JPH0351062A - Iontophoresis device - Google Patents

Abstract

PURPOSE:To minimize the energy consumption by water electrolysis and utilize most of electric energy for chemical injection energy by arranging a material lowering the gas generation by water electrolysis on the surface of positive and negative electrodes kept in contact with a chemical solution. CONSTITUTION:An electrode made of gold on the surface is used for the positive electrode 2 of a thin battery 1 for applying the DC voltage, and an electrolyte 3 solved with a chemical in physiological salt water 5 is kept in contact with it. An electrode made of zinc on the surface is used for a negative electrode 4, and it is kept in contact with physiological salt water 5 contained in gauze. Platinum, indium, rhodium and nickel are effective for suppressing the generation of gas in addition to gold as the electrode materiel of the positive electrode 2, and lead, copper and silver are effective in addition to zinc as the electrode material of the negative electrode 4. The generation of gas from electrodes can be suppressed, thus the chemical can be efficiently injected. The voltage of the battery 1 can be set low, and safety is improved.

Description

DETAILED DESCRIPTION OF THE INVENTION Field of Industrial Application The present invention relates to an iontophoresis device that injects a drug into the skin or mucous membrane using ion flow caused by direct current.

Conventional technology and its problems Oral medicine requires taking 100 times or more of the required amount to be supplied to the affected area, but with iontophoresis Vy-, the amount can be 1/100 because it can be injected locally. In addition, topical patches have been proposed, but these are slow to be absorbed. According to iontophores++Ps, it is absorbed several tens to hundreds of times faster.

Furthermore, medicines can be administered without the pain of needles and the risk of infection, as is the case with injections.

Although iontophores have advantages as mentioned above, there is a problem in that most of the power consumption is consumed for water electrolysis.

OBJECTS OF THE INVENTION The present invention eliminates the above-mentioned drawbacks, and aims to provide an iontophoresis device that minimizes the energy consumption due to water electrolysis and utilizes most of the electrical energy for chemical injection energy.

Structure of the Invention In order to achieve the above-mentioned object, the present invention provides a decontamination electrode that comes into contact with a drug solution in an iontophoresis device that applies a voltage to the skin or mucous membrane, electrophoresizes the drug, and injects it into the human body. This is an iontophoresis device characterized in that a substance that reduces gas generation due to water electrolysis is placed on the surface of the iontophoresis device. Further, the present invention is the above-mentioned iontophoresis device in which heavy metals are arranged on the electrode surface.

In a device that applies a voltage to the skin or the skin and injects drugs transdermally, the metal on the electrode surface is arranged such that the anode is a material that generates little oxygen and the cathode is a material that generates little hydrogen. suppressed gas generation caused by

EXAMPLE Below 1 Details of the present invention will be explained by way of an example. Figure 1 shows an iontophoret V according to an example of the present invention.
In Fig. 1, 1 is a thin battery for applying a DC voltage, 2 is an anode with a gold surface, and 3 is an electrolytic solution in which a drug is dissolved in physiological saline. ing. 4 is a cathode, which is an electrode with a zinc surface, and is in contact with the physiological saline soaked in gauze 5.

FIG. 2 is a schematic diagram of a test apparatus for confirming the effects of different electrodes, and the test apparatus has the same configuration as the above embodiment except for the DC power supply 6 which can vary the applied voltage. 7 is the skin.

In an embodiment of the present invention, an iontophoresis device using gold as an anode and zinc as a cathode is used! and conventional anode,
Both the cathode and the cathode are iontophoresis device using platinum.The electrode area is 1d1 and the current application time is 5 minutes. In addition to gold, platinum, iridium to rhodicum, and nickel μ have the effect of suppressing gas generation.As for the cathode wL electrode materials, in addition to zinc, lead, copper,
Silver was effective.

As described above, according to the present invention, the generation of gas from the electrodes is suppressed, so that the drug can be injected efficiently, and the battery voltage can be set low, resulting in the effect of improving safety. .

Effects of the Invention As mentioned above, the present invention can provide an ion door array V7 device that minimizes the energy consumed by water electrolysis and uses most of the electrical energy for chemical injection energy, so its industrial value is extremely high. It's large.

[Brief explanation of drawings]

FIG. 1 is a schematic diagram of an iontophoresis device according to an embodiment of the present invention, and FIG. 2 is a schematic diagram of a test device. 1...Battery 2...Anode 3...
Drug-containing physiological saline 4...Cathode 5...Physiological saline 6...DC power supply 7...Skin

Claims (2)

[Claims] (1) In iontophoresis devices that apply voltage to the skin, electrophores the drug, and inject it into the human body, reduce gas generation due to water electrolysis on the surfaces of the positive and negative electrodes that come into contact with the drug solution. An iontophoresis device characterized by having a substance arranged therein. (2) The iontophoresis device according to claim 1, wherein a heavy metal is arranged on the surface of the electrode.