JPH0321006B2 - - Google Patents
Info
- Publication number
- JPH0321006B2 JPH0321006B2 JP56138524A JP13852481A JPH0321006B2 JP H0321006 B2 JPH0321006 B2 JP H0321006B2 JP 56138524 A JP56138524 A JP 56138524A JP 13852481 A JP13852481 A JP 13852481A JP H0321006 B2 JPH0321006 B2 JP H0321006B2
- Authority
- JP
- Japan
- Prior art keywords
- weight
- composition
- glycine
- sodium
- diarrhea
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 26
- 239000000203 mixture Substances 0.000 claims description 26
- 239000000843 powder Substances 0.000 claims description 14
- 239000004471 Glycine Substances 0.000 claims description 13
- 206010012735 Diarrhoea Diseases 0.000 claims description 12
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 10
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 10
- 229920002907 Guar gum Polymers 0.000 claims description 9
- 239000000665 guar gum Substances 0.000 claims description 9
- 235000010417 guar gum Nutrition 0.000 claims description 9
- 229960002154 guar gum Drugs 0.000 claims description 9
- 235000013372 meat Nutrition 0.000 claims description 8
- 244000144972 livestock Species 0.000 claims description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 6
- 239000008103 glucose Substances 0.000 claims description 6
- 239000001103 potassium chloride Substances 0.000 claims description 5
- 235000011164 potassium chloride Nutrition 0.000 claims description 5
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 5
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 4
- 239000001509 sodium citrate Substances 0.000 claims description 4
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 4
- 239000001508 potassium citrate Substances 0.000 claims description 3
- 229960002635 potassium citrate Drugs 0.000 claims description 3
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims description 3
- 235000011082 potassium citrates Nutrition 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000003792 electrolyte Substances 0.000 description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 4
- 235000019629 palatability Nutrition 0.000 description 4
- 235000002639 sodium chloride Nutrition 0.000 description 4
- 208000010444 Acidosis Diseases 0.000 description 3
- 230000007950 acidosis Effects 0.000 description 3
- 208000026545 acidosis disease Diseases 0.000 description 3
- 235000015278 beef Nutrition 0.000 description 3
- 244000309466 calf Species 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 229960003975 potassium Drugs 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 1
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 229920006184 cellulose methylcellulose Polymers 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- GBCAVSYHPPARHX-UHFFFAOYSA-M n'-cyclohexyl-n-[2-(4-methylmorpholin-4-ium-4-yl)ethyl]methanediimine;4-methylbenzenesulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1.C1CCCCC1N=C=NCC[N+]1(C)CCOCC1 GBCAVSYHPPARHX-UHFFFAOYSA-M 0.000 description 1
- 235000006286 nutrient intake Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Description
【発明の詳細な説明】 上記組成よりなる家畜下痢治療用組成物。[Detailed description of the invention] A composition for treating livestock diarrhea comprising the above composition.
本発明は、家畜の下痢を治療するための経口組
成物に関するものである。 The present invention relates to oral compositions for treating diarrhea in livestock.
一般に、仔牛や子豚などの家畜が下痢をすると
大量の水分や重炭酸塩、ナトリウム、カリウム等
が体内から失われそのまま放置すると、アシドー
シスを起す場合が多い。また下痢により栄摂取量
が低下すると、慢性的栄養不良や肺炎その他の感
染症に罹病しやすく、死亡する場合もあり、いず
れにしても、経済的損失は大きいものとなつてし
まう。 Generally, when livestock such as calves and piglets have diarrhea, large amounts of water, bicarbonate, sodium, potassium, etc. are lost from the body, and if left untreated, acidosis often occurs. In addition, when nutrient intake decreases due to diarrhea, people are more susceptible to chronic malnutrition, pneumonia and other infectious diseases, and may even die, resulting in large economic losses.
そこで、仔牛、子豚等の家畜が下痢をしたと
き、できるだけ早く治療するために、電解質物質
を供給する方法がとられるようになつて来た。一
例をあげると、消化管からの吸収が最大になるよ
う、ぶどう糖、グリシン、ナトリウム等の電解質
を含む等張液を経口投与する方法がある。そし
て、そのための組成物も一部市販されているが、
治療効果は、十分満足できることは言い難いもの
であつた。 Therefore, in order to treat livestock such as calves and piglets as soon as possible when they have diarrhea, methods have been adopted to supply electrolytes. One example is the oral administration of an isotonic solution containing electrolytes such as glucose, glycine, and sodium to maximize absorption from the gastrointestinal tract. Although some compositions for this purpose are commercially available,
The therapeutic effect was hardly satisfactory.
本発明者らは、これらの観点から、よりすぐれ
た家畜下痢治療用組成物を求めて研究した結果、
下記の組成物がすぐれた家畜の下痢治療効果を示
すことを見出した。 From these viewpoints, the present inventors conducted research in search of a better composition for treating livestock diarrhea, and found that
It has been found that the following composition exhibits an excellent therapeutic effect on diarrhea in domestic animals.
ぶどう糖 39〜47重量％
グリシン及び肉エキス
粉末混合物 10〜30重量％
食塩 ５〜15重量％
グアガム ６〜30重量％
塩化カリウム 1.8〜６重量％
炭酸水素ナトリウム及び／又は
クエン酸ナトリウム又は
クエン酸カリウム ３〜10重量％
本発明の組成物は、一般に組成物30〜50ｇを１
の水に溶解させて経口投与される。本発明の組
成物は、失われた水分と電解質を迅速かつ効率的
に補給し、アシドーシスを防ぐ効果がより良好で
あることを臨床実験で確認される。 Glucose 39-47% by weight Glycine and meat extract powder mixture 10-30% by weight Salt 5-15% by weight Guar gum 6-30% by weight Potassium chloride 1.8-6% by weight Sodium bicarbonate and/or Sodium citrate or Potassium citrate 3 ~10% by weight The compositions of the present invention generally contain 30 to 50 g of the composition.
It is dissolved in water and administered orally. It has been confirmed in clinical experiments that the composition of the present invention quickly and efficiently replenishes lost water and electrolytes and is more effective in preventing acidosis.
本発明においては、ぶどう糖とナトリウムイオ
ン濃度比、ナトリウムとカリウムイオンの比率を
適正化しグリシンと肉エキス粉末の併用により嗜
好性と栄養性の向上をはかり、炭酸水素ナトリウ
ムあるいは、くえん酸ナトリウム（又はカリウム
塩）の添加によりアシドーシスを防ぎ、腸内通過
速度を遅延させ、電解質の吸収率を向上させるた
めグアガムを添加することを特長とするものであ
る。 In the present invention, we aim to improve palatability and nutritional properties by optimizing the glucose to sodium ion concentration ratio and the sodium to potassium ion concentration ratio, and by using glycine and meat extract powder in combination. It is characterized by the addition of guar gum to prevent acidosis, slow the rate of intestinal transit, and improve the absorption rate of electrolytes.
本発明組成物において、特に特色とするところ
はグリシンと肉エキス粉末の併用とグアガムの添
加にある。 The composition of the present invention is particularly characterized by the combination of glycine and meat extract powder and the addition of guar gum.
一般に、家畜用整腸剤としてペクチン、CMC、
アルギン酸、キサンタンガムが用いられることも
あるが、溶解性、溶解時の粘度、価格等を総合し
て判断した場合、グアガムが最も良好である。グ
アガムを経口輸液に使用するという報告はこれま
で例がなく、新規である。 Generally, pectin, CMC,
Alginic acid and xanthan gum are sometimes used, but guar gum is the best when considering solubility, viscosity when dissolved, price, etc. There have been no previous reports of the use of guar gum for oral infusion, and this is new.
本発明組成物においてはグリシンと肉エキス粉
末は必ず併用して10〜30重量％用いられるが、そ
の量比はグリシン：肉エキス粉末＝10：１〜１：
２程度で、グリシンを多量とするのが好ましい。 In the composition of the present invention, glycine and meat extract powder are always used in combination in an amount of 10 to 30% by weight, and the ratio of glycine to meat extract powder is 10:1 to 1:
It is preferable to use a large amount of glycine, about 2.
炭酸水素ナトリウムは、水分存在下で炭酸ガス
を放出しやすいため、製品水分を２％以下にする
必要がある。また、その一部または全量をくえん
酸ナトリウムあるいはくえん酸カリウムに置換し
てもよい。 Sodium hydrogen carbonate easily releases carbon dioxide gas in the presence of moisture, so the moisture content of the product needs to be 2% or less. Further, part or all of it may be replaced with sodium citrate or potassium citrate.
本発明組成物は、長期保存可能な乾燥粉末ある
いは顆粒状の形で供給され、使用時一定量の水ま
たは温湯に溶解するものである。 The composition of the present invention is supplied in the form of a dry powder or granules that can be stored for a long period of time, and is dissolved in a certain amount of water or hot water when used.
以下に本発明の組成物について、更に、詳細な
説明を加える。 A more detailed explanation of the composition of the present invention will be given below.
家畜の下痢を効果的に治療するために、主要電
解質ナトリウムは、70〜110mEq／、カリウム
は、10〜30mEq／、塩素は60〜100mEq／、
炭酸水素イオンは、15〜45mEq／（くえん酸
塩で代替する場合も同濃度）の範囲に入れるよう
に配合する。これを配合原料百分率に換算する
と、食塩５〜15％、塩化カリウム1.8〜６％、炭
酸水素ナトリウム（またはくえん酸塩）３〜10％
になる。ぶどう糖は、重量に基づき47％以下で、
望ましくは、ナトリウムの吸収が良い50〜
60nEq／（粉末製品で39〜47％）が最適であ
る。グリシンは、肉エキス粉末（牛肉エキス粉末
が最良）と混合使用した方が嗜好性の点でよく、
下痢治療効果もグリシン単独と差がない。グリシ
ンと肉エキス粉末の混合比は、10：１〜１：２の
範囲が良く、添加量は混合物として製品中10〜30
％が適している。10％未満の添加量では、嗜好
性、治療効果が低下するため、一方30％以上にす
ると治療効果が低下するため不適当である。電解
質組成は添加原料すべてを考慮して前記濃度範囲
に入るようにし、製品溶解時の浸透圧は280〜
500mOsm／に調整する。 To effectively treat diarrhea in livestock, the main electrolytes sodium should be 70-110 mEq/, potassium 10-30 mEq/, chlorine 60-100 mEq/,
The hydrogen carbonate ion is mixed in a range of 15 to 45 mEq/(same concentration when replacing with citrate). Converting this into percentages of raw materials, common salt 5-15%, potassium chloride 1.8-6%, sodium bicarbonate (or citrate) 3-10%
become. Glucose is less than 47% by weight;
Preferably 50 to 50, which has good sodium absorption.
60nEq/(39-47% for powder products) is optimal. Glycine is better when mixed with meat extract powder (beef extract powder is best) in terms of palatability.
The diarrhea treatment effect is also similar to that of glycine alone. The mixing ratio of glycine and meat extract powder is preferably in the range of 10:1 to 1:2, and the amount added is 10 to 30% in the product as a mixture.
% is suitable. If the amount is less than 10%, the palatability and therapeutic effect will decrease, while if it is more than 30%, the therapeutic effect will decrease, which is inappropriate. The electrolyte composition should be within the above concentration range considering all added raw materials, and the osmotic pressure when dissolving the product should be 280 ~
Adjust to 500mOsm/.
グアガムは、溶解時の溶液粘度が1000〜
5000cp（35℃）になるように製品中に６〜30％添
加したとき、腸内通過時間が10ml／分以下になり
電解質の吸収が良くなる。６％未満の添加量では
粘度が低く、一方30％以上添加すると粘度が
5000cp以上となり不均一な組織になるため不適
当である。 Guar gum has a solution viscosity of 1000~ when dissolved.
When 6 to 30% is added to the product to give a concentration of 5000 cp (35°C), the intestinal transit time becomes 10 ml/min or less, improving electrolyte absorption. If the amount added is less than 6%, the viscosity will be low, while if it is added more than 30%, the viscosity will be low.
It is unsuitable because it exceeds 5000cp and results in a non-uniform structure.
本発明組成物は一般に粉末又は顆粒状で供給さ
れ、使用時には１の温湯又は水で組成物30〜50
ｇを溶解して経口投与される。 The composition of the present invention is generally supplied in the form of powder or granules, and when used, the composition is mixed with 1 part of warm water or water for 30 to 50 parts of the composition.
g is dissolved and administered orally.
本発明組成物の経口投与によつて、家畜の下痢
を短期間に治療することができるものである。 Diarrhea in domestic animals can be treated in a short period of time by oral administration of the composition of the present invention.
以下に実施例について述べる。 Examples will be described below.
実施例 １
無水結晶ぶどう糖 40％
グアガム 25
グリシン 14
食塩 ８
炭酸水素ナトリウム ６
塩化カリウム ４
牛肉エキス粉末 ３
上記混合物40ｇを１の温水に溶解し、下痢の
仔牛に１日３回１ずつ投与した所、嗜好性がよ
く、投与開始後３日目には正常便にもどつた。ま
た、上記混合物は防湿性の良い袋に充填し密封し
たものは、常温４カ月保存しても、特に異常は認
められなかつた。Example 1 Anhydrous crystalline glucose 40% Guar gum 25 Glycine 14 Salt 8 Sodium bicarbonate 6 Potassium chloride 4 Beef extract powder 3 40 g of the above mixture was dissolved in 1 warm water and administered to a calf with diarrhea 3 times a day. It had good palatability, and stool returned to normal on the third day after the start of administration. Further, when the above mixture was filled into a bag with good moisture resistance and sealed, no abnormality was observed even when the bag was stored at room temperature for 4 months.
実施例 ２
無水結晶ぶどう糖 42％
グアガム 25
グリシン 12
食塩 ７
くえん酸ナトリウム ５
塩化カリウム ５
牛肉エキス粉末 ４
上記混合物も実施例１同様、治療効果があり、
保存性も良好であつた。Example 2 Anhydrous crystalline glucose 42% Guar gum 25 Glycine 12 Salt 7 Sodium citrate 5 Potassium chloride 5 Beef extract powder 4 The above mixture also has a therapeutic effect as in Example 1,
The storage stability was also good.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56138524A JPS5839625A (en) | 1981-09-04 | 1981-09-04 | Composition for remedying diarrhea of domestic animal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56138524A JPS5839625A (en) | 1981-09-04 | 1981-09-04 | Composition for remedying diarrhea of domestic animal |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5839625A JPS5839625A (en) | 1983-03-08 |
| JPH0321006B2 true JPH0321006B2 (en) | 1991-03-20 |
Family
ID=15224159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56138524A Granted JPS5839625A (en) | 1981-09-04 | 1981-09-04 | Composition for remedying diarrhea of domestic animal |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5839625A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU571011B2 (en) * | 1983-10-07 | 1988-03-31 | State Of Victoria, The | Treatment of neonatal calf diarrhoea |
| JPH04322971A (en) * | 1991-04-24 | 1992-11-12 | Osaka Diamond Ind Co Ltd | Diamond grinding wheel |
| JPH04322972A (en) * | 1991-04-24 | 1992-11-12 | Osaka Diamond Ind Co Ltd | Binder material for diamond abrasive grain |
| JPH06346234A (en) * | 1993-06-08 | 1994-12-20 | Anelva Corp | Sputtering equipment |
-
1981
- 1981-09-04 JP JP56138524A patent/JPS5839625A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5839625A (en) | 1983-03-08 |
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