JPH0338514A - Mouth-washing agent for inhibiting bacterial plaque on teeth - Google Patents

Abstract

PURPOSE:To obtain a mouth-washing agent for inhibiting bacterial plaque on teeth which has action to prohibit dental cavity microorganisms from taking roots and prevent and treat tooth decay and periodontoses by using a specific acrylic copolymer, a specific nonionic surface active agent and water. CONSTITUTION:The subject mouth-washing agent contains, as essential components, 0.001 to 10wt.% of a copolymer from monomers of formula 1, formula II and formula III (R1 to R3 are H, methyl; R4 and R5 are 1 to 18c alkyl wherein R2 and R3, R4 and R5 are not same simultaneously) and 0.05 to 15wt.% of a nonionic surfactant selected from the group consisting of polyoxyethyleneoxyfatty acid triglyceride derivatives, polyoxyethylene sorbitan fatty acid esters and block polymer type surfactants, and water. Additionally, other usually used components are appropriately added and the total mixture is compounded in a usual manner to give the subject agent. The average molecular weight of the copolymer is 10,000 to 200,000.

Description

[Detailed Description of the Invention] The present invention has the effect of suppressing the adhesion of oral bacteria, that is, dental plaque, to the teeth, and has the effect of preventing caries and preventing periodontal disease. This invention relates to a mouthwash that suppresses plaque adhesion and has a therapeutic effect.

Conventional techniques and challenges It has been revealed that dental caries and periodontal disease are caused by dental plaque. It is caused by the acid produced by metabolizing the sugars in the tooth that demineralizes tooth enamel. Also, some bacteria in plaque can irritate the gums.
secretes enzymes and endotoxins that cause inflammation of the gums.

The gums then bleed, lose elasticity, and eventually separate from the teeth, creating periodontal pockets. This periodontal pocket becomes a home for anaerobic bacteria, and the enzymes and endotoxins produced by these bacteria destroy the periodontal tissue and cause periodontal disease.

Therefore, in order to prevent such onset, many methods have been proposed to suppress the adhesion of dental plaque to teeth (Japanese Patent Laid-Open No. 60-16
No. 9423, Japanese Unexamined Patent Publication No. 63-8325, etc.), but none of them are completely satisfactory.

An object of the present invention is to provide a novel mouthwash that is excellent in suppressing the adhesion of dental plaque (oral bacteria) to teeth.

Means for Solving the Problems The present inventors have now demonstrated that the adhesion of Streptococcus mutans to saliva-covered hydroxyapatite beads, which is a model system for the adhesion of dental plaque to teeth, is observed in a specific acrylic-based system. The present inventors have discovered that a mouthwash containing a copolymer and a specific nonionic surfactant effectively suppresses plaque adhesion and is useful as a mouthwash for suppressing plaque adhesion, and has completed the present invention.

That is, the present invention provides the following essential components: (a) Formula: [wherein R8, R2, R5 are hydrogen or methyl groups, j3
and R4 and R6 represent an alkyl group having a carbon number of t-tS. However, R1 and R5 and R4 and R6 cannot be the same group at the same time. ] A copolymer obtained by copolymerizing the monomers shown below.

(b) 1 selected from the group consisting of polyoxyethylene oxyfatty acid triglyceride derivatives, polyoxyethylene sorbitan fatty acid esters, and block polymer types;
The present invention provides a dental plaque adhesion inhibiting mouth rinse characterized by containing one or more nonionic surfactants and (c) water.

Note that oral compositions are known that suppress tartar formation by blending a copolymer of polyacrylic acid and 3-hydroquinopropyl methacrylate to chelate calcium ions that form tartar. (Unexamined Japanese Patent Publication No. 1983-
No. 165317) is completely different from the present invention in the type of copolymer used and the purpose of application.

The copolymer used in the present invention includes the monomer of the formula [1],
It is obtained by copolymerizing the monomer of formula [11] and the monomer of formula [In], and has a weight average molecular weight of
Preferably about 10,000 to about 200°000, more preferably about 50,000 to 10°, o o o. These are product names: Plus Size L-53D, Plus Size L-53
It is available as P (manufactured by Gooh Kagaku Co., Ltd.).

The amount of the copolymer used in the mouthwash of the present invention is generally about 0.001% to about 10.0% by weight, preferably about 0.05% to about 8.0% by weight, and Preferably from about 0.1% to about 50% by weight. The blending amount is 0.00
If it is less than 1% by weight, the effect of inhibiting plaque adhesion will not be sufficient, while if it is more than 100% by weight, the viscosity will become too high and it will not be suitable for use.

In addition, the nonionic surfactants used in the present invention include (1) polyoxyethylene oxyfatty acid triglyceride derivatives, such as polyoxyethylene hydrogenated castor oil derivatives, polyoxyethylene castor oil derivatives, etc., (2) polyoxyethylene sol tan fatty acid ester,
For example, borioquinoethylene solhitan monooleate, polyoquinoethylene solhitan monostearate,
(3) Block polymer types, such as pluronic, tetronic, etc., such as polyoxoethylene solhikun monopalmitate.

Such nonionic surfactants may be used alone or in combination with 2F+1 or more.

The amount of nonionic surfactant used in the mouthwash of the present invention is generally about 0.05% to about 150% by weight, preferably about 0.1% to about 5.0% by weight, and more preferably about 0.1% to about 5.0% by weight. From about 0.45% to about 5% by weight. The blending amount is 0.
If it is less than 0.5 doublet%, the effect of suppressing plaque adhesion will not be sufficient, while if it is more than 150% by weight, the viscosity will become too high and it will not be suitable for use.

The mouthwash of the present invention can be produced by a conventional method, and other ingredients are not particularly limited, and any commonly used ingredients can be blended. For example, wetting agents such as polyethylene glycol, sorbitol, glycerin, propylene glycol, blowing agents such as sodium lauryl sulfate, sodium dodecylbenzenesulfonate, sodium hydrogenated coconut fatty acid monoglyceride sulfate, sodium laurylsulfoacetate, N-acylglutamate, Flavoring agents, sweeteners, preservatives, etc. can be added as appropriate.

EXAMPLES Next, the present invention will be explained in more detail with reference to experimental examples, working examples, and comparative examples.

Experimental Example Effect on the adsorption of Streptococcus mutans 6715 onto saliva-coated hydroxyapatite (HAP) beads (1) 20xy HAP beads were added to human saliva (blood limb type 0).
) Incubated with 0.5zQ for 1 hour at room temperature. The beads were mixed with 0.05M KC (2,1mM Ktt*
po, lsM CaCQz and 1mM MgC12
The cells were washed twice with INR, a pH 6.0 buffer consisting of T.

(This buffer is an imitation of salivary inorganic fluid.)
.

The beads were then incubated for 1 hour at room temperature with a pH 7.0 polymer solution (sample solution) 0,5 z (l) and washed twice with the above buffer 1x (l).

Next, a suspension containing 5.0 x 10' [3H]thymidine-labeled bacteria (Streptococcus mutans) in the buffer/fL0, 5 cells was added to the beads,
Incubated for 1 hour at room temperature. The buffer solution 1zQ
The beads were washed three times with water, the beads were transferred to a vial, and the radioactivity was counted using a liquid non-deletion counter. on the other hand,
The percentage of known [3H]-labeled cells was counted using the same method, and a standard curve for the number of bacteria was created.

The sample solutions used are shown in the column of treatment of saliva coated HAP in Table 1.

As shown in Table 1, it was confirmed that an aqueous solution of 0.1% of the acrylic copolymer and a specific nonionic surfactant significantly inhibited the adsorption of bacteria to saliva-coated HAP.

Examples 1 to 8 and Comparative Examples 1 to 6 Mouthwashes were manufactured by a conventional method according to the formulations shown in Table 2,
As in the experimental example, the effect on the adsorption of Streptococcus mutans 6715 onto HAP beads was investigated. The results are shown in Table 2.

In Table 2, the viscosity and overall evaluation were determined based on the following criteria.

Viscosity (according to organoleptic) ○: Good ×: Too expensive to be used.

Overall evaluation ○: The relative ratio of the effect on adsorption is 50% or less and the viscosity is ○.

×: The relative ratio of the effect on adsorption is greater than 50%, or the viscosity is ×.

Example 9 According to the following prescription, Ta.

Manufacture mouthwash using conventional methods component glycerin polyoxyethylene hardening Castor oil (60E, O,) ethanol Sodium hydroxide saccharin sodium Plus size [, -53P Methyl roseoxybenzoate fragrance purified water Example 1O According to the following prescription, Ta.

A mouthwash was manufactured using a conventional method. Ingredients: Glycerin content (%) 0 1.5 0 0.2 2 +, 0 0.5 0.5 Remaining content (%) Sorbitol polysorbate ethanol 5 Sodium hydroxide 0.002 Plus Size L-53D 0.01 Sodium Benzoate 05 Fragrance
0.5 purified water
Remaining Effects of the Invention According to the present invention, a mouthwash that effectively suppresses the adhesion of dental plaque to teeth can be obtained.

Claims (3)

[Claims] (1) As essential components, (a) Formulas: ▲There are mathematical formulas, chemical formulas, tables, etc.▼［I］▲There are mathematical formulas, chemical formulas, tables, etc.▼［II］▲There are mathematical formulas, chemical formulas, tables, etc.▼［III [In the formula, R_1, R_2, and R_3 represent hydrogen or a methyl group, and R_4 and R_5 represent an alkyl group having 1 to 18 carbon atoms. However, R_2 and R_3, R_4 and R_5
and cannot be based on the same base at the same time. ] A copolymer obtained by copolymerizing the monomers shown below. (b) 1 selected from the group consisting of polyoxyethylene oxyfatty acid triglyceride derivatives, polyoxyethylene sorbitan fatty acid esters, and block polymer types;
A mouthwash for inhibiting dental plaque adhesion, characterized in that it contains one or more nonionic surfactants (c) and water. (2) The average molecular weight of the copolymer is 10,000 to 200
.,000. The mouthwash of claim (1). (3) The mouthwash of claim (1) or claim (2), which contains 0.001 to 10% by weight of the copolymer.