JPH04259461A - Drug container and method for filling drug - Google Patents
Drug container and method for filling drugInfo
- Publication number
- JPH04259461A JPH04259461A JP3042725A JP4272591A JPH04259461A JP H04259461 A JPH04259461 A JP H04259461A JP 3042725 A JP3042725 A JP 3042725A JP 4272591 A JP4272591 A JP 4272591A JP H04259461 A JPH04259461 A JP H04259461A
- Authority
- JP
- Japan
- Prior art keywords
- drug
- container
- storage container
- bottle
- drug storage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
Description
【発明の詳細な説明】
【０００１】
【産業上の利用分野】本発明は、薬剤の収納容器および
薬剤の充填方法に関し、さらに詳しくは、溶解液の調製
が必要な薬剤の収納容器において、溶解液の調製および
服用が簡便に行える薬剤収納容器と、薬剤の品質劣化を
防止する薬剤の充填方法に関するものである。
【０００２】
【従来の技術】薬剤のなかには、腸管洗浄液用組成物、
滋養強壮変質剤および診断用薬剤のように、水または希
釈剤で溶解した後、多量に服用しなければならないもの
がある。このような薬剤に品質劣化しやすい成分が含ま
れている場合、その収納容器としては、ガラス瓶、水分
および酸素透過性のない合成樹脂製のボトル、あるいは
アルミニュウム箔と合成樹脂のラミネート袋等がある。
【０００３】前述のような容器に薬剤を充填した包装形
態では、薬剤の取り出し、溶媒の計量、溶解容器の準備
および薬剤と溶媒の混合等の一連の溶解液調製操作が必
要で、さらに多量の溶解液の服用に際しては、服用に便
利な小型容器の準備が必要となる。このような溶解液服
用までに煩雑な操作を伴う包装形態は、溶解液の調製お
よび服用の便宜性を考慮したものとはいえない。 【
０００４】一方、溶解操作を必要とする薬剤の溶解液調
製の便宜性を考慮した容器としては、例えば、溶解容器
として使用できる大型の容器に少量の薬剤が充填された
溶解容器兼用の薬剤収納容器が知られている（商品名：
ゴライテリー（ＧＯＬＡＹＴＥＬＹ））。しかし、この
容器は、薬剤の充填容積に対して空間部の容積が大きく
、空間部に存在する空気中の酸素によって品質劣化する
問題がある。
【０００５】
【発明が解決しようとする課題】本発明は、溶解液の調
製が必要な薬剤の収納容器において、溶解液の調製およ
び服用が簡便に行える薬剤収納容器と、薬剤の品質劣化
を防止する薬剤の充填方法を提供することを課題とする
。
【０００６】
【課題を解決するための手段】本発明者らは、上記の課
題を解決する研究を行った結果、薬剤収納容器をコップ
状に成形すると、薬剤を収納する容器と服用の際に必要
となる小型容器に兼用できること、さらに前記薬剤収納
容器を溶解容器口部に挿抜可能に嵌挿することで、溶解
液の調製および服用の便宜性が著しく改善できること、
また、薬剤を薬剤収納容器に充填する際、薬剤収納容器
のヘッドスペースを制限することで簡便に品質劣化の防
止を図れることを見いだして、本発明を完成した。
【０００７】前述の課題を解決した本発明の第１は、ガ
スバリア性の優れた樹脂よりなり、コップ状に形成され
たことを特徴とする剛性あるいは準剛性の薬剤収納容器
である。
【０００８】本発明の第２は、前記薬剤収納容器が樹脂
製のボトル開口部に挿抜可能に嵌挿されていることを特
徴とする薬剤収納容器である。
【０００９】本発明の第３は、前記薬剤収納容器に、ヘ
ッドスペースが全容量の５〜２０％となるように薬剤を
充填することを特徴とする薬剤の充填方法である。
【００１０】本発明の薬剤収納容器は、例えばポリエチ
レングリコールと電解質が相対的に下記の範囲に含まれ
る腸管洗浄液用組成物に利用できる。
【００１１】
【表１】
【００１２】本発明の薬剤収納容器の材質としては、ポ
リエチレン、ポリプロピレン、塩化ビニル樹脂、メチル
ペンテン樹脂、ポリカーボネート、メタクリル樹脂、ポ
リスチレン、スチレン系樹脂、アセタール樹脂、アクリ
ロニトリル−ブタジエン−スチレン樹脂、ふっ素樹脂、
ポリエステル系樹脂、ポリウレタン系樹脂等、およびこ
れらの材質に酸素バリアー性の優れたエチレン・酢酸ビ
ニル共重合体けん化物を組み合わせたものが挙げられる
。
【００１３】前記容器は例えばブロー成形により成形さ
れるが、容器側面部は曲面および多面いずれでもよく、
手に持ち易くまた自立性のものが好ましい。
【００１４】また、溶解容器として溶媒を充填後、薬剤
を充分に混合することができる容積をもつ合成樹脂製ボ
トルに、前記薬剤収納容器を収納すると、使用の際の便
宜性はさらに向上する。薬剤収納容器の前記ボトルへの
収納方法は、例えば薬剤収納容器を前記ボトルの開口部
に挿入し、薬剤収納容器の開口部をボトルの開口部に嵌
装する方法が挙げられる。
【００１５】
【実施例】以下、図面に従って本発明に係わる一実施例
を詳細に説明する。なお、本実施例では腸管洗浄液用組
成物を収納する薬剤収納容器に応用した場合について説
明する。
【００１６】図１は本発明の薬剤収納容器（１）の斜視
図である。本図の薬剤収納容器（１）は、ポリエチレン
、エチレン−酢酸ビニル共重合体けん化物とポリエチレ
ンを組み合わせた樹脂を使用し、コップ状にブロー成形
して製造したものであり、フランジ部（２）を備えてい
る。その開口部は、薬剤充填後にシール剤を用いて密閉
する。
【００１７】図２は、前記薬剤収納容器（１）を薬剤溶
解用ボトル（３）に嵌挿したときの斜視図で、ボトル（
３）はキャップ（４）および取っ手部（５）を備えてい
る。
【００１８】図３は図２の分解斜視図で、薬剤収納容器
（１）はボトル（３）の開口部（６）に嵌挿され、前記
のフランジ部（２）が開口部（６）の周縁上に置かれた
後、キャップ（４）が締栓される。
【００１９】溶解液の調製はキャップ（４）を開栓し薬
剤収納容器（１）を取り出した後、薬剤収納容器（１）
のシール材（７）を剥し、充填されている薬剤をボトル
（３）に投入する。続いてボトル（３）に水を注ぎ薬剤
を溶解した後、空となった薬剤収納容器（１）に溶解液
を注いで服用する。
【００２０】腸管洗浄の効果は、溶解液の服用速度に影
響されることから、一定量の溶解液を所定の時間をかけ
て服用しなければならない。従って、薬剤収納容器（１
）が計量コップとして兼用できることは洗浄効果にバラ
ツキを生じることなく以後の内視鏡検査等を問題なく実
施できる利点をもつ。
【００２１】 一方、本発明者は腸管洗浄液用組成物
の主成分であるポリエチレングリコール４０００を加温
虐待（６０℃、１ヶ月間）した結果、ホルムアルデヒド
が発生する事を認め、毒性の強いホルムアルデヒドの発
生を防止する包装形態を種々研究した結果、薬剤収納容
器（１）に腸管洗浄液用組成物を充填する際のヘッドス
ペースとホルムアルデヒドの発生に密接な関係があるこ
とを見いだした。以下に前記の試験結果を示す。
【００２２】
【表２】
【００２３】 表２から、ホルムアルデヒドの発生は
、薬剤収納容器（１）の全容量に対するヘッドスペース
が２０％以上となると急激に増加することが判る。
従って、薬剤収納容器のヘッドスペースをできる限り減
じた状態で腸管洗浄液用組成物を充填する事が望ましい
といえる。しかし、前記組成物の充填バラツキ、充填速
度および溶解容器に投入する際の便宜性を考慮すると、
薬剤収納容器におけるヘッドスペースは５％以上必要で
あることから、腸管洗浄液用組成物を薬剤収納容器に充
填する際、前記容器のヘッドスペースは５〜２０％が好
ましく、特に好ましいのは１０〜１５％である。
【００２４】
【発明の効果】以上説明したように本発明によれば、溶
解液の調製が伴う薬剤の溶解液調製操作および調製液の
服用がスムーズに行え、その便益は大である。さらに、
本発明の薬剤充填方法によれば薬剤の品質劣化を抑制で
きる。Description: [0001] The present invention relates to a drug storage container and a method for filling the drug, and more particularly, the present invention relates to a drug storage container and a method for filling the drug, and more specifically, in a drug storage container that requires the preparation of a solution, The present invention relates to a drug storage container that allows easy preparation and administration of liquid, and a drug filling method that prevents deterioration of drug quality. BACKGROUND OF THE INVENTION Some drugs include compositions for intestinal cleansing;
Some drugs, such as tonics and diagnostic drugs, must be dissolved in water or a diluent and then taken in large amounts. If such drugs contain ingredients that are susceptible to quality deterioration, storage containers include glass bottles, bottles made of synthetic resin that are not permeable to moisture and oxygen, or laminate bags made of aluminum foil and synthetic resin. . [0003] In the above-mentioned packaging form in which a drug is filled in a container, a series of solution preparation operations are required, such as taking out the drug, measuring the solvent, preparing a dissolution container, and mixing the drug and solvent. When taking the solution, it is necessary to prepare a small container that is convenient for taking. Such a packaging form that requires complicated operations before taking the solution cannot be said to take into account the convenience of preparing and taking the solution. [
On the other hand, examples of containers that take into account the convenience of preparing solutions for drugs that require dissolution operations include drug storage containers that also serve as dissolution containers, in which a large container that can be used as a dissolution container is filled with a small amount of drug. is known (product name:
GOLAYTELY). However, this container has a problem in that the volume of the space is large relative to the filled volume of the medicine, and the quality deteriorates due to oxygen in the air present in the space. SUMMARY OF THE INVENTION The present invention provides a container for storing drugs that requires the preparation of a solution, and provides a container for storing drugs that allows easy preparation and administration of the solution, and prevents deterioration of the quality of the drug. The purpose of this invention is to provide a method for filling drugs. [Means for Solving the Problems] As a result of research to solve the above-mentioned problems, the inventors of the present invention found that when a drug storage container is formed into a cup shape, the container for storing the drug and the container for taking the drug are separated. It can also be used as a necessary small container, and furthermore, by removably inserting the drug storage container into the opening of the dissolution container, the convenience of preparing and taking the solution can be significantly improved;
Furthermore, the present invention was completed by discovering that quality deterioration can be easily prevented by limiting the head space of the drug storage container when filling the drug into the container. [0007] The first aspect of the present invention that solves the above-mentioned problems is a rigid or semi-rigid drug storage container that is made of a resin with excellent gas barrier properties and is shaped like a cup. A second aspect of the present invention is a drug storage container, characterized in that the drug storage container is removably inserted into an opening of a resin bottle. A third aspect of the present invention is a drug filling method, characterized in that the drug storage container is filled with the drug so that the head space is 5 to 20% of the total capacity. The drug storage container of the present invention can be used, for example, in a composition for intestinal cleansing liquid in which polyethylene glycol and electrolyte are contained in the following relative ranges. [Table 1] Materials for the drug storage container of the present invention include polyethylene, polypropylene, vinyl chloride resin, methylpentene resin, polycarbonate, methacrylic resin, polystyrene, styrene resin, acetal resin, acrylonitrile-butadiene. -Styrene resin, fluororesin,
Examples include polyester resins, polyurethane resins, etc., and combinations of these materials with saponified ethylene/vinyl acetate copolymers having excellent oxygen barrier properties. [0013] The container is molded, for example, by blow molding, and the container side portion may be curved or multifaceted;
It is preferable that it be easy to hold in the hand and that it can stand on its own. [0014] Furthermore, when the drug storage container is housed in a synthetic resin bottle having a volume that allows the drug to be sufficiently mixed after being filled with a solvent as a dissolution container, the convenience in use is further improved. A method for storing the drug storage container in the bottle includes, for example, a method of inserting the drug storage container into the opening of the bottle and fitting the opening of the drug storage container into the opening of the bottle. [Embodiment] An embodiment of the present invention will be described in detail below with reference to the drawings. In this example, a case will be described in which the present invention is applied to a drug storage container that stores a composition for intestinal cleansing liquid. FIG. 1 is a perspective view of a drug storage container (1) of the present invention. The drug storage container (1) shown in this figure is manufactured by blow molding into a cup shape using a resin that combines polyethylene, saponified ethylene-vinyl acetate copolymer, and polyethylene. It is equipped with The opening is sealed using a sealant after filling with the drug. FIG. 2 is a perspective view of the drug storage container (1) inserted into the drug dissolution bottle (3).
3) includes a cap (4) and a handle (5). FIG. 3 is an exploded perspective view of FIG. 2, in which the drug storage container (1) is fitted into the opening (6) of the bottle (3), and the flange (2) is inserted into the opening (6). After being placed on the periphery, the cap (4) is screwed on. To prepare the solution, open the cap (4) and take out the drug storage container (1).
Peel off the sealing material (7) and pour the filled medicine into the bottle (3). Subsequently, water is poured into the bottle (3) to dissolve the medicine, and then the solution is poured into the empty medicine storage container (1) and taken. [0020] The effect of intestinal cleansing is affected by the speed at which the solution is taken, so a certain amount of the solution must be taken over a predetermined period of time. Therefore, the drug storage container (1
) can also be used as a measuring cup, which has the advantage that subsequent endoscopic examinations, etc., can be carried out without any problems without causing variations in the cleaning effect. On the other hand, the present inventor recognized that formaldehyde is generated as a result of heating and abusing polyethylene glycol 4000, which is the main component of a composition for intestinal cleansing liquid (60° C., 1 month), and found that formaldehyde, which is highly toxic, is generated. As a result of researching various packaging forms to prevent the occurrence of formaldehyde, it was found that there is a close relationship between the head space and the generation of formaldehyde when filling the composition for intestinal cleansing liquid into the drug storage container (1). The above test results are shown below. Table 2 shows that the generation of formaldehyde sharply increases when the head space relative to the total capacity of the drug storage container (1) becomes 20% or more.
Therefore, it is desirable to fill the drug storage container with the intestinal cleansing liquid composition while reducing the head space as much as possible. However, considering the filling variation of the composition, the filling speed, and the convenience of charging the composition into a dissolution container,
Since the head space in the drug storage container is required to be 5% or more, when filling the drug storage container with the intestinal cleansing liquid composition, the head space of the container is preferably 5 to 20%, particularly preferably 10 to 15%. %. [0024] As explained above, according to the present invention, the operation of preparing a drug solution and the administration of the preparation can be carried out smoothly, and the benefits thereof are great. moreover,
According to the drug filling method of the present invention, deterioration in the quality of drugs can be suppressed.
【図面の簡単な説明】
【図１】 本発明における一実施例の斜視図である。
【図２】 本発明における一実施例の斜視図である
。
【図３】 本発明における一実施例の分解斜視図であ
る。
【符号の説明】
１ 薬剤収納容器
２ フランジ部
３ ボトル
４ キャップ
５ 取っ手部
６ 開口部
７ シール材BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a perspective view of an embodiment of the present invention. FIG. 2 is a perspective view of one embodiment of the present invention. FIG. 3 is an exploded perspective view of one embodiment of the present invention. [Explanation of symbols] 1 Drug storage container 2 Flange portion 3 Bottle 4 Cap 5 Handle portion 6 Opening portion 7 Sealing material
Claims (3)
スバリア性の優れた樹脂よりなり、コップ状に形成され
たことを特徴とする剛性あるいは準剛性の薬剤収納容器
。1. A rigid or semi-rigid drug storage container, characterized in that the container is made of a resin with excellent gas barrier properties and is shaped like a cup.
脂製のボトル開口部に、挿抜可能に嵌挿されていること
を特徴とする薬剤収納容器。2. A drug storage container, wherein the drug storage container according to claim 1 is removably fitted into an opening of a resin bottle.
ッドスペースが全容量の５〜２０％となるように、薬剤
を充填することを特徴とする薬剤の充填方法。3. A method for filling a drug, comprising filling the drug storage container according to claim 1 with the drug so that the head space is 5 to 20% of the total capacity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP03042725A JP3117148B2 (en) | 1991-02-13 | 1991-02-13 | Drug storage container and drug filling method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP03042725A JP3117148B2 (en) | 1991-02-13 | 1991-02-13 | Drug storage container and drug filling method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH04259461A true JPH04259461A (en) | 1992-09-16 |
| JP3117148B2 JP3117148B2 (en) | 2000-12-11 |
Family
ID=12644041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP03042725A Expired - Lifetime JP3117148B2 (en) | 1991-02-13 | 1991-02-13 | Drug storage container and drug filling method |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3117148B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011136336A1 (en) | 2010-04-30 | 2011-11-03 | 味の素株式会社 | Liquid preparation for oral administration which can be used in ct colonography, and composition for imaging of digestive tract |
| WO2012046847A1 (en) | 2010-10-08 | 2012-04-12 | 味の素株式会社 | Liquid preparation for oral administration which can be used in ct colonography, and composition for imaging digestive tract |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0583514U (en) * | 1992-04-20 | 1993-11-12 | 松下電器産業株式会社 | Driving force transmission device |
-
1991
- 1991-02-13 JP JP03042725A patent/JP3117148B2/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011136336A1 (en) | 2010-04-30 | 2011-11-03 | 味の素株式会社 | Liquid preparation for oral administration which can be used in ct colonography, and composition for imaging of digestive tract |
| WO2012046847A1 (en) | 2010-10-08 | 2012-04-12 | 味の素株式会社 | Liquid preparation for oral administration which can be used in ct colonography, and composition for imaging digestive tract |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3117148B2 (en) | 2000-12-11 |
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