JPH04217613A - Composition for oral cavity - Google Patents

Abstract

PURPOSE:To obtain a composition for oral cavity having high effect on suppressing crystal growth of hydroxyapatite and capable of giving excellent effect on suppressing formation of dental calculus. CONSTITUTION:The objective composition in which a processed starch such as starch phosphate or oxidized starch is blended.

Description

[Detailed description of the invention]

0001

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral cavity composition having an effect of inhibiting tartar formation.

0002

[Prior Art and Problems to be Solved by the Invention] Dental calculus is calcified plaque, and its inorganic component is a hydroxyapatite-like calcified product. Conventionally, the active ingredients for preventing tartar include pyrophosphate,
Condensed phosphates such as polyphosphates and diphosphonate compounds are known (JP-A-1-207227, JP-A-52-108029, JP-A-1-26501).
Publication No. 3, etc.).

[0003] These compounds have the function of inhibiting the crystal growth of hydroxyapatite, and by inhibiting the crystal growth of hydroxyapatite, they inhibit the formation of tartar, but condensed phosphates exist in the oral cavity. It may be degraded by phosphate hydrolase and lose its effectiveness. Furthermore, although diphosphonate compounds do not undergo such decomposition, there are still concerns regarding biosafety.

Recently, artificially synthesized polymers whose constituent units are carboxylic acid groups, amino acid groups, etc. (some of the constituent units may include phosphoric acid groups) have been used alone or with the above-mentioned condensed phosphates. It has also been proposed to suppress the crystal growth of hydroxyapatite and the activity of phosphate hydrolase by using them in combination (JP-A-1-153621, JP-A-2-4708). However, all of these synthetic polymers are new substances for living organisms, and safety issues remain in the future.

[0005] The present invention has been made in view of the above circumstances.
The object of the present invention is to provide an oral composition that has excellent hydroxyapatite crystal growth inhibiting activity and is free from safety problems.

[0006]

[Means and effects for solving the problem] As a result of intensive studies to achieve the above object, the inventors of the present invention have found that starch chemically modified with phosphate ester and oxidized starch without any safety problems. It has been discovered that chemically modified or treated starch (modified starch) such as starch has excellent hydroxyapatite crystal inhibiting activity, and oral compositions containing such modified starch exhibit good tartar formation inhibiting effects. However, the present invention has been completed.

The oral composition of the present invention is prepared and applied as a toothpaste, a toothpaste, a moist toothpaste, a liquid toothpaste, a mouthwash, a chewing gum, a gargling tablet, etc., and is chemically applied as an active ingredient for inhibiting tartar formation. It is made by blending modified or processed starch (processed starch).

[0008] Here, as the above-mentioned modified starch, starch chemically modified with phosphate ester and starch treated with oxidation are preferably used, and these are substances listed in the Japanese Food Additives Official Standards and are safe. It has a high value. The starch chemically modified with the above-mentioned phosphate ester (phosphate esterified starch, its salt) is obtained by phosphorylating starch separated and purified from various grains, and this phosphate ester is free or cross-linked. The amount of bound phosphorus present is usually 0.2 to 3% by weight as bound phosphorus. Also,
Oxidized starch is obtained by treating starch isolated and purified from various grains with hypochlorous acid, which cleaves some amylose units and converts hydroxyl groups into carboxylic acid groups. It is something. This starch corresponds to soluble starch or food-grade processed starch in terms of variety.

[0009] The amount of the above-mentioned modified starch may be at least a concentration that exhibits crystal growth inhibiting activity of hydroxyapatite, and is usually 0.001 to 2% (wt%) of the entire composition.
(same below), more preferably 0.01 to 2%.

Other components of the oral composition of the present invention are:
Appropriate ingredients can be used depending on the type of composition, for example, in the case of toothpaste, abrasives, binders, thickeners, surfactants, sweeteners, fragrances, preservatives, and various effective ingredients. Ingredients etc. can be mixed. In addition, in the present invention, in addition to the above-mentioned modified starch, other active ingredients for inhibiting tartar formation may be used in combination.

[0011]

[Experiment example 1]

10% each of phosphoric acid esterified starch, oxidized starch, and 3 types of positive starches (Amylofax HS, Neoposiparin 42SL, Posamyl E-7)
150 mg of powdered apatite was added to 250 ml of a calcifying solution having the following composition at a concentration of 0 ppm, and the pH of the calcifying solution was measured over time to determine the effect on the rate of apatite crystal growth. Note that, as a control, a mineralizing solution to which no starch was added was used. The results are shown in Table 1 and Figure 1. In this case, Table 1 lists A as a positive starch.
Only the results of mylofax HS are shown.

[0012]The effect of modified starch can be evaluated by monitoring the pH of the calcifying solution based on the reaction formula for apatite crystal growth shown below.

[0013]

[Chemical 1] In other words, as the apatite crystal grows, the pH of the reaction solution increases.
The slower the degree of decrease, the more suppressed crystal growth is.

[0014]

[Table 1]

[Experimental Example 2] The calcification inhibitory effect of phosphoric acid esterified starch was evaluated at the concentrations shown in Table 2. The experimental conditions were the same as in Example 1. The results are shown in Table 2 and Figure 2.

[0016]

[Table 2]

[0017] From the above results, it was confirmed that modified starch, especially phosphated starch, has an excellent apatite crystal growth inhibiting effect.

The present invention will be specifically explained below with reference to Examples, but the present invention is not limited to the following Examples.

[Example 1] Toothpaste dicalcium phosphate dihydrate
50% glycerin

20 carboxymethylcellulose sodium
1.0 Sodium lauryl sulfate
1.0 fragrance

1.0 saccharin sodium
0.1
sodium fluoride

0.22 Sodium polyphosphate

1.0 phosphate esterified starch

1.0 water

Residue

100
．． 0%

[Example 2] Toothpaste dicalcium phosphate dihydrate
50% sorbitol

10 glycerin
10
sodium lauryl sulfate
2.0
Carboxymethyl cellulose sodium
1.0 fragrance

1
．． 0 saccharin sodium

0.1 Sodium monofluorophosphate
0.7
8-phosphate starch
1.0
oxidized starch

1.0 water

Residue

10
0.0%

[Example 3] Toothpaste calcium carbonate
5
0% glycerin

20 carrageenan

0.5 carboxymethylcellulose sodium
1.0 sucrose monolaurate

2.0 lauryl diethanolamide
1
．． 0 saccharin sodium

0.1 Chlorhexidine

0.005 phosphate esterified starch

1.0 Sodium alginate

1.0 water

Residue


100.0%

[Example 4] Toothpaste silica

30% glycerin

30 sorbitol

20 Sodium lauryl sulfate

2.0 Carboxymethylcellulose Sodium
1.0 fragrance

1.0 saccharin sodium

0.1 Sodium fluoride

0.1 phosphate starch
0.22 Sodium polyphosphate
1.0 water


Residue

100.0%

[Example 5] Toothpaste silica

30% glycerin

30 sorbitol

20 Sodium lauryl sulfate

1.0 carboxymethylcellulose sodium
1.0 fragrance

1.0 saccharin sodium

0.1 stannous fluoride

0.41 phosphate esterified starch
1.5 water


Residue

100.0%

[Example 6] Toothpaste aluminum hydroxide
50%
glycerin

13 sorbitol

7.0 Sodium lauryl sulfate

1.0 Sodium carboxymethyl cellulose 1
．． 0 fragrance

1.0 saccharin sodium

0.1 Sodium monofluorophosphate
0.78 Phosphated Starch

1.0 water

Residue


100.0%

[Example 7] Toothpaste calcium carbonate
5
0% glycerin

20 carboxymethylcellulose sodium
1.0 lauryl diethanolamide
1.0 sucrose monolaurate
2.0 Saccharin Sodium
0.1 dextranase
0.
01 phosphate esterified starch
2.
0 water

Residue

100.0%

[Example 8] Toothpaste silicic anhydride

30% glycerin

30 sorbitol

20 carboxymethylcellulose sodium
1.0 Sodium lauryl sulfate

2.0 fragrance

1.0 saccharin sodium

0.1 tranexamic acid

0.1 phosphate starch
1.0 oxidized starch

1.0 water


Residue

100.0%

0027
] [Example 9] Mouthwash ethanol

20.0% saccharin sodium

0.05 fragrance

1.0 lauryl diethanolamide
0.3 Sodium monofluorophosphate
0.39 phosphate esterified starch

0.1 water

Residue


100.0%

[Example 10] Mouthwash ethanol

30.0% dibasic sodium phosphate

0.8 Monobasic potassium phosphate

0.1 saccharin sodium

0.05 fragrance

0.5 glycyrrhizinate
0.1 Chlorhexidine
0.0
Monophosphate starch
0.5
water

Residue

100.0%

[
[Example 11] Mouthwash ethanol

30.0% saccharin sodium

0.05 fragrance

0.5 phosphate starch
1.5 stannous fluoride

0.1 water


Residue

100.0%

[Example 12] Liquid toothpaste glycerin

35.0% Monosodium N-cocoylglutamate 1.5 Carrageenan

1.5 coupling sugar

2.0 fragrance

0.9 ethanol

1.0 Sodium monofluorophosphate
0.1 phosphate starch
1.0 Sodium polyphosphate
1.0 water

Residue


100.0%

[Example 13] Chewing gum gum base

40.0% calcium carbonate

2.0 Starch syrup

15.0 powdered sugar

40.0
fragrance

0.5 phosphate starch

1.0 water

Residue


100.0%

[Example 14] Gargling tablet sodium bicarbonate
54.
0% dibasic sodium phosphate
10
．． 0 polyethylene glycol
3
．． 0 fragrance

1.0 oleic acid

0.1 Chlorhexidine
0.05 citric acid
17
．． 0 phosphate starch
2.
0 water

Residue

100.0%

[0033]

Effects of the Invention The oral composition of the present invention exhibits an excellent effect of inhibiting hydroxyapatite crystal growth by incorporating the above-mentioned modified starch, can effectively prevent tartar formation, and is safe in use. It's expensive.

[Brief explanation of the drawing]

FIG. 1 is a graph illustrating the remineralization inhibiting effect of various modified starches.

FIG. 2 is a graph illustrating the remineralization inhibiting effect of phosphoesterified starch at various concentrations.

Claims (1)

[Claims] 1. An oral composition comprising a chemically modified or treated starch.