JPH03200717A - Oral composition - Google Patents

Abstract

PURPOSE:To obtain a composition for oral cavity application containing sodium chloride, useful for the prevention of periodontosis and foul breath and having excellent foamability and aging stability by compounding a glucose fatty acid ester to sodium chloride. CONSTITUTION:A glucose fatty acid salt is compounded to an oral cavity composition containing sodium chloride. The glucose fatty acid ester is preferably an ester having a monoester content of >=90%, especially >=95%. The amount of the ester in the composition is usually 0.1-10%, especially 0.5-5%.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a sodium chloride-containing oral composition, and more specifically to a sodium chloride-containing oral composition with good foamability and stability over time.

[Prior art and problems to be solved by the invention] In addition to the original function of removing food residue after meals, cleaning the oral cavity, and preventing the occurrence of dental caries, oral compositions also have the following functions: There is a demand for higher functionality such as preventing periodontal disease and bad breath.

For this reason, it has been proposed to incorporate various medicinal ingredients into oral compositions. Among them, sodium chloride has been shown to have moderate bacteriostatic and bactericidal effects, and to suppress swelling of the gums caused by gingivitis. Highly effective in tightening the gums,
Moreover, it is often added to toothpastes because of its excellent properties such as its excellent refreshing feeling after use.

However, sodium chloride is a strong electrolyte substance, and when added in large amounts, it causes problems such as destroying the emulsification and dispersion system, causing separation, suppressing the foaming properties of the surfactant, and significantly reducing the feeling of use.

To address this problem, conventional techniques have included increasing the amount of anionic surfactant used as a foaming agent.

The solution has been to incorporate large amounts of nonionic surfactants to improve stability. However, this method of using large amounts of surfactants causes other problems such as significantly degrading the taste of the oral composition and irritating the oral mucosa, so countermeasures are not always sufficient. isn't it.

Therefore, there has been a need for a highly safe oral care composition that improves the foamability and stability over time of a sodium chloride-containing oral care composition, has a good feeling in use, and does not cause problems of oral mucosal irritation.

[Means and effects for solving the problem] As a result of extensive studies to achieve the above object, the present inventor has determined that glucose fatty acid ester is blended as a foaming agent into an oral composition containing sodium chloride. was found to be effective.

That is, when a glucose fatty acid ester, especially a glucose fatty acid ester whose acyl group has 8 to 14 carbon atoms, is blended into a sodium chloride-containing oral composition, foaming properties are inhibited even if a large amount of sodium chloride is blended. The present inventors have found that the composition does not suffer from liquid separation even after long-term storage. In addition, the above-mentioned glucose fatty acid ester is not bitter and does not make the taste of the oral composition bad, and it does not irritate the oral mucosa and is highly safe, so there are no problems even when using it in large quantities. Therefore, the present invention has been made based on the discovery that the combination of sodium chloride effectively provides a refreshing feeling after use and provides an excellent oral composition that has the effect of sodium chloride in reducing swelling of the gums. This is what we have come to.

The present invention will be explained in more detail below.

The oral composition according to the present invention is prepared and applied as a toothpaste, a moist toothpaste, a liquid toothpaste, a mouthwash, a denture cleaner, etc., and is made by combining sodium chloride with glucose fatty acid ester. It is.

Here, in the present invention, the amount of sodium chloride blended is not particularly limited, but is 1 to 30% of the entire composition.
(wt%, the same applies hereinafter) is preferable, particularly preferably 5 to
It is 20%. As sodium chloride, any of those obtained by simply concentrating and drying seawater, those obtained by ion exchange membrane method, crushed rock salt, and those purified by various chemical methods can be used. .

The glucose fatty acid ester used in the present invention is preferably one obtained from glucose and a fatty acid having 8 to 14 carbon atoms or a fatty acid derivative such as a lower alkyl ester thereof from the viewpoint of taste and effervescence.

In this case, the raw material glucose can be one obtained by hydrolyzing naturally-obtained glucose, starch from corn, potato, or other polysaccharides with acid or enzymes, and then decolorizing and purifying this.

Examples of such substances include crystalline glucose, powdered glucose, and granular glucose defined by JAS.

On the other hand, the fatty acid preferably has 8 to 14 carbon atoms, and can be suitably used regardless of whether it is natural, 2-synthesized, saturated, unsaturated, straight-chain 2-branched, single, or mixed. Further, as the lower ester of the fatty acid, an alkyl ester having 1 to 8 carbon atoms such as methyl, ethyl, and propyl of the above-mentioned fatty acids can be used, and a halogenated fatty acid can also be used as the raw material.

Glucose fatty acid ester is produced using these raw materials.
Ester synthesis using lipase etc. 1 For example, methods such as transesterification between raw oil and fat and glucose, transesterification between lower alcohol esters of fatty acids and glucose, ester synthesis between fatty acids and glucose, and further using fatty acid chloride and glucose. It is preferable to synthesize by a synthetic method or various other known methods.

In this case, in the present invention, the glucose fatty acid ester has a monoester content of 90% or more, particularly 95%.
It is preferable to use the above glucose fatty acid ester in order to achieve the above-mentioned object of the present invention, and the content of polyester of triester or higher is 1% or less, particularly 0.5%.
% or less, but the above-mentioned known methods all produce esters with a low monoester content and a high tri- or higher polyester content.

When obtaining a monoester, it may take time and effort to perform fractionation and isolation after synthesis. Therefore, in this respect, the method using heat-stable lipase, which was previously proposed by the present applicant in Japanese Patent Application No. 1-210495, is preferably adopted for the production of monoester.

In addition, as glucose fatty acid monoester, the following formula (1
) is preferred.

(In the formula, R represents a residue of a saturated or unsaturated fatty acid having 8 to 14 carbon atoms.) Examples of such glucose fatty acid monoester include glucose monocaprylate, glucose monocaprate, glucose monolaurate, and glucose monolaurate. Examples include myristate, glucose monoundecylenate, glucose mono-2-ethyl octanate, and the like.

In addition, in the present invention, one type of the above-mentioned glucose fatty acid ester may be used alone, or two or more types may be used in combination.

The amount of glucose fatty acid ester blended can be selected in various ways, but it is usually 0.1 to 10% of the total composition, especially 0.
．． It is 5-5%.

In addition to the above-mentioned components, the oral composition of the present invention can contain various components depending on the type thereof.

For example, other surfactants may be blended within a range that does not impair the effects of the glucose fatty acid ester. Examples of such surfactants include anionic surfactants such as alkyl sulfate ester salts and N-acylamino acid salts, and fatty acid monoglycerides.

Nonionic surfactants such as fatty acid alkanolamide, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, sucrose fatty acid ester, amphoteric surfactants such as alkyl betaine, imidazolinium betaine, alkyl sulfobetaine, alkylamines Examples include semipolar surfactants such as oxides, and these 1
A species or a combination of two or more species can be used.

Furthermore, toothpastes contain abrasives such as dicalcium phosphate, calcium carbonate, calcium pyrophosphate, insoluble sodium metaphosphate, aluminum hydroxide, and silicic anhydride, wetting agents such as glycerin, sorbitol, propylene glycol, and polyethylene glycol, and carboxymethyl cellulose. Sodium, carrageenan, sodium alginate, vegum, hydroxyethyl cellulose, xanthan gum, binders such as sodium polyacrylate, sodium saccharin, glycyrrhizin salts, stevioside,
Sweeteners such as paramethoxycinnamic aldehyde, neohesberidyl dihydrochalcone, perilartine, and flavoring agents such as menthol, carvone, and anethole are used.
Furthermore, if necessary, fluorides such as sodium monofluorophosphate, sodium fluoride, and tin fluoride, and tranexamic acid.

Medicinal ingredients such as anti-inflammatory agents such as ε-aminocaproic acid and allantoinate, and phosphoric acid compounds such as sodium phosphate are used as appropriate.

Further, other oral compositions may similarly be formulated with commonly used ingredients, and these oral compositions may be prepared according to conventional methods.

〔Effect of the invention〕

The oral composition according to the present invention has good foaming properties even if a large amount of sodium chloride is blended, has excellent feel and feel when used, is resistant to liquid separation, and has high stability over time. It is.

Next, the effects of the present invention will be specifically explained using experimental examples.

[Experiment example]

A toothpaste composition having the following formulation was prepared using the foaming agent (surfactant) shown in Table 1. The foamability and stability over time of these toothpaste compositions were evaluated by the following methods. Results first
Shown in the table.

Kurezatsu Naosei Kotoyo Yotomo Weight% dicalcium phosphate 45.0 Silicic anhydride
3.0 Carrageenan sorbit solution Propylene glycol Sodium saccharin Flavor Sodium chloride Foaming agent 0.2 26, 0 3, 0 0.2 1.0 Amount shown in Table 1 Amount shown in Table 1 Water Positioning needle 100.0 1υ
i Dilute 1 g of the toothpaste composition prepared according to the above recipe 20 times with ion-exchanged water at 25°C, put it in a 100D colorimetric tube with a sealed stopper, shake it 20 times for 10 seconds, and measure the foam volume after 5 minutes. was measured, and this was taken as the foaming amount.

100 ml of the toothpaste composition prepared according to the above formulation was packed into a roomQ colorimetric tube with a seal, and the tube was heated at 50°C while standing vertically.
After storage for one month, the amount of liquid separated into the upper layer was measured.

As shown in Table 1, toothpaste compositions using glucose fatty acid ester as a foaming agent maintain high foaming properties even in the presence of high concentrations of sodium chloride.

Furthermore, it was observed that the amount of liquid separated was very small and showed good stability over time. On the other hand, sodium lauryl sulfate and sucrose fatty acid ester, which have conventionally been commonly used as foaming agents for toothpaste, have significantly reduced foaming properties and also deteriorated stability over time when sodium chloride coexists.

Examples will be shown below, but the present invention is not limited to the following examples.

[Example 1] Toothpaste ingredient weight % 2nd
Calcium phosphate 41.0 carrageenan
0.2 sorbitol solution
26.0 Propylene glycol 3.0
Satucharin Sodium 0.2 Sodium Chloride 15.0 Flavor Preservative Ice Maker [Example 2] Toothpaste Ingredients Zirconosilicate Anhydrous Polyethylene Glycol Silicate 400 Sorbitol Saccharin Sodium Chloride Flavor Color Basic Preservative 1.0 Trace amount Amount 100.0 Weight % 15.0 2.0 3.0 60.0 0.2 5.0 1.0 Trace trace water meter [Example 3] Toothpaste ingredients Aluminum hydroxide Aluminum oxide Sodium alginate Sorbiturate Glycerin Propylene Glycol Saccharin Sodium Monofluorophosphate Sodium Chloride Flavor Preservative Purified Water Meter [Example 4] Toothpaste Ingredients 100° Weight % 40.0 2.0 1.0 15.0 10.0 3.0 0. 2 0.76 10, O 1.

slight weight% Calcium carbonate (heavy) Calcium carbonate (light) Propylene glycol sorbitol liquid saccharin sodium tranexamic acid sodium chloride fragrance Preservative purified water total [Example 5] Toothpaste Completed Dibasic calcium phosphate Silicic anhydride carrageenan carboxymethyl cellulose 30° 15° 3゜ 30° 0, 1 0, 1 10, 0 1.0 Very small amount amount 100.0 weight% 40.0 2.0 0.8 0.2 sodium Propylene glycol sorbitol liquid tranexamic acid 3,0 26,0 0.1 sodium chloride saccharin sodium fragrance Preservative

Claims (1)

[Claims] 1. An oral composition characterized in that a glucose fatty acid ester is blended into an oral composition containing sodium chloride.