JPH03215411A - Mouth washing solution - Google Patents
Mouth washing solutionInfo
- Publication number
- JPH03215411A JPH03215411A JP23894289A JP23894289A JPH03215411A JP H03215411 A JPH03215411 A JP H03215411A JP 23894289 A JP23894289 A JP 23894289A JP 23894289 A JP23894289 A JP 23894289A JP H03215411 A JPH03215411 A JP H03215411A
- Authority
- JP
- Japan
- Prior art keywords
- solution
- chlorhexidine gluconate
- weight
- ethyl alcohol
- mouthwash
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000005406 washing Methods 0.000 title abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 35
- 229960003333 chlorhexidine gluconate Drugs 0.000 claims abstract description 28
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims abstract description 28
- 235000019441 ethanol Nutrition 0.000 claims abstract description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000011187 glycerol Nutrition 0.000 claims abstract description 7
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 6
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims abstract description 6
- 229930006000 Sucrose Natural products 0.000 claims abstract description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 6
- 150000007524 organic acids Chemical class 0.000 claims abstract description 6
- 229960002920 sorbitol Drugs 0.000 claims abstract description 6
- 239000005720 sucrose Substances 0.000 claims abstract description 6
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims abstract description 5
- DBTMGCOVALSLOR-UHFFFAOYSA-N 32-alpha-galactosyl-3-alpha-galactosyl-galactose Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(OC2C(C(CO)OC(O)C2O)O)OC(CO)C1O DBTMGCOVALSLOR-UHFFFAOYSA-N 0.000 claims abstract description 5
- RXVWSYJTUUKTEA-UHFFFAOYSA-N D-maltotriose Natural products OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1OC1C(O)C(O)C(O)C(CO)O1 RXVWSYJTUUKTEA-UHFFFAOYSA-N 0.000 claims abstract description 5
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims abstract description 5
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims abstract description 5
- LUEWUZLMQUOBSB-UHFFFAOYSA-N UNPD55895 Natural products OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC2C(OC(OC3C(OC(O)C(O)C3O)CO)C(O)C2O)CO)C(O)C1O LUEWUZLMQUOBSB-UHFFFAOYSA-N 0.000 claims abstract description 5
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims abstract description 5
- UYQJCPNSAVWAFU-UHFFFAOYSA-N malto-tetraose Natural products OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(O)C(CO)O2)O)C(CO)O1 UYQJCPNSAVWAFU-UHFFFAOYSA-N 0.000 claims abstract description 5
- LUEWUZLMQUOBSB-OUBHKODOSA-N maltotetraose Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O[C@@H]3[C@@H](O[C@@H](O)[C@H](O)[C@H]3O)CO)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-OUBHKODOSA-N 0.000 claims abstract description 5
- FYGDTMLNYKFZSV-UHFFFAOYSA-N mannotriose Natural products OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC2C(OC(O)C(O)C2O)CO)C(O)C1O FYGDTMLNYKFZSV-UHFFFAOYSA-N 0.000 claims abstract description 5
- FYGDTMLNYKFZSV-BYLHFPJWSA-N β-1,4-galactotrioside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-BYLHFPJWSA-N 0.000 claims abstract description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims abstract description 4
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims abstract description 4
- 239000008103 glucose Substances 0.000 claims abstract description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract description 18
- 238000002156 mixing Methods 0.000 abstract description 8
- 239000008213 purified water Substances 0.000 abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 8
- 235000003599 food sweetener Nutrition 0.000 abstract description 7
- 239000003765 sweetening agent Substances 0.000 abstract description 7
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract description 5
- 235000010323 ascorbic acid Nutrition 0.000 abstract description 2
- 239000011668 ascorbic acid Substances 0.000 abstract description 2
- 229960005070 ascorbic acid Drugs 0.000 abstract description 2
- 239000000975 dye Substances 0.000 abstract 2
- 235000013599 spices Nutrition 0.000 abstract 2
- 230000002421 anti-septic effect Effects 0.000 abstract 1
- 229940064004 antiseptic throat preparations Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000019634 flavors Nutrition 0.000 abstract 1
- 230000002070 germicidal effect Effects 0.000 abstract 1
- 239000002324 mouth wash Substances 0.000 description 28
- 229940051866 mouthwash Drugs 0.000 description 23
- 230000000844 anti-bacterial effect Effects 0.000 description 14
- 235000019629 palatability Nutrition 0.000 description 11
- 238000012360 testing method Methods 0.000 description 10
- 239000000203 mixture Substances 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 8
- 238000011156 evaluation Methods 0.000 description 8
- 239000002244 precipitate Substances 0.000 description 7
- 229920001817 Agar Polymers 0.000 description 5
- 239000008272 agar Substances 0.000 description 5
- 239000003205 fragrance Substances 0.000 description 5
- 230000001580 bacterial effect Effects 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 235000019640 taste Nutrition 0.000 description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 229940093915 gynecological organic acid Drugs 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000001630 malic acid Substances 0.000 description 2
- 235000011090 malic acid Nutrition 0.000 description 2
- 235000005985 organic acids Nutrition 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 239000000419 plant extract Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 239000011975 tartaric acid Substances 0.000 description 2
- 235000002906 tartaric acid Nutrition 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- WTPPRJKFRFIQKT-UHFFFAOYSA-N 1,6-dimethyl-8,9-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione;1-methyl-6-methylidene-8,9-dihydro-7h-naphtho[1,2-g][1]benzofuran-10,11-dione Chemical compound O=C1C(=O)C2=C3CCCC(=C)C3=CC=C2C2=C1C(C)=CO2.O=C1C(=O)C2=C3CCC=C(C)C3=CC=C2C2=C1C(C)=CO2 WTPPRJKFRFIQKT-UHFFFAOYSA-N 0.000 description 1
- CIWBSHSKHKDKBQ-DUZGATOHSA-N D-araboascorbic acid Natural products OC[C@@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-DUZGATOHSA-N 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- 244000170916 Paeonia officinalis Species 0.000 description 1
- 235000006484 Paeonia officinalis Nutrition 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000010350 erythorbic acid Nutrition 0.000 description 1
- 239000004318 erythorbic acid Substances 0.000 description 1
- -1 etc. Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 229940070818 glycyrrhizate Drugs 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 229940094952 green tea extract Drugs 0.000 description 1
- 235000020688 green tea extract Nutrition 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 229940026239 isoascorbic acid Drugs 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000013588 oral product Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 244000132619 red sage Species 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- WRZYGPIFICWRCG-OOFFSTKBSA-M sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4s,5s,6s)-2-[[(3s,4ar,6ar,6bs,8as,11s,12ar,14ar,14bs)-11-carboxylato-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1h-picen-3-yl]oxy]-6-carboxylato-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trih Chemical compound [Na+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O WRZYGPIFICWRCG-OOFFSTKBSA-M 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
，ｔ発明は抗菌剤として、グルコン酸クロルヘキシジン
を安定に配合した洗口液に関し、更に詳しくは、殺菌効
果及び鴫好特性に優れ、且つ経日安定性の良好なグルコ
ン酸クロルヘキシジンを含有した洗口液に関するもので
ある。[Detailed Description of the Invention] [Industrial Application Field] The invention relates to a mouthwash stably containing chlorhexidine gluconate as an antibacterial agent. This invention relates to a mouthwash containing chlorhexidine gluconate that has good daily stability.
従来から、抗菌剤として、グルコン酸クロルヘキシジン
は数多く洗口液に配合されており、抗菌剤として、口腔
商品に使用するのに適した薬効成分である事が知られて
いる。しかしながら、洗口液にグルコン酸クロルヘキシ
ジンを配合すると、時間経過により、グルコン酸クロル
ヘキシジンと他の洗口液に使用されている成分とが一種
の複合体を形成し、沈澱物となる結果、その効力が極端
に低下したり、又外観性状に変化を引き起こす例が多々
見られた。そのため、グルコン酸クロルヘキシジンの配
合量を可能な限り低濃度（例えば約０．０００４重量％
の配合）に抑えているいる為、殺菌効果に乏しい製品で
あったり、又味覚が極端に悪く、嗜好特性において問題
のある製品であった。Chlorhexidine gluconate has traditionally been incorporated into many mouthwashes as an antibacterial agent, and is known to be a medicinal ingredient suitable for use in oral products as an antibacterial agent. However, when chlorhexidine gluconate is blended into a mouthwash, over time, chlorhexidine gluconate and the ingredients used in other mouthwashes form a type of complex and become a precipitate, resulting in its effectiveness. There were many cases in which there was an extreme decrease in the quality or a change in the appearance and properties. Therefore, the blended amount of chlorhexidine gluconate should be kept as low as possible (for example, about 0.0004% by weight).
Because of the low sterilization (formulation), the product has poor bactericidal effects, has an extremely poor taste, and has problems with palatability.
真に殺菌効果及び嗜好特性に優れ、且つ経日安定性の良
好なグルコン酸クロルヘキシジンを含有した洗口液を得
る事は困難とされていた。It has been considered difficult to obtain a mouthwash containing chlorhexidine gluconate that truly has excellent bactericidal effects and palatability, and has good stability over time.
そこで、本発明者は、このような現状に鑑み鋭意研究を
行った結果、ある特定量のグルコン酸クロルヘキシジン
とエタノールと有機酸と、グリセリン．Ｄ−ソルビトー
ル．シュクロース，グルコス．マルトース．マルトトリ
オース，マルトテトラオース、Ｄ−キシロースの一種又
は二種以上の配合により、充分に殺菌効果を発揮する量
のグルコン酸クロルヘキシジンを配合しているにもかか
わらず、嗜好特性に優れ、且つ経口安定性に優れた洗口
液が調製される事を見出し、本発明を完成するに到った
．
すなはち本発明の目的は殺菌効果及び嗜好特性に優れ、
且つ経口安定性の良好な、グルコン酸クロルヘキシジン
を含有した洗口液を提供することにある。Therefore, as a result of intensive research in view of the current situation, the present inventors found that certain amounts of chlorhexidine gluconate, ethanol, an organic acid, and glycerin. D-Sorbitol. Sucrose, glucos. Maltose. By combining one or more of maltotriose, maltotetraose, and D-xylose, it has excellent palatability and is highly palatable, even though it contains an amount of chlorhexidine gluconate that is sufficient to exhibit a bactericidal effect. It was discovered that a mouthwash with excellent stability could be prepared, and the present invention was completed. In other words, the purpose of the present invention is to have excellent bactericidal effects and palatability,
Another object of the present invention is to provide a mouthwash containing chlorhexidine gluconate, which has good oral stability.
本発明は、グルコン酸クロルヘキシジン０．０１〜０．
２重量％とエチルアルコール４〜３０重量％と有機ＭＯ
．０１〜０．８重量％と、グリセリン Ｄソルビトール
，シュクロース，グルコース，マルトース，マルトトリ
オース．マルトテトラオース．Ｄ−キシロースの一種又
は二種以上を２〜１０重量％を配合した洗口液である．
以下、本発明について更に詳しく説明する。The present invention provides chlorhexidine gluconate of 0.01 to 0.
2% by weight, 4-30% by weight of ethyl alcohol, and organic MO
．． 01-0.8% by weight, glycerin D-sorbitol, sucrose, glucose, maltose, maltotriose. Maltotetraose. This is a mouthwash containing 2 to 10% by weight of one or more types of D-xylose. The present invention will be explained in more detail below.
グルコン酸クロルヘキシジンの配合量は０．０１〜０．
２重量％である。０．０１重量％未満では殺菌効果が低
下し、０．２重量％を超えると殺菌効果は略一定となり
、それ以上の配合は無意味となり、又苦みを増し、嗜好
特性も悪くなり、洗口液としての使用が困難となる．
エチルアルコールの配合量は４〜３０重量％、好ましく
は５〜２５重量％である。The blending amount of chlorhexidine gluconate is 0.01 to 0.
It is 2% by weight. If it is less than 0.01% by weight, the bactericidal effect will decrease, and if it exceeds 0.2% by weight, the bactericidal effect will be almost constant, and adding more than that will be meaningless, will increase the bitterness, will have poor palatability, and will not be used as a mouthwash. It becomes difficult to use it as a liquid. The amount of ethyl alcohol blended is 4 to 30% by weight, preferably 5 to 25% by weight.
４重量％未満では爽快感に乏し《なり、その結果、嗜好
特性で問題が生じる。３０重量％を超えると刺激感が高
まり、通常の使用には困難が生じる。If it is less than 4% by weight, the refreshing feeling will be poor, and as a result, problems will arise in palatability. If it exceeds 30% by weight, the irritation will increase and it will be difficult to use it normally.
本発明に使用される有機酸には、アスコルビン酸，エリ
ソルビン酸．クエン酸，酒石酸．リンゴ酸，アジピン酸
．グルコン酸，コハク酸，フマル酸，酢酸．乳酸等が挙
げられる．
これらの有機酸を１種又は２種以上混合して使用し、そ
の配合量は０．０１〜０．８重量％（一般的にはＰＨは
６．５〜２．５である）の範囲であり、好ましくは ０
．０２〜０．６重量％（一般的にはＰＨ６．０〜２．８
）の範囲にて使用するのが良い。Organic acids used in the present invention include ascorbic acid, erythorbic acid. Citric acid, tartaric acid. Malic acid, adipic acid. Gluconic acid, succinic acid, fumaric acid, acetic acid. Examples include lactic acid. These organic acids are used alone or in combination of two or more, and the blending amount is in the range of 0.01 to 0.8% by weight (generally the pH is 6.5 to 2.5). Yes, preferably 0
．． 02-0.6% by weight (generally pH6.0-2.8
) should be used within the range.
０．０１重量％未満（一般的にはＰＨは６．５を超える
）では、グルコン酸クロルヘキシジンが時間経過により
析出し始めると同時に殺菌力も低下する．０．８重量％
を超えると（一般的にはＰ Ｈ ２． ５未満）では嗜
好特性が悪くなり、洗口液としては使用に耐えなくなる
。If it is less than 0.01% by weight (generally the pH exceeds 6.5), chlorhexidine gluconate begins to precipitate over time, and at the same time the bactericidal activity decreases. 0.8% by weight
If the pH exceeds 2.5 (generally less than PH 2.5), the palatability becomes poor and it becomes unusable as a mouthwash.
本発明に使用される甘味剤にはグリセリン．Ｄソルビト
ール．シュクロース．グルコース，マルト−ス，マルト
トリオース．マルトテトラオース，Ｄ−キシロース．が
挙げらる。Sweeteners used in the present invention include glycerin. D Sorbitol. Sucrose. Glucose, maltose, maltotriose. Maltotetraose, D-xylose. are mentioned.
これらの甘味剤を１種又は２種以上混合して使用し、そ
の配合量は２〜１０重量％の範囲であり好ましくは３〜
８重量％である。These sweeteners may be used alone or in a mixture of two or more, and the blending amount is in the range of 2 to 10% by weight, preferably 3 to 10% by weight.
It is 8% by weight.
それ以外の甘味剤、例えばサッカリンナトリウム，グリ
チルリチン酸ナトリウム等のアルカリ金属との塩化物は
、グルコン酸クロルヘキシジンと一種の不溶解性複合体
を形成し、沈澱物となり、好ましく無い。更に、グリチ
ルリチン酸ナトリウムは使用後の甘さの残存感が高く、
使用後の爽快性に欠ける。Other sweeteners, such as chlorides with alkali metals such as sodium saccharin and sodium glycyrrhizate, form a kind of insoluble complex with chlorhexidine gluconate and form a precipitate, which is not preferable. Furthermore, sodium glycyrrhizinate has a high residual sweetness after use,
Lack of refreshing feeling after use.
本発明に係わる洗口液の他の成分としては、香料．色素
．各種防腐剤並びに各種の植物抽出液等の成分も配合さ
れる．
本発明の洗口液は例えば次のようにして調製される．
エチルアルコールに香料，植物抽出物等を混合溶解させ
る．次いで精製水に、甘味剤．グルコン酸クロルヘキシ
ジン．有機酸．色素等を混合溶解させた後、先のエチル
アルコール溶液と混合し、洗口液を得る．
〔実施例〕
以下、本発明の実施例を記載して、本発明を説明する．
尚、実施例に記載のグルコン酸クロルヘキシジンの殺菌
力評価方法、嗜好特性調査方法、経口安定性評価方法（
沈澱物発生評価方法）等の試験方法は次の通りである．
（ｌ）．殺菌力評価方法
供試菌を３２”Ｃにて２４時間培養した後、その菌液を
１０μ！、試験液を１００μｆｆｉ， ＳＣＤ液体培地
を９０μＥ分注し、３２゜Ｃにて２４時間培養した後、
ＳＣＤ寒天培地にストリークし、３２゜Ｃにて４８時間
培養した。Other ingredients of the mouthwash according to the present invention include perfume. Pigment. Ingredients such as various preservatives and various plant extracts are also included. The mouthwash of the present invention is prepared, for example, as follows. Mix and dissolve fragrances, plant extracts, etc. in ethyl alcohol. Next, add a sweetener to the purified water. Chlorhexidine gluconate. Organic acid. After mixing and dissolving the pigment, etc., mix with the ethyl alcohol solution from above to obtain a mouthwash. [Example] The present invention will be explained below by describing Examples of the present invention.
In addition, the bactericidal power evaluation method, palatability characteristics investigation method, oral stability evaluation method (
The test methods such as precipitate generation evaluation method are as follows. (l). Bactericidal power evaluation method After culturing the test bacteria at 32"C for 24 hours, dispense 10μ! of the bacterial solution, 100μffi of the test solution, and 90μE of SCD liquid medium, and after culturing at 32℃ for 24 hours. ,
The mixture was streaked onto an SCD agar medium and cultured at 32°C for 48 hours.
殺菌力の強さは、ストリークした部分の寒天に菌が生育
しているか否か肉眼判定し、下記の如くに評価した。The strength of bactericidal activity was evaluated as follows by visually determining whether bacteria were growing on the agar in the streaked area.
＊寒天上に菌の成育を認めない
＊寒天上に菌の成育を若干認める ±＊寒天上に
菌の成育を認める ＋供試菌 Ｅ．ｃ
ｏＬｉ
Ｓｔ．ｅｐｉｄｅｒｒａｉｄｉｓ
（２）．嗜好特性調査方法
２０名の試験者により、使用時の官能特性についての調
査を行った。評価結果は［良好コ．［やや良好］，「普
通」．［劣る］，と回答した中で［良好］．［やや良好
］と回答した人の数で示した。*No bacterial growth observed on the agar *Some bacterial growth observed on the agar ±*Bacterial growth observed on the agar +Test bacteria E. c.
oLi St. epiderraidis (2). 20 testers conducted a survey on the sensory characteristics during use. The evaluation results were [Good]. [Slightly good], "average". Among those who answered ``poor'', ``good'' was the answer. Shown as the number of people who answered "fairly good".
（３）．経口安定性評価方法（沈澱物発生評価方法）試
験液を１００ｄのガラス瓶に取り、４５゜Ｃ，２５’Ｃ
，５”Ｃの温度の恒温室に１ケ月間保存した後、沈澱物
発生の有無を肉眼にて観察し、下記の判定方法により評
価した。(3). Oral stability evaluation method (precipitate generation evaluation method) The test solution was placed in a 100 d glass bottle and heated at 45°C, 25'C.
After being stored in a thermostatic chamber at a temperature of .5"C for one month, the presence or absence of precipitates was observed with the naked eye and evaluated using the following evaluation method.
＊恒温室保存品に於いて沈澱物観察せず。二〇（２）１
ｉ製方法
エチルアルコールに香料及び緑茶抽出物を混合溶解させ
る。次いで、精製水にグリセリン，グルコン酸クロルヘ
キシジン，クエン酸，パラオキシ安息香酸メチル．青色
１号，黄色４号を混合溶解させる。*No precipitate was observed in products stored in a constant temperature room. Twenty (2) 1
i Production method Mix and dissolve the fragrance and green tea extract in ethyl alcohol. Next, add glycerin, chlorhexidine gluconate, citric acid, and methyl paraoxybenzoate to purified water. Mix and dissolve Blue No. 1 and Yellow No. 4.
エチルアルコール溶解物及び精製水溶解物を混合し、洗
口液を得た。The ethyl alcohol solution and the purified water solution were mixed to obtain a mouthwash.
（３）特性
各々の洗口液について、前記試験を実施した結果を第１
表に示した。(3) Characteristics The results of the above tests for each mouthwash are
Shown in the table.
第１表の如く、本発明の洗口液である実施例１〜３は諸
試験において良好なる結果を得た。As shown in Table 1, Examples 1 to 3, which are mouthwashes of the present invention, obtained good results in various tests.
比較例１はグルコン酸クロルヘキシジンの配合量が少な
く、殺菌効果が低下し、本来の目的物を得る事が出来な
かった．
比較例２はグルコン酸クロルヘキシジンの配合量が多く
、殺菌効果の増大は期待出来ない．又、味が苦さを増し
、嗜好特性が極端に悪く、洗口液としての連用は困難な
ものであった．
（２）調製方法
エチルアルコールにＰＯＥ（６０） 硬化ヒマソ油誘導
体、香料及び丹参抽出物を混合溶解させる。次いで、精
製水にソルビトール液，グルコン酸クロルヘキシジン，
リンゴ酸及び青色１号を混合溶解させる。In Comparative Example 1, the blended amount of chlorhexidine gluconate was small, the bactericidal effect was reduced, and the intended product could not be obtained. Comparative Example 2 contains a large amount of chlorhexidine gluconate, and no increase in bactericidal effect can be expected. In addition, the taste became bitter and the palatability was extremely poor, making it difficult to use continuously as a mouthwash. (2) Preparation method POE (60) hardened castor oil derivative, fragrance, and Danshen extract are mixed and dissolved in ethyl alcohol. Next, sorbitol solution, chlorhexidine gluconate,
Mix and dissolve malic acid and Blue No. 1.
エチルアルコール溶解物及び精製水溶解物を混合し、洗
口液を得た。The ethyl alcohol solution and the purified water solution were mixed to obtain a mouthwash.
（３）特性
各々の洗口液について、前記試験を実施した結果を第１
表に示した。(3) Characteristics The results of the above tests for each mouthwash are
Shown in the table.
第１表の如く、本発明の洗口液である実施例４〜６は諸
試験において良好なる結果を得た。As shown in Table 1, Examples 4 to 6, which are mouthwashes of the present invention, obtained good results in various tests.
比較例３はエチルアルコールの配合量が少ないため、喝
好特性が悪く爽快感に乏しくなった。In Comparative Example 3, since the amount of ethyl alcohol blended was small, the drinkability was poor and the refreshing feeling was poor.
比較例４はエチルアルコールの配合量が多く、刺激性が
強く使用に耐えなかった。Comparative Example 4 contained a large amount of ethyl alcohol and was highly irritating and could not be used.
（以下余白）
（２）調製方法
エチルアルコールに香料及びＰＯＥ （６０）硬化ヒマ
シ油誘導体を溶解混合させる。次いで、精製水にクエン
酸，グルコン酸クロルヘキシジン，グルコス，シャクヤ
ク抽出物及び黄色４号を混合溶解させる。(Left below) (2) Preparation method Fragrance and POE (60) Hydrogenated castor oil derivative are dissolved and mixed in ethyl alcohol. Next, citric acid, chlorhexidine gluconate, glucos, peony extract, and Yellow No. 4 are mixed and dissolved in purified water.
（３）特性
各々の洗口液について、前記試験を実施した結果を第１
表に示した。(3) Characteristics The results of the above tests for each mouthwash are
Shown in the table.
第１表の如く、本発明の洗口液である実施例７〜９は諸
試験において良好なる結果を得た。As shown in Table 1, Examples 7 to 9, which are mouthwashes of the present invention, obtained good results in various tests.
比較例５はクエン酸の配合量が少なく、グルコン酸クロ
ルヘキシジンが時間経過により、析出しはじめ、それと
同時に殺菌力の低下が見られた．比較例６はクエン酸の
配合量が多く、嗜好特性が極端に悪く、洗口液としての
使用は困難であっ（２）調製方法
エチルアルコールに香料及びＰＯＥ （２０） ソル
ビタンモノオレエートを混合溶解させる。次いで、精製
水に、酒石酸，グルコン酸クロルヘキシジンシュクロー
ス５ （グリセリン）．（サノカリンナトリウム），青
色１号及び黄色４号を混合溶解させる。In Comparative Example 5, the amount of citric acid blended was small, and chlorhexidine gluconate began to precipitate over time, and at the same time, a decrease in bactericidal activity was observed. Comparative Example 6 contains a large amount of citric acid, has extremely poor palatability, and is difficult to use as a mouthwash.(2) Preparation method: Mix and dissolve fragrance and POE (20) sorbitan monooleate in ethyl alcohol. let Next, add tartaric acid, chlorhexidine gluconate sucrose 5 (glycerin) to purified water. (Sanocalin Sodium), Blue No. 1 and Yellow No. 4 are mixed and dissolved.
エチルアルコール溶解物及び精製水溶解物を混合し、洗
口液を得た。The ethyl alcohol solution and the purified water solution were mixed to obtain a mouthwash.
（３）特性
各々の洗口液について、前記試験を実施した結果を第１
表に示した。(3) Characteristics The results of the above tests for each mouthwash are
Shown in the table.
第１表の如く、本発明の洗口液である実施例１０〜１２
は諸試験において良好なる結果を得た。As shown in Table 1, Examples 10 to 12 of the mouthwash of the present invention
obtained good results in various tests.
比較例７は甘味剤の配合量が少なく、噌好特性が悪かっ
た。Comparative Example 7 contained a small amount of sweetener and had poor taste characteristics.
比較例８は甘味剤の配合量が多く、嗜好特性が極端に悪
く、又サッカリンナトリウムを使用したため、時間経過
により、グルコン酸クロルヘキシジンとの不溶解性沈澱
物質が発生し、容器の底部に沈澱した。更に、グルコン
酸クロルヘキシジンが沈澱したため、殺菌効果が逓減し
、洗口液としての使用は困難であった。Comparative Example 8 contained a large amount of sweetener and had extremely poor palatability, and because saccharin sodium was used, over time, a precipitate that was insoluble with chlorhexidine gluconate was generated and precipitated at the bottom of the container. Furthermore, since chlorhexidine gluconate precipitated, the bactericidal effect gradually decreased, making it difficult to use as a mouthwash.
Claims (1)
、エチルアルコール４〜３０重量％と、有機酸０．０１
〜０．８重量％と、グリセリン、Ｄ−ソルビトール、シ
ュクロース、グルコース、マルトース、マルトトリオー
ス、マルトテトラオース、Ｄ−キシロースの一種又は二
種以上を２〜１０重量％を配合した洗口液。0.01-0.2% by weight of chlorhexidine gluconate, 4-30% by weight of ethyl alcohol, and 0.01% by weight of organic acid.
~0.8% by weight and 2 to 10% by weight of one or more of glycerin, D-sorbitol, sucrose, glucose, maltose, maltotriose, maltotetraose, and D-xylose. .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23894289A JPH03215411A (en) | 1989-09-14 | 1989-09-14 | Mouth washing solution |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23894289A JPH03215411A (en) | 1989-09-14 | 1989-09-14 | Mouth washing solution |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH03215411A true JPH03215411A (en) | 1991-09-20 |
Family
ID=17037571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP23894289A Pending JPH03215411A (en) | 1989-09-14 | 1989-09-14 | Mouth washing solution |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH03215411A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0707794A1 (en) * | 1994-10-21 | 1996-04-24 | Shiseido Company Limited | Disinfectant composition |
| EP1340490A1 (en) * | 2002-03-01 | 2003-09-03 | Restituta Castellaccio | Chlorhexidine-based collutory for oral hygiene |
| ITMI20100149A1 (en) * | 2010-02-02 | 2011-08-03 | Ilaria Lastri | COMPOSITION FOR ORAL HYGIENE CONTAINING CLOREXIDINE AND A SYSTEM TO PREVENT THE FORMATION OF DARK PIGMENTS ON THE SURFACE OF TEETH AND ORAL MUCOSA. |
| EP2548585A1 (en) * | 2011-07-19 | 2013-01-23 | Laboratoires Anios | Cleaning and/or disinfecting composition |
| JP2013166742A (en) * | 2012-01-20 | 2013-08-29 | Hirotoshi Tagami | Dentifrice and mouth wash mainly composed of malic acid |
-
1989
- 1989-09-14 JP JP23894289A patent/JPH03215411A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0707794A1 (en) * | 1994-10-21 | 1996-04-24 | Shiseido Company Limited | Disinfectant composition |
| US5800827A (en) * | 1994-10-21 | 1998-09-01 | Shiseido Co., Ltd. | Disinfectant composition |
| EP1340490A1 (en) * | 2002-03-01 | 2003-09-03 | Restituta Castellaccio | Chlorhexidine-based collutory for oral hygiene |
| WO2003074018A1 (en) * | 2002-03-01 | 2003-09-12 | Restituta Castellaccio | Chlorhexidine-based collutory for oral hygiene |
| ITMI20100149A1 (en) * | 2010-02-02 | 2011-08-03 | Ilaria Lastri | COMPOSITION FOR ORAL HYGIENE CONTAINING CLOREXIDINE AND A SYSTEM TO PREVENT THE FORMATION OF DARK PIGMENTS ON THE SURFACE OF TEETH AND ORAL MUCOSA. |
| EP2548585A1 (en) * | 2011-07-19 | 2013-01-23 | Laboratoires Anios | Cleaning and/or disinfecting composition |
| FR2978050A1 (en) * | 2011-07-19 | 2013-01-25 | Anios Lab Sarl | CLEANING AND / OR DISINFECTING COMPOSITION |
| JP2013166742A (en) * | 2012-01-20 | 2013-08-29 | Hirotoshi Tagami | Dentifrice and mouth wash mainly composed of malic acid |
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