JPH03200713A - Composition for oral cavity application - Google Patents

Abstract

PURPOSE:To provide the subject composition for oral cavity application, containing an alkylsulfuric acid ester salt and a glucose fatty acid ester, having excellent foamability and feeling to the palate and exhibiting mild stimulation to the oral mucosa. CONSTITUTION:The objective composition is produced by using (A) an alkylsulfuric acid ester salt such as sodium laurylsulfate and sodium myristylsulfate and (B) a glucose fatty acid ester containing 8-14C acyl group as essential components and properly compounding with surfactant, abrasive, humectant, binder, sweetener, perfumery and drug component. The alkylsulfuric acid ester salt and the glucose fatty acid ester are used at a weight ratio of 1:4 to 4:1 and the sum of the substances is 0.01-10wt.%. The composition can be used in the form of tooth paste, wet dentifrice, liquid dentifrice, mouth wash, cleaning agent for denture, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to an oral composition that has excellent foaming properties and a feeling of use, and is mild in irritation to the oral mucosa.

[Prior art and problems to be solved by the invention] Oral compositions contain surfactants in order to enhance their cleaning power and provide a pleasant feeling when used. Surfactants used in such oral compositions have the effect of dispersing the oral composition in the mouth when used, the effect of promoting the dispersion and penetration of medicinal ingredients in the oral composition, and the effect of foaming into the oral cavity. In addition to the foam spreading effect, it is required to have a good taste and odor because it is used in one mouth, and to have a high degree of safety, such as having an extremely mild effect on the oral mucosa.

Conventionally, surfactants used in oral compositions include:
Anionic surfactants such as alkyl sulfate ester salts, fatty acid monoglyceride sulfate ester salts, α-olefin sulfonates, N-acyl sarcosine salts, and nonionic surfactants such as sucrose fatty acid esters are used.

However, alkyl sulfate salts, fatty acid monoglyceride sulfate salts, α-olefin sulfonate salts,
All of them are found to be irritating to the oral mucosa, to varying degrees, and each has an unpleasant taste and odor. Furthermore, although the taste of N-acyl sarcosine salts is improved, there is a problem of oral mucosal peeling. Furthermore, although sucrose fatty acid esters exhibit very high safety, they have problems with foaming properties and taste.

It has also been known to use glucose fatty acid ester as a foaming agent for toothpaste (International Publication W088
However, the foaming properties of glucose fatty acid esters are still insufficient, and in particular, the glucose fatty acid esters described in this publication have a low monoester content and contain a considerable amount of diesters, tri- or higher polyesters. Therefore, there are problems in terms of taste, effervescence, etc.

Therefore, there is a need for a surfactant that can be used in oral compositions and has the original function of a surfactant of increasing cleaning power, as well as being highly safe, foaming, and having a good feel when used. .

[Means and effects for solving the problem] As a result of extensive studies in order to meet the above-mentioned needs, the inventors of the present invention discovered that an alkyl sulfate ester salt such as sodium lauryl sulfate or sodium myristyl sulfate and an acyl group having a carbon number of 8 - 14, particularly in a ratio of 1:4 to 4:
It has been found that it is effective to use them together at a weight ratio of 1.

That is, the combination of an alkyl sulfate salt and a glucose fatty acid ester, and in this case, preferably a monoester having one acyl group in one molecule as a glucose fatty acid ester (in the present invention, a monoester refers to a monoester (meaning a content of 90% by weight or more) provides the excellent cleaning power required as a surfactant for oral compositions, and also has good foaming properties and good taste. We have discovered that it has an excellent feel when used, and that by using these active agents in combination, the irritation to the oral mucosa, which is a disadvantage when using alkyl sulfate ester salts, can be significantly reduced, and we have achieved the present invention. It is something that

The present invention will be explained in more detail below.

The oral composition according to the present invention is prepared and applied as a toothpaste, a moist toothpaste, a liquid toothpaste, a mouthwash, a denture cleaner, etc., and is prepared by using a combination of an alkyl sulfate salt and a glucose fatty acid ester. This is what happens.

Here, the alkyl sulfate ester salt used in the present invention is preferably a sulfate ester salt of a saturated or unsaturated alcohol having 8 to 18 carbon atoms, and more preferably a sulfate ester salt of a saturated or unsaturated alcohol having 8 to 18 carbon atoms.
-14 alcohol sulfate ester salts. Specifically, sodium lauryl sulfate, sodium myristyl sulfate, etc. are preferably used.

On the other hand, the glucose fatty acid ester used in the present invention is obtained from glucose and a fatty acid having 8 to 14 carbon atoms or a fatty acid derivative such as a lower alkyl ester thereof. Those with less than 8 carbon atoms taste bad, and 1
A value larger than 4 is not preferable because it reduces foaming properties.

In this case, the raw material glucose can be one obtained by hydrolyzing naturally-obtained glucose, starch from corn, potato, or other polysaccharides with acid or enzymes, and then decolorizing and purifying this.

Examples of such substances include crystalline glucose, powdered glucose, and granular glucose defined by JAS.

On the other hand, any fatty acid having 8 to 14 carbon atoms can be suitably used regardless of whether it is naturally synthesized, saturated, unsaturated, straight chain 9-branched, single, or mixed. Furthermore, as lower esters of fatty acids, methyl, ethyl,
Alkyl esters having 1 to 8 carbon atoms such as propyl can be used, and halides of fatty acids can also be used as raw materials.

Glucose fatty acid ester is produced using these raw materials.
Methods such as ester synthesis using lipase, for example, transesterification reaction between raw oil and fat and glucose, transesterification reaction between lower alcohol esters of fatty acids and glucose, ester synthesis between fatty acids and glucose, and further using fatty acid chloride and glucose. It is preferable to synthesize by a synthetic method or various other known methods.

In this case, in the present invention, the glucose fatty acid ester has a monoester content of 90% or more, particularly 95%.
It is preferable to use the above glucose fatty acid ester in order to achieve the above-mentioned object of the present invention, and the content of polyester of triester or higher is 1% or less, particularly 0.5%.
% or less, but the above-mentioned known methods all produce esters with a low monoester content and a high tri- or higher polyester content, so when obtaining a monoester, fractionation after synthesis, Isolation may be time-consuming. Therefore, in this respect, the method using heat-stable lipase, which was previously proposed by the present applicant in Japanese Patent Application No. 1-210495, is preferably adopted for the production of monoester.

In addition, as a glucose fatty acid monoester, the following formula (f
) is preferred.

(In the formula, R represents a residue of a saturated or unsaturated fatty acid having 8 to 14 carbon atoms.) Such glucose fatty acid monoesters include glucose monocaprylate, glucose monocaprate, glucose monolaurate, glucose Examples include monomyristate, glucose monoundecylenate, glucose mono-2-ethyl octanate, and the like.

In addition, in the present invention, one type of the above-mentioned glucose fatty acid ester may be used alone, or two or more types may be used in combination.

The alkyl sulfate salt and glucose fatty acid ester have a weight ratio of 1:4 to 4:1, particularly 1:3 to 2:1.
It is preferable to use them together at a weight ratio of . The above ratio is 174
If the proportion of glucose fatty acid ester increases beyond 4/1, the foaming properties may deteriorate, and conversely, if the proportion of alkyl sulfate ester salt increases beyond 4/1, the effect of reducing irritation to the oral mucosa may not be sufficiently observed. There are cases.

In this case, the total amount of alkyl sulfate salt and glucose fatty acid ester is 0.01 to 10
% (weight %, the same applies hereinafter), more preferably 0.1 to 5%.

In addition to the above-mentioned components, the oral composition of the present invention can contain various components depending on the type thereof.

For example, other surfactants, such as other anionic surfactants and fatty acid monoglycerides, as long as they do not impair the effects of the glucose fatty acid ester.

Nonionic surfactants such as fatty acid alkanolamide, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, sucrose fatty acid ester, amphoteric surfactants such as alkyl betaine, imidazolinium betaine, alkyl sulfobetaine, alkylamines Examples include semipolar surfactants such as oxides, and these 1
It can be used as a species or in combination of two or more species.

Furthermore, toothpastes contain abrasives such as dicalcium phosphate, calcium carbonate, calcium pyrophosphate, insoluble sodium metaphosphate, aluminum hydroxide, and silicic anhydride, wetting agents such as glycerin, sorbitol, propylene glycol, and polyethylene glycol, and carboxymethyl cellulose. Sodium, carrageenan, sodium alginate, vegum, hydroxyethyl cellulose, xanthan gum, binders such as sodium polyacrylate, sodium saccharin, glycyrrhizin salts, stevioside,
Sweeteners such as paramethoxycinnamic aldehyde, neohesberidyl dihydrochalcone, perilartine, and flavoring agents such as menthol, carvone, and anethole are used.
Furthermore, if necessary, use sodium monofluorophosphate, sodium fluoride, fluorides such as fluoride, and tranexamic acid.

Medicinal ingredients such as anti-inflammatory agents such as ε-aminocaproic acid and allantoinate, and phosphoric acid compounds such as sodium phosphate are used as appropriate.

Further, other oral compositions may similarly be formulated with commonly used ingredients, and these oral compositions may be prepared according to conventional methods.

〔Effect of the invention〕

The oral composition according to the present invention uses an alkyl sulfate salt and a glucose fatty acid ester in combination, so that
It has excellent foaming properties, feels good in use, and has significantly reduced irritation to the oral mucosa.

Next, the effects of the present invention will be specifically explained using experimental examples.

[Experimental Example 1] Using a mixed aqueous solution of sodium lauryl*ate and glucose-6-nocaprate in the ratios shown in Table 1, a 20 panelist conducted a hydration test to determine the irritation and sludge content in animals. The discomfort that remained on the oral mucosa after rinsing with water was evaluated. The test results are shown in Table 1. The numbers in the evaluation results column in the table indicate the number of people who complained of irritation or discomfort.

Table 1 As shown in Table 1, it was found that the combined use of sodium lauryl sulfate and glucose-6-Motsuka plate significantly reduced irritation to the oral mucosa.

[Experimental Example 2] Using the foaming agents (surfactants) shown in Table 2, a toothpaste composition having the following formulation was prepared in a conventional manner. The foamability of these toothpaste compositions was evaluated by the following method.

Button category I value Weight % Dibasic calcium phosphate 45.0 Silicic anhydride 3.0 Sodium carboxymethyl cellulose 0.8 Carrageenan 0.2 Sorbiturate liquid
26.0 Propylene glycol 3.0 Saccharin sodium
0.2 fragrance
1.0 blowing agent
2.0 Purified Water Remaining Meter 100.0 101 Ships IL Group Using the toothpaste composition prepared according to the above formulation, a toothpaste test was conducted by five well-trained expert panelists, and based on the following evaluation criteria: Foaming properties were evaluated.

Foaming property evaluation criteria O: Good foaming property 0: Moderate foaming property Δ: Slightly foaming property It was observed that when sodium and glucose-6-Motsuka plate were used together, high foaming properties and weak oral mucosal irritation were exhibited.

Examples will be shown below, but the present invention is not limited to the following examples.

[Example 1] Toothpaste formulation Weight % Aluminum hydroxide 40.0 Silicic anhydride 2.0 Propylene glycol 3.0 Sorbitous solution
26.0 Sodium alginate 1.0 Saccharin sodium 0.2 Glucose-6-motlaurate 0.7 Sodium lauryl am
0.7 fragrance
1.0 Preservative Trace amount 100.0 [Example 2] Toothpaste formulation Dibasic calcium phosphate Sodium carboxymethyl cellulose anhydrous silicate Carrageenan Propylene glycol Sorbitol liquid Saccharin Sodium monofluorophosphate Glucose-6-monolaurate Sodium lauryl sulfate Fragrance Preservative Purified water [Example 3] Toothpaste formulation Dibasic calcium phosphate Silicic anhydride weight% 45.0 3.0 1.0 0.2 3.0 26, O O,2 0,76 1,0 0 ,5 1,0 Trace remaining weight % 45゜3゜Aluminum oxide propylene glycol sorbitol Sodium carboxymethylcellulose Carrageenan Sodium saccharin Glucose-6-monocaprate Sodium lauryl sulfate 7 Lantoin Chlorhydroxyaluminum Flavor Preservative 1.0 3.0 25.0 0.8 0.3 0.2 1.0 0.5 0, 1 1.0 Trace meter [Example 4] Toothpaste Zirconosilicate Polyethylene glycol silicate anhydride 400 Sorbitol liquid Sodium carboxymethyl cellulose 100.0 15.0 2.0 3.0 60.0 1.4 Sodium saccharin glucose-6-monocaprylate Sodium lauryl sulfate β-glycyrrhetinic acid Tocopherol acetate Fragrance Color Pure purified water meter [Example 5] Toothpaste formulation Aluminosilicate Glycerin sorbitol Polyethylene glycol 400 Sodium carboxymethyl cellulose Sodium saccharin Glucose-6-monocaprate Sodium lauryl sulfate Flavor 0.2 1.5 0.5 0.01 0, 1 1.0 Trace amount remaining 100, 0 Weight 20° 15° 40゜4゜1゜0゜1゜0゜1゜ Color Pure purified water toothpaste formula Calcium carbonate (heavy) Calcium carbonate (light) Propylene glycol sorbitol Sodium carboxymethyl cellulose Saccharin Sodium Glucose tranexamate 6-monocaprylate Myristyl Sodium sulfate fragrance preservative [Example 6] Total [Example 7] Junsei toothpaste trace amount remaining weight % 30, O 15,0 3,0 30,0 1,0 0,1 0,1 1,5 0 ,5 1,0 Trace amount 100° Prescription Dibasic calcium phosphate Calcium carbonate Glycerin Sodium carboxymethyl cellulose Sodium saccharin Glucose-6-monolaurate Sodium lauryl sulfate Flavor Purified water Weight % 35.0 40, 0 10, O O, 3 0, 2 1,0 0,5 1,5 Remaining amount Sodium lauryl sulfate fragrance purified water

Claims (1)

[Claims] 1. Alkyl sulfate salt and acyl group with 8 carbon atoms
An oral composition characterized in that it is formed in combination with a glucose fatty acid ester of ~14.