JPH038435A - Water soluble soft capsule - Google Patents
Water soluble soft capsuleInfo
- Publication number
- JPH038435A JPH038435A JP1143261A JP14326189A JPH038435A JP H038435 A JPH038435 A JP H038435A JP 1143261 A JP1143261 A JP 1143261A JP 14326189 A JP14326189 A JP 14326189A JP H038435 A JPH038435 A JP H038435A
- Authority
- JP
- Japan
- Prior art keywords
- gelatin
- water
- polypeptide
- soft capsule
- soluble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007901 soft capsule Substances 0.000 title claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 15
- 108010010803 Gelatin Proteins 0.000 claims abstract description 47
- 229920000159 gelatin Polymers 0.000 claims abstract description 47
- 239000008273 gelatin Substances 0.000 claims abstract description 47
- 235000019322 gelatine Nutrition 0.000 claims abstract description 47
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 47
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229920001184 polypeptide Polymers 0.000 claims abstract description 14
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 14
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 14
- 235000011187 glycerol Nutrition 0.000 claims abstract description 10
- 125000003277 amino group Chemical group 0.000 claims abstract description 9
- 238000002156 mixing Methods 0.000 claims abstract description 9
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims abstract description 4
- 229960003511 macrogol Drugs 0.000 claims abstract description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 4
- 239000000600 sorbitol Substances 0.000 claims description 4
- 235000010356 sorbitol Nutrition 0.000 claims description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 150000007524 organic acids Chemical class 0.000 claims description 2
- 239000002253 acid Substances 0.000 abstract description 3
- 230000003301 hydrolyzing effect Effects 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract description 3
- 238000009472 formulation Methods 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 239000007864 aqueous solution Substances 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 239000003599 detergent Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 239000004014 plasticizer Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
Landscapes
- Fodder In General (AREA)
- General Preparation And Processing Of Foods (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Detergent Compositions (AREA)
Abstract
Description
【発明の詳細な説明】
（産業上の利用分野）
この発明は、３５℃以下の水溶液で溶解する、例えば液
体或は粉末の洗剤、飼料混入薬剤等の被包に使用する水
溶性軟カプセルに関するものである。DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) This invention relates to water-soluble soft capsules that dissolve in an aqueous solution at 35° C. or below and are used for encapsulating liquid or powder detergents, feed-mixed drugs, etc. It is something.
（従来の技術）
一般に食品及び医薬品等の被包のために使用される軟カ
プセル剤は、無害であり、しかも易溶性であることを必
要とするところから、ゼラチンを基剤とし、これにグリ
セリン或はソルビットなどを加えて粘性を増加させたも
のが使用されている。(Prior art) Soft capsules, which are generally used for encapsulating foods and pharmaceuticals, are made of gelatin and glycerin, as they need to be harmless and easily soluble. Alternatively, sorbitol or the like is added to increase the viscosity.
軟カプセル剤の用途は上述の医薬品に限られず、洗剤、
飼料等に拡大する傾向にあるが、これらの用途では軟カ
プセル剤に冷水溶液に易溶性である等の物性が要求され
ている。The uses of soft capsules are not limited to the pharmaceuticals mentioned above, but also detergents,
There is a tendency to expand its use to feeds, etc., and for these uses, soft capsules are required to have physical properties such as being easily soluble in cold water solutions.
（発明が解決しようとする問題点）
しかし、従来のゼラチンを基剤とする軟カプセル剤はゼ
ラチンの物性上、３５〜３７℃でなければ水溶液に溶解
しないなどの難点がある。(Problems to be Solved by the Invention) However, conventional gelatin-based soft capsules have the disadvantage that they do not dissolve in an aqueous solution unless the temperature is 35 to 37°C due to the physical properties of gelatin.
また、このようなゼラチンを基剤とする軟カプセル剤の
欠点を解消するために、通常のゼラチンにゼラチン分子
中のアミノ基を加水分解したポリペプチドゼラチンを配
合して軟カプセル剤を構成する試み、或は通常のゼラチ
ンにゼラチン分子中のアミノ基を有機酸で封鎖したモデ
ィファイドゼラチンを配合して軟カプセル剤を構成する
試み等があるが、冷水溶液に溶解せず、何れも十分な成
果を納めるに至っていない。In addition, in order to overcome the drawbacks of soft capsules based on gelatin, an attempt was made to form soft capsules by blending polypeptide gelatin, which is obtained by hydrolyzing the amino groups in the gelatin molecule, with ordinary gelatin. There have also been attempts to form soft capsules by blending regular gelatin with modified gelatin in which the amino groups in the gelatin molecule are blocked with organic acids, but these efforts have failed to dissolve in cold aqueous solutions and have not produced satisfactory results. I haven't been able to pay it yet.
そこで、この発明は３５℃以下の冷水溶液に溶解する軟
カプセル剤を提供することを目的とする。Therefore, an object of the present invention is to provide a soft capsule that dissolves in a cold aqueous solution at 35° C. or lower.
（問題点を解決するための手段）
そして、この発明においては以上の目的を達成するため
鋭意研究の結果、ゼラチン分子中のアミノ基を加水分解
したポリペプチドゼラチンとゼラチン分子中のアミノ基
を有ｌｉ酸で封鎖したモディファイドゼラチンとの混合
割合がモディファイドゼラチン９０〜６０ＷｔＸ 、ポ
リペプチドゼラチン１０〜４０ｗｔＸを基剤とし、これ
に柔軟性と保水性とを与えるグリセリン、ソルビット、
マクロゴール等を加えてなる水溶性軟カプセルを提案す
るものである。(Means for Solving the Problems) In order to achieve the above object, in this invention, as a result of intensive research, we have developed a polypeptide gelatin obtained by hydrolyzing the amino group in the gelatin molecule and a polypeptide gelatin that has the amino group in the gelatin molecule. The mixing ratio of modified gelatin sequestered with lithium acid is 90 to 60 wtX of modified gelatin, 10 to 40 wtX of polypeptide gelatin, and glycerin, sorbitol, which gives flexibility and water retention to this base material.
We propose water-soluble soft capsules containing macrogol and the like.
ここで、モディファイドゼラチンとしてはゼラチン中の
アミノ基を有ｍ酸で３０％〜１０ｏｚに置換したもの、
好ましくは９０Ｘ〜１００πに置換したものが使用され
る。Here, modified gelatin includes gelatin in which amino groups are substituted with 30% to 10 oz of m-acid;
Preferably, those substituted with 90X to 100π are used.
ポリペプチドゼラチンとしては分子量１５，０００以下
、好ましくは１ 、０００〜２，０００のものが使用さ
れる。The polypeptide gelatin used has a molecular weight of 15,000 or less, preferably 1,000 to 2,000.
また、モディファイドゼラチンの量を９０〜６０ｗｔＸ
としたのは、９０ｗｔＸ以上では冷水溶性にはなりに（
（，６０ｗｔＸ以下では軟カプセル化が不可能など等の
難点があるためである。Also, increase the amount of modified gelatin to 90 to 60wtX.
The reason for this is that above 90wtX, it becomes less soluble in cold water (
(This is because there are drawbacks such as the impossibility of soft encapsulation at 60 wtX or less.
また、ポリペプチドゼラチンの量を１０〜４０ｗｔＸと
したのは、４０ｗｔＸ以上では軟カプセルが不可能とな
り、１０ｗｔＸ以下では冷水溶性になりにくい等の難点
があるためである。Moreover, the reason why the amount of polypeptide gelatin is set to 10 to 40 wtX is because if it is more than 40 wtX, it becomes impossible to form a soft capsule, and if it is less than 10 wtX, it is difficult to become cold water soluble.
なお、グリセリンの配合量は３０ＷｔＸ〜６０ｗｔ％程
度であり、またソルビットは可塑剤及び保水性の目的の
ために加えられ、その配合量は５ｗｔＸ〜２０ｗｔＸ程
度である。The blending amount of glycerin is about 30wtX to 60wt%, and sorbitol is added for the purpose of plasticizer and water retention, and the blending amount is about 5wtX to 20wtX.
更に、マクロゴールは可塑剤及び保水性の目的で加えら
れ、その配合量は５ｗｔトｌ０ｗｔ％程度である。Furthermore, macrogol is added for the purpose of plasticizer and water retention, and its blending amount is about 5wt% to 10wt%.
（実施例） 以下、この発明の実施例を示す。(Example) Examples of this invention will be shown below.
実施例１
配合例１
モデファイトゼラチン ９０゜ポリペプ
チドゼラチン １Ｇ。Example 1 Formulation Example 1 Modephite gelatin 90° polypeptide gelatin 1G.
グリセリン ５０ｚ水
８Ｇ。glycerin 50z water
8G.
配合例２
モデファイトゼラチン ７０ｔポリペプ
チドゼラチン ３０゜グリセリン
４０ｔマクロゴール ４００
１０゜水
８０ｇ配合例３
モデファイトゼラチン ６０ｓｒボリベ
グチドゼラチン ４０゜グリセリン
３Ｇ。Formulation example 2 Modephite gelatin 70t polypeptide gelatin 30° glycerin
40t macro goal 400
10゜water
80g formulation example 3 Modephite gelatin 60sr voribegtide gelatin 40°glycerin
3G.
マクロゴール ４０Ｇ １Ｇ。Macro goal 40G 1G.
配合例１〜３をそれぞれ充分に混合し、次いでゼラチン
溶解タンクにて約６０〜８０℃の温度にて加熱し、完全
に溶解させた後、軟カプセル成型機にて軟カプセルを成
型した。Formulation Examples 1 to 3 were thoroughly mixed, and then heated in a gelatin dissolving tank at a temperature of about 60 to 80°C to completely dissolve them, and then molded into soft capsules using a soft capsule molding machine.
実施例２
配合例１〜３の皮膜に内容液として７ｔの洗剤を入れて
カプセルを製造し、通常の電気洗濯機を用いて洗濯時間
１０分、すすぎ時間８分の洗濯を行なったところ水に溶
解した。Example 2 Capsules were manufactured by adding 7 tons of detergent as the liquid content to the films of Formulation Examples 1 to 3, and when washed using a normal electric washing machine for 10 minutes and 8 minutes for rinsing, the capsules were washed with water. Dissolved.
比較例
比較配合例１
ゼラチン ９０１ｒモデフ
アイトゼラチン １０゜グリセリン
５０ｇ水
ａＯ。Comparative Example Comparative Formulation Example 1 Gelatin 901r modephite gelatin 10°glycerin
50g water
aO.
比較配合例２
ゼラチン ９０ｇポリペプチ
ドゼラチン １０ｔグリセリン
５０ｇ水
８０ｇ比較比較例１．２につ
いて実施例２と同様に、電気洗濯機における溶解度試験
を行った。その結果、カプセルの溶解性がみられなかっ
た。Comparative formulation example 2 Gelatin 90g polypeptide gelatin 10t glycerin
50g water
A solubility test in an electric washing machine was conducted on 80 g Comparative Example 1.2 in the same manner as in Example 2. As a result, no solubility of the capsule was observed.
（発明の効果）
以上要するに、この発明に係る軟カプセルは無害で、し
かも３５℃以下の冷水溶液に易溶性であるので、
液体乃至粉末の洗剤、
或は飼料混入薬剤の
被包にｉ＆適である。(Effects of the Invention) In summary, the soft capsules according to the present invention are harmless and are easily soluble in cold water solutions at temperatures below 35°C, so they are suitable for encapsulating liquid or powder detergents or drugs mixed in feed. be.
特 許 出 願 人 株式会社 梁永商事Special permission Out wish Man Co., Ltd. Liangei Shoji
Claims (1)
ゼラチンとゼラチン分子中のアミノ基を有機酸で封鎖し
たモディファイドゼラチンとの混合割合がモディファイ
ドゼラチン９０〜６０ｗｔ％、ポリペプチドゼラチン１
０〜４０ｗｔ％を基剤とし、これに柔軟性と保水性とを
与えるグリセリン、ソルビット、マクロゴール等を加え
て軟カプセルを形成し、該カプセルの水溶解を可能とし
たことを特徴とする水溶性軟カプセル。The mixing ratio of polypeptide gelatin in which the amino groups in the gelatin molecule are hydrolyzed and modified gelatin in which the amino groups in the gelatin molecule are blocked with an organic acid is 90 to 60 wt% of modified gelatin and 1 part of polypeptide gelatin.
0 to 40 wt% as a base, to which glycerin, sorbitol, macrogol, etc. that give flexibility and water retention are added to form soft capsules, and the capsules can be dissolved in water. Soft capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1143261A JPH0620534B2 (en) | 1989-06-06 | 1989-06-06 | Water-soluble soft capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1143261A JPH0620534B2 (en) | 1989-06-06 | 1989-06-06 | Water-soluble soft capsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH038435A true JPH038435A (en) | 1991-01-16 |
| JPH0620534B2 JPH0620534B2 (en) | 1994-03-23 |
Family
ID=15334631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1143261A Expired - Lifetime JPH0620534B2 (en) | 1989-06-06 | 1989-06-06 | Water-soluble soft capsule |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0620534B2 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004021800A1 (en) * | 2002-09-06 | 2004-03-18 | Nippon Suisan Kaisha, Ltd. | Bound feed and process for producing the same |
| WO2006128685A3 (en) * | 2005-05-31 | 2007-04-19 | Gelita Ag | Process for making a low molecular weight gelatine hydrolysate and gelatine hydrolysate compositions |
| KR100770858B1 (en) * | 2006-09-08 | 2007-10-26 | 삼성전자주식회사 | Portable folding cradle |
| WO2012002464A1 (en) * | 2010-06-30 | 2012-01-05 | 持田製薬株式会社 | ω3 FATTY ACID COMPOUND PREPARATION |
| JP2013515715A (en) * | 2009-12-28 | 2013-05-09 | カプスゲル・ベルギウム・ナムローゼ・フェンノートシャップ | Gelatin capsule and gelatin composition for forming capsule film |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1043390A1 (en) * | 1999-04-09 | 2000-10-11 | The Procter & Gamble Company | Detergent tablet |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5532382B2 (en) | 2008-05-09 | 2014-06-25 | 株式会社リコー | Image forming apparatus |
-
1989
- 1989-06-06 JP JP1143261A patent/JPH0620534B2/en not_active Expired - Lifetime
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004021800A1 (en) * | 2002-09-06 | 2004-03-18 | Nippon Suisan Kaisha, Ltd. | Bound feed and process for producing the same |
| WO2006128685A3 (en) * | 2005-05-31 | 2007-04-19 | Gelita Ag | Process for making a low molecular weight gelatine hydrolysate and gelatine hydrolysate compositions |
| JP2008541743A (en) * | 2005-05-31 | 2008-11-27 | ゲリタ アクチェンゲゼルシャフト | Process for producing low molecular weight gelatin hydrolyzate and gelatin hydrolyzate composition |
| US7897728B2 (en) | 2005-05-31 | 2011-03-01 | Gelita Ag | Process for making a low molecular weight gelatine hydrolysate |
| KR100770858B1 (en) * | 2006-09-08 | 2007-10-26 | 삼성전자주식회사 | Portable folding cradle |
| JP2013515715A (en) * | 2009-12-28 | 2013-05-09 | カプスゲル・ベルギウム・ナムローゼ・フェンノートシャップ | Gelatin capsule and gelatin composition for forming capsule film |
| WO2012002464A1 (en) * | 2010-06-30 | 2012-01-05 | 持田製薬株式会社 | ω3 FATTY ACID COMPOUND PREPARATION |
| US8609138B2 (en) | 2010-06-30 | 2013-12-17 | Mochida Pharmaceutical Co., Ltd. | ω3 fatty acid compound preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0620534B2 (en) | 1994-03-23 |
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