JPH04182427A - キサントシリンｘジメチルエーテルを含有する抗腫瘍剤 - Google Patents

キサントシリンｘジメチルエーテルを含有する抗腫瘍剤

Info

Publication number: JPH04182427A
Authority: JP; Japan
Prior art keywords: dimethyl ether; xanthocillin; antitumor; agent containing; compound
Prior art date: 1990-11-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP2308843A

Other languages

English (en)

Japanese (ja)

Inventor

Tsutomu Tsuruoka

勉鶴岡

Shunkai Fukuyasu

福安　春海

Katsumi Kawarajiyou

河原條　勝己

Masao Koyama

小山　正夫

Hiroshi Kurihara

寛栗原

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Meiji Seika Kaisha Ltd

Original Assignee

Meiji Seika Kaisha Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-16

Filing date

1990-11-16

Publication date

1992-06-30

1990-11-16 Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd

1990-11-16 Priority to JP2308843A priority Critical patent/JPH04182427A/ja

1991-11-14 Priority to DE69119199T priority patent/DE69119199T2/de

1991-11-14 Priority to EP91119442A priority patent/EP0486944B1/fr

1991-11-15 Priority to US07/792,993 priority patent/US5312833A/en

1992-06-30 Publication of JPH04182427A publication Critical patent/JPH04182427A/ja

Status Pending legal-status Critical Current

Links

239000002246 antineoplastic agent Substances 0.000 title claims abstract description 9
VJKZMXOJMQCHRI-AXPXABNXSA-N 1-[(1z,3z)-2,3-diisocyano-4-(4-methoxyphenyl)buta-1,3-dienyl]-4-methoxybenzene Chemical compound C1=CC(OC)=CC=C1\C=C(/[N+]#[C-])\C(\[N+]#[C-])=C\C1=CC=C(OC)C=C1 VJKZMXOJMQCHRI-AXPXABNXSA-N 0.000 title abstract 2
DSUFFPKJNFNJNM-UHFFFAOYSA-N Xanthocillin-X-dimethyl-ether Natural products COc1ccc(C=C(/N=C)C(=Cc2ccc(OC)cc2)N=C)cc1 DSUFFPKJNFNJNM-UHFFFAOYSA-N 0.000 title abstract 2
LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims description 24
IHXIOPCXRPNJDO-UHFFFAOYSA-N N1C(=O)NC=2N=CNC2C1=O.[P] Chemical compound N1C(=O)NC=2N=CNC2C1=O.[P] IHXIOPCXRPNJDO-UHFFFAOYSA-N 0.000 claims description 2
150000001875 compounds Chemical class 0.000 abstract description 12
239000000126 substance Substances 0.000 abstract description 7
230000000694 effects Effects 0.000 abstract description 6
230000002401 inhibitory effect Effects 0.000 abstract description 3
231100000053 low toxicity Toxicity 0.000 abstract description 3
239000007787 solid Substances 0.000 abstract description 3
230000000340 anti-metabolite Effects 0.000 abstract description 2
239000002256 antimetabolite Substances 0.000 abstract description 2
229940100197 antimetabolite Drugs 0.000 abstract description 2
230000015572 biosynthetic process Effects 0.000 abstract description 2
150000003180 prostaglandins Chemical class 0.000 abstract description 2
238000003786 synthesis reaction Methods 0.000 abstract description 2
201000009030 Carcinoma Diseases 0.000 abstract 1
241001374813 Dichotomomyces Species 0.000 abstract 1
230000005809 anti-tumor immunity Effects 0.000 abstract 1
239000003972 antineoplastic antibiotic Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000001747 exhibiting effect Effects 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 description 18
-1 xanthone phosphorus Chemical compound 0.000 description 8
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
230000000259 anti-tumor effect Effects 0.000 description 4
201000011510 cancer Diseases 0.000 description 4
238000002512 chemotherapy Methods 0.000 description 4
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
239000004480 active ingredient Substances 0.000 description 3
239000008187 granular material Substances 0.000 description 3
230000005764 inhibitory process Effects 0.000 description 3
235000019359 magnesium stearate Nutrition 0.000 description 3
238000000034 method Methods 0.000 description 3
238000011282 treatment Methods 0.000 description 3
230000005740 tumor formation Effects 0.000 description 3
229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
230000007059 acute toxicity Effects 0.000 description 2
231100000403 acute toxicity Toxicity 0.000 description 2
239000003242 anti bacterial agent Substances 0.000 description 2
229940088710 antibiotic agent Drugs 0.000 description 2
230000022534 cell killing Effects 0.000 description 2
229940127089 cytotoxic agent Drugs 0.000 description 2
239000003814 drug Substances 0.000 description 2
229940079593 drug Drugs 0.000 description 2
239000008101 lactose Substances 0.000 description 2
239000002609 medium Substances 0.000 description 2
239000000203 mixture Substances 0.000 description 2
238000007911 parenteral administration Methods 0.000 description 2
239000001267 polyvinylpyrrolidone Substances 0.000 description 2
229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
238000002560 therapeutic procedure Methods 0.000 description 2
244000215068 Acacia senegal Species 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
239000001856 Ethyl cellulose Substances 0.000 description 1
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
201000008808 Fibrosarcoma Diseases 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
229920000084 Gum arabic Polymers 0.000 description 1
206010058467 Lung neoplasm malignant Diseases 0.000 description 1
238000000134 MTT assay Methods 0.000 description 1
231100000002 MTT assay Toxicity 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
241000699666 Mus <mouse, genus> Species 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
239000000205 acacia gum Substances 0.000 description 1
235000010489 acacia gum Nutrition 0.000 description 1
239000003125 aqueous solvent Substances 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
235000013539 calcium stearate Nutrition 0.000 description 1
239000008116 calcium stearate Substances 0.000 description 1
239000002775 capsule Substances 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
229940110456 cocoa butter Drugs 0.000 description 1
235000019868 cocoa butter Nutrition 0.000 description 1
235000005687 corn oil Nutrition 0.000 description 1
239000002285 corn oil Substances 0.000 description 1
230000000445 cytocidal effect Effects 0.000 description 1
230000000235 effect on cancer Effects 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
235000019325 ethyl cellulose Nutrition 0.000 description 1
229920001249 ethyl cellulose Polymers 0.000 description 1
LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
229940093471 ethyl oleate Drugs 0.000 description 1
230000001605 fetal effect Effects 0.000 description 1
238000009472 formulation Methods 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
230000012010 growth Effects 0.000 description 1
230000009422 growth inhibiting effect Effects 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
208000032839 leukemia Diseases 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
201000005202 lung cancer Diseases 0.000 description 1
208000020816 lung neoplasm Diseases 0.000 description 1
229960003511 macrogol Drugs 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
239000004570 mortar (masonry) Substances 0.000 description 1
239000012457 nonaqueous media Substances 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920001592 potato starch Polymers 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000001959 radiotherapy Methods 0.000 description 1
239000002994 raw material Substances 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
235000015424 sodium Nutrition 0.000 description 1
239000000243 solution Substances 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
239000000725 suspension Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
239000003826 tablet Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
230000004614 tumor growth Effects 0.000 description 1
238000002604 ultrasonography Methods 0.000 description 1
230000035899 viability Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

JP2308843A 1990-11-16 1990-11-16 キサントシリンｘジメチルエーテルを含有する抗腫瘍剤 Pending JPH04182427A (ja)

Priority Applications (4)

Application Number	Priority Date	Filing Date	Title
JP2308843A JPH04182427A (ja)	1990-11-16	1990-11-16	キサントシリンｘジメチルエーテルを含有する抗腫瘍剤
DE69119199T DE69119199T2 (de)	1990-11-16	1991-11-14	Methode zur Hemmung von Tumorwachstum unter Verwendung von Xanthocillin-X-dimethylether
EP91119442A EP0486944B1 (fr)	1990-11-16	1991-11-14	Méthode d'inhibition de la croissance de tumeurs en utilisant l'éther diméthyl de xanthocilline X
US07/792,993 US5312833A (en)	1990-11-16	1991-11-15	Method of inhibiting tumor growth using xanthocillin X dimethylether

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2308843A JPH04182427A (ja)	1990-11-16	1990-11-16	キサントシリンｘジメチルエーテルを含有する抗腫瘍剤

Publications (1)

Publication Number	Publication Date
JPH04182427A true JPH04182427A (ja)	1992-06-30

Family

ID=17985950

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2308843A Pending JPH04182427A (ja)	1990-11-16	1990-11-16	キサントシリンｘジメチルエーテルを含有する抗腫瘍剤

Country Status (4)

Country	Link
US (1)	US5312833A (fr)
EP (1)	EP0486944B1 (fr)
JP (1)	JPH04182427A (fr)
DE (1)	DE69119199T2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7595415B2 (en)	2005-04-14	2009-09-29	Nissan Chemical Industries, Ltd.	α-Substituted vinyltin compound
US7851503B2 (en)	2002-08-14	2010-12-14	Nissan Chemical Industries, Ltd.	Thrombopoetin receptor activator and process for producing the same

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5710916A (en) *	1994-05-24	1998-01-20	Panasonic Technologies, Inc.	Method and apparatus for similarity matching of handwritten data objects

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3635930A1 (de) *	1986-10-22	1988-04-28	Basf Ag	Wirkstoffe zur anwendung bei der behandlung von tumoren
JP2511709B2 (ja) *	1989-05-18	1996-07-03	明治製菓株式会社	キサントシリンｘモノメチルエ―テル誘導体及びそれを含有する抗腫瘍剤

1990
- 1990-11-16 JP JP2308843A patent/JPH04182427A/ja active Pending
1991
- 1991-11-14 DE DE69119199T patent/DE69119199T2/de not_active Expired - Fee Related
- 1991-11-14 EP EP91119442A patent/EP0486944B1/fr not_active Expired - Lifetime
- 1991-11-15 US US07/792,993 patent/US5312833A/en not_active Expired - Fee Related

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7851503B2 (en)	2002-08-14	2010-12-14	Nissan Chemical Industries, Ltd.	Thrombopoetin receptor activator and process for producing the same
US7595415B2 (en)	2005-04-14	2009-09-29	Nissan Chemical Industries, Ltd.	α-Substituted vinyltin compound

Also Published As

Publication number	Publication date
DE69119199D1 (de)	1996-06-05
US5312833A (en)	1994-05-17
EP0486944B1 (fr)	1996-05-01
EP0486944A2 (fr)	1992-05-27
EP0486944A3 (fr)	1992-06-03
DE69119199T2 (de)	1996-10-31

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JPH04182427A - キサントシリンｘジメチルエーテルを含有する抗腫瘍剤 - Google Patents

Info

Links

Classifications

Landscapes

Priority Applications (4)

Applications Claiming Priority (1)

Publications (1)

Family

ID=17985950

Family Applications (1)

Country Status (4)

Cited By (2)

Families Citing this family (1)

Family Cites Families (2)

Cited By (2)

Also Published As

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