JPH0319852Y2 - - Google Patents
Info
- Publication number
- JPH0319852Y2 JPH0319852Y2 JP9839188U JP9839188U JPH0319852Y2 JP H0319852 Y2 JPH0319852 Y2 JP H0319852Y2 JP 9839188 U JP9839188 U JP 9839188U JP 9839188 U JP9839188 U JP 9839188U JP H0319852 Y2 JPH0319852 Y2 JP H0319852Y2
- Authority
- JP
- Japan
- Prior art keywords
- box
- guinea pig
- guinea
- excised
- cut
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 241000700199 Cavia porcellus Species 0.000 claims description 54
- 238000002347 injection Methods 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 5
- 230000036412 respiratory physiology Effects 0.000 claims description 3
- 238000000605 extraction Methods 0.000 description 6
- 230000000241 respiratory effect Effects 0.000 description 5
- 238000005259 measurement Methods 0.000 description 4
- 241000700198 Cavia Species 0.000 description 3
- 238000012856 packing Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000005809 Carpobrotus aequilaterus Nutrition 0.000 description 1
- 235000004550 Disphyma australe Nutrition 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 201000001155 extrinsic allergic alveolitis Diseases 0.000 description 1
- 238000011554 guinea pig model Methods 0.000 description 1
- 208000022098 hypersensitivity pneumonitis Diseases 0.000 description 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 210000001364 upper extremity Anatomy 0.000 description 1
Landscapes
- Examining Or Testing Airtightness (AREA)
- Sampling And Sample Adjustment (AREA)
Description
【考案の詳細な説明】
〔産業上の利用分野〕
人間の気管支喘息および過敏性肺臓炎の病態解
明のため、モルモツトのモデルで呼吸生理を調べ
るには瞬時の呼吸抵抗値を測定することが必要で
ある。その測定はデユボイス（DuBois）のオシ
レイシヨン法による呼吸抵抗測定法の原理に基づ
いて行われている。[Detailed description of the invention] [Industrial application field] In order to elucidate the pathology of human bronchial asthma and hypersensitivity pneumonitis, it is necessary to measure instantaneous respiratory resistance values in order to investigate respiratory physiology in a guinea pig model. It is. The measurement is based on the principle of DuBois's oscillation method for measuring respiratory resistance.
本考案はモルモツトの呼吸抵抗値を測定する際
に使用するモルモツトボツクスに関するものであ
る。 The present invention relates to a guinea pig box used for measuring the respiratory resistance of guinea pigs.
モルモツトの呼吸抵抗値は、気密なモルモツト
ボツクス内にモルモツトの体だけを入れ、頭部を
外に出して、このボツクスに正弦（Sin）波形の
圧または容量変化を加え、ボツクス内圧とモルモ
ツトの口腔内圧との差圧と、その加えた振動圧に
よつて生ずるモルモツトの肺胸廓系の気流速度の
変動の比から呼吸抵抗を求めている。
The respiratory resistance value of a guinea pig is determined by placing only the guinea pig's body in an airtight guinea pig box, with the head outside, and applying a sinusoidal waveform pressure or volume change to the box. Respiratory resistance is determined from the ratio of the difference between the internal pressure and the variation in airflow velocity in the guinea pig's lung-thorax system caused by the applied oscillating pressure.
第１図および第２図は従来のモルモツトボツク
スを示すもので、第１図のものは、垂直に両端を
切断した円筒１の片面２に円板状の盲板３を接着
し、この盲板の中心に、ボツクス内に正弦波形の
圧力を加える注入パイプ４を取付け、この円筒１
の下側の２個所に足板５1，５2を取付け、円筒の
他面にはこの円筒の直径より大きい長方形の板６
を、同寸法のゴム板７を挟んで当て、これらの両
板６，７と円筒１とを紐８で固定している。そし
て外側の板６の中心にはモルモツトの頭より少々
大きめの穴９をあけ、又内側のゴム板７の中心に
はモルモツトの頭が少しきつめに入る穴をあけて
ある。又円筒１の上側にはボツクス内の圧力検出
用取出しパイプ１０が取付けられている。 Figures 1 and 2 show a conventional Morimotsuto box. In the one shown in Figure 1, a disk-shaped blind plate 3 is glued to one side 2 of a cylinder 1 with both ends cut vertically. An injection pipe 4 that applies sinusoidal pressure inside the box is installed at the center of the cylinder 1.
Foot plates 5 1 and 5 2 are attached to the lower two places of the cylinder, and a rectangular plate 6 larger than the diameter of this cylinder is attached to the other side of the cylinder.
are placed across a rubber plate 7 of the same size, and these plates 6, 7 and the cylinder 1 are fixed with a string 8. A hole 9 slightly larger than the guinea pig's head is made in the center of the outer plate 6, and a hole 9 slightly larger than the guinea pig's head is made in the center of the inner rubber plate 7. Further, a take-out pipe 10 for detecting the pressure inside the box is attached to the upper side of the cylinder 1.
第２図のものは、モルモツトの体のボツクス内
に入れ、頭を外に出し、当て板６でモルモツトを
おさえたときに、モルモツトが前足を前方向に楽
にのばせるように、ボツクスの端面１１（モルモ
ツトの頭部側端面）が垂直でなく、ある角度を有
する傾斜面になるように切断されている点以外は
第１図のものと同じである。 The one shown in Fig. 2 is designed so that when the guinea pig is placed in the box around its body, its head is exposed outside, and the guinea pig is held down by the backing plate 6, the end face 11 of the box ( It is the same as that shown in FIG. 1, except that the end surface on the side of the guinea pig's head is not cut vertically, but into an inclined surface having a certain angle.
第１図及び第２図に示す従来のモルモツトボツ
クスはボツクス１と当て板６との間からの空気漏
れが大きく、また当て板より頭部を外に出したそ
の首の周囲から漏れが大きく、気密なモルモツト
ボツクスが得られないので、モルモツト呼吸抵抗
の正確な測定が出来ない。また頭部を外に出し、
体だけをボツクスの内に挿入してモルモツトをボ
ツクスに固定する際に、当て板６の穴にモルモツ
トの頭部を通し、モルモツトをおさえながらモル
モツトの体だけをボツクス内に挿入して、その当
て板６をボツクス１に紐で固定するものであるか
らその作業は煩雑である。 In the conventional guinea pig box shown in FIGS. 1 and 2, there is a large amount of air leakage from between the box 1 and the backing plate 6, and there is also a large amount of air leakage from around the neck where the head is outside the backing plate. Since an airtight guinea pig box cannot be obtained, accurate measurement of guinea pig breathing resistance is not possible. Take the head out again,
When inserting only the body of the guinea pig into the box and fixing the guinea pig in the box, pass the guinea pig's head through the hole in the cover plate 6, insert only the body of the guinea pig into the box while holding the guinea pig, and then insert the guinea pig's body into the box. Since the board 6 is fixed to the box 1 with strings, the work is complicated.
又、モルモツトに加えられた振動圧によつて生
ずるモルモツトの気流速度の変動を測定するに
は、従来第３図に示す構造のものが使用されてい
る。これは気流方向に沿つた２点間の圧力差と気
流速度が比例する法則に従つた構造のものであ
る。第３図おいて１２はモルモツトの呼吸する顔
の部分を覆うラツパ状の当て部、１３はこのラツ
パ状顔当部の中心に連通する細管部で、この細管
部には気流方向に沿つた２点１４1，１４2間の圧
力差を測定するために、その中間にステンレスの
金網１５を挟んでその前後に２本の圧力取出用の
パイプ１６1，１６2が取付けられている。第３図
において１７は、このラツパ状部分に顔を当てた
モルモツトの口腔内圧を測定するための内圧取出
用パイプである。 Furthermore, in order to measure fluctuations in the air velocity of a guinea pig caused by vibration pressure applied to the guinea pig, a structure shown in FIG. 3 has conventionally been used. This structure follows the law that the airflow velocity is proportional to the pressure difference between two points along the airflow direction. In Fig. 3, reference numeral 12 denotes a flap-like part that covers the part of the guinea pig's face that breathes, and 13 denotes a narrow tube part that communicates with the center of this flap-shaped face rest. In order to measure the pressure difference between the points 14 1 and 14 2 , two pressure extraction pipes 16 1 and 16 2 are installed in front and behind the stainless wire mesh 15 with a stainless wire mesh 15 in between. In FIG. 3, reference numeral 17 denotes an internal pressure extraction pipe for measuring the intraoral pressure of a guinea pig whose face is placed on this flap-shaped portion.
以上のように、従来のモルモツトボツクスおよ
びモルモツトの気流速度変動測定構造部について
説明したが、本考案は、従来のモルモツトボツク
スの欠点即ちボツクスの空気漏れやモルモツトの
頭部を外に出し、体だけをボツクス内に入れて、
モルモツトをボツクスに固定する際の作業の煩雑
さを解消するために、モルモツトボツクスの構造
を改良したものである。本考案のモルモツトボツ
クスにおいてもモルモツトの気流速度変動を測定
するときには、第３図に示すような従来の測定構
造のものを使用するものである。
As described above, the conventional guinea pig box and the structure for measuring the air velocity fluctuations of the guinea pig have been explained. However, the present invention solves the drawbacks of the conventional guinea pig box, such as air leakage in the box, and by exposing the guinea pig's head to the outside and allowing only the body of the guinea pig to be exposed. put it in the box,
The structure of the guinea pig box has been improved in order to eliminate the complexity of work when fixing the guinea pig in the box. In the guinea pig box according to the present invention, a conventional measurement structure as shown in FIG. 3 is used when measuring airflow velocity fluctuations in the guinea pig.
上記目的を達成するために、本考案におけるモ
ルモツトボツクスは第４図および第５図に示すよ
うに、円筒ボツクス１８の圧力注入側Ａと反対側
Ｂを下から上にα゜の傾きで斜めに、約1/2の高さ
まで切り、それからボツクスの軸方向にボツクス
長さの約1/3に切つた後、直角に上方に切つて、
円筒ボツクスの反対側上半部を切除する。そして
その切除したボツクス部分には、切除したボツク
スと同じ形状で、その前面にボツクス１８の前端
面と同じ傾きの盲板１９を接着した半円筒状のか
ぶせ上蓋２０を載置し、この上蓋２０とボツクス
本体１８とを引掛け止め金具２１で固定するよう
にしてある。又上半部の切除されたボツクス本体
１８の前端傾斜面にも、盲板２２を接着して、こ
れら上下の盲板１９と２２が合体して同じ傾斜の
ボツクス前端面を形成するようにしてある。又盲
板１９および２２のそれぞれの中心部には相対応
してモルモツト２３の首の周りを固定する半円状
の穴が設けられている。
In order to achieve the above object, the guinea pig box according to the present invention is constructed such that the pressure injection side A and the opposite side B of the cylindrical box 18 are tilted at an angle of α° from bottom to top, as shown in FIGS. 4 and 5. , cut to about 1/2 the height, then cut in the axial direction of the box to about 1/3 of the box length, then cut upward at a right angle.
Cut out the upper half of the opposite side of the cylindrical box. A semi-cylindrical cover lid 20 having the same shape as the excised box and having a blind plate 19 with the same inclination as the front end surface of the box 18 glued to the front surface is placed on the excised box part. and the box main body 18 are fixed with a hook 21. A blind plate 22 is also glued to the front inclined surface of the box main body 18 from which the upper half has been cut, so that the upper and lower blind plates 19 and 22 are combined to form a front end surface of the box with the same slope. be. Further, in the center of each of the blind plates 19 and 22, a corresponding semicircular hole is provided for fixing the neck of the guinea pig 23.
第６図は本考案モルモツトボツクスの実施例を
示すもので、円筒ボツクス１８の片面Ａは円板２
４で密閉され、その中心に、ボツクス内に正弦波
の圧力を注入するパイプ２５が取付けられてい
る。Ａ側と反対のモルモツト頭部固定側Ｂのボツ
クス下半部とその上部に載置される上蓋２０の構
造は第４図および第５図で説明した構造に形成さ
れている。モルモツトの首の周りを固定する上蓋
盲板１９およびボツクス前端下半部の盲板２２の
中心穴２６，２７の周囲には防水性で弾性を有す
るパツキン２８が取付けられている。２１は上蓋
２０をボツクス本体に固定する引掛け止め金具
で、両側と上部の３個所に設けられている。２９
はボツクス上部に設けたボツクス内圧検出用取出
パイプであり、３０1，３０2はボツクス下側に設
けた２個の足板である。第７図はモルモツトの体
重の差により、首の太さが違うために、上蓋２０
の中心穴２６の大きさを大小２種類違うものを容
易しておいてモルモツトの体重の差異に応じて何
れかを使用するようにした上蓋の実施例である。
FIG. 6 shows an embodiment of the guinea pig box of the present invention, in which one side A of the cylindrical box 18 is a disk 2.
4, and a pipe 25 for injecting sinusoidal pressure into the box is attached to the center of the box. The structure of the lower half of the box on the side B where the guinea pig's head is fixed, which is opposite to the side A, and the upper lid 20 placed on the upper part of the box are formed as described in FIGS. 4 and 5. A waterproof and elastic packing 28 is attached around the center holes 26 and 27 of the upper cover blind plate 19 and the blind plate 22 in the lower half of the front end of the box, which fix the area around the neck of the guinea pig. Reference numeral 21 denotes hook fittings for fixing the top cover 20 to the box body, which are provided at three locations on both sides and the top. 29
is an extraction pipe for detecting the internal pressure of the box provided at the top of the box, and 30 1 and 30 2 are two foot plates provided at the bottom of the box. Figure 7 shows that the thickness of the neck is different due to the difference in weight of the guinea pigs, so
This is an embodiment of the upper lid in which the size of the center hole 26 of the guinea pig is made into two different sizes, and one of the two types can be used depending on the difference in the weight of the guinea pig.
本考案のモルモツトボツクスは上述のように構
成されているので次に記載する効果を奏する。
Since the guinea pig box of the present invention is constructed as described above, it produces the following effects.
モルモツトの頭部を外に出し、体だけをボツク
スの内に入れてモルモツトをボツクスに固定する
際、ボツクスの前端面にモルモツトの頭部を通す
穴を設けた従来のようなボツクスでなく、ボツク
ス前端面部を上下２つに分けて、下半部端面と上
半部の上蓋端面に設けた弾性パツキン付の中心穴
部でモルモツト首部の周囲をおさえ込む構造を本
考案においては使用しているので、前者の頭部を
通す穴より小さな穴ですむため、ボツクス前端の
モルモツト首部周囲よりの空気漏れを防止でき
る。又モルモツトをボツクスに固定するとき、モ
ルモツトの首部をボツクス前端盲板の中心穴部２
７に入れ、モルモツトを片手でおさえながら他方
の手で上蓋２０をかぶせ、引掛け金具でボツクス
本体に止めれば、モルモツトを容易かつ迅速にボ
ツクスに固定することができるので、その作業は
従来のモルモツトボツクスよりも簡易に行うこと
ができる。又ボツクス前端面が前方に傾斜させて
いるのでモルモツトが前足を前方に楽にのばせる
姿勢で、モルモツトの呼吸生理測定を行うことが
できる。 When fixing the guinea pig in the box with the guinea pig's head outside and only the body inside the box, a box is used instead of a conventional box with a hole for the guinea pig's head to pass through on the front end of the box. The present invention uses a structure in which the front end is divided into upper and lower halves, and the center hole with elastic packing provided on the end of the lower half and the end of the upper lid of the upper half holds down the periphery of the neck of the guinea pig. Since the former requires a smaller hole than the hole through which the head passes, it is possible to prevent air leakage from around the guinea pig's neck at the front end of the box. Also, when fixing the guinea pig to the box, insert the neck of the guinea pig into the center hole 2 of the blind plate at the front end of the box.
7, hold the Morimotsu with one hand, cover the top cover 20 with the other hand, and secure the Morimotsu to the box body with the hook.The Morimotsu can be easily and quickly fixed to the box, so this work is no longer necessary than the conventional Morimotsu. It can be done more easily than boxing. Furthermore, since the front end surface of the box is tilted forward, the respiratory physiology of the guinea pig can be measured in a posture in which the guinea pig can comfortably extend its front legs forward.
第１図および第２図は従来のモルモツトボツク
スの構造説明図、第３図はモルモツトの気流速度
変動測定構造部の説明図、第４図および第５図は
本考案のモルモツトボツクスの構造説明図、第６
図は本考案モルモツトボツクス 実施例の斜視
図、第７図は本考案モルモツトボツクスのかぶせ
上蓋の実施例を示す。
１……円筒、３……円筒の一方の盲板、４……
正弦波圧注入パイプ、６……円筒の他方に当てる
長方形の板、７……ゴム板、８……円筒１と当板
６，７を固定する紐、１２……ラツパ状の当て
部、１３……連通細管部、１６1，１６2……気流
方向の２点１４1，１４2間の圧力差取出用パイ
プ、１５……金網、１７……モルモツトの口腔内
圧測定用の圧取出パイプ、１８……本考案の円筒
ボツクス、１９，２２……盲板、２０……かぶせ
上蓋、２１……止め金具、２３……モルモツト、
２５……正弦波圧注入パイプ、２６，２７……モ
ルモツトの首部をおさえる穴部、２８……弾性パ
ツキン、２９……ボツクス内圧取出用パイプ。
Figures 1 and 2 are structural explanatory diagrams of the conventional Morimotsuto box, Figure 3 is an explanatory diagram of the air velocity fluctuation measurement structure of the Morimotsu, and Figures 4 and 5 are structural illustrations of the Morimotsu box of the present invention. , 6th
The figure is a perspective view of an embodiment of the guinea pig box of the present invention, and FIG. 7 shows an embodiment of the top cover of the guinea pig box of the present invention. 1...Cylinder, 3...Blind plate on one side of the cylinder, 4...
Sine wave pressure injection pipe, 6... Rectangular plate applied to the other side of the cylinder, 7... Rubber plate, 8... Strap for fixing the cylinder 1 and the contact plates 6 and 7, 12... Laptop-shaped contact part, 13 . . . Communication thin tube portion, 16 1 , 16 2 . . . Pressure difference extraction pipe between two points 14 1 and 14 2 in the air flow direction, 15 …… Wire mesh, 17 . . . Pressure extraction pipe for measuring the intraoral pressure of guinea pigs, 18... Cylindrical box of the present invention, 19, 22... Blind plate, 20... Covering top lid, 21... Stopper, 23... Morimotsu,
25... Sine wave pressure injection pipe, 26, 27... Hole for holding the neck of the guinea pig, 28... Elastic packing, 29... Box internal pressure extraction pipe.
Claims (1)
注入側と反対側のボツクス前端面を後方に傾斜さ
せて約1/2の高さまで切り、それからボツクス軸
方向に後方に約1/3の長さ切り、さらに垂直に切
除した個所に、その切除した形状と同じ形状の上
蓋を載置し、この上蓋の前端面と切除されたボツ
クス前端面には同じ傾斜の盲板をそれぞれ接着
し、これら上下の両盲板の接合する中心部には、
モルモツトの首部を挟み固定する弾性パツキン付
の半円状の穴を設け、かつ上蓋とボツクス本体と
の間には引掛け止め金具を設けて両者を固定させ
てなる呼吸生理測定用モルモツトボツクス。 For a cylindrical Guinea box, cut the front end of the box on the side opposite to the sinusoidal pressure injection side by tilting it backwards to about 1/2 the height, then cut it backwards in the axial direction of the box to about 1/3 the length, and then An upper lid with the same shape as the excised part is placed on the vertically excised area, and a blind plate with the same slope is glued to the front end surface of this upper lid and the front end face of the excised box. At the center where the boards join,
This guinea pig box for measuring respiratory physiology is provided with a semicircular hole with an elastic gasket for holding and fixing the neck of the guinea pig, and a hook fitting is provided between the top lid and the box body to fix both.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9839188U JPH0319852Y2 (en) | 1988-07-27 | 1988-07-27 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9839188U JPH0319852Y2 (en) | 1988-07-27 | 1988-07-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0220520U JPH0220520U (en) | 1990-02-09 |
| JPH0319852Y2 true JPH0319852Y2 (en) | 1991-04-26 |
Family
ID=31324612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9839188U Expired JPH0319852Y2 (en) | 1988-07-27 | 1988-07-27 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0319852Y2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0569431U (en) * | 1992-02-25 | 1993-09-21 | 豊田工機株式会社 | Torsional damper |
-
1988
- 1988-07-27 JP JP9839188U patent/JPH0319852Y2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0220520U (en) | 1990-02-09 |
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