JPH0422920B2 - - Google Patents
Info
- Publication number
- JPH0422920B2 JPH0422920B2 JP61014389A JP1438986A JPH0422920B2 JP H0422920 B2 JPH0422920 B2 JP H0422920B2 JP 61014389 A JP61014389 A JP 61014389A JP 1438986 A JP1438986 A JP 1438986A JP H0422920 B2 JPH0422920 B2 JP H0422920B2
- Authority
- JP
- Japan
- Prior art keywords
- antibiotics
- formula
- producing
- vancomycin
- methicillin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Description
【発明の詳細な説明】
イ 産業上の利用分野
本発明は式；
（式中、ＸがCH3およびＹがNH2を表わすか、
またはＸがＨおよびＹがOHを表わす。）
で表わされる抗生物質PA−42867−ＡおよびPA
−42867−Ｂとそれらの製薬上許容される塩、な
らびにその製造方法に関する。[Detailed Description of the Invention] A. Field of Industrial Application The present invention relates to the formula; (In the formula, X represents CH 3 and Y represents NH 2 or
Or X represents H and Y represents OH. ) Antibiotics PA-42867-A and PA represented by
-42867-B, pharmaceutically acceptable salts thereof, and methods for producing the same.
ロ 従来の技術
最近の抗生物質の汎用に伴い、多剤耐性菌特に
メチシリン耐性菌の出現が問題となつてきてい
る。メチシリン耐性菌とは、単にメチシリンに対
して耐性を示すだけではなく、アミノグリコシド
系抗生物質、テトラサイクリン系抗生物質、セフ
エム系抗生物質、ペニシリン系抗生物質、カルバ
ペナム系抗生物質、マクロライド系抗生物質など
多くの抗生物質に対して耐性である。B. Prior Art With the recent widespread use of antibiotics, the emergence of multidrug-resistant bacteria, particularly methicillin-resistant bacteria, has become a problem. Methicillin-resistant bacteria are not only resistant to methicillin, but also to many other antibiotics such as aminoglycoside antibiotics, tetracycline antibiotics, cefem antibiotics, penicillin antibiotics, carbapenam antibiotics, and macrolide antibiotics. It is resistant to many antibiotics.
このメチシリン耐性菌に対してグリコペプチド
系抗生物質特にバンコマイシン系抗生物質が活性
を示すことが注目されている（アンチマイクロバ
イアル・エージエント・アンド・ケモセラビー
（ANTIMICROBIAL AGENT AND
CHEMOTHERAPY）28，660−662（1985））。バ
ンコマイシンは古くから知られている抗生物質
（特公昭33−8450）であり、また、新たなバンコ
マイシン類縁体も発見されてきた（アンチマイク
ロバイアル・エージエント・アンド・ケモセラビ
ー（ANTIMICROBIAL AGENT AND
CHEMOTHERAPY）28，660−662（1985）、
ザ・ジヤーナル・オブ・アンチバイオテイクス
（THE JOURNAL OF ANTIBIOTICS）37，
446−453（1984）、38，１−８（1985）、38，51−57
（1985）、特開昭60−139623、60−199397、60−
231698、60−237099、など）。しかし、本発明の
抗生物質PA−42867−ＡおよびPA−42867−Ｂは
以上の化合物とは一致しない、全く新規な構造を
有するバンコマイシン系抗生物質である。 It has been noticed that glycopeptide antibiotics, especially vancomycin antibiotics, are active against methicillin-resistant bacteria (ANTIMICROBIAL AGENT AND
CHEMOTHERAPY) 28 , 660-662 (1985)). Vancomycin is an antibiotic that has been known for a long time (Special Publication No. 33-8450), and new vancomycin analogues have also been discovered (ANTIMICROBIAL AGENT AND
CHEMOTHERAPY) 28 , 660-662 (1985),
THE JOURNAL OF ANTIBIOTICS 37 ,
446-453 (1984), 38 , 1-8 (1985), 38 , 51-57
(1985), JP-A-60-139623, 60-199397, 60-
231698, 60−237099, etc.). However, the antibiotics PA-42867-A and PA-42867-B of the present invention are vancomycin antibiotics having completely new structures that do not match the above compounds.
ハ 発明が解決しようとする問題点
現在市販のバンコマイシンは経口用であり純度
が低く、そのまま注射剤として用いることは困難
である。また、従来のバンコマイシン系抗生物質
よりもさらにメチシリン耐性菌に対して強い活性
を有する抗生物質が待望されていた。C. Problems to be solved by the invention Vancomycin currently on the market is for oral use and has low purity, making it difficult to use it directly as an injection. Furthermore, there has been a long-awaited antibiotic that has stronger activity against methicillin-resistant bacteria than conventional vancomycin antibiotics.
ニ 問題点を解決するための手段
本発明者らは、ノカルデイア属に属する菌株が
式；
（式中、ＸがCH3およびＹがNH2を表わすか、
またはＸがＨおよびＹがOHを表わす。）
で表わされる、メチシリン耐性菌に対して強い活
性を有する化合物を産生することを見出し、式
中がＸがCH3およびＹがNH2である化合物をPA
−42867−Ａ、ＸがＨおよびＹがOHである化合
物をPA−42867−Ｂと命名した。本発明はこれら
の化合物だけでなく、その製薬上許容される塩も
包含する。D. Means for Solving the Problems The present inventors discovered that a bacterial strain belonging to the genus Nocardia has the following expressions: (In the formula, X represents CH 3 and Y represents NH 2 or
Or X represents H and Y represents OH. PA _
-42867-A, the compound in which X is H and Y is OH was named PA-42867-B. The present invention encompasses not only these compounds, but also their pharmaceutically acceptable salts.
以下に本発明の化合物の物理化学的性状を示
す。 The physicochemical properties of the compound of the present invention are shown below.
物理化学的性質 PA−42867−Ａ 紫外吸収スペクトル λ0.01NHCl nax nm（Ｅ１％ １cm）：281.8（41.15） λ0.01NNaOH Physicochemical properties PA-42867-A Ultraviolet absorption spectrum λ 0.01NHCl nax nm (E1% 1cm): 281.8 (41.15) λ 0.01NNaOH
Claims (1)
またはＸがＨおよびＹがOHを表わす。） で表わされる抗生物質PA−42867−ＡまたはPA
−42867−Ｂとその製薬上許容される塩。 ２ 式においてＸがCH3およびＹがNH2であ
る特許請求の範囲第１項に記載のPA−42867−
Ａ。 ３ 式においてＸがＨおよびＹがOHである特
許請求の範囲第１項に記載にPA−42867−Ｂ。 ４ ノカルデイア属に属するPA−42867−Ａおよ
び／またはPA−42867−Ｂ産生菌を培地に培養
し、培養物からPA−42867−Ａおよび／または
PA−42867−Ｂを分離採取することを特徴とする
PA−42867−Ａおよび／またはPA−42867−Ｂの
製造法。 ５ 該PA−42867−Ａおよび／またはPA−42867
−Ｂ産生菌がノカルデイア・オリエンタリス種に
属する菌である特許請求の範囲第４項に記載の製
造法。 ６ 該PA−42867−Ａおよび／またはPA−42867
−Ｂ産生菌がノカルデイア・オリエンタリスPA
−42867である特許請求の範囲第４項に記載の製
造法。[Claims] 1 formula; (In the formula, X represents CH 3 and Y represents NH 2 or
Or X represents H and Y represents OH. ) Antibiotic PA-42867-A or PA
-42867-B and its pharmaceutically acceptable salts. PA-42867- according to claim 1, wherein in the formula 2, X is CH 3 and Y is NH 2
A. 3. PA-42867-B according to claim 1, wherein in the formula, X is H and Y is OH. 4. Culture PA-42867-A and/or PA-42867-B producing bacteria belonging to the genus Nocardia in a medium, and extract PA-42867-A and/or PA-42867-B from the culture.
Characterized by separating and collecting PA-42867-B
Method for producing PA-42867-A and/or PA-42867-B. 5 Said PA-42867-A and/or PA-42867
5. The production method according to claim 4, wherein the -B-producing bacterium is a bacterium belonging to the species Nocardia orientalis. 6 The PA-42867-A and/or PA-42867
-B-producing bacteria is Nocardia orientalis PA
-42867, the manufacturing method according to claim 4.
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61014389A JPS62174099A (en) | 1986-01-24 | 1986-01-24 | Novel glycopeptide antibiotic substance pa-42867-a and pa-42867-b and production thereof |
| US07/003,252 US4946941A (en) | 1986-01-24 | 1987-01-14 | Novel glycopeptide antibiotics |
| AU67963/87A AU602327B2 (en) | 1986-01-24 | 1987-01-23 | Novel glycopeptide antibiotics |
| DK198700395A DK172545B1 (en) | 1986-01-24 | 1987-01-23 | Antibiotic glycopeptides and methods for their preparation |
| CA000528094A CA1339348C (en) | 1986-01-24 | 1987-01-23 | Novel glycopeptide antibiotics |
| DE8787300614T DE3771882D1 (en) | 1986-01-24 | 1987-01-23 | GLYCOPEPTIDE ANTIBIOTICS, THEIR PRODUCTION AND USE, AND MICROORGANISMS THAT MANUFACTURE THEM. |
| ES198787300614T ES2039230T3 (en) | 1986-01-24 | 1987-01-23 | PROCEDURE FOR PREPARING GLYCOPEPTIDIC ANTIBIOTICS. |
| KR1019870000553A KR940000759B1 (en) | 1986-01-24 | 1987-01-23 | Novel glycopeptide antibiotics |
| EP87300614A EP0231111B1 (en) | 1986-01-24 | 1987-01-23 | Glycopeptide antibiotics, their preparation and use and microorganisms for producing them |
| DK024598A DK24598A (en) | 1986-01-24 | 1998-02-23 | Antibiotic glycopeptides and methods for their preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61014389A JPS62174099A (en) | 1986-01-24 | 1986-01-24 | Novel glycopeptide antibiotic substance pa-42867-a and pa-42867-b and production thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3303995A Division JPH06102018B2 (en) | 1991-10-22 | 1991-10-22 | Novel glycopeptide antibiotics PA-42867-A and PA-42867-B producing microorganisms |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62174099A JPS62174099A (en) | 1987-07-30 |
| JPH0422920B2 true JPH0422920B2 (en) | 1992-04-20 |
Family
ID=11859700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61014389A Granted JPS62174099A (en) | 1986-01-24 | 1986-01-24 | Novel glycopeptide antibiotic substance pa-42867-a and pa-42867-b and production thereof |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62174099A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01190633A (en) * | 1988-01-26 | 1989-07-31 | Shionogi & Co Ltd | Growth promotion agent for animal |
| CA1339808C (en) * | 1988-10-19 | 1998-04-07 | Manuel Debono | Glycopeptide antibiotics |
-
1986
- 1986-01-24 JP JP61014389A patent/JPS62174099A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS62174099A (en) | 1987-07-30 |
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