumbo nucifera Gaertn., Tribulus terrestris L., Lycoris radiata Herb., Pyrrosia linguna Farell, comfrey, butterbur, hoelen, Paederia scandens Merrill, balsam, MURASAKlBARENGlKO, Leonurus sibiricus L., citron, YOSHUKARAMATSU, Aster yomena MAKINO, Momordica cochinensis and/or Euphorbia ebracteolatus Hayata.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention is directed to the use of Aoki (Aoki), Aogiri (Aogiri),
Amadokoro (wilt, industrial), American hemlock, Ichiyakusou (one-medicinal herb, deer-hoof grass), turmeric (Ukon), horsetail (Kamimae-koro, Doki-ko, Horse-bell), Japanese staghorn, Pasque (Pascus) , Onamomi (Aoomiko), Ominaeshi (Naejokon), Gagaimo (Ramako), Gama (Gamako),
Ka'a), Karasubishaku (half summer), Katsuraketsumei (
mountain bean, astringent tea, soybean tea), yellow daisy, gyransou (
Shiroishi summer dry grass), Kiri (autophyllum), Kuzanou (white currant cabbage),
Sanekazura (Minami Schisandra), Shunran (Jianranhua), Stinging first Kiri (Kanba Rennie), Japanese radish (Water plum,
radish root), dandelion (Kamakoei), Tsuwabuki (glossy butterfly)
, Eggplant (Eggplant), Nahakonokasou, Nanten (Nanten)
, Nishikigi (Hehuanpi), Chive (Plate, Non-0), Green onion (Scallion), Noisami (foreground, Japanese daisy), Nobile (Japanese garlic), Lotus (
Terrestris terrestris, Amaryllid terrestris (Shikyanthu), Hitotsuba (Sekijing), Japanese terrestris (Consolida root, Simhuitum root), Butterbur, Bukuriyou (Fukuryo), Hexokasula (
cowskin frozen), balsam (hosengusa, translucent bone grass), purple baldweed, mehajiki (massive grass), yuzu (basaniko), Japanese larch, yomena (womena), mokhetsushi (kishibako),
The present invention relates to a skin preparation for external use that is excellent in preventing and improving skin roughness by incorporating one or more extracts selected from Marumino sumac (wolf poison).

[Prior Art] One of the major purposes of external skin preparations such as cosmetics is to prevent and improve skin roughness. To achieve this purpose, glycerin, maltitol, mannitol, 1,3-
Various polyhydric alcohols such as butylene glycol, polysaccharides such as hyaluronic acid and carboxymethyl chitin, and amino acids such as chondroitin sulfate or DL-threonine,
It has been added as a moisturizing ingredient. In addition, products containing vitamin A derivatives have been seen in recent years for the purpose of promoting skin metabolism and hastening so-called skin turnover.

[Problems to be Solved by the Invention] However, moisturizers such as polysaccharides, which are alcohol-based formulas, cause precipitation, and polyhydric alcohols and chondroitin sulfate, when added in large amounts, cause a feeling of dryness and hot flashes.
Furthermore, amino acids such as DL-threonine have disadvantages such as coloring and odor. In addition, it is not only difficult to stabilize vitamin A derivatives, but when used on skin that has undergone excessive turnover accompanied by inflammation, such as when skin becomes rough due to detergents in the winter, it may actually promote inflammation. There was a room for things like that. Further, the moisturizing agents mentioned above cannot exhibit sufficient effects on such skin roughness accompanied by inflammation.

Purpose of the Invention As a result of intensive research in view of these circumstances, the present inventors have discovered that
Aoki (Aoki) Aokiri (front tank, Goto), Amadokoro (wilt, industrial), American hemlock, Ichiyakusou (one-medicinal herb, deershoe grass), turmeric (labour gold), horsetail watercup (appellant water cup, earthwork incense, horse bell) ), Oshu Saishin, Pasque (r-1 old man), Onamomi (Blue ear child), Ominaeshi (Naeshikon), Gagaimo (Ramako), Cattail (Gamako, Kofu)
, Crow bishaku (half summer), Katsuraketsumei (yamabian bean,
Astringent tea, bean tea), Kikuunougiku, Kiranso (white hair summer dry grass), Kiri (Japanese amber), Ribo-no-ou (white-curved cabbage), Kutnekazura (Minamigomiryo), Shunran (Jianlanka), Seiyou No. 1
・Apricot (flowering leaves), Japanese radish (water plum, Japanese radish root), dandelion (Kamakoei), Tsuwabuki (glossy butterfly), eggplant (
Eggplant), Nahakonokasou, Nanten (Nanten fruit), Nishikigi (Hehuanpi), Chinese chive (Plate, non-0), Green onion (green onion), Noa thistle (foreground, Japanese daisy), Nobile (Japanese garlic), Lotus (front leaf, continuous) fruit), Tribulus terrestris, Amaryllid terrestris (Stone pepper), Hitotsuba (right and left), Fieryllus terrestris (Consolida root, Simphytum root),
Butterbur, Bukuriyo, Hexokazura,
Balsamum japonica (Fengxian grass, Transparent grass), Murazaki varengiku,
Extracts from amethyst, yuzu, Japanese larch, yomena, mokubetsushi, and marumino sumac prevent and improve skin roughness, especially inflammation and excess caused by active agents. The present inventors have discovered that it has an excellent effect of calming the light path of light turnover, and has the advantage of being able to be stably incorporated into alcohol-based formulations, and has completed the present invention.

[Means for Solving the Problems 1] That is, the present invention can be applied to Aoki (Aoki), Aokiri (Maetan, Gokou), Amaichikukoro (wilt, Artificial), American hemlock,
Ichiyakusou (one medicinal herb, deer hoof grass), turmeric (chinkin), horse suzukuri (tsuchiaoki incense, doki incense, horsebell bell), oushi j1 kusaishin, okinagusa (white head old man), onamomi (sao miko), ominaeshi (shujokon) ), Gagaimo (Ramako),
Cattail (Japanese yellow, fragrant), Karasbishaku (half-summer), Kawaraketmei (yamagame, astringent tea, soybean tea), Kikou nogiku, Kiransou (white summer dried grass), Kiri (self-flowering), Ri→no'noou (white-curved greens) ), →j Nekasuzuru (Southern Schisandra), Shunran (Jianlanka), Japanese radish (Water 1 easy plum, radish leaf root), Dandelion (Kaba Gongying), Tsuwafuki (Glossy butterfly), Eggplant (eggplant), Nahakonokasou, Nanten (Nanten fruit), Nishikigi (Hehuanpi), chive (Plate,
Green onion), Green onion (Scallion), Nobile (Japanese radish), Nobile (Japanese radish), Lotus (front leaf, continuous fruit), Tribulus terrestris, Amaryllid terrestris (Higanbana), Hitotsuba (Stone ♀), Hireharisou (Consolida root, Symphytum root), Butterbur, Bukuriyou (71 蓓)
, Hexokazura (cowskin method), Pousenriki (Phoenix grass, Transparent bone grass), Murasaki Barengiku, Medhajiki (Yoshimo grass), Yuzu (Yangzi), Japanese larch, Yomena (Yumena), Mokubetsushi (Kizaki), Marumino sumac ( The present invention relates to a skin preparation for external use, which is characterized by containing one or more extracts selected from wolf venom.

Hereinafter, the configuration of the present invention will be explained in detail.

The leaves, skins, fruits, roots, stems, etc. of these plants are used in the present invention.

The method for producing the plant extract used in the present invention involves using these plants in a solvent such as esters such as ethyl acetate, butyl acetate, and amyl acetate, ketones such as acetone, methyl ethyl ketone, and acetylacetone, methanol, ethanol, etc. It is obtained by heating under reflux or soaking with one or more selected from lower alcohols, polyhydric alcohols such as propylene glycol and 1,3-butylene glycol, or water, and concentrating the extract obtained by filtration. , ethanol, 1,3-butylene glycol, etc., alcohol and water mixed solvent, mixing ratio]
:】~9:1 extract is the most effective.

The blending amount of the plant extract in the present invention is as follows:
0.005 to 10% by weight, preferably 0.005 to 10% by weight as dry matter.
01-5% of heavy view. If the amount is less than 0.0-05% by weight, the effects of the present invention will not be sufficiently exhibited, which is undesirable, and even if the amount exceeds 10% by weight, no further effect can be expected.

In addition to the above-mentioned essential ingredients, the external preparation for skin of the present invention may optionally include various ingredients commonly used in cosmetics, quasi-drugs, pharmaceuticals, etc., as long as they do not impair the effects of the present invention. Edylene (8 mol) Oleyl alcohol ether, oil such as glyceryl monooleate, blood flow promoter 1 such as vitamin E acetate, sorbitan monolaurate, sorbicun monovalmidate, sorbicun sesquitinate, sorbicun trioleate, monolaurin Non-ionic interfaces such as acid polyoxyethylene sorbitan, monostearate monostearate, monooxyethylene sorbitan, polyethylene glycol monooleate, polyoxyethylene alkyl ether, polyglycol diester, lauryl jetanolamide, fatty acid isopropanolamide, etc. Active agent, stearyltrimethylammonium chloride, cationic surfactant such as benzalkonium chloride, sodium palmitate, sodium laurate, sodium lauryl sulfate, potassium lauryl sulfate, alkyl sulfate triethanolamine, funnel oil, linear dodecylbenzene sulfate, poly Anionic surfactants such as oxyethylene hardened mustard oil and maleic acid, semi-polar surfactants such as lauryl dimedylamine oxai 1<, oleyl dimethylamine ogizide, amphoteric surfactants, glycerin, 1,3-butylene glycol , a moisturizing agent such as hyaluronic acid, a thickener, a preservative, an antioxidant, a fragrance, a coloring agent, etc. can be blended. Further, the dosage form of the skin external preparation of the present invention is arbitrary, such as an aqueous solution type, a solubilized type, an emulsion type, a powder type, an oil liquid type, a gel type, an ointment type, a water-oil bilayer type, and a water-oil type. It can take a wide range of forms, such as a one-powder, three-layer system.

[Effects of the Invention] The skin external preparation of the present invention is excellent in preventing rough skin, improving skin roughness, and in particular calming inflammation and excessive turnover caused by active agents.

Moreover, the skin external preparation of the present invention has the advantage that it can be stably formulated even in alcohol-based formulations.

[Example] The present invention will be specifically described below with reference to Examples.

Note that the present invention is not limited to this. In addition, the test methods and evaluation methods employed in each example will also be explained here. .

Example of manufacturing a 70% water-containing ethanol extract of Ichiyakuso (one medicinal herb, Shikahoiso) 100g of Ichiyakuso (h-ko-o-ichi-do-sha-kei) for 500 liters
Extraction was carried out by immersion in nl of 70% aqueous ethanol for 2 weeks. This was filtered and concentrated to obtain 12.3 g of an extract.

Lee [Zuko] 12 Yu Mokbetsushi (Kishonji) 50% water content] 3
- Production example of butylene glycol extract Mokubetsushi (bJ
100 g of the extract was extracted with 50% water-containing 1,3-butylene glycol at 700C for 2 hours, filtered, and concentrated to obtain 6.4 g of an extract.

In order to demonstrate the effect of the above plant extracts on preventing and improving rough skin,
Tests for preventing rough skin and increasing turnover were conducted using the method shown below.

(Efficacy test) ■) Skin roughness prevention test Bar I - Cut the back skin of Ray type alpino guinea pigs.
Apply 30 μQ5 of a 3% thorium dodecyl sulfate aqueous solution every day to a 2 cm diameter section of the dorsal skin symmetrical to the midline.
Apply continuously for several days. After applying a 3% sodium dodecyl sulfate aqueous solution, two 1% aqueous suspensions were prepared for Aoki (Aoki), Aoki (Maetan, Goto), Amatokoro (12 wilted, Artificial), and Hemlock. , Ichiyakuso (one medicinal herb,
Deer hoof grass), turmeric (Gokin), horse suzukuri (Kamiyoshikika, Dokika, Makabutsuzu), Okinagusa (Baektoose), Onamomi (Aoomiko), Ominaeshi (Bashujokon), Asclepias (Ramako), Cattails (Gamako, Kofu), Karasubishaku (half-summer), Katsuraketsumei (yamabian beans, astringent tea, bean tea), Kyonougiku, Kiransou (white-haired summer dry grass)
, Kiri (1 paulownia), Kuzanou (white cabbage), Zanekazura (
Southern Schisandra), Shunran (Kianlanka), Japanese radish (Kanba renbon), Japanese radish (Water plum, Japanese radish root), Dandelion (Fuukongying), Tsuwabuki (glossy butterfly), Eggplant (eggplant)
, Nahakonokasou, Nanten (Nanten fruit), Nishikigi (Hekanpi), Chinese chive (Sarako, Hanahiro), Green onion (Green onion), Noa thistle (
Manual, large azalea), nobile (both layers), lotus (front leaf, continuous fruit),
Tribulus terrestris, Higanbana (stone layer), Hitotsuba (stone layer), Hireharisou (Consolida root, Simphytum root), Butterbur,
Bukuriyou (Hagirei), Hexokazura (Cowskin frozen), Pousengriki (Hosengusa, Transparent bonegrass), Murazakibarengiku, Japanese hazelnut (Yumehajiki), Yuzu (Yuzu), Japanese larch, Yomena (Yomena), Osmanthus japonica (Kibuko), Marumino sumac (
A 70% ethanolic extract of venom) was applied openly. One week later, the degree of rough skin and erythema was determined based on the following criteria. In addition, water was used as a control, and for comparison,
A 1% glycerin aqueous solution and a 1% vitamin A ethanol solution were used.

3 4 Hyperactivity suppression test The dorsal skin of Hartley Alpino guinea pigs was shaved and pricked, and 30 U (1,03% sodium dodecyl sulfate aqueous solution) was applied twice a day to a 2 cm diameter section of the back skin symmetrical to the midline for 3 consecutive days. Open application.Then, ointment containing Danzil Chlorai I was applied on the application area for one day, and from the next day, Aoki (Aoki), Aoki (Maetan, Goto), and Aokiri (Maetan, Goto) prepared in a 1% water suspension were applied. Amadokoro (wilt, tamatake), hemlock, Ichiyakusou (one medicinal herb, deer hoof grass)
, Turmeric (@Kin), Umanosuzuku υ (Kika Kamimae, Kabuto Suzuki, Kabuto Suzu), Okinagusa (Baekduo), Onamomi (Momiko), Ominaeshi (Natsujokon), Gagaimo (Ramako) ), cattails (bamboo yellow, fragrant), crow bishaku (half-summer), kawarakekmei (yamabian beans, astringent tea, bean tea), kyonogi, kiransou (white summer dried grass), Kiri (1 paulownia), celandine (white currant), Kanekazura (Minamigomaiko),
Xunlan (Jianranhua)
, Japanese radish (water plum, Japanese radish root), dandelion (蒲小英), Tsuwabuki (glossy butterfly), eggplant (Eggplant), Nahakonokasou, Nanten (Nantian fruit), Nishikigi (Hehuanpi), Chinese chive (Mzi, Nirahaku), Green onion (green onion), Noisami (small and large daikon)
, Nobile (both layers), Lotus (front leaf, continuous fruit), Tribulus terrestris, Amaryllid (stone layer), Hitotsuba (stone dragon), Hireharinwu (
Conchinrida root, Simphytum root), Butterbur, Bukuriyou (
Hagirei), Hexokasula (Genesis), Balsamum (Hosengusa, Translucency grass), Murazakibarengiku, Medhajiki (Mashimogusa)
, Yuzu, Japanese larch, Yomena,
70 of Mokubetsushi (Mokubetsushi) and Marumino sumac (top)
% ethanol extract was applied open. The fluorescence intensity of danzyl chloride was measured every day, and the number of days in which the fluorescence disappeared was determined, which was taken as skin turnover.

Table 1 shows the number of days until fluorescence disappears.

5 6 7 8 As can be seen from Table 1, it was suggested that each plant extract exhibited an excellent effect on preventing rough skin, and also suppressed the excessive acceleration of skin turnover associated with inflammation during rough skin.

9 0" - Lotion Weight % (1) Plant extract of Production Example 1 0.15 (2) Glycerin 4.0 (3) 1.3-butylene glycol 4.0 (4,) Ethanol
7.0(5) Polyoxyethylene oleyl alcohol
0.5(6) Methylparaben 0.
05(7) Citric acid 0.
01(8) Sodium citrate 0.1
(9) Fragrance 0.05 (
10) Purified water remainder (manufacturing method) Dissolve (1), (2), (3), (7), and (8) in purified water.

Separately, (5), (6), and (9) were dissolved in ethanol, and this was added to the above-mentioned purified aqueous solution to solubilize it, and then filtered to obtain a lotion.

The obtained lotion was excellent in preventing and improving skin roughness, and had good stability and safety.

1-Example 21 Cream weight% (1) Cetostearyl alcohol 3.5 (2
) Squalane 40.0 (3)
Beeswax 3.0 (4) Reduced lanolin 5.0 (5) Ethylparaben 0.3 (6) Polyoxyethylene (20) Sorbitacimonobalmitic acid ester
2.0(7) Stearic acid monoglyceride
2.0(8) Plant extract of Production Example 2 1.
0(9) Fragrance 0.03
(10) 1,3-butylene glycol 5.0 (
11) Glycerin 5.0 (1
2) Purified water Residue (manufacturing method) Dissolve (1) to (9) by heating and maintain at 75°C. Add to (10) to (12) heated to 75°C with stirring. After processing with a homomixer to make the emulsified particles fine, the mixture was rapidly cooled while stirring to obtain cream.

1 2 The obtained cream was excellent in preventing and improving skin roughness, and had good stability and safety.

Seed oyster 1. Emulsion by weight (1) Corvus japonica 0.0190% methanol extract (2 Stearic acid 1.5 (3 Seedyl alcohol 0.5 (4) Beeswax 2.0 (5) Polyoxyethylene (10) monomer acid ester
1.0 (6 glycerin monostearate
1.0 (7 Quince seed extract (5% aqueous solution) 20.0 (8 Propylene glycol 5.0 (9) Ethanol
3.0(]0) Ethylparahen
0.3 (11) Fragrance
0.03 (12) Purified water
Residue (manufacturing method) Add (10) and (11) to ethanol and dissolve. (
Alcohol phase) Add (8) to purified water and keep at 70°C. (Aqueous phase) Mix other ingredients except for (7), heat and dissolve and keep at 70°C. (Oil phase) Add the oil phase to the water phase for preliminary emulsification, and homogeneously emulsify with a homomixer. While stirring, add the alcohol phase and quince seed extract. Thereafter, the mixture was cooled to 30°C while stirring to obtain a milky lotion.

The resulting emulsion has excellent effects on preventing and improving skin roughness, and has excellent stability and
Both safety was good.

Pack (1) Marumino sumac 60% glycerin extract (2) Polyvinyl alcohol (3) Polyethylene glycol (4) Propylene glycol (5) Ethanol (6) Methylparaben (7) Fragrance (8) Propylene glycol ( 9) Purified water weight% 0.5 15.0 3.0 7.0 10.0 0.05 0.05 5.0 Remainder 3 4 (Production method) Add (3) (406) to purified water and stir to dissolve. . next(
2) was added and dissolved with stirring, and ethanol in which (7) had been dissolved and (1) were added and dissolved with stirring to obtain a pack.

The obtained pack was excellent in preventing and improving skin roughness, and had good stability and safety.

Fuhuang Wudan Solid White Powder (1) Talc (2) Stearic Acid (3) Lanolin (4) Squalane (5) Sorbitan Sesquioleate (6) Triethanolamine (7) Dandelion 80% 1.3-Butylene Astragalus Recall extract (8) Pigment (9) Fragrance (manufacturing method) Mix (1) and (8) well with a kneader.

Weight % 85.4 1.5 5.0 5.0 2.0 1.0 Oll Appropriate amount Add appropriate amount (powder part) (6) to 50% equivalent amount of purified water and maintain at 70°C. (Aqueous phase) Mix other ingredients except for (9), heat and dissolve and maintain at 70°C. (Oil phase) The oil phase is added to the water phase, uniformly emulsified using a homomixer, added to the powder, kneaded using a kneader, water is evaporated, and processed using a pulverizer. While stirring the mixture well, (9) is evenly sprayed on it and compression molded.

The obtained solid white powder was excellent in preventing and improving skin roughness, and had good stability and safety.

Kosenbutan Ointment (1) Human saliva 60% acetone extract (2) Stearyl alcohol (3) Japanese wax (4) Polyoxyethylene (10) Monooleic acid ester (5) Glycerin monostearate (6)
Vaseline (7) Purified water (8) Storium hyaluronate weight % 5.0 18.0 20.0 0.25 0.25 40.0 Residual Q, 5 5 6 (9) Collagen hydrolyzate 0.1 ( Manufacturing method) Stir and dissolve (8) and (9) in purified water and heat to 700C.
Keep it. (Aqueous phase) Other components are mixed and dissolved at 70°C. (Oil phase) The oil phase was added to the water phase, uniformly emulsified using a homomixer, and then cooled to obtain an ointment.

The obtained ointment has excellent effects on preventing and improving skin roughness, and has excellent stability and
Both safety was good.

Claims (1)

[Claims] Aoki (green tree), Aogiri (green paulownia, Goto paulownia), Amadokoro (wilt, tamatake), American hemlock, Ichiyakusou (one-medicinal herb, deer hoof grass), turmeric (Ukon), horse-tailed sycamore (earth tree incense, earth wood incense, horse helmet) Suzu), Oshu Saishin, Okinagusa (Bad-headed Old Man), Onamomi (Aoimiko), Ominaeshi (
Netsushokon), Gagaimo (Ramako), Gama (Gamako, Kofu),
Karasubishiku (half-summer), Kawaraketsumei (mountain beans, beach tea, bean tea), Kyonougiku, Kiransou (white-haired summer dry grass), Kiri (white paulownia), Kusanou (white-curved cabbage), Sanekazura (minami schisandra), Shunran (built-up) Orchid flower), St. John's daisy (Kanba renkei), Japanese radish (Suiage plum, radish root),
Dandelion (Kamakoei), Tsuwabuki (Glossy Butterfly), Eggplant (Eggplant), Nahakonokasou, Nanten (Nantenmi), Nishikigi (
Chinese chives (Japanese chives), green onions (green onions), noa thistles (small and large daikon), nobile (Japanese radish), lotus (leaf leaves, continuous fruit)
, Tribulus terrestris, Red pepper
Japanese trumpet (Consolida root, Simphytum root), Butterbur, Bukryo (Fukuryo), Hexokazura (Cowskin frost), Balsamum (Fengxian grass, Transparent bone grass), Murasaki varengiku, Japanese amethyst, Yuzu (orange), Japanese larch, Yomena A topical preparation for skin, characterized by containing one or more extracts selected from (Yomena), Mokubetsushi (Wolf poison), and Marumino sumac (Wolf poison).