JPH0418620B2 - - Google Patents
Info
- Publication number
- JPH0418620B2 JPH0418620B2 JP59112537A JP11253784A JPH0418620B2 JP H0418620 B2 JPH0418620 B2 JP H0418620B2 JP 59112537 A JP59112537 A JP 59112537A JP 11253784 A JP11253784 A JP 11253784A JP H0418620 B2 JPH0418620 B2 JP H0418620B2
- Authority
- JP
- Japan
- Prior art keywords
- blood sample
- blood
- hemoglobin
- gas analyzer
- circuit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000004369 blood Anatomy 0.000 claims description 39
- 239000008280 blood Substances 0.000 claims description 39
- 102000001554 Hemoglobins Human genes 0.000 claims description 23
- 108010054147 Hemoglobins Proteins 0.000 claims description 23
- 239000007789 gas Substances 0.000 claims description 17
- 238000005259 measurement Methods 0.000 claims description 13
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 10
- 239000003085 diluting agent Substances 0.000 claims description 10
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 5
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 5
- 239000001569 carbon dioxide Substances 0.000 claims description 5
- 238000004737 colorimetric analysis Methods 0.000 claims description 5
- 229910052760 oxygen Inorganic materials 0.000 claims description 5
- 239000001301 oxygen Substances 0.000 claims description 5
- 238000001514 detection method Methods 0.000 claims description 3
- 238000007865 diluting Methods 0.000 claims description 2
- 239000000523 sample Substances 0.000 description 11
- 210000004027 cell Anatomy 0.000 description 6
- 239000012895 dilution Substances 0.000 description 4
- 238000010790 dilution Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 239000012470 diluted sample Substances 0.000 description 2
- 238000004868 gas analysis Methods 0.000 description 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4915—Blood using flow cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/492—Determining multiple analytes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Ecology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は希釈ヘモグロビン測定装置を内蔵した
血液ガス分析装置に関する。DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a blood gas analyzer incorporating a diluted hemoglobin measuring device.
血液ガス分析装置は診断の有力なパラメータで
ある血液中に溶解する酸素及び炭酸ガスの各分
圧、並びにPH値を測定するものであり、又ヘモグ
ロビン測定装置は血液のbase excess（BE：ベー
スエクセス）などの演算に用いられるヘモグロビ
ン値を測定する装置である。従来、ヘモグロビン
値は、独立の装置により別個に測定され、この測
定値を前記血液ガス分析装置にキイで入力する方
法と、前記血液ガス分析装置に内蔵して直接比色
法により測定する方法が行われていた。しかると
ころ、前記キイで入力する方法は操作に手間がか
かり、且つ誤入力の原因になる。又、直接比色法
による方法は血液を透過により直接測定する方法
であるから、血液の粘度、赤血球の数及び測定セ
ル内における透過率の不均一などの原因により、
その測定結果は直線性の良い安定した再現性が得
られない欠点があつた。
Blood gas analyzers measure the partial pressures of oxygen and carbon dioxide dissolved in blood, which are important parameters for diagnosis, as well as the PH value, and hemoglobin measuring devices measure blood base excess (BE). This is a device that measures hemoglobin values used in calculations such as ). Conventionally, the hemoglobin value has been measured separately by an independent device, and the measured value is entered into the blood gas analyzer using a key, or it is built into the blood gas analyzer and directly measured using a colorimetric method. It was done. However, the method of inputting data using the keys is time-consuming and may cause input errors. In addition, since the direct colorimetric method directly measures blood by permeation, it may be affected by factors such as blood viscosity, number of red blood cells, and non-uniformity of transmittance within the measurement cell.
The measurement results had the disadvantage that stable reproducibility with good linearity could not be obtained.
本発明は、血液のヘモグロビン値を独立の装置
により測定し、この測定値を血液ガス分析装置に
キイで入力する場合の前記問題点を解決するため
なされたもので、ヘモグロビン測定装置を従来の
血液ガス分析装置に内蔵させるとともに希釈サン
プル希釈方式を採用することにより、ヘモグロビ
ン値を高精度に、且つ簡便に測定できる血液ガス
分析装置を提供することを目的とする。
The present invention was made in order to solve the above-mentioned problems when measuring the hemoglobin value of blood with an independent device and inputting this measured value into a blood gas analyzer using a key. It is an object of the present invention to provide a blood gas analyzer that can easily and accurately measure hemoglobin values by incorporating the present invention into the gas analyzer and employing a diluted sample dilution method.
本発明は、ヘモグロビン測定装置を血液ガス分
析装置に内蔵するにあたり、血液ガス分析用測定
セルに導入後の血液サンプルのい一部をロータリ
ーバルブにより分取し、この分取した血液サンプ
ルを希釈液により希釈したのち、その一定量をヘ
モグロビン測定部に導き、比色法によりヘモグロ
ビン値を測定することにより、前記目的を達する
ものである。
In the present invention, when a hemoglobin measurement device is built into a blood gas analyzer, a portion of the blood sample introduced into the blood gas analysis measurement cell is fractionated using a rotary valve, and the fractionated blood sample is transferred to a diluent. The above objective is achieved by diluting the diluted sample with a methane, introducing a certain amount into the hemoglobin measurement section, and measuring the hemoglobin value by a colorimetric method.
本発明の詳細を第１図に示す一実施例により説
明する。
The details of the present invention will be explained with reference to an embodiment shown in FIG.
第１図において、血液ガス分析装置の図示しな
いサンプラー導入口より主回路１に吸引された血
液サンプルは、酸素電極３、炭酸ガス電極４及び
PH電極５が付設された測定セル２に導かれ、ここ
で酸素及び炭酸ガスの各分圧、並びにPH値がそれ
ぞれ測定される。 In FIG. 1, a blood sample drawn into the main circuit 1 from the sampler inlet (not shown) of the blood gas analyzer is connected to an oxygen electrode 3, a carbon dioxide electrode 4,
It is led to a measurement cell 2 equipped with a PH electrode 5, where the partial pressures of oxygen and carbon dioxide gas and the PH value are measured.
測定セル２の出口回路６はロータリーバルブ８
に連結される。このロータリーバルブ８は前記回
路６に設けられたフローセンサ７の検知により回
転し、回路をヘモグロビン測定部１０に達する２
次回路９に切り換える。なお、１１は排液用弁で
ある。 The outlet circuit 6 of the measuring cell 2 is a rotary valve 8
connected to. This rotary valve 8 rotates upon detection by a flow sensor 7 provided in the circuit 6, and the circuit reaches a hemoglobin measuring section 10.
Switch to the next circuit 9. Note that 11 is a drain valve.
次に、１２はヘモグロビン用希釈液を収容する
容器、１３は希釈用シリンジ、１４は回路切換
弁、１５は希釈用回路であり、その先端部は前記
ロータリーバルブ８に連結される。 Next, 12 is a container containing a hemoglobin diluent, 13 is a dilution syringe, 14 is a circuit switching valve, and 15 is a dilution circuit, the tip of which is connected to the rotary valve 8.
この発明による前記構成の血液ガス分析装置の
作用を説明する。
The operation of the blood gas analyzer having the above configuration according to the present invention will be explained.
主回路１を経て導入された血液サンプルは、測
定セル２において酸素及び炭酸ガスの各分圧、並
びにPH値が測定されると同時に、フローセンサ７
の検知により、ロータリーバルブ８が作動し、回
路６が回路９に切換えられる。このとき、前記ロ
ータリーバルブ８の中の血液サンプルは希釈液に
より希釈される。 The blood sample introduced through the main circuit 1 is measured in the measurement cell 2 for the partial pressures of oxygen and carbon dioxide as well as the PH value, and at the same time, the flow sensor 7
Upon detection of this, the rotary valve 8 is activated and the circuit 6 is switched to the circuit 9. At this time, the blood sample in the rotary valve 8 is diluted with the diluent.
希釈液はシリンジ１３の吸引により容器１２よ
り回路１５及び切換弁１４を経てシリンジ１３内
に入り、ついでシリンジ１３の吐出行程により再
び回路１５及び切換弁１４を経て前記ロータリー
バルブ８に達する。ここで、血液サンプルと合流
した希釈液は血液サンプルを希釈したのち、２次
回路９を経てヘモグロビン測定部１０に導かれ
る。 The diluent enters the syringe 13 from the container 12 through the circuit 15 and the switching valve 14 due to the suction of the syringe 13, and then reaches the rotary valve 8 through the circuit 15 and the switching valve 14 again due to the discharge stroke of the syringe 13. Here, the diluent that has merged with the blood sample dilutes the blood sample, and then is led to the hemoglobin measuring section 10 via the secondary circuit 9.
ヘモグロビン測定部１０内に希釈注入された血
液サンプルは、２回の攪拌動作により溶解され、
発光ダイオードを光源とする比色装置によりヘモ
グロビン値が測定される。測定終了後は排液用弁
１１の開口により排液が外部へ排出されると共
に、ヘモグロビン測定部１０内は前記希釈液によ
り洗浄される。 The blood sample diluted and injected into the hemoglobin measurement unit 10 is dissolved by two stirring operations.
The hemoglobin value is measured by a colorimetric device using a light emitting diode as a light source. After the measurement is completed, the drain liquid is discharged to the outside by opening the drain valve 11, and the inside of the hemoglobin measuring section 10 is cleaned with the diluent.
本発明による血液ガス分析装置は、従来の前記
分析装置にヘモグロビン測定部１０を内蔵するに
あたり、ロータリーバルブ８により血液サンプル
の一定量を回路６より２次回路９に分取すると同
時に、希釈液を収容する容器１２、シリンジ１
３、切換弁１４及び回路１５により構成される希
釈装置により血液サンプルを希釈したのち、ヘモ
グロビン測定部１０に注入し、比色法によるヘモ
グロビン値測定を行うようにしたから、高精度且
つ安定した測定値が得られると共に、特に、手術
室などにおいて測定される血液ガス分析に有用な
るデータを提供できる効果がある。
In the blood gas analyzer according to the present invention, when the hemoglobin measuring unit 10 is built into the conventional analyzer, a fixed amount of blood sample is dispensed from the circuit 6 to the secondary circuit 9 using the rotary valve 8, and at the same time, a diluent is dispensed. Container 12, syringe 1
3. After the blood sample is diluted by the dilution device composed of the switching valve 14 and the circuit 15, it is injected into the hemoglobin measuring section 10 and the hemoglobin value is measured by a colorimetric method, resulting in highly accurate and stable measurement. In addition to obtaining values, it is particularly effective in providing data useful for blood gas analysis measured in operating rooms and the like.
更に、従来のヘモグロビン測定装置を附属しな
い血液ガス分析装置の場合のように、他の独立装
置にて測定したヘモグロビン値をキイで入力して
演算する必要がないから、極めて簡単であるばか
りでなく、同一血液サンプルにより、PO2，
PCO2、PH及びHbを同時に測定できるので、信頼
性のある測定値並びに演算値が短時間で得られる
大きな効果がある。 Furthermore, unlike conventional blood gas analyzers that do not come with a hemoglobin measurement device, there is no need to input hemoglobin values measured by another independent device using keys, so it is not only extremely simple but also , with the same blood sample, PO 2 ,
Since PCO 2 , PH and Hb can be measured simultaneously, there is a great effect that reliable measured values and calculated values can be obtained in a short time.
第１図は本発明による血液ガス分析装置の一実
施例を示す説明図である。
１……主回路、２……測定セル、３，４，５…
…測定用電極、６……出口回路、７……フローセ
ンサ、８……ロータリーバルブ、９……２次回
路、１０……ヘモグロビン測定部、１１……排液
用弁、１２……希釈液容器、１３……シリンジ、
１４……切換弁、１５……希釈回路。
FIG. 1 is an explanatory diagram showing one embodiment of a blood gas analyzer according to the present invention. 1... Main circuit, 2... Measurement cell, 3, 4, 5...
... Measuring electrode, 6 ... Outlet circuit, 7 ... Flow sensor, 8 ... Rotary valve, 9 ... Secondary circuit, 10 ... Hemoglobin measuring section, 11 ... Drainage valve, 12 ... Diluent Container, 13...Syringe,
14...Switching valve, 15...Dilution circuit.
Claims (1)
サンプルを導入し、酸素及び炭酸ガスの各分圧、
並びにPH値を測定する血液ガス分析装置におい
て、前記主回路に設けたフローセンサーの検知に
より血液サンプルの一部を分取するロータリーバ
ルブ装置と、前記分取の血液サンプルを希釈する
希釈装置と、この希釈血液サンプルのヘモグロビ
ン値を比色法により測定するヘモグロビン測定装
置と、この装置に前記希釈血液サンプルを導く二
次回路を内蔵してなることを特徴とする血液ガス
分析装置。 ２ 血液サンプルの希釈装置は希釈液容器と、こ
の希釈液を切換弁を介し吸引及びロータリーバル
ブへ送出するシリンジよりなることを特徴とする
特許請求の範囲第１項に記載の血液ガス分析装
置。[Claims] 1. A blood sample is introduced into a measurement cell equipped with an electrode provided in the main circuit, and the partial pressures of oxygen and carbon dioxide are measured.
Further, in a blood gas analyzer that measures a PH value, a rotary valve device that separates a part of the blood sample by detection by a flow sensor provided in the main circuit, and a diluter that dilutes the separated blood sample; A blood gas analyzer comprising: a hemoglobin measuring device for measuring the hemoglobin value of the diluted blood sample by a colorimetric method; and a secondary circuit for guiding the diluted blood sample into the device. 2. The blood gas analyzer according to claim 1, wherein the blood sample diluting device comprises a diluent container and a syringe that aspirates the diluent through a switching valve and delivers it to the rotary valve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59112537A JPS60256044A (en) | 1984-06-01 | 1984-06-01 | Apparatus for analysis of blood gas |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59112537A JPS60256044A (en) | 1984-06-01 | 1984-06-01 | Apparatus for analysis of blood gas |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60256044A JPS60256044A (en) | 1985-12-17 |
| JPH0418620B2 true JPH0418620B2 (en) | 1992-03-27 |
Family
ID=14589122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59112537A Granted JPS60256044A (en) | 1984-06-01 | 1984-06-01 | Apparatus for analysis of blood gas |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60256044A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113702328B (en) * | 2021-08-20 | 2024-05-17 | 广东省惠州市石油产品质量监督检验中心 | Method, device, equipment and storage medium for analyzing properties of finished oil |
-
1984
- 1984-06-01 JP JP59112537A patent/JPS60256044A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60256044A (en) | 1985-12-17 |
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