JPH0372044B2 - - Google Patents

Info

Publication number: JPH0372044B2
Authority: JP; Japan
Prior art keywords: enkephalin; leucine; arg; endorphin; mice
Prior art date: 1981-10-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP57175255A

Other languages

English (en)

Japanese (ja)

Other versions

JPS58126811A (ja

Inventor

Pii Purotonikofu Nikorasu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Individual

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-10-05

Filing date

1982-10-05

Publication date

1991-11-15

1982-10-05 Application filed by Individual filed Critical Individual

1983-07-28 Publication of JPS58126811A publication Critical patent/JPS58126811A/ja

1991-11-15 Publication of JPH0372044B2 publication Critical patent/JPH0372044B2/ja

Status Granted legal-status Critical Current

Links

108010022337 Leucine Enkephalin Proteins 0.000 claims description 20
URLZCHNOLZSCCA-UHFFFAOYSA-N leu-enkephalin Chemical compound C=1C=C(O)C=CC=1CC(N)C(=O)NCC(=O)NCC(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=CC=C1 URLZCHNOLZSCCA-UHFFFAOYSA-N 0.000 claims description 20
YFGBQHOOROIVKG-FKBYEOEOSA-N Met-enkephalin Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 YFGBQHOOROIVKG-FKBYEOEOSA-N 0.000 claims description 14
108010042237 Methionine Enkephalin Proteins 0.000 claims description 13
108010049140 Endorphins Proteins 0.000 claims description 10
102000009025 Endorphins Human genes 0.000 claims description 10
WOPZMFQRCBYPJU-NTXHZHDSSA-N beta-endorphin Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C1=CC=CC=C1 WOPZMFQRCBYPJU-NTXHZHDSSA-N 0.000 claims description 10
101800005049 Beta-endorphin Proteins 0.000 claims description 8
102400000748 Beta-endorphin Human genes 0.000 claims description 8
230000004614 tumor growth Effects 0.000 claims description 7
WECYRWOMWSCWNX-XUXIUFHCSA-N Ile-Arg-Leu Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(O)=O WECYRWOMWSCWNX-XUXIUFHCSA-N 0.000 claims description 2
SENJXOPIZNYLHU-UHFFFAOYSA-N L-leucyl-L-arginine Natural products CC(C)CC(N)C(=O)NC(C(O)=O)CCCN=C(N)N SENJXOPIZNYLHU-UHFFFAOYSA-N 0.000 claims description 2
SENJXOPIZNYLHU-IUCAKERBSA-N Leu-Arg Chemical compound CC(C)C[C@H](N)C(=O)N[C@H](C(O)=O)CCCN=C(N)N SENJXOPIZNYLHU-IUCAKERBSA-N 0.000 claims description 2
108010000761 leucylarginine Proteins 0.000 claims description 2
239000003966 growth inhibitor Substances 0.000 claims 3
102100024622 Proenkephalin-B Human genes 0.000 claims 2
108010012970 dynorphin (1-8) Proteins 0.000 claims 2
WRPLGMBDXVBPEG-ZFBBIHQWSA-N (2s,3s)-2-[[2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[2-[[2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoy Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 WRPLGMBDXVBPEG-ZFBBIHQWSA-N 0.000 claims 1
101800000279 Beta-neoendorphin Proteins 0.000 claims 1
108010065372 Dynorphins Proteins 0.000 claims 1
SVSJNSUODBXQIG-RCNKGVCCSA-N methyl (2s,3r)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[2-[[2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneam Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@H](C)CC)C(=O)OC)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 SVSJNSUODBXQIG-RCNKGVCCSA-N 0.000 claims 1
RTXIYIQLESPXIV-VLOLPVCOSA-N β-neoendorphin Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 RTXIYIQLESPXIV-VLOLPVCOSA-N 0.000 claims 1
241000699670 Mus sp. Species 0.000 description 23
238000002474 experimental method Methods 0.000 description 15
URLZCHNOLZSCCA-VABKMULXSA-N Leu-enkephalin Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 URLZCHNOLZSCCA-VABKMULXSA-N 0.000 description 12
108010092674 Enkephalins Proteins 0.000 description 11
108090000765 processed proteins & peptides Proteins 0.000 description 11
210000004881 tumor cell Anatomy 0.000 description 10
210000004027 cell Anatomy 0.000 description 9
230000004083 survival effect Effects 0.000 description 9
210000001744 T-lymphocyte Anatomy 0.000 description 8
230000000694 effects Effects 0.000 description 8
102000004196 processed proteins & peptides Human genes 0.000 description 7
210000000987 immune system Anatomy 0.000 description 6
239000002243 precursor Substances 0.000 description 5
108020003175 receptors Proteins 0.000 description 5
102000005962 receptors Human genes 0.000 description 5
108010050904 Interferons Proteins 0.000 description 4
102000014150 Interferons Human genes 0.000 description 4
241001465754 Metazoa Species 0.000 description 4
230000000259 anti-tumor effect Effects 0.000 description 4
239000003814 drug Substances 0.000 description 4
230000002992 thymic effect Effects 0.000 description 4
241000699666 Mus <mouse, genus> Species 0.000 description 3
108090000137 Opioid Receptors Proteins 0.000 description 3
102000003840 Opioid Receptors Human genes 0.000 description 3
230000000202 analgesic effect Effects 0.000 description 3
238000001727 in vivo Methods 0.000 description 3
230000005764 inhibitory process Effects 0.000 description 3
238000011081 inoculation Methods 0.000 description 3
229940079322 interferon Drugs 0.000 description 3
241000282412 Homo Species 0.000 description 2
206010062767 Hypophysitis Diseases 0.000 description 2
102000003960 Ligases Human genes 0.000 description 2
108090000364 Ligases Proteins 0.000 description 2
206010028980 Neoplasm Diseases 0.000 description 2
102000007501 Thymosin Human genes 0.000 description 2
108010046075 Thymosin Proteins 0.000 description 2
210000004556 brain Anatomy 0.000 description 2
210000003169 central nervous system Anatomy 0.000 description 2
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
229940079593 drug Drugs 0.000 description 2
108010047064 gamma-Endorphin Proteins 0.000 description 2
229940088597 hormone Drugs 0.000 description 2
238000007918 intramuscular administration Methods 0.000 description 2
238000001990 intravenous administration Methods 0.000 description 2
210000004698 lymphocyte Anatomy 0.000 description 2
238000000034 method Methods 0.000 description 2
210000003635 pituitary gland Anatomy 0.000 description 2
239000003488 releasing hormone Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 description 2
210000001541 thymus gland Anatomy 0.000 description 2
238000012546 transfer Methods 0.000 description 2
GASYAMBJHBRTOE-WHDBNHDESA-N γ-endorphin Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 GASYAMBJHBRTOE-WHDBNHDESA-N 0.000 description 2
206010003445 Ascites Diseases 0.000 description 1
101800000414 Corticotropin Proteins 0.000 description 1
239000000055 Corticotropin-Releasing Hormone Substances 0.000 description 1
238000011765 DBA/2 mouse Methods 0.000 description 1
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Natural products C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 1
108010093625 Opioid Peptides Proteins 0.000 description 1
102000001490 Opioid Peptides Human genes 0.000 description 1
102100027467 Pro-opiomelanocortin Human genes 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
210000004100 adrenal gland Anatomy 0.000 description 1
239000000443 aerosol Substances 0.000 description 1
230000032683 aging Effects 0.000 description 1
150000001413 amino acids Chemical group 0.000 description 1
238000010171 animal model Methods 0.000 description 1
230000001430 anti-depressive effect Effects 0.000 description 1
239000000935 antidepressant agent Substances 0.000 description 1
229940005513 antidepressants Drugs 0.000 description 1
230000006472 autoimmune response Effects 0.000 description 1
230000008499 blood brain barrier function Effects 0.000 description 1
210000001218 blood-brain barrier Anatomy 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000000546 chi-square test Methods 0.000 description 1
238000004891 communication Methods 0.000 description 1
IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 description 1
229960000258 corticotropin Drugs 0.000 description 1
210000003792 cranial nerve Anatomy 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
229960003638 dopamine Drugs 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
239000012634 fragment Substances 0.000 description 1
230000012010 growth Effects 0.000 description 1
239000005556 hormone Substances 0.000 description 1
210000003016 hypothalamus Anatomy 0.000 description 1
230000036039 immunity Effects 0.000 description 1
230000003308 immunostimulating effect Effects 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
229940047124 interferons Drugs 0.000 description 1
238000007912 intraperitoneal administration Methods 0.000 description 1
238000002955 isolation Methods 0.000 description 1
208000032839 leukemia Diseases 0.000 description 1
210000000265 leukocyte Anatomy 0.000 description 1
239000003446 ligand Substances 0.000 description 1
230000010534 mechanism of action Effects 0.000 description 1
230000001404 mediated effect Effects 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
108010041713 methionine-enkephalin receptor Proteins 0.000 description 1
230000000955 neuroendocrine Effects 0.000 description 1
239000003399 opiate peptide Substances 0.000 description 1
239000002245 particle Substances 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
230000004044 response Effects 0.000 description 1
230000028327 secretion Effects 0.000 description 1
229940125723 sedative agent Drugs 0.000 description 1
239000000932 sedative agent Substances 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
230000002194 synthesizing effect Effects 0.000 description 1
230000009897 systematic effect Effects 0.000 description 1
238000012360 testing method Methods 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
229940125725 tranquilizer Drugs 0.000 description 1
239000003204 tranquilizing agent Substances 0.000 description 1
230000002936 tranquilizing effect Effects 0.000 description 1
230000004565 tumor cell growth Effects 0.000 description 1
239000006216 vaginal suppository Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

JP57175255A 1981-10-05 1982-10-05 抗腫瘍剤 Granted JPS58126811A (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US30828781A	1981-10-05	1981-10-05
US308287		1981-10-05

Publications (2)

Publication Number	Publication Date
JPS58126811A JPS58126811A (ja)	1983-07-28
JPH0372044B2 true JPH0372044B2 (fr)	1991-11-15

Family

ID=23193353

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP57175255A Granted JPS58126811A (ja)	1981-10-05	1982-10-05	抗腫瘍剤

Country Status (4)

Country	Link
EP (1)	EP0076676B1 (fr)
JP (1)	JPS58126811A (fr)
AU (1)	AU566663B2 (fr)
DE (1)	DE3274798D1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0680079B2 (ja) *	1984-11-09	1994-10-12	エーザイ株式会社	ポリペプチド
DE4232594A1 (de) *	1992-09-24	1993-02-11	Siegfried Knauf	Neues medikament "endorphine" zur bekaempfung von chronischen gelenkrheumatismus und migraene
KR20100061481A (ko) *	2007-09-11	2010-06-07	몬도바이오테크 래보래토리즈 아게	치료제로서의 미니가스트린
WO2009033730A2 (fr) *	2007-09-11	2009-03-19	Mondobiotech Laboratoires Ag	Utilisation d'un peptide comme agent thérapeutique
WO2010033240A2 (fr)	2008-09-19	2010-03-25	Nektar Therapeutics	Polymères à base de glucide pour administration de médicaments et leurs conjugués
US20110171165A1 (en) *	2008-09-19	2011-07-14	Nektar Therapeutics	Polymer conjugates of opioid growth factor peptides

1982
- 1982-10-04 EP EP82305254A patent/EP0076676B1/fr not_active Expired
- 1982-10-04 DE DE8282305254T patent/DE3274798D1/de not_active Expired
- 1982-10-05 AU AU89113/82A patent/AU566663B2/en not_active Ceased
- 1982-10-05 JP JP57175255A patent/JPS58126811A/ja active Granted

Also Published As

Publication number	Publication date
AU8911382A (en)	1983-04-14
JPS58126811A (ja)	1983-07-28
AU566663B2 (en)	1987-10-29
EP0076676A3 (en)	1984-09-26
EP0076676A2 (fr)	1983-04-13
DE3274798D1 (en)	1987-02-05
EP0076676B1 (fr)	1986-12-30

Publication	Publication Date	Title
Jurna et al.	1981	Antinociceptive effect of centrally administered caerulein and cholecystokinin octapeptide (CCK-8)
BR0012200B1 (pt)	2013-08-06	composição de peptídeo para o tratamento de disfunção sexual e composição farmacêutica para o tratamento de disfunção sexual em um mamífero.
IL94052A (en)	1995-06-29	Pharmaceutical preparations containing cytokines for the treatment of pre-neoplastic lesions and the use of the above cytokines
GB1604850A (en)	1981-12-16	Biologically active peptides
Chang	1984	Opioid peptides have actions on the immune system
DE2438352A1 (de)	1976-02-26	Peptidcyclopropylamide mit lh-rh/fshrh-wirkung
JPH0372044B2 (fr)	1991-11-15
US20060106049A1 (en)	2006-05-18	Histone deacetylase inhibitors and methods of use
Furusawa et al.	1988	Effect of pretazettine and viva-natural, a dietary seaweed extract, on spontaneous AKR leukemia in comparison with standard drugs
Shah et al.	1994	Spinal and supraspinal effects of pertussis toxin on opioid analgesia
EP0213676B1 (fr)	1992-08-12	Compositions pharmaceutiques contenant l'ACTH(1-24)pour la thérapie des états de choc et des insuffisances respiratoires et cardiocirculatoires
JPH07277964A (ja)	1995-10-24	抗腫瘍剤
EP0000559B1 (fr)	1983-10-05	Pentapeptide-N-alkoylamides et leurs sels, procédé de préparation de ces produits et leurs compositions pharmacologiques
WO2017014604A1 (fr)	2017-01-26	Nouveau peptide et utilisation associée
US4435409A (en)	1984-03-06	Method of stimulating production of IgM antibodies
EP0315681B1 (fr)	1992-09-30	Utilisation de nalmefère pour l'obtention d'un médicament destiné au traitement des lesions du système nerveux central
US9486493B2 (en)	2016-11-08	Use of a peptide and an analgesic pharmaceutical agent
WO2002043748A1 (fr)	2002-06-06	Procede de traitement comportant l'administration de la substance p
WO2004000870A2 (fr)	2003-12-31	Deux peptides synthetiques pour le traitement et la prevention de cancers
AU707158B2 (en)	1999-07-01	A drug for the treatment of cancer
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