JPH03220113A - Hair tonic - Google Patents
Hair tonicInfo
- Publication number
- JPH03220113A JPH03220113A JP1470990A JP1470990A JPH03220113A JP H03220113 A JPH03220113 A JP H03220113A JP 1470990 A JP1470990 A JP 1470990A JP 1470990 A JP1470990 A JP 1470990A JP H03220113 A JPH03220113 A JP H03220113A
- Authority
- JP
- Japan
- Prior art keywords
- alcohol
- hair
- docosenoic acid
- acid ester
- hair growth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004209 hair Anatomy 0.000 title claims abstract description 43
- 230000001256 tonic effect Effects 0.000 title abstract description 11
- DPUOLQHDNGRHBS-UHFFFAOYSA-N Brassidinsaeure Natural products CCCCCCCCC=CCCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-UHFFFAOYSA-N 0.000 claims abstract description 34
- -1 docosenoic acid ester Chemical class 0.000 claims abstract description 25
- ATNNLHXCRAAGJS-QZQOTICOSA-N (e)-docos-2-enoic acid Chemical compound CCCCCCCCCCCCCCCCCCC\C=C\C(O)=O ATNNLHXCRAAGJS-QZQOTICOSA-N 0.000 claims abstract description 9
- ACIAHEMYLLBZOI-ZZXKWVIFSA-N Unsaturated alcohol Chemical compound CC\C(CO)=C/C ACIAHEMYLLBZOI-ZZXKWVIFSA-N 0.000 claims abstract description 9
- 239000004480 active ingredient Substances 0.000 claims abstract description 6
- ALSTYHKOOCGGFT-MDZDMXLPSA-N oleyl alcohol Chemical compound CCCCCCCC\C=C\CCCCCCCCO ALSTYHKOOCGGFT-MDZDMXLPSA-N 0.000 claims abstract description 4
- JXNPEDYJTDQORS-HZJYTTRNSA-N (9Z,12Z)-octadecadien-1-ol Chemical compound CCCCC\C=C/C\C=C/CCCCCCCCO JXNPEDYJTDQORS-HZJYTTRNSA-N 0.000 claims abstract description 3
- IKYKEVDKGZYRMQ-PDBXOOCHSA-N (9Z,12Z,15Z)-octadecatrien-1-ol Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCCO IKYKEVDKGZYRMQ-PDBXOOCHSA-N 0.000 claims abstract description 3
- JXNPEDYJTDQORS-UHFFFAOYSA-N linoleyl alcohol Natural products CCCCCC=CCC=CCCCCCCCCO JXNPEDYJTDQORS-UHFFFAOYSA-N 0.000 claims abstract description 3
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims abstract 2
- 125000003158 alcohol group Chemical group 0.000 claims abstract 2
- 229940055577 oleyl alcohol Drugs 0.000 claims abstract 2
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 11
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 18
- 230000000694 effects Effects 0.000 abstract description 14
- 239000003814 drug Substances 0.000 abstract description 6
- 201000004384 Alopecia Diseases 0.000 abstract description 3
- 239000002537 cosmetic Substances 0.000 abstract description 3
- 229940079593 drug Drugs 0.000 abstract description 3
- 150000001298 alcohols Chemical class 0.000 abstract description 2
- 241001615463 Trichogenes Species 0.000 abstract 1
- 231100000360 alopecia Toxicity 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 230000003779 hair growth Effects 0.000 description 32
- 238000012360 testing method Methods 0.000 description 16
- 239000004615 ingredient Substances 0.000 description 13
- 239000002253 acid Substances 0.000 description 8
- 239000000523 sample Substances 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 235000015961 tonic Nutrition 0.000 description 7
- 230000001737 promoting effect Effects 0.000 description 6
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 5
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 5
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 5
- 239000005642 Oleic acid Substances 0.000 description 5
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 5
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 5
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 5
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 4
- 206010040880 Skin irritation Diseases 0.000 description 4
- SZAMSYKZCSDVBH-CLFAGFIQSA-N [(z)-octadec-9-enyl] (z)-docos-13-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCC(=O)OCCCCCCCC\C=C/CCCCCCCC SZAMSYKZCSDVBH-CLFAGFIQSA-N 0.000 description 4
- 239000006071 cream Substances 0.000 description 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 4
- 229940120511 oleyl erucate Drugs 0.000 description 4
- 230000036556 skin irritation Effects 0.000 description 4
- 231100000475 skin irritation Toxicity 0.000 description 4
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 3
- URXZXNYJPAJJOQ-UHFFFAOYSA-N Erucic acid Natural products CCCCCCC=CCCCCCCCCCCCC(O)=O URXZXNYJPAJJOQ-UHFFFAOYSA-N 0.000 description 3
- DPUOLQHDNGRHBS-KTKRTIGZSA-N erucic acid Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-KTKRTIGZSA-N 0.000 description 3
- 229940057995 liquid paraffin Drugs 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 208000019300 CLIPPERS Diseases 0.000 description 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 2
- 229960000541 cetyl alcohol Drugs 0.000 description 2
- 208000021930 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids Diseases 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 239000007952 growth promoter Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 235000020778 linoleic acid Nutrition 0.000 description 2
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 210000004761 scalp Anatomy 0.000 description 2
- 235000011076 sorbitan monostearate Nutrition 0.000 description 2
- 239000001587 sorbitan monostearate Substances 0.000 description 2
- 229940035048 sorbitan monostearate Drugs 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical class CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- 206010068168 androgenetic alopecia Diseases 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000006482 condensation reaction Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 230000031774 hair cycle Effects 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 239000003676 hair preparation Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000003752 improving hair Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000016507 interphase Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229920000259 polyoxyethylene lauryl ether Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000003658 preventing hair loss Effects 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 230000004215 skin function Effects 0.000 description 1
- 229950004959 sorbitan oleate Drugs 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野コ
本発明はドコセン酸エステルを含有して成る新規な養毛
料に関するものである。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a novel hair nourishing agent containing docosenoic acid ester.
具体的には、医薬品、医薬部外品、化粧品などに規定さ
れる全ての毛髪用製剤に用いることができる脱毛防止お
よび発毛促進効果の優れた養毛料に関するものである。Specifically, the present invention relates to a hair nourishing agent that can be used in all hair preparations defined as pharmaceuticals, quasi-drugs, cosmetics, etc., and has excellent hair loss prevention and hair growth promoting effects.
［従来の技術］
従来より、男性型脱毛症に対して各種の薬効成分を配合
した多くの養毛剤が知られており、その作用としては、
頭皮の血行促進 毛母細胞の活性（？、 頭皮の皮脂
分泌抑制を促すものなどであり、薬効成分としては、例
えば、ビタミンＥ、パントテン酸等のビタミン類、サリ
チル酸、 ヒノキチオール等の殺菌斉１ エチニルエス
トラジオール等のホルモン類、アセチルコリン誘導体等
の血管拡張弁Ｌ セファランチン等の皮膚機能抗進剤な
どが挙げられる。また、オレイン酸、 リノール酸等の
不飽和脂肪酸を配合した養毛料に関する発明（特開昭５
９−１４１５１４．５９−１５２３０８）が公開されて
いるが、ドコセン酸エステルを養毛剤として用いた例は
知られていない。[Prior Art] Many hair tonics containing various medicinal ingredients have been known for treating male pattern baldness, and their effects include:
It promotes blood circulation in the scalp, activates hair matrix cells, and suppresses sebum secretion in the scalp.Medicinal ingredients include vitamins such as vitamin E and pantothenic acid, salicylic acid, and antibacterial agents such as hinokitiol. Examples include hormones such as estradiol, vasodilator valves such as acetylcholine derivatives, skin function inhibitors such as cephalanthine, etc.In addition, an invention related to a hair nourishing agent containing unsaturated fatty acids such as oleic acid and linoleic acid (Japanese Patent Publication No. 5
9-141514.59-152308), but there are no known examples of using docosenoic acid ester as a hair nourishing agent.
「発明が解決しようとする問題点］
これらの薬効成分を配合した養毛料は、フケ、カユミ、
抜毛等の予防・改善に有効で、発毛あるいは育毛効果を
促すとされている。一般に、養毛剤として使用される物
質は、優れた養毛効果を有すると共に比較的長期間連用
することから特に安全性の高いことが要求されているが
、いまだ満足すべきものがないのが現状である。``Problems to be solved by the invention'' The hair nourishment containing these medicinal ingredients is effective against dandruff, itching,
It is said to be effective in preventing and improving hair loss, etc., and to promote hair growth or hair growth effects. In general, substances used as hair growth agents are required to have excellent hair growth effects and to be particularly safe as they can be used for a relatively long period of time, but there is currently no product that satisfies this requirement. .
［問題点を解決しようとする為の手段］本発明者らは、
更に優れた発毛および育毛効果を有する物質を鋭意検索
した結果、 ドコセン酸と不飽和アルコールから成るド
コセン酸エステルを人または動物の皮膚に塗布すること
により、従来にない極めて顕著な発毛および育毛効果が
あることを見出し本発明を完成させた。[Means for trying to solve the problem] The present inventors
As a result of intensive searches for substances with even better hair growth and hair growth effects, we found that by applying docosenoic acid ester, which is made of docosenoic acid and unsaturated alcohol, to the skin of humans or animals, extremely remarkable hair growth and hair growth that has never been seen before was achieved. They found that it is effective and completed the present invention.
本発明に用いるドコセン酸エステルは、 ドコセン酸と
不飽和アルコールの脱水縮合反応等の方法により合成す
ることができる。The docosenoic acid ester used in the present invention can be synthesized by a method such as a dehydration condensation reaction of docosenoic acid and an unsaturated alcohol.
本発明で用いるドコセン酸エステルを構成するドコセン
酸としては、エルカ酸（Ｃ２２Ｈ４２０２ｅｒｕｃｉｃ
ａｃｉｄ； ｃｉａ−１３−ｄｏｃｏａｅｎｏｉｃ
ａｃｉｄ）、プラシン酸（Ｃ２２Ｈ，□０２： ｂｒ
ａｓｓｉｄｉｃ ａｃｉｄＩｔｒａｎｓ−１３−ｄｏ
ｃｏｓｅｎｏｉｃ ａｃｉｄ）が挙げられる・本発明に
用いるドコセン酸エステルを構成する不飽和アルコール
としては、例えば分子内に二重結合が１乃至３個を有す
る炭素数が１８個のアルコール、具体的にはオレイルア
ルコール（Ｃ＋ｅ−＋ｃ １ｓ−９−ｏｃｔａｄｅｃｅ
ｎ−１−ｏｌ）、エライジルアルコール（Ｃ＋ｅ−＋
： ｔｒａｎｓ−９−ｏｃｔａｄｅｃｅｎ−１−ｏｌ）
、 リノレイルアルコール（Ｃ１１１−２°ｃｉＳ−９
，ｃｉｓ−１２−ｏｃｔａｄｅｃａｄｉｅｎ−１−ｏｌ
）及びリノレニルアルコール（ＣＩｌ！−３：ｃｉｓ−
９ｃｉｓ−＋２ ｃｉｓ−１５−ｏｃｔａｄｅｃａｔｒ
ｉｅｎ−１−ｏｌ）などが挙げられる。As docosenoic acid constituting the docosenoic acid ester used in the present invention, erucic acid (C22H4202erucic acid
acid; cia-13-docoaenoic
acid), prasic acid (C22H, □02: br
assidic acidIttrans-13-do
Examples of the unsaturated alcohol constituting the docosenoic acid ester used in the present invention include alcohols having 18 carbon atoms and having 1 to 3 double bonds in the molecule, specifically oleyl. Alcohol (C+e-+c 1s-9-octadece
n-1-ol), elaidyl alcohol (C+e-+
: trans-9-octadecen-1-ol)
, linoleyl alcohol (C111-2°ciS-9
, cis-12-octadecadien-1-ol
) and linolenyl alcohol (CIl!-3: cis-
9cis-+2 cis-15-octadecatr
ien-1-ol) and the like.
すなわち、本発明で用いるドコセン酸エステルは、下記
の一般式に示す構造を有する。That is, the docosenoic acid ester used in the present invention has a structure shown in the general formula below.
Ｃ２，Ｈ，、Ｃ○０Ｒ
（Ｒは不飽和アルコール残基を示す。）本発明の養毛料
の有効成分であるドコセン酸エステルとしては、例えば
、つぎの化合物が使用できる。C2,H,,C0R (R represents an unsaturated alcohol residue) As the docosenoic acid ester which is an active ingredient of the hair nourishment of the present invention, for example, the following compounds can be used.
（１）エルカ酸オレイル、 （２）エルカ酸エライジル
、（３）エルカ酸すルイル、 （４）エル美醜すルニル
、（５）プラシン酸オレイル、（６）プラシン酸エライ
ジル、（７）プラシン酸すルイル、（８）プラシン酸す
ルニル。(1) oleyl erucate, (2) elaidyl erucate, (3) suruyl erucate, (4) erucic acid lunyl, (5) oleyl plasinate, (6) elaidyl plasinate, (7) suruyl erucate. (8) Sunyl prusinate.
本発明で用いるドコセン酸エステルは、例えば、上記化
合物の１種あるいは２種以上から選ばれる。The docosenoic acid ester used in the present invention is selected from, for example, one or more of the above compounds.
また、本発明で用いるドコセン酸エステルの１種あるい
は２種以上と既存の養毛剤を混合して用いてもよい。本
発明で用いるドコセン酸エステルは、養毛剤組成物（処
方成分）の全重量に対して通常０．１−１００重量％、
好ましくは、 １．０重量％以上配合するのが適当であ
る。本発明で用いるドコセン酸エステルは、油状を呈し
、製剤化が容易なことから、特に配合量を規制されるも
のではない。Furthermore, one or more docosenoic acid esters used in the present invention may be mixed with an existing hair nourishing agent. The docosenoic acid ester used in the present invention is usually 0.1-100% by weight based on the total weight of the hair care composition (prescribed ingredients).
Preferably, it is appropriate to add 1.0% by weight or more. Since the docosenoic acid ester used in the present invention has an oily form and is easy to formulate, there are no particular restrictions on its blending amount.
すなわち、本発明の養毛剤は、種々の化粧品および医薬
品等の基材と共に、ヘアートニッ久 へアークリーム、
ヘアーローション、ヘアーオイル。That is, the hair tonic of the present invention can be used as a base material for various cosmetics and pharmaceuticals, as well as hair tonic, hair cream, hair cream, etc.
Hair lotion, hair oil.
シャンプー、 リンス、チンキ剤、エアゾール製剤。Shampoos, conditioners, tinctures, aerosol preparations.
軟膏剤等の形で用いることができる。It can be used in the form of an ointment or the like.
本発明で用いるドコセン酸エステルを白色ワセリンに１
および１５重重量配合した試料をドレイズの方法に準じ
皮膚刺激試験を行った結策 動物皮膚刺激およびヒト皮
膚刺激のスコアーはいずれもＯであり、皮膚刺激もなく
、人体に対し極めて安全であることを確認した。従って
、本発明のドコセン酸エステルを有効成分とする養毛剤
は発毛効果が著しく、しかも安全性においても好ましい
ものである。1 docosenoic acid ester used in the present invention is added to white petrolatum.
The results of a skin irritation test conducted on a sample containing 15% and 15% weight according to Draize's method.The animal skin irritation and human skin irritation scores were both O, indicating that there was no skin irritation and it was extremely safe for the human body. It was confirmed. Therefore, the hair growth agent of the present invention containing docosenoic acid ester as an active ingredient has a remarkable hair growth effect and is also preferable in terms of safety.
［発明の効果］
以下に、実験例を挙げて本発明の詳細な説明する。実験
例に示す部とは重量部を、％とは重量％を意味する。[Effects of the Invention] The present invention will be described in detail below with reference to experimental examples. Parts shown in the experimental examples mean parts by weight, and % means % by weight.
直コ九１」久】１例」２ 発毛促進試験（発毛試験）本
発明で用いるドコセン酸エステル、オレイン酸、 リノ
ール酸およびリルン酸の２％エタノール溶液と実施例１
、実施例４に示した養毛剤組成物を試料として用いた。Example 1 Example 2 Hair Growth Promotion Test (Hair Growth Test) 2% Ethanol Solution of Docosenoic Acid, Oleic Acid, Linoleic Acid and Rilunic Acid Used in the Present Invention and Example 1
The hair tonic composition shown in Example 4 was used as a sample.
毛周期が発毛休止期にあるＩＣＲマウス（雄、６週齢、
平均体重２６ｇ）を用い、背部から両側腹部全体をバリ
カンにて別宅した。翌日より上記の試料溶液を被試験部
皮膚に毎日朝夕２回、 １匹あたり０．１ ｍｌを塗布
した。動物は一群６匹とし、実験動物の右側腹部に試料
を、左側腹部に対照としてエタノールまたは実施例１．
実施例４に示した養毛剤組成物より有効成分（ドコセン
酸エステル）を削除した組成物を塗布した。発毛状態は
、肉眼判定の評価を比較することにより行った。発毛の
効果は１表１に示す判定規準で評価し、６匹の平均値で
表した。ICR mouse (male, 6 weeks old, in the resting phase of the hair cycle)
(average weight: 26 g), the whole area from the back to both sides of the abdomen was removed using clippers. Starting from the next day, 0.1 ml of the above sample solution per animal was applied to the skin of the test area twice daily, morning and evening. A group of six animals was used, and the sample was placed on the right flank of the experimental animal, and ethanol or Example 1 was placed on the left flank as a control.
A composition obtained by omitting the active ingredient (docosenoic acid ester) from the hair tonic composition shown in Example 4 was applied. The state of hair growth was determined by comparing the visual evaluations. The hair growth effect was evaluated according to the criteria shown in Table 1 and expressed as the average value of 6 animals.
試験開始後、３００日目、表１に示す判定規準に従って
肉眼判定し、 １匹当りの平均評価点を求めた。これら
の試験結果を表２に示す。On the 300th day after the start of the test, visual judgment was performed according to the criteria shown in Table 1, and the average score per animal was determined. The results of these tests are shown in Table 2.
表２から明らかなように、本発明のドコセン酸エステル
およびこれを製剤化した組成物（実施例１および実施例
４）の発毛効果は著しく、発毛剤としての有効性が認め
られた。また、対照とじて用いたオレイン酸、 リノー
ル酸、およびリルイン酸についても発毛効果は認められ
るが、本発明のドコセン酸エステルはこれらより更に強
い発毛効果を示した。As is clear from Table 2, the hair growth effect of the docosenoic acid ester of the present invention and the compositions formulated therewith (Example 1 and Example 4) was remarkable, and their effectiveness as a hair growth agent was recognized. Furthermore, although oleic acid, linoleic acid, and liluic acid used as controls had a hair growth effect, the docosenoic acid ester of the present invention showed an even stronger hair growth effect than these.
１肱土ス皇ｊユ 発毛促進試験（濃度変化）ドコセン酸
オレイルの０．Ｏｌ、０．１． １．０．５．０゜１５
および３０％エタノール溶液を試料として用いて、有効
性試験例１の方法に準じて発毛促進試験を行った。また
、上記ドコセン酸エステルを直接塗布した場合（塗布濃
度１００％）についても、未塗布部を対照として同様に
試験を行った。これらの結果を表３に示す。1. Hair growth promotion test (concentration change) 0.0% of oleyl docosenoate. Ol, 0.1. 1.0.5.0゜15
A hair growth promotion test was conducted according to the method of Efficacy Test Example 1 using 30% ethanol solution as a sample. Further, a similar test was conducted in the case where the docosenoic acid ester was directly applied (coating concentration: 100%) using the uncoated area as a control. These results are shown in Table 3.
表３より明らかなように、試料濃度０．０１％以上で発
毛促進効果を示し、試料濃度１５％以上で、はぼ一定の
値となっ九
１夏ユ星皇１１ 毛成長促進試験（育毛試験）ドコセン
酸エステル、オレイン酸、 リノール酸およびリルン酸
の２％エタノール溶液と実施例１、実施例４に示した養
毛剤組成物を試料として用いた。As is clear from Table 3, a sample concentration of 0.01% or more shows a hair growth promoting effect, and a sample concentration of 15% or more shows a constant value. Test) A 2% ethanol solution of docosenoic acid ester, oleic acid, linoleic acid, and lylunic acid and the hair nourishing compositions shown in Examples 1 and 4 were used as samples.
毛周期が発毛期にあるＩＣＲマウス（Ｊｌ、 ６週齢
、平均体重２６ｇ）の背部から両側腹部全体をバリカン
にて別宅後、 さらに脱毛クリームを用いて除毛し、試
験に用い池 翌日より上記の試料溶液を被試験部皮膚に
毎日朝夕２回、 １匹あたり ０１ｍ１を塗布し池 動
物は一群６匹とし、実験動物の右側腹部に試料溶液を、
左側腹部に対照としてエタノールまたは実施例１、実施
例４に示した養毛剤組成物より発毛促進剤を削除した組
成物を塗布した。２日目、 ６日目、および１００日目
脱毛部位より新生毛をサンプリングし、体毛長を測定し
た結果を表４に示す。体毛長の測定は田中らの方法（Ｊ
、 Ｍｅｄｉｃｉｎａｌ Ｐｌａｎｔ Ｒｅ５ｅａｒ
ｃｈ、 ５ｕｐｐｌｅ＋ａｅｎｔ。ICR mice (Jl, 6 weeks old, average weight 26 g) in the hair growth phase were removed from the back and the entire abdomen on both sides using clippers, and then hair was removed using hair removal cream and used for testing. Apply the above sample solution to the skin of the test area twice a day in the morning and evening, 01 ml per animal.
As a control, ethanol or the hair growth promoter compositions shown in Examples 1 and 4 without the hair growth promoter was applied to the left flank. Newly grown hair was sampled from the hair removal site on the 2nd, 6th, and 100th day, and the body hair length was measured. Table 4 shows the results. Body hair length was measured using the method of Tanaka et al. (J
, Medical Plant Re5ear
ch, 5upple+aent.
Ｐ、８４．１９８０）に従って行った。すなわち、実体
顕微鏡を用いて、サンプリングした任意の２０本の毛の
長さを測定し、その中から最も長いものから順に５本を
選び、平均値を求めてマウスの体毛長とした。P., 84.1980). That is, using a stereomicroscope, the lengths of 20 arbitrary sampled hairs were measured, and the 5 hairs were selected in order from the longest among them, and the average value was calculated and used as the body hair length of the mouse.
表４に示すように、対照詳に対し、本発明のドコセン酸
エステルおよびそれを製剤化した組成物（実施例１およ
び４）を塗布した群は、平均値の有意差検定（Ｔ検定）
において、危険率５％で有意に毛成長促進効果を示した
。一方、オレイン酸、リノール酸およびリルン酸につい
ても、毛成長促進効果は認められるが、本発明のドコセ
ン酸エステルはこれらより更に顕著な毛成長促進効果を
示した。As shown in Table 4, the group to which the docosenoic acid ester of the present invention and the composition prepared therefrom (Examples 1 and 4) were applied compared to the control group was subjected to a significant difference test (T-test) of the mean values.
showed a significant hair growth promoting effect with a risk rate of 5%. On the other hand, although oleic acid, linoleic acid, and lylunic acid also have a hair growth promoting effect, the docosenoic acid ester of the present invention showed a more remarkable hair growth promoting effect than these.
表１ 発毛の判定規準
表２
発毛促進試験結果
表４
毛成長促進効果
表３
発毛促進効果
注に 表２と同じ試料を用いた。試料番号（＋４）およ
び（１５）は、それぞれ試料番号（＋２） （実施例１
）および（１３） （実施例４）の組成物より本発明の
養毛剤を削除した試料（対照）を示し、 （１６）はエ
タノール（対照）を示す。対照には＊印を付した。Table 1 Hair growth criteria Table 2 Hair growth promotion test results Table 4 Hair growth promotion effect Table 3 Hair growth promotion effect Note The same samples as in Table 2 were used. Sample numbers (+4) and (15) are respectively sample numbers (+2) (Example 1
) and (13) show samples (control) in which the hair tonic of the present invention was removed from the composition of (Example 4), and (16) shows ethanol (control). Controls are marked *.
以下に、実施例を挙げて本発明を更に具体的に説明する
が、本発明はこれに限定されるものではない。The present invention will be described in more detail below with reference to Examples, but the present invention is not limited thereto.
［実施例コ
実施例１ ヘアートニックＡ
０９５％エタノール ９４．０部■エル
カ酸オレイル ４．０■グリセリン
２．０〔製法コ成分■〜■を充
分撹拌混合後、ろ過して製品とする。[Example Example 1 Hair Tonic A 095% ethanol 94.0 parts ■ Oleyl erucate 4.0 ■ Glycerin
2.0 [Manufacturing method] After thoroughly stirring and mixing ingredients ① to ①, filter to obtain a product.
実施例２ ヘアートニックＢ ０９５％エタノール ６０．０部 ■プラシン酸オレイル １．０ ■ポリオキシエチレン ラウリルエーテル（２０） ■１．３−ブチレングリコール ■防腐剤 ■精製水 ［製法］成分■〜■を充分撹拌混合後、製品とする。Example 2 Hair tonic B 095% ethanol 60.0 copies ■Oleyl plasinate 1.0 ■Polyoxyethylene Lauryl ether (20) ■1.3-Butylene glycol ■Preservative ■Purified water [Manufacturing method] After sufficiently stirring and mixing ingredients ① to ②, prepare a product.
０．７
３．０
適量
３５．３
ろ過して
＠グリセリン ５．００水酸化
カリウム ０．２［相］防腐剤
適量■精製水
６４・３［製法コ成分■〜■および成分＠〜
■をそれぞれ７０〜７５℃に加温溶解した後、成分■〜
■に成分＠〜■を加えて乳化し、３０℃まで冷却し製品
とする。0.7 3.0 Appropriate amount 35.3 Filter @ Glycerin 5.00 Potassium hydroxide 0.2 [Phase] Preservative
Appropriate amount ■Purified water
64.3 [Manufacturing method ingredients ■～■ and ingredients @～
After heating and dissolving each of ■ at 70 to 75℃, the ingredients ■～
Ingredients @~■ are added to (2) and emulsified, and the mixture is cooled to 30°C to form a product.
実施例３ ヘアークリーム
■ステアリン酸
■セチルアルコール
■ステアリルアルコール
■流動パラフィン
■ワセリン
■ソルビタンモノステアレート
■モノステアリン酸
ポリオキシエチレン（２５）
■エルカ酸オレイル
［相］エルカ酸すルイル
■プラシン酸オレイル
４８０部
３．０
１．０
５．０
１Ｏ６０
１，５
３、Ｏ
１，Ｏ
１，０
１，０
実施例４ ヘアーローション
■ステアリン酸
■セチルアルコール
■ステアリルアルコール
■流動パラフィン
■モノステアリン酸ソルビタン
■モノオレイン酸ソルビタン
■モノオレイン酸
ポリオキシエチレン（ｌＯ）
■エルカ酸エライジル
［相］プラシン酸すルイル
■グリセリン
５．０部
４、Ｏ
１，０
１，０
１，３
１，５
０，８
１，５
１，５
６，０
＠水酸化カリウム ０．２０防腐剤
適量０精製水
７６．２［製法コ成分■〜［相］および
成分■〜［相］をそれぞれ７０〜７５℃に加温溶解した
後、成分■〜［相］に成分■〜［相］を加えて乳化し、
３０℃まで冷却し製品とする。Example 3 Hair cream ■Stearic acid ■Cetyl alcohol ■Stearyl alcohol ■Liquid paraffin ■Vaseline ■Sorbitan monostearate ■Polyoxyethylene monostearate (25) ■Oleyl erucate [phase] Suruyl erucate ■Oleyl prusinate 480 Part 3.0 1.0 5.0 1O60 1,5 3, O 1,O 1,0 1,0 Example 4 Hair lotion ■ Stearic acid ■ Cetyl alcohol ■ Stearyl alcohol ■ Liquid paraffin ■ Sorbitan monostearate ■ Mono Sorbitan oleate ■ Polyoxyethylene monooleate (lO) ■ Elaidyl erucate [phase] Suruyl plasinate ■ Glycerin 5.0 parts 4, O 1,0 1,0 1,3 1,5 0,8 1, 5 1,5 6,0 @ Potassium hydroxide 0.20 Preservative appropriate amount 0 Purified water
76.2 [Manufacturing method] After heating and dissolving ingredients ■ ~ [phase] and ingredients ■ ~ [phase] at 70 to 75°C, add ingredients ■ ~ [phase] to ingredients ■ ~ [phase] and emulsify. ,
Cool to 30°C and use as a product.
実施例５ 軟膏剤
■精製ラノリン Ｓ、Ｏ部■サ
ラシミッロウ ５．０■エルカ酸
オレイル ５．００ワセリン
８５．０［製法］成分■〜■を加
熱溶解して混合した後、冷却して製品とする。Example 5 Ointment■Purified lanolin S, O parts■Sarasimillow 5.0■Oleyl erucate 5.00Vaseline
85.0 [Manufacturing method] Components (1) to (2) are heated and dissolved, mixed, and then cooled to form a product.
［製法］成分■〜■を加熱溶解して混合した後、冷却し
て製品とする。[Manufacturing method] Components (1) to (2) are heated and dissolved, mixed, and then cooled to form a product.
実施例７ ヘアーオイル ■エルカ酸すルニル ■流動パラフィン ［製法］成分■および■を混合した後、製品とする。Example 7 Hair oil ■Lunyl erucic acid ■Liquid paraffin [Manufacturing method] After mixing ingredients (1) and (2), prepare a product.
８０．０
部
２０．０
ろ過して
実施例２、実施例３、実施例５、実施例６および実施例
７についても良好な発毛促進および毛成長促進効果が認
められた。80.0 parts 20.0 filtration Examples 2, 3, 5, 6 and 7 were also found to have good hair growth promoting effects.
Claims (4)
の一般式で示されるドコセン酸エステルの１種または２
種以上を有効成分とする養毛料。 Ｃ＿２＿１Ｈ＿４＿１ＣＯＯＲ Ｒはアルコール残基を表す。(1) One or two docosenoic acid esters represented by the following general formula consisting of docosenoic acid and an unsaturated alcohol.
A hair nourishing agent containing seeds or more as an active ingredient. C_2_1H_4_1COOR R represents an alcohol residue.
個を有し炭素数が１８個であることを特徴とする請求項
第１項記載の養毛料。(2) Unsaturated alcohol has 1 to 3 double bonds in the molecule
2. The hair nourishing agent according to claim 1, wherein the hair nourishing agent has 18 carbon atoms.
ジルアルコール、リノレイルアルコール、またはリノレ
ニルアルコールから選ばれることを特徴とする請求項第
１項または第２項記載の養毛料。(3) The hair nourishing composition according to claim 1 or 2, wherein the unsaturated alcohol is selected from oleyl alcohol, elaidyl alcohol, linoleyl alcohol, or linolenyl alcohol.
であることを特徴とする請求項第１項記載の養毛料。(4) The hair nourishment according to claim 1, wherein the content of docosenoic acid ester is 1.0% by weight or more.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1470990A JPH03220113A (en) | 1990-01-24 | 1990-01-24 | Hair tonic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1470990A JPH03220113A (en) | 1990-01-24 | 1990-01-24 | Hair tonic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH03220113A true JPH03220113A (en) | 1991-09-27 |
Family
ID=11868692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1470990A Pending JPH03220113A (en) | 1990-01-24 | 1990-01-24 | Hair tonic |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH03220113A (en) |
-
1990
- 1990-01-24 JP JP1470990A patent/JPH03220113A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPH026403A (en) | Cosmetic for hair and hair tonic | |
| JP2000016917A (en) | Skin whitening cosmetic | |
| JPH0745387B2 (en) | Hair growth and hair growth promoter | |
| JPH08133950A (en) | Skin preparation for external use | |
| JP2546813B2 (en) | Hair nourishing cosmetics | |
| JP2676226B2 (en) | Hair cosmetics and hair nourishment | |
| JPH03220113A (en) | Hair tonic | |
| JPH11302133A (en) | Cosmetic for scalp and hair | |
| JPS63183518A (en) | hair composition | |
| JPH08113516A (en) | Composition for scalp | |
| JPH0987148A (en) | Hair growing composition | |
| JPH01207224A (en) | Cosmetic for hair and hair tonic | |
| JPH02145507A (en) | Dandruff preventing cosmetic | |
| JP2003012468A (en) | Promoter for restoration and growth of hair | |
| JPS60116616A (en) | Cosmetic | |
| JP3496896B2 (en) | Hair restorer and hair cosmetic | |
| JPH0563450B2 (en) | ||
| JPS63196507A (en) | Hair nourishing cosmetic | |
| JPH03236310A (en) | Hair tonic | |
| JPH03206020A (en) | Hair tonic base | |
| JPS6041046B2 (en) | Anti-dandruff hair cosmetics | |
| JPH04308523A (en) | Hair-tonic cosmetic | |
| JP2003012509A (en) | Ski care preparation | |
| JPH10120532A (en) | Keratin plug remover for scalp and cosmetic for scalp and hair | |
| JPS6388113A (en) | Hair cosmetic |