JPH0414583B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION Field of Industrial Application The present invention relates to a cement composition that is characterized by being easy to adhere to soft tissue, gingiva or tooth substance, cementing, and not disintegrating or falling off for a long period of time.

BACKGROUND OF THE INVENTION Various cement preparations have been used as wound dressings not only in the oral cavity or dental field but also in surgery, plastic surgery, and veterinary medicine, and are commercially available. Most of these have zinc oxide and eugenol as basic materials, and asbestos fibers are used as reinforcing agents for the cement. It is said that asbestos fibers have good compatibility with zinc oxide and eugenol, and have the effect of suppressing the stickiness of a mixture of these materials on the palm of the hand. Commercially available products have been formulated that take advantage of this property.

Open oral surgery is routinely performed in the fields of plastic surgery, oral surgery, and dentistry. For example, in plastic surgery, surgery for palate deformities, in oral surgery, appropriate removal of cancerous tissue in the oral cavity, surgery that reaches the jawbone, in dentistry, orthodontics, gingivectomy, tartar removal, etc.
This includes tooth extraction.

Due to its daily functions, the oral cavity is constantly wet with saliva, and is an important organ for chewing food and having conversations, and is home to a wide variety of bacteria. After surgery in such areas, for example, the wound surface after a tooth extraction may be compressed with a cotton ball to stop the bleeding and heal naturally, or the wound surface may be disinfected with iodine, such as on the wound surface after removing tartar. In some cases, patients are sent home with medication. However, when the wound surface is large and deep, and when the wound surface is to be recovered while the patient continues to lead a normal life, a special cement that hardens in the oral cavity is often used.

When applied, this cement is soft and plastic like clay, and in the oral cavity, the hardening reaction is accelerated by moisture and temperature, solidifying in a few minutes and covering the wound surface. This cement is called a pack or bandage. A suitable example of such cement for packs is the surgical pack "Showa" (trade name) (manufactured by Showa Yakuhin Kako KK), which is a combination of powder and liquid, and the powder is mainly composed of zinc oxide. The liquid agent is a type of zinc oxide eugenol cement, which is mainly composed of eugenol. The characteristic of this pack lies in the asbestos fiber that is formulated into the powder.The fiber is an essential ingredient in handling operations from mixing to application. It has the role of a ``tethering material,'' which maintains its toughness within the oral cavity and serves to cover the patient as a bandage without breaking until the open wound surface has healed.

Of the above-mentioned roles of asbestos fibers, which are to impart operability and toughness, the latter can be substituted to some extent with other fibers such as cotton, nylon, vinylon, acrylic, etc., but the operability of the former is delicate. This is a matter of feel, and until now it was thought that this could only be achieved using asbestos.

To explain the operability, the operator first takes an appropriate amount of powder and liquid, mixes them with a spatula to make a paste, rolls the paste with a spatula, and stretches it into a cylinder with a diameter of 5 mm and a length of about 4 cm. . If asbestos is not mixed in this operation, it will not become cylindrical,
The paste is sticky to the spatula or kneading board and difficult to handle. Next, the operator picks up the cylindrical mixture with his fingers, applies it to the wound surface in the oral cavity, and stretches it flat with his fingertips to completely cover the wound surface. When the operator handles the mixture with his/her fingers, it is difficult to adhere the mixture to the wound surface if the mixture becomes sticky on the fingers. It is known that a dressing that is easy for the operator to use, that is, a dressing that has good operability, can be achieved by incorporating asbestos, and it is not possible to achieve this operability with fibers other than asbestos. I've been

Problems to be Solved by the Invention However, in recent years, it has become a problem that asbestos has an adverse effect on the human body.Therefore, there is a demand for a substitute for asbestos, and at the same time, the surface of oral soft tissues, teeth, and other tissues is becoming more important than ever. There is a need for improved adhesion to and long-term local retention.

Means for Solving the Problems According to the present invention, in view of the above points, in order to obtain an improved cement composition, asbestos in the conventional cement composition is substituted and mixed with pulp fiber, and carboxyvinyl Polymer (hereinafter
(abbreviated as CVP). The novel cement composition obtained in this manner easily adheres to the gums or tooth structure, has a longer local retention than before, is difficult to fall off or disintegrate, and is easy to manufacture. Due to its low cost, it is ideal as a dressing for tissue and wound surfaces.

The characteristics of the present invention are that pulp fibers are mixed in place of asbestos fibers in the conventionally known cement composition composed of zinc oxide, eugenol, asbestos fibers, and organic saturated fatty acids or organic unsaturated fatty acids; and mixing CVP to improve adhesion to tooth or wound surfaces, early shedding after application, and disintegration of cement parenchyma. When a cement composition made of zinc oxide and eugenol made without asbestos is used as a wound dressing, the mixture becomes sticky on the hands and fingers, so it is difficult to roll the mixture into a ball shape on the palm of the hand. It has disadvantages such as great difficulty.

The present invention consists of an agent A mainly containing zinc oxide and an agent B containing eugenol or an organic acid.
At the time of use, appropriate amounts of Agents A and B are mixed and applied to the affected area, and since fibers are usually formulated in Agent A, Agent A was first studied in the present invention. As a result, when pulp fiber is mixed in place of the conventional asbestos in the A component of the cement composition, the strength of the cement hardened product (hereinafter abbreviated as cement body) is improved, and the addition and mixing of CVP improves the strength of the cement body. The adhesion to the tissue or gingival surface was improved, and the shedding and disintegration of the cement body were significantly improved, making it possible to use it for a long period of time.

In this case, other fibers such as nylon, vinylon, or tetron fibers were used in place of pulp fibers, but they were not able to achieve the same effect as pulp fibers. This is because the pulp fibers are manufactured by cutting cotton fibers, and because of the presence of hydrophilic groups such as free -OH groups and -CHO groups on the glucose molecule surface of the fiber components, it has an affinity with the B agent. B at the same time as sex
It is believed that these properties contribute to ensuring the toughness of the cement mixture and ensuring that it does not stick to the surgeon's fingers because the fibers exhibit physical retention properties for the agent.

On the other hand, as mentioned above, CVP is a water-soluble polymer obtained by copolymerizing acrylic acid and allylated polyhydric alcohol, and has been used as a thickener or dispersion stabilizer for cosmetics and pharmaceuticals. Although known, there have been no examples of its use in cement compositions for dentistry or the like prior to the present invention. For example, water-soluble polymers such as methylcellulose, gum arabic, polyvinylpyrrolidone, and opolyethylene oxide were tried in place of CVP, but they were not as effective as CVP. This is because CVP has an OH group in the molecule and
The presence of COOH groups acts as a strong surfactant in the cement composition, thus increasing the mutual affinity of the composition, and upon encountering saliva, increases the viscosity of the surface of the cement and improves the affinity with living tissue. It is thought that as a result of this improvement, the adhesion to the tissue surface, tooth substance, or gingival surface is increased, and together with the action of the pulp fibers, the properties of the cement body are improved.

Furthermore, as a result of various studies on substitutes for CVP, it has been found that organic fatty acids such as palmitic acid and stearic acid exhibit effects similar to those of CVP. In the present invention, as a substitute for CVP or
The organic fatty acids in Part A used in combination with CVP are lauric acid, myristic acid, palmitic acid, or stearic acid, which are solid fatty acids at room temperature. These organic fatty acids have a -COOH group in their molecules, which is common to CVP, which has a -COOH group in its molecules. -CH ₂ - of organic fatty acids is hydrophobic, but -COOH group is hydrophilic, and in order to increase the affinity between the surface of the cement body and biological tissue,
As a result, it is thought that the properties of the cement body are improved in the same way as when CVP is used.

Furthermore, it is desirable that the pulp fiber be mixed in an amount of 2 to 7% by weight in the A agent of the cement composition, and
CVP and/or organic fatty acids are preferably mixed in an amount of 0.1 to 3.0% by weight of agent A in the cement composition.

Next, regarding agent B, it consists of eugenol and olive oil, eugenol is 50 to 75% by weight,
The appropriate amount of olive oil is 20 to 40% by weight, and the organic fatty acid has 10 to 22 carbon atoms and has the general formula C _o H _{2o + 1.}
COOH, C _o H _2o-1 COOH, C _o H _2o-3 COOH and C _o
It is an organic saturated or unsaturated fatty acid corresponding to any of H _2o-5 COOH, and propylene glycol and polyalkylene glycol can also be used as the B agent component. Furthermore, mixtures of these glycol compounds may also be used.

Eugenol is the main component of clove oil (usually containing 70% or more), but the Japanese Pharmacopoeia clove oil has a content standard of 80% or more as total eugenol, including eugenol and related compounds. In the present invention, eugenol is considered to be almost the same substance as the above-mentioned pharmacopoeia clove oil, and the product of the present invention can be manufactured.

The specific components of the cement composition of the present invention have been described in detail above, but as shown in the examples, the cement composition is manufactured by first weighing the charged amount of each component of Agent A, pulverizing it, and then mixing it with a stirrer. It is manufactured after being made into a nearly uniform mixture (powder). For the B agent, it is sufficient that the components of the B agent are weighed and mixed together to make the whole (liquid) uniform. During use, the operator takes appropriate amounts of Agents A and B, mixes them together, and applies them to the affected area.

Example 1 (Part A) (Weight %) Zinc oxide 55 Rosin 25 Diatomaceous earth 15 Pulp fiber 4 CVP 1 (Part B) (Weight %) Clove oil 75 Olive oil 24.5 Propionic acid 0.5 The rosin lump was cut into about 10 mesh in advance. It is ground, and 25 kg of this ground rosin and 55 kg of zinc oxide are mixed and finely ground. 15 kg of diatomaceous earth, 4 kg of pulp fiber and 1 kg of CVP were added to the pulverized material and mixed at a slow speed to prepare Form A. For agent B, clove oil 75kg, olive oil
24.5 kg and propionic acid 0.5 kg were weighed out and mixed to prepare Form B.

The product in this example is applicable not only to dentistry and oral surgery, but also to surgery.
It can be suitably used in plastic surgery, veterinary medicine, etc.

Example 2 (Part A) (% by weight) Zinc oxide 60 Rosin 25 Magnesium stearate 7.8 Pulp fiber 7 CVP 0.2 (Part B) (% by weight) Clove oil 65 Olive oil 35 According to Example 1, add 60 kg of zinc oxide and 25 kg of rosin. A mixed pulverized product was prepared, for which 7.8Kg of magnesium stearate, 7Kg of pulp fiber and 0.2Kg of CVP were added.
was added to prepare Form A.

For agent B, follow the method of Example 1 and add 65 kg of clove oil.
and 35 kg of olive oil were mixed to prepare agent B.

Example 3 (Part A) (% by weight) Zinc oxide 55 Rosin 30 Diatomaceous earth 10 Pulp fiber 4 Stearic acid 1 (Part B) (Actual amount %) Eugenol 60 Olive oil 40 According to Example 1, add 55 kg of zinc oxide and 30 kg of rosin. A mixed pulverized product is prepared, and 10% of diatomaceous earth is added to this.
1 kg, pulp fiber 4 kg and stearic acid 1 kg were added to prepare Form A. For agent B, 60 kg of eugenol and 40 kg of olive oil were mixed according to the method of Example 1.
A drug was prepared.

Example 4 (Part A) (% by weight) Zinc oxide 55 Rosin 20 Diatomaceous earth 20 Pulp fiber 4.5 CVP 0.5 (Part B) (% by weight) Linoleic acid 20 Isostearic acid 30 Propylene glycol 50 55 kg of zinc oxide and rosin according to Example 1 A pulverized product is prepared by mixing 20 kg of diatomaceous earth, and 20 kg of diatomaceous earth
Kg, pulp fiber 4.5Kg and CVP 0.5Kg were added to prepare A agent. A B agent was prepared by mixing 20 kg of linoleic acid, 30 kg of isostearic acid, and 50 kg of propylene glycol in the same manner as in Example 1.

Example 5 (Part A) (% by weight) Zinc oxide 40 Rosin 40 Diatomaceous earth 12 Pulp fiber 5 CVP 3 (Part B) (% by weight) Linoleic acid 50 Propylene glycol 50 Mix 40 kg of zinc oxide and 40 kg of rosin according to Example 1 12 diatomaceous earth
Kg, pulp fiber 5Kg and CVP 3Kg were added to prepare A agent. Regarding B agent, 50 kg of linoleic acid and 50 kg of propylene glycol were weighed out and mixed to prepare B agent.

Example 6 (Part A) (Weight%) Zinc oxide 50 Rosin 28 Diatomaceous earth 15 Pulp fiber 5 CVP 1 Myristic acid 1 (Part B) (Weight%) Eugenol 65 Olive oil 34.5 Propionic acid 0.5 Zinc oxide 50Kg according to Example 1 A crushed product was prepared by mixing 28 kg of rosin and 15 kg of diatomaceous earth.
1 kg of pulp fiber, 1 kg of CVP, and 1 kg of myristic acid to prepare Form A.

For agent B, the method of Example 1 was followed, including 65 kg of eugenol, 34.5 kg of olive oil, and 0.5 kg of propionic acid.
were mixed to prepare Form B.

Effects of the Invention The mixture obtained by kneading appropriate amounts of Agent A (powder) and Agent B (liquid) produced in each of the above Examples can be used not only in the oral cavity but also in surgery, plastic surgery, veterinary medicine, etc. It easily adheres to moist wound surfaces in other areas, and the cement body (hardened material) is expected to be sufficiently effective in protecting the wound surface by stably staying locally for a long time.

Furthermore, since the composition of this preparation does not contain asbestos, it is highly safe for the human body. Furthermore, the cement composition of the present invention is easy to manufacture and the product cost is low.

Claims (1)

[Claims] 1. 35-60% by weight of zinc oxide, 20-40% by weight of rosin, 10-20% by weight of diatomaceous earth, 0.1-3.0% by weight of galboxyvinyl polymer and/or organic fatty acid.
and A agent containing 2 to 7% by weight of pulp fiber,
Eugenol is clove oil; general formula C _o H _2o+1 COOH
Organic saturated fatty acids represented by C _o H _2o-1 COOH, C _o H _2o-3 COOH or C _o H _2o-5 COOH (in the formula, n is an integer of 10 to 22); ~22 integers)
A composition consisting of an organic unsaturated fatty acid represented by any one of; propylene glycol, polyalkylene glycol, or a mixture of these glycol compounds; and agent B containing at least one component selected from the group consisting of olive oil. being a thing,
and a cement composition characterized in that a mixture obtained by adding agent B to agent A and kneading the mixture becomes cement. 2. The cement composition according to claim 1, wherein the carboxyvinyl polymer is a copolymer of acrylic acid and allylated polyhydric alcohol. 3. The cement composition according to claim 1, wherein the organic fatty acid in agent A is an organic saturated fatty acid represented by the general formula C _o H _2o COOH (in the formula, n represents an integer of 10 to 22). 4. The cement composition according to claim 3, wherein the organic fatty acid in agent A is at least one compound selected from the group consisting of lauric acid, myristic acid, palmitic acid, and stearic acid.