JPH03215406A - Curable glue root canal filling material - Google Patents

Abstract

PURPOSE:To obtain the title filler not requiring labor of kneading, having eco nomic efficiency, excellent tissue affinity and proper X-ray contrast free from uselessness of material, comprising calcium quaternary phosphate, water-soluble organic acid, water-soluble polyhydric alcohol and X-ray contrast material. CONSTITUTION:Dust comprising (A) powder of calcium quaternary phosphate, (B) a water soluble organic acid selected from malic acid, citric acid, maleic acid and a copolymer of acrylic acid and itaconic acid and (C) an X-ray contrast material selected from bismuth carbonate and barium sulfate in a ratio of 55-75wt.% component A, 5-30wt.% component B and 15-35wt.% component C based on the whole amounts of the dust is kneaded with (D) a water-soluble polyhydric alcohol selected from glycerin, ethylene glycol and propylene glycol in a dust liquid ratio of the dust/the component D= preferably 1.0-5.0g/ml to give a pasty root canal filler of durable paste not curing during preservation.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a hardening glue root canal filling material used in dental treatment as a root canal filling material after pulp extraction or infected root canal treatment.

[Conventional technology]

Root canal filling operation in dental treatment involves sealing the root canal cavity after pulp extraction or root canal treatment by applying root canal filling material.
This treatment aims to protect and heal the root end wound and preserve the tooth after surgery.

Conventionally, such treatments include non-hardening adhesive root canal filling materials (e.g., formalin-based), hardening adhesive root canal filling materials (for example, formalin-based), and hardening adhesive root canal filling materials (for example, formalin-based) for the purpose of promoting healing of the root tip tissue or healing bony scars. (e.g. zinc oxide mono-eugenol) or the use of solid root canal filling materials for physical occlusion (e.g. gutta-percher points), or the use of solid root canal filling materials as a filling core (master point). However, in order to fill the dead space between the root canal wall and the master point, methods such as the combined use of adhesive root canal filling material (sealer) have been implemented.

Among these, non-hardening adhesive root canal filling materials can be expected to heal tissues, but since they do not harden within the root canal, there are concerns about their long-term application. Moreover, solid root canal filling materials only physically occlude, and tissue healing cannot be expected.

On the other hand, a hardening paste root canal filling material that hardens within a root canal after a certain period of time after kneading can be expected to achieve both the objectives of tissue healing and root canal occlusion. Furthermore, when used together with a solid root canal filling material as a sealer, it is expected that the solid root canal filling material, such as gutta verture point, will adhere to the root canal wall and the presence of dead space will be completely eliminated.

As the second hardening glue root canal filling material, zinc oxide-eugenol cement, which contains zinc oxide as a main component and mixes this with eugenol, has been widely used. However, the components of this cement are chemically different from those of teeth, and it has been pointed out that eugenol causes tissue irritation to the tissues surrounding the root tip, so it is not always a satisfactory material from the standpoint of tissue affinity. .

In order to solve this problem, recently, α-tricalcium phosphate powder or α-tricalcium phosphate powder and hydroxyapatite powder, which has a structure similar to the main components of bones and teeth, have been made into powders, and guaiacol etc. A curable glue root canal filling material using the compound as a mixing liquid has been proposed (for example, Japanese Patent Application Laid-Open No. 62-255403).

[Problem that the invention seeks to solve]

However, in order to avoid hardening during storage, the above composition is handled in two parts: a powder and a kneading agent, and these are kneaded together immediately before use. Therefore, there are operational problems such as the need for skill to prepare a paste with a consistency suitable for treatment. Furthermore, even if only a small amount is used for treatment, a large amount of material must be kneaded, which poses an economical problem.

[Means for solving problems]

The present invention involves kneading a powder consisting of tetracalcium phosphate powder, a water-soluble organic acid, and an This invention relates to a paste-like curable glue root canal filling material that has been kneaded in advance with polyhydric alcohol as a liquid. The curable glue root canal filling material of the present invention can be used immediately after taking out the required amount of paste material from the storage container during treatment, and is different from the conventional two-part curable glue root canal filling material. In comparison, it requires no effort for kneading, and there is almost no wastage of materials, making it extremely economical. Furthermore, the hardening adhesive root canal filling material of the present invention gradually forms a hardened body of hydroxyapatite, a major component of tooth substance, through a permanent reaction with moisture in the body after filling the root canal, resulting in excellent tissue formation. have affinity.

As the tetracalcium phosphate powder used in the curable adhesive root canal filling material of the present invention, any tetracalcium phosphate powder produced by a known method can be used without any particular limitation.

In the present invention, the water-soluble organic acids include malic acid,
At least one organic acid selected from the group of citric acid, maleic acid, and copolymers of acrylic acid and itaconic acid is used. In the root canal, these organic acids react with tetracalcium phosphate by hydrating with in-vivo moisture that enters from the root apex and dentinal tubules to form a hardened body.

In the present invention, at least one type of polyhydric alcohol selected from the group of glycerin, ethylene glycol, and propylene glycol is used as the water-soluble polyhydric alcohol. These polyhydric alcohols adjust the consistency of the hardening adhesive root canal filling material of the present invention to make it into a paste, and also prevent in-vivo moisture entering from the root apex and dentinal tubules in the root canal. Easily replaces and prepares curing reaction conditions within the system.

In the present invention, bismuth subcarbonate and/or barium sulfate are used as the XvA contrast medium.

These X-ray contrast materials are necessary to distinguish tooth substance from the hardening glue root canal filling material of the present invention on an X-ray film during treatment.

Each component of the powder in the curable glue root canal filling material of the present invention contains 55% tetracalcium phosphate powder based on the total weight of the powder.
It is preferable to use the water-soluble organic acid in a proportion of ~75% by weight, the water-soluble organic acid in the range of 5-30% by weight, and the X-ray contrast material in the proportion of 15-35% by weight.

The powder agent (weight: unit g) and the water-soluble polyhydric alcohol (volume 2 units d) as a kneading liquid are 1.0 to 5.0 (g/
From the viewpoint of consistency, it is preferable to knead at the ratio of d) (this ratio is referred to as powder-liquid ratio) to form a paste-like curable glue root canal filling material.

Further, the method of kneading the powder agent and the kneading liquid is not particularly limited, and a kneading method using a known mixing and kneading machine can be adopted without restriction. For example, a common method is to use a mixing and kneading machine such as an automatic mortar, ball mill, or Niichigu mixer.

The packaging form of the curable adhesive root canal filling material of the present invention is not particularly limited, but is typically filled into a syringe, tube, or the like.

The present invention will be explained in more detail below with reference to Examples.

[Examples and comparative examples]

(Production example) Calcium hydrogen phosphate dihydrate and calcium carbonate are mixed into 1
: Mix uniformly at a molar ratio of 1, and mix at a temperature of 1600°C.
Tetracalcium phosphate was synthesized by quenching after firing for a period of time. This tetracalcium phosphate is finely ground in a ball mill, and
It was passed through a 50 mesh sieve to obtain tetracalcium phosphate powder with a predetermined particle size. Furthermore, it was confirmed by X-ray diffraction that this powder was tetracalcium phosphate.

(Example 1) 63% by weight of the tetracalcium phosphate powder produced in the production example,
D-L-'J malic acid 12% precious and bismuth subcarbonate 25%
A powder consisting of % by weight and glycerin as a kneading liquid were kneaded at a powder/liquid ratio of 3.0 (g/ml) to form a paste. The flow rate of this paste is ISO-6 8
As a result of measurement according to 76, it was 31.5 mm. Further, after this paste was placed in a polyethylene airtight container and stored in a thermostat at 30°C for 3 months, the flow rate was 31.2 mm, indicating good storage stability.

Further, this paste was filled into a disk-shaped mold with a diameter of 10 m and a thickness of 1 mm, and after being stored in a thermostatic chamber at 37°C and IOORH for 24 hours, it was further immersed in water at 37°C. 2
The cured product taken out after 4 hours was confirmed to be hydroxyapatite by X-ray diffraction. Further, the radiopacity of this cured product was measured in accordance with ISO-6876, and as a result, it showed a radiopacity equivalent to that of a 3.5 plate aluminum plate.

(Examples 2 to 12) A powder prepared by blending other powder components in the proportions shown in Table 1 with the tetracalcium phosphate powder produced in the production example, and polyhydric alcohol as a kneading liquid were added as shown in Table 1. The mixture was kneaded to form a paste using the powder/liquid ratio shown below. These pastes were placed in a polyethylene airtight container and stored in a thermostat at 30°C, and the flow rates of the pastes at the initial stage and after 3 months were measured to examine storage stability. Further, regarding the cured product obtained in the same manner as in Example 1, the composition and radiopacity of the product were investigated.

These results are shown in Table 1. The abbreviations in the table are as follows.

TECP: Tetracalcium phosphate DL-MAL: DL-malic acid CA: Citric acid MA: Maleic acid AA; Acrylic acid and itaconic acid in a molar ratio of 7:
3, and its number average molecular weight is 9,000.

BI: Bismuth subcarbonate BA: Barium sulfate G: Glycerin EG: Ethylene glycol PG: Propylene glycol P/L First F, L 3F. L R, O H, C IAP: Powder-liquid ratio: Initial flow rate: Flow rate after 3 months: Radiopacity: Cured body composition: Hydroxyabatite [Effects of the invention] Curable glue root canal of the present invention Since the filling material is in the form of a paste that does not harden during storage, the required amount of the paste material can be removed from the storage container and used immediately during treatment. Therefore, compared to the conventional two-component curable glue root canal filling material, it does not require the effort of kneading, and is extremely economical as there is no waste of materials. In addition, the hardening adhesive root canal filling material of the present invention gradually forms a hardened body of hydroxyapatite, which is a major component of tooth substance, through a permanent reaction with moisture in the body after filling the root canal, and has excellent tissue compatibility. have sex. Further, since it contains bismuth subcarbonate and/or barium sulfate as an X-ray contrast material, it has appropriate X-ray contrast properties, and the state of root canal filling can be easily observed.

Claims (1)

[Claims] A hardening adhesive root canal filling material consisting of tetracalcium phosphate powder, water-soluble organic acid, water-soluble polyhydric alcohol, and X-ray contrast material.