JPH0424436Y2 - - Google Patents
Info
- Publication number
- JPH0424436Y2 JPH0424436Y2 JP161484U JP161484U JPH0424436Y2 JP H0424436 Y2 JPH0424436 Y2 JP H0424436Y2 JP 161484 U JP161484 U JP 161484U JP 161484 U JP161484 U JP 161484U JP H0424436 Y2 JPH0424436 Y2 JP H0424436Y2
- Authority
- JP
- Japan
- Prior art keywords
- light
- emitting element
- disturbance
- turned
- circuit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000023555 blood coagulation Effects 0.000 claims description 10
- 238000005259 measurement Methods 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 8
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 238000002835 absorbance Methods 0.000 claims description 3
- 238000000149 argon plasma sintering Methods 0.000 claims description 3
- 230000004397 blinking Effects 0.000 claims description 2
- 238000009499 grossing Methods 0.000 claims 1
- 230000001360 synchronised effect Effects 0.000 claims 1
- 238000012360 testing method Methods 0.000 description 8
- 238000010586 diagram Methods 0.000 description 7
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000015271 coagulation Effects 0.000 description 3
- 238000005345 coagulation Methods 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 108010094028 Prothrombin Proteins 0.000 description 1
- 102100027378 Prothrombin Human genes 0.000 description 1
- 108010000499 Thromboplastin Proteins 0.000 description 1
- 102000002262 Thromboplastin Human genes 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- 238000012113 quantitative test Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
Landscapes
- Measurement Of Current Or Voltage (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Description
【考案の詳細な説明】
本考案は臨床検査分野で用いられる血液凝固測
定装置に関するものであり、血液の凝固過程を光
の散乱および吸光度変化でとらえる際に、外乱光
の影響を除去するような機能を備え、測定部を暗
室にしなくても十分に凝固過程を測定することが
出来るような血液凝固測定装置を提供することを
目的とするものである。[Detailed description of the invention] This invention relates to a blood coagulation measuring device used in the field of clinical testing, and is a device that eliminates the influence of ambient light when measuring the blood coagulation process by light scattering and absorbance changes. It is an object of the present invention to provide a blood coagulation measuring device that is capable of sufficiently measuring the coagulation process without using a dark room in the measuring section.
従来から血液凝固検査は出血関連の情報を医療
に提供する意味で重要な検査項目の一つであり、
血液凝固は血液中の12種類の液性成分を体外に取
り出した際に次々に相互反応してフイブリンを形
成する過程と細胞成分である血小板の凝集、付着
が並行して行われることによつて生ずる。 Blood coagulation tests have traditionally been one of the important test items in the sense of providing medical care with bleeding-related information.
Blood coagulation is a process in which 12 types of humoral components in blood are taken out of the body and react with each other one after another to form fibrin, and the aggregation and adhesion of platelets, which are cellular components, occur in parallel. arise.
臨床検査項目には出血時間、全血凝固時間検査
など出血血液全体が凝固する時間を見るものと、
液性成分中の諸酵素が繊維を形成する過程を見る
プロトロンビン時間、活性化部分トロンボプラス
チン時間、フイブリノーゲン定量検査等が広く行
われている。 Clinical test items include bleeding time, whole blood coagulation time test, which measures the time it takes for the entire blood to coagulate.
Prothrombin time, activated partial thromboplastin time, fibrinogen quantitative tests, etc., which examine the process by which various enzymes in humoral components form fibers, are widely used.
検査測定量としては試料の凝固の過程を光の散
乱或は吸光度の変化としてとらえる方式のものが
多く使用されている。 Many methods are used for testing and measuring quantities that detect the coagulation process of a sample as light scattering or changes in absorbance.
従来から用いられている光式の凝固測定器の場
合は一般の光電計と同様、検査試料を暗室に入れ
て外乱光を遮断し、所定光源光のみを試料に照射
して測定を行つていた。 In the case of conventionally used optical coagulation analyzers, the test sample is placed in a dark room to block out any external light, and measurements are performed by irradiating only the specified light source light onto the sample, similar to a general photometer. Ta.
一方試料は検査終了後には固体化して流動性を
失つているので、一般の比色計などにおけるよう
な液体の流動性を利用した検体試料交換（フロー
方式）が不可能である。 On the other hand, since the sample becomes solid and loses its fluidity after the test is completed, it is impossible to exchange the sample using the fluidity of the liquid (flow method) as in a general colorimeter.
従つて試料交換は試料容器と共に行うことが必
要である。 Therefore, it is necessary to exchange the sample together with the sample container.
そのため、特に試料交換の回数の多い自動化測
定器機等においては試料交換を効率化するために
完全な暗室に入れず、簡単な遮光板で済ませる形
で実用化されている。 Therefore, in order to improve the efficiency of sample exchange, especially in automated measuring instruments where samples are exchanged frequently, a simple light-shielding plate is used instead of using a completely dark room.
従つて測定時には照明など周囲で大きな光量の
変化を起さないよう注意することが必要であり、
一方検査を効率良く行うために多少の測定値の精
度低下は止むを得ないとされていた。 Therefore, when making measurements, it is necessary to be careful not to cause large changes in the amount of light in the surroundings, such as lighting.
On the other hand, in order to perform inspections efficiently, it was considered that some decrease in the accuracy of measured values was unavoidable.
本考案はそれらの欠点に鑑みなされたものであ
り、測定部を暗室にしなくとも外乱光の影響を除
去することが出来るような比較的安定性の高い血
液凝固測定装置を提供するものである。 The present invention has been devised in view of these drawbacks, and it is an object of the present invention to provide a blood coagulation measuring device with relatively high stability, which can eliminate the influence of ambient light without placing the measuring section in a dark room.
発振器で点滅させた発光ダイオードとその発光
時には測定光と外乱光とを受光し、一方消光時に
は外乱光のみを受光するフオトダイオードと、前
記発振器で駆動するチヨツパユニツトと差動増幅
器とで外乱光による影響を除去して、測定試料を
暗室に入れなくとも測定出来るようにしたもので
ある。 A light-emitting diode that is blinked by an oscillator, a photodiode that receives measurement light and disturbance light when it emits light, and receives only disturbance light when it is extinguished, and a chopper unit and a differential amplifier that are driven by the oscillator to detect the influence of disturbance light. This makes it possible to perform measurements without placing the measurement sample in a dark room.
第１図は本考案の構成を示すブロツク図であ
る。 FIG. 1 is a block diagram showing the configuration of the present invention.
本考案装置は試料を入れる透明容器１、光電変
換素子（フオトダイオード）２、発光ダイオード
３、保持体４からなる検出部２１と、前記フオト
ダイオード２からの出力を増幅する増幅器５と、
チヨツパユニツト２２、差動増幅器２０等よりな
る外乱光除去回路７と、前記発光ダイオード３を
パルスで点滅させる駆動回路６と、試料に試薬を
混合した時入れるマニユアルスイツチ１３と、前
記チヨツパユニツト２２、発光ダイオード３の点
滅を制御する発振回路８と、前記外乱光除去回路
７からの出力電圧を所定比較電圧と比較する比較
回路９と、マニユアルスタート時から比較回路の
出力を受ける迄の時間を計測するタイマー１２
と、前記タイマーからの測定値を数字表示する表
示器１１から構成されている。 The device of the present invention includes a detection section 21 consisting of a transparent container 1 containing a sample, a photoelectric conversion element (photodiode) 2, a light emitting diode 3, and a holder 4, an amplifier 5 for amplifying the output from the photodiode 2,
A disturbance light removal circuit 7 consisting of a chopper unit 22, a differential amplifier 20, etc., a drive circuit 6 that blinks the light emitting diode 3 with pulses, a manual switch 13 that is turned on when a reagent is mixed with the sample, the chopper unit 22, the light emitting diode an oscillator circuit 8 for controlling the blinking of 3; a comparison circuit 9 for comparing the output voltage from the disturbance light removal circuit 7 with a predetermined comparison voltage; and a timer for measuring the time from manual start until receiving the output of the comparison circuit. 12
and a display 11 that numerically displays the measured values from the timer.
血液を遠心器等で分離した液性成分である血漿
を希釈液で希釈したものを容器１に入れ、試薬を
混合し前記保持体４の容器１の位置にセツトし、
前記マニユアルスイツチ１３を入れる。 Plasma, which is a liquid component obtained by separating blood using a centrifuge or the like, is diluted with a diluent and placed in a container 1, mixed with a reagent, and set in the container 1 position of the holder 4;
Turn on the manual switch 13.
試料に発光ダイオード３からの光を照射し、光
軸と直角方向の散乱光をフオトダイオード２で受
光し、光電変換を行う。 A sample is irradiated with light from a light emitting diode 3, and scattered light in a direction perpendicular to the optical axis is received by a photodiode 2 to perform photoelectric conversion.
変換された信号は増幅器５で増幅された後、外
乱光除去回路７に入力される。 The converted signal is amplified by an amplifier 5 and then input to a disturbance light removal circuit 7.
以下の動作を第２図、第３図で説明する。 The following operation will be explained with reference to FIGS. 2 and 3.
第２図は第１図中の外乱光除去回路７の詳細図
であり、第３図の各波形図は第２図のＡ〜Ｅの符
号点の電圧波形を示している。 FIG. 2 is a detailed diagram of the disturbance light removal circuit 7 in FIG. 1, and each waveform diagram in FIG. 3 shows the voltage waveforms of the code points A to E in FIG. 2.
第２図Ｂ点の外乱光除去回路入力波は、第３図
の波形Ｂで示されるように、前記発光素子３の消
灯周期２４で外乱光のみの出力電圧を示し、点灯
周期２３で外乱光と測定光の重畳した出力電圧を
示している。 As shown by waveform B in FIG. 3, the input wave of the disturbance light removal circuit at point B in FIG. It shows the output voltage superimposed with the measurement light.
前記入力波は緩衝器１４，１５を経て、チヨツ
パユニツト２２によつて、第３図の波形Ｃと波形
Ｄに分けられる。 The input wave passes through buffers 14 and 15 and is divided into waveforms C and D in FIG. 3 by a chopper unit 22.
即ちチヨツパユニツト２２は第３図の波形Ａに
よつて駆動され、周期２３の時スイツチ１６，１
８を閉じスイツチ１７，１９を開き、周期２４で
は１７，１９を閉じ、１６，１８を開く。 That is, the chopper unit 22 is driven by the waveform A shown in FIG.
8 is closed and switches 17 and 19 are opened, and in cycle 24, 17 and 19 are closed and switches 16 and 18 are opened.
従つて周期２３で波形Ｃが差動増幅器２０の
（＋）入力端子に現れ（−）入力端子は接地され
る。 Therefore, in period 23, waveform C appears at the (+) input terminal of the differential amplifier 20, and the (-) input terminal is grounded.
周期２４では（−）端子に波形Ｄが現れ（＋）
端子は接地される。 At period 24, waveform D appears at the (-) terminal (+)
The terminal is grounded.
そのため差動増幅器２０の出力端子Ｅには第３
図波形Ｅの如く周期２４の外乱光のみの出力電圧
波形が反転した出力波形が現れる。 Therefore, the output terminal E of the differential amplifier 20 has a third
As shown in waveform E in the figure, an output waveform appears in which the output voltage waveform of only the disturbance light with period 24 is inverted.
波形Ｅの交流分を除去した平滑化したものが波
形Ｆで、これは外乱光が相殺された測定光のみの
出力電圧となつている。 Waveform F is a smoothed version of waveform E with the alternating current component removed, and this is the output voltage of only the measurement light with the disturbance light canceled out.
外乱光除去回路７からの出力は比較回路９を経
てタイマー１２に入りマニユアルスイツチ１３の
スタートから比較回路９の入力電圧が所定の比較
電圧を越える時までの時間が計測され、凝固時間
として表示器１１で数字表示される。 The output from the disturbance light removal circuit 7 passes through the comparator circuit 9 and enters the timer 12, where the time from the start of the manual switch 13 to when the input voltage of the comparator circuit 9 exceeds a predetermined comparison voltage is measured, and the solidification time is displayed on the display. The number is displayed at 11.
本考案装置によれば暗室の機能がなくとも、外
乱光に影響されない血液凝固測定装置を提供する
ことが出来る。 According to the device of the present invention, it is possible to provide a blood coagulation measuring device that is not affected by ambient light even without a darkroom function.
又、試料の交換に際して、暗室にするための機
構例えば蓋等を操作する必要がなく効率の良い測
定ができる。 Furthermore, when replacing the sample, there is no need to operate a mechanism for making the room dark, such as a lid, and efficient measurements can be performed.
又、経時変化による零点ドリフトが相殺される
ので安定性が向上する。 Furthermore, the zero point drift due to changes over time is canceled out, so stability is improved.
第１図は本考案装置のブロツク図であり、第２
図は外乱光除去回路７の詳細図であり、第３図は
各部の電圧波形を示す説明図である。
１……透明容器、２……光電変換素子、３……
発光素子、５……増幅器、６……駆動回路、７…
…外乱光除去回路、８……発振回路、９……比較
回路、１１……表示器、１２……タイマー、１３
……マニユアルスイツチ、２０……差動増幅器、
２１……検出部、２２……チヨツパユニツト。
Figure 1 is a block diagram of the device of the present invention, and Figure 2 is a block diagram of the device of the present invention.
The figure is a detailed diagram of the disturbance light removal circuit 7, and FIG. 3 is an explanatory diagram showing voltage waveforms at various parts. 1... Transparent container, 2... Photoelectric conversion element, 3...
Light emitting element, 5...Amplifier, 6...Drive circuit, 7...
...Disturbance light removal circuit, 8...Oscillation circuit, 9...Comparison circuit, 11...Display device, 12...Timer, 13
...Manual switch, 20...Differential amplifier,
21...Detection section, 22...Chipper unit.
Claims (1)
らえる光電計において、所定周波数で点滅する発
光素子と、前記発光素子の点灯時に外乱光と測定
光とを受光し、かつ前記発光素子の消灯時に外乱
光のみを受光する光電変換素子と、前記発光素子
の点滅周波数に同期し、前記発光素子の点灯時に
おける前記光電変換素子からの信号のみを通過さ
せる回路と、同じく前記発光素子の消灯時におけ
る前記光電変換素子からの信号のみを通過させる
回路とを設け、前記２つの回路の信号を受けて前
記２つの信号のうちの消灯時の信号を反転させて
増幅させる差動増幅器と、前記差動増幅回路の出
力を平滑し、外乱光を除去した信号を得る平滑回
路とからなる血液凝固測定装置。 A photometer that detects the process of blood coagulation by light scattering and changes in absorbance includes a light-emitting element that blinks at a predetermined frequency, a light-emitting element that receives disturbance light and measurement light when the light-emitting element is turned on, and a light-emitting element that receives disturbance light and measurement light when the light-emitting element is turned off. a photoelectric conversion element that receives only disturbance light; a circuit that is synchronized with the blinking frequency of the light emitting element and passes only a signal from the photoelectric conversion element when the light emitting element is turned on; a differential amplifier that receives signals from the two circuits and inverts and amplifies a signal when the light is turned off of the two signals; A blood coagulation measuring device consisting of a smoothing circuit that smoothes the output of an amplifier circuit and obtains a signal with disturbance light removed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP161484U JPS60113560U (en) | 1984-01-09 | 1984-01-09 | Blood coagulation measuring device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP161484U JPS60113560U (en) | 1984-01-09 | 1984-01-09 | Blood coagulation measuring device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60113560U JPS60113560U (en) | 1985-08-01 |
| JPH0424436Y2 true JPH0424436Y2 (en) | 1992-06-09 |
Family
ID=30474518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP161484U Granted JPS60113560U (en) | 1984-01-09 | 1984-01-09 | Blood coagulation measuring device |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60113560U (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7261861B2 (en) * | 2003-04-24 | 2007-08-28 | Haemoscope Corporation | Hemostasis analyzer and method |
-
1984
- 1984-01-09 JP JP161484U patent/JPS60113560U/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60113560U (en) | 1985-08-01 |
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