JPH0339152A - 中空器官縫合用の異型コラーゲン管からなる人工器官 - Google Patents

中空器官縫合用の異型コラーゲン管からなる人工器官

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Publication number
JPH0339152A
JPH0339152A JP90168619A JP16861990A JPH0339152A JP H0339152 A JPH0339152 A JP H0339152A JP 90168619 A JP90168619 A JP 90168619A JP 16861990 A JP16861990 A JP 16861990A JP H0339152 A JPH0339152 A JP H0339152A
Authority
JP
Japan
Prior art keywords
prosthesis according
prosthesis
collagen
organ
tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP90168619A
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English (en)
Inventor
Beniamino Palmieri
ベニアミーノ　パルミエーリ
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EURO RES Srl
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EURO RES Srl
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Application filed by EURO RES Srl filed Critical EURO RES Srl
Publication of JPH0339152A publication Critical patent/JPH0339152A/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/11—Surgical instruments, devices or methods for performing anastomosis; Buttons for anastomosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/11—Surgical instruments, devices or methods for performing anastomosis; Buttons for anastomosis
    • A61B17/1114—Surgical instruments, devices or methods for performing anastomosis; Buttons for anastomosis of the digestive tract, e.g. bowels or oesophagus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00004—(bio)absorbable, (bio)resorbable or resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/3008—Properties of materials and coating materials radio-opaque, e.g. radio-opaque markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30205—Three-dimensional shapes conical
    • A61F2002/30214—Three-dimensional shapes conical having tapered sections of different conicities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30205—Three-dimensional shapes conical
    • A61F2002/30217—Three-dimensional shapes conical hollow cones, e.g. tubular-like cones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0067—Three-dimensional shapes conical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
    • A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/43—Hormones, e.g. dexamethasone

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。

Description

【発明の詳細な説明】 ［産業上の利用分野］ 本発明は異型（）ｌｅｔｅｒｏｌｏｇｏｕｓ）コラーゲ
ンからなり、中空器官の縫合形成に用いられた場合に、
著しい長所を発揮する管状人工器官に関する。
［従来の技術］ 切断片を切除した後に中空器官の両端を再組成させる場
合には、該両端付近を次の様にして縫合する； 両端を旨く合わせる様に一端面と他端面とを配置する。
この際には、粘膜平面が完全に正常位置に在る様にする
外、一端の各層が他端の対応各層と完全に一致する様に
配置する。
［発明が解決しようとする課題］ 本発明はこの手術を確実に成功させる為に特に有用な人
工器官を提供することを目的とするものである。即ち、
この人工器官は縫合の操作を容易にすると共に縫合部の
一端を他端と完全に向き合わせることができる様にする
。
該人工器官は内臓向けに特に好適であるが、大きさが適
当であれば、胆管その他の中空器官の縫合にも用いると
有益である。
〔課題を解決するための手段］ 本発明の人工器官の特色は次の通りである：円錐台形の
端部を有する管状体であって、その中間位置に鍔状の周
縁部を備え、 放射線半透明性である。
該人工器官の特性及び長所は第１図を参照する後記の説
明から、−層間らかになる。この説明は実施例の形で行
なわれているが、それは本発明を限定する６のではない
。
該図面から、次のことが明らかになる：・この人工器官
は円筒状の内壁面ｌ及び円錐台形（先細）の外壁面２と
を有する管状体である。
・この人工器官の長さは１５〜１５０ｍｍの範囲で、内
径は２〜１４ｅｖ＋の範囲で変えることができる。
・この人工器官の外径は末端部では１０〜２０ａ＋ｍの
範囲で、中間位置では２０〜５０ｍ＋ａの範囲で変える
ことができる。
・この人工器官の寸法は要求に合わせて手直しでき、使
用時点でも可能である０例えば、その長さは端部を鋏で
切れば短くできるし、その直径及び厚さは圧縮によって
変えることができる。
この人工器官は中間位置に、鍔状の周縁部を備えている
。該周縁部は厚さ１〜２ｆｆｌＩ１１で、幅２〜３ｍｇ
のものである。
この人工器官の材質に放射線半透明性を付与するには、
放射線半透明性の針金を挿入するか、硫酸バリウムを混
合する。
この人工器官の円錐台形の端部は対象とする器官末端の
管腔へこの人工器官を挿入する為に有益である。他方、
鍔状周縁部３はこの人工器官を縫合部へ一層良く固定す
ると共に、コラーゲンにより、縫合部を一体化させる機
能を果たす。その目的は縫合部を適切に癒着させること
及び如何に細い導管であっても液洩れを生じ得るものを
凝固閉塞する効果を発揮することにある。
望むならば、ここに述べる人工器官を次の手段によって
完成させることができる： 縫合部をコラーゲンの細帯（厚さ１〜２ＩＩＩＩ１１、
幅２０〜３０ｍｍ）で帯を巻く様に包む。
この管状の人工器官は手術部位を糞便による汚染から守
る上で重要な機能を果たす。即ち、ガス体、液体及び固
形物を通過させるが、他方、コラーゲンの細帯が二重の
防禦機能を発揮する：・外部からの感染を防禦する ・癒着が生ずることを防止する。
本発明の人工器官の別の長所としては、最適廠痕形成を
促進することである。
本発明の人工器官を作成する為に用いられるコラーゲン
は親液媒体化型のものであり、３日以上の時間経過後に
は分解によって再吸収される。
この人工器官はその表面に吸着された状態で、次の様な
薬理作用物質を含有し得る： 抗生物質、消炎剤、ホルモン、フィプリン及びポリアク
リレート、フィブロネクチン、ＥＧＦ、ＰＧＦ等の様な
癲痕化因子。この人工器官には、次の系を組合わせるこ
ともできる： 瘢痕化正常性検定系、標識付き系、酵素系又は細胞系。
この人工器官は個々の用途に応じて、その表面に上皮を
形成させる為に、その表面に内皮を形成させる為に又は
その表面をフィプリンもしくは線維性物質で覆わせる為
に、前取て生体の他の部分例えば、皮膚の下又は腹膜の
下に挿入されても良い。
この人工器官は室温においても、４℃においても装着す
ることができる。尤も、その温度においては、縫合中に
そのａｔを更に安定化する上で望ましい場合であること
を前提とする。
［発明の効果］ 本発明の人工器官はその端部を円錐台形としていること
から、対象とする器官末端の管腔へ容易に挿入すること
ができる。他方、鍔状周縁部３はこの人工器官を縫合部
へ一層良く固定すると共に、コラーゲンにより、縫合部
を一体化させる機能を果たす。
この管状の人工器官は手術部位を汚染がら守る上で重要
な機能を果たす。即ち、ガス体、液体及び固形物を通過
させる一方で、コラーゲンの細帯が二重の防禦機能を発
揮する。
本発明の人工器官を作成する為に用いられるコラーゲン
は親液媒体化型のちのであり、３日以上の時間経過後に
は分解によって再吸収される。
本発明の人工器官は更に最適廠痕形成を促進する。
【図面の簡単な説明】
第１図は本発明の人工器官の部分切開側面図である。 ｌ・・・筒状の内壁面、２・・・円錐台形の端部、３・
・・鍔状の周縁部

Claims (1)

  1. 【特許請求の範囲】 （ｌ）円錐台形の端部を有する管状体であって、中間位
    置に鍔状の周縁部を備え、放射線半透明性であることを
    特徴とする中空器官縫合用の異型コラーゲン管からなる
    人工器官。 （２）該管が円筒状の内壁面（１）及び外壁面（２）並
    びに円錐台形の端部を備えていることを特徴とする請求
    項１に記載の人工器官。 （３）長さ１５〜１５０ｍｍ及び内径２〜１４ｍｍであ
    ることを特徴とする請求項１に記載の人工器官。 （４）末端における外径１０〜２０ｍｍ及び中間位置に
    おける外径２０〜５０ｍｍであることを特徴とする請求
    項１に記載の人工器官。 （５）該鍔状の周縁部（３）が厚さ１〜２ｍｍで幅２〜
    ３ｍｍであることを特徴とする請求項１に記載の人工器
    官。 （６）該放射線半透明性が該コラーゲン中に放射線半透
    明性の針金を挿入することによって得られることを特徴
    とする請求項１に記載の人工器官。 （７）該放射線半透明性が該コラーゲン中に硫酸バリウ
    ムを混合することによって得られることを特徴とする請
    求項１に記載の人工器官。 （８）コラーゲンの細帯を縫合部の周囲に帯として巻付
    けることによって完成されたものであることを特徴とす
    る請求項１に記載の人工器官。 （９）該コラーゲンの細帯が厚さ１〜２ｍｍで幅２０〜
    ３０ｍｍであることを特徴とする請求項１に記載の人工
    器官。 （１０）該コラーゲンが親液媒化型で、３日以上の時間
    経過後には溶解によって再吸着可能であることを特徴と
    する請求項１に記載の人工器官。 （１１）抗生物質、消炎性物質、ホルモン、結合性物質
    及び癲痕化因子の様な物質を表面に吸着された状態で含
    有することを特徴とする請求項１に記載の人工器官。 （１２）次の何れかの系を組み込んでいることを特徴と
    する請求項１に記載の人工器官： 瘢痕化正常性検定系、標識付き系、酵素系又は細胞系。 （１３）その表面に上皮を形成させる為に、その表面に
    内皮を形成させる為に又はその表面をフィプリンもしく
    は線維性物質で覆わせる為に、前以って生体の他の部分
    に挿入されていることを特徴とする請求項１に記載の人
    工器官。 （１４）中空器官縫合用の異型コラーゲン管からなるこ
    とを特徴とする請求項１〜１３の何れかに記載され、特
    定の目的に用いられることが記載されている人工器官。
JP90168619A 1989-06-30 1990-06-28 中空器官縫合用の異型コラーゲン管からなる人工器官 Pending JPH0339152A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT21345B/89 1989-06-30
IT8921345U IT216721Z2 (it) 1989-06-30 1989-06-30 Tutore costituito da un tubolare di collageno eterologo, atto all'impiego nelle suture di organi cavi.

Publications (1)

Publication Number Publication Date
JPH0339152A true JPH0339152A (ja) 1991-02-20

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Application Number Title Priority Date Filing Date
JP90168619A Pending JPH0339152A (ja) 1989-06-30 1990-06-28 中空器官縫合用の異型コラーゲン管からなる人工器官

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US (1) US5139505A (ja)
EP (1) EP0405429B1 (ja)
JP (1) JPH0339152A (ja)
AT (1) ATE99963T1 (ja)
CA (1) CA2020136A1 (ja)
DE (1) DE69005922T2 (ja)
IT (1) IT216721Z2 (ja)

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Also Published As

Publication number Publication date
IT8921345V0 (it) 1989-06-30
US5139505A (en) 1992-08-18
DE69005922T2 (de) 1994-05-19
IT216721Z2 (it) 1991-09-19
EP0405429A3 (en) 1991-08-14
ATE99963T1 (de) 1994-01-15
DE69005922D1 (de) 1994-02-24
EP0405429B1 (en) 1994-01-12
CA2020136A1 (en) 1990-12-31
EP0405429A2 (en) 1991-01-02

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