JPH04122249A - Ovulation period judging tool - Google Patents

Abstract

PURPOSE:To immediately judge the ovulation period via only an easy self-action on the spot at the action by fitting a judging reaction chemical colored or discolored by the change in a vagina in coincidence with the ovulation period to a judging tool main body to be inserted into the vagina of a woman. CONSTITUTION:A judging reaction chemical 2 such as a reaction accelerating chemical, a cornification cell stain chemical and a hydrogen ion concentration indicator proportional to the reduction of the cervical canal mucus viscosity is fitted at one end of a judging tool main body 1. The judging tool main body 1 is held with fingers at the holding side, a reaction section at the opposite side is inserted into the vagina of a person under test from the tip, and the judging reaction chemical 2 is colored or discolored based on the reduction of the cervical canal mucus viscosity in the vagina, an increase of the epithelium cell cornification exfoliation quantity, and the rise of the hydrogen ion concentration. The increase of the cervical canal mucus quantity, the reduction of its viscosity, the increase of the epithelium cell cornification exfoliation quantity in the vagina, and the rise of the hydrogen ion concentration are remarkable in coincidence with the ovulation period, thus she can judge whether she is in the ovulation period or not based on the degree of the coloring or discoloring of the judging reaction chemical 2 on the spot at the insertion action herself.

Description

[Detailed description of the invention] [Industrial application field]

The present invention addresses changes in the secretion of cervical mucus and decrease in its viscosity that occur in the vagina during the ovulatory period of the female sexual cycle, but which are not normally seen during the non-ovulatory period. By making it possible for women to objectively confirm their own ovulation period by utilizing changes such as an increase in the amount of keratinization of epithelial cells and an increase in the hydrogen ion concentration of vaginal secretions, the ovulation period can be compared to the fertilization period. Since this is equivalent, this is related to an ovulation stage determination tool that is also useful for fertility control6.

[Conventional technology]

Conventionally, the methods for women to know the ovulation period in their sexual cycle include subjective symptoms such as leucorrhoea and abdominal pain, as well as a method of measuring body temperature every day when waking up, mainly for the purpose of fertility control (Hagino et al. There was something called the ceremonial abstinence law. This latter method uses periodic changes in body temperature between high and low temperatures, obtained through long-term measurement habits, as changes in basal body temperature.
The day of ovulation is the 5-day period from the 12th to the 16th day of the expected menstrual period, and for fertility control, add the 3 days of the fertile period to this,
The 8-day period on the 19th is the conception period. In addition, if the doctor needs to confirm the ovulation period for some reason, the doctor will mainly measure the subject's urinary pregnanediol, which is one of the sex hormones (24 to 4 days after ovulation).
(increases after 8 hours), searching for cells by biopsy of the uterine lining, measuring the amount and viscosity of cervical mucus, and probing the contents of the vagina. Analyzers and equipment are required to carry out this test, and testing outside of medical institutions is not possible.

[Problem to be solved by the invention]

Among the conventional methods of determining the ovulation period, the method of determining basal body temperature requires measuring body temperature every morning as a habit and tabulating the measurement results, which is a hassle that many women do not continue using. do not have. In addition, even women with regular menstrual cycles experience fluctuations, and the measurement itself may become inaccurate due to fever due to illness, various living conditions, and changes in body temperature may not be obvious for some people. is not available equally to everyone. Conventionally, pregnancy diagnostic tests have been used to determine whether a woman has conceived or not, by using in vitro diagnostic tests to detect glycoprotein hormones, such as gonadotropins, which appear in increasing amounts in the urine of women with one gestation. There are pregnancy test products that can determine whether a reaction is positive or negative, but they do not know in advance the ovulation period, which is the fertilization period, but are only used to determine whether or not a pregnancy has occurred.

[Purpose of the invention]

The purpose of the invention is to help women perform special preparations and routine tasks.
To provide an ovulation period determination tool which can immediately determine whether or not it is one's own ovulation period, that is, the fertilization period, by simple self-operation and on the spot of operation without the need for such a tool.

[Means to solve the problem]

Prior to the development of the present invention, the present inventor discovered that each woman's sexual cycle fluctuates depending on her different constitution and living conditions, without relying solely on subjective symptoms, counting the number of days, or measuring basal body temperature. As a result of intensive research into how to use the tool, we realized that we should create an ovulation period determination tool that can be used according to individual convenience.
In addition to the various hormones and basal body temperature that change during a woman's sexual cycle as shown in Figure 3, there is an increase in the amount of cervical mucus and a decrease in viscosity that can be observed in the vagina during the ovulation period, and an increase in the amount of exfoliation of epithelial cells in the B. We found that this method can directly capture changes in the hydrogen ion concentration of vaginal secretions. In Figure 3, a, b, c, and d are diagrams showing increases and decreases in the secretion of antibody-forming hormone (LH), follicle-stimulating hormone (FSH), estrogen, and progesterone, respectively, and e is a diagram showing changes in basal body temperature. The line section f is a diagram showing changes in the amount of cervical mucus, the amount of exfoliation of vaginal epithelial cells, and the hydrogen ion concentration of vaginal secretions. The vertical axis of the figure is the secretion amount in the case of lines a, b, c, and d, the high and low values of basal body temperature in the case of line e, and the amount of cervical mucus and epithelial cell exfoliation in the case of line f. , and the increase in vaginal secretion hydrogen ion concentration, and the horizontal axis represents the passage of time and date. What can be understood from this diagram is that various gonadotropins,
There is a correlation between changes in basal body temperature, cervical mucus, the amount of vaginal epithelial cell exfoliation, hydrogen ion concentration in vaginal secretions, etc. and the estrous cycle, and there is a particular correlation with the estrous cycle, which shows marked fluctuations especially during the ovulation period. By the way, changes in the vagina during ovulation include an increase in the amount of cervical mucus due to the action of estrogen, which becomes watery and less viscous. The keratinization of vaginal epithelial cells is active, the number of white blood cells decreases significantly, the hydrogen ion concentration of vaginal secretions increases, and the number of bacteria decreases. The ovulation stage determination tool of the present invention was developed based on this knowledge, and is capable of addressing multiple phenomena: an increase in cervical mucus volume and a decrease in viscosity, exfoliation of vaginal epithelial cells, and an increase in hydrogen ion concentration. This method uses synchronous changes to determine the ovulation period. As shown in Fig. 1, the ovulation stage determination tool has a determination tool body 1 that can be inserted into a woman's vagina, and a determination reaction drug 2 that develops or changes color in response to changes in the vagina that correspond to the ovulation stage is attached. It is something that exists.

[Function] As shown in FIG. 1, the ovulation stage determination tool of the present invention includes a determination tool body 1 containing a reaction promoter proportional to the decrease in cervical mucus viscosity, keratinocyte staining straw, a hydrogen ion temperature indicator, etc. Since the reactive drug 2 is attached to one end, hold the holding side of the evaluation tool body l with your fingers and insert the reactive part on the opposite side into the subject's vagina from the tip. The reaction straw 2 for determination develops or changes color based on a decrease in cervical mucus viscosity, an increase in the amount of epithelial cell keratinization, and an increase in hydrogen ion concentration. As shown in Figure 3, the increase in the amount of cervical mucus and the decrease in viscosity, the increase in the amount of keratinization of vaginal epithelial cells, and the increase in hydrogen ion concentration change significantly in accordance with the ovulation period, so the above-mentioned reaction for determination Based on the degree of color development or discoloration of the drug 2, it is possible to determine whether or not it is the ovulation period on the spot after the insertion operation.

【Example】

In the figure showing an embodiment of the ovulation period determining tool of the present invention, 1 is the main body of the determining tool. The main body of this test tool is, for example, a long and thin one resembling a cotton swab that is easy to insert into a woman's vagina and has a shape that does not cause damage to the inside of the vagina. l is a round bar with a uniform diameter over the entire length in the longitudinal direction, but depending on the shape of the judgment tool main body 1 and W4
Structures other than those shown may be used. For example, as shown in FIG. 2, one end in the elongated direction may be formed into a spherical shape with a large diameter. In this way, the surface area becomes large, so the surface for participating in the reaction becomes large, and the reliability of the results is improved. The material for the main body 1 of the determination tool is preferably one that is soft, does not deteriorate, is inexpensive, and is suitable for disposable use, such as paper, plastic, or porous rubber. A determination reaction agent attachment portion 3 is provided at one end in the longitudinal direction of the determination tool main body 1. For example, absorbent cotton is attached to this judgment reaction agent attachment part 3, and this absorbent cotton includes a reaction promoter proportional to the viscosity of cervical mucus, a dye for exfoliated keratinized epithelial cells, a hydrogen ion concentration indicator, etc. It is impregnated with a reaction agent 2 for determination. In addition, when a material with good water absorption is used for the determination tool main body 1, the reaction agent 2 for determination is directly applied or impregnated onto the determination tool main body 1 without attaching absorbent cotton to the reaction agent attachment part 3 for determination. You can leave it alone. As the reaction agent 2 for determination, for example, hemadoxylin and eosin staining straw and methylene blue staining agent are used for coloring exfoliated cells, and Lidomus test straw is used as an indicator for hydrogen ion concentration. [Effects of the Invention] The ovulation period determination tool of the present invention has the following effects. a. Since the vaginal phenomena that fluctuate in accordance with the ovulation period, which is the fertilization period, are directly determined, it is not determined whether the fertilization period is reached by indirect methods such as theory or calculation, but by the estrous cycle of the individual test subject. It can be confirmed reliably according to the living conditions and living conditions. b The reaction drug 2 for determination that directly develops or changes the color of the phenomenon in the vagina characteristic of the ovulation period, which is the period of conception, is the main body of the determination tool l
Therefore, it is sufficient to judge whether or not the fertilization period is reached by simply looking at the color of the reaction straw 2 for this judgment, and normally the factors of misjudgment can be excluded. C-It is very convenient because it can be used by an amateur alone, not by a specialist such as a doctor, and it is possible to determine whether or not it is the ovulation period on the spot by reflex operation. d1 By using the ovulation period determination tool of the present invention,
The test subject is freed from the preparations and routine work required to confirm his or her own ovulation period.

[Brief explanation of the drawing]

FIGS. 1 and 2 are explanatory diagrams showing different examples of the ovulation period determination tool of the present invention, and FIG. 3 shows various hormones, basal body temperature, and cervical mucus levels during a woman's sexual cycle. FIG. 2 is an explanatory diagram showing changes in viscosity, amount of surface keratinocyte exfoliation, hydrogen ion concentration, etc. 1 is the determination tool body 2 is the reaction drug for determination

Claims (1)

[Claims] The test tool body 1, which can be inserted into a woman's vagina, detects changes in the function of the ovaries and uterus that appear in the vagina during the ovulatory period of the female sexual cycle, but are not normally seen during the non-ovulatory period. Increased secretion and decreased viscosity of certain cervical mucus,
An ovulation period determination tool, characterized in that a reaction agent 2 for determination is attached that develops or changes color in response to an increase in the amount of keratinization of vaginal epithelial cells, an increase in the hydrogen ion concentration of vaginal secretions, etc.