JPH04288011A - Soft capsule agent - Google Patents
Soft capsule agentInfo
- Publication number
- JPH04288011A JPH04288011A JP4962091A JP4962091A JPH04288011A JP H04288011 A JPH04288011 A JP H04288011A JP 4962091 A JP4962091 A JP 4962091A JP 4962091 A JP4962091 A JP 4962091A JP H04288011 A JPH04288011 A JP H04288011A
- Authority
- JP
- Japan
- Prior art keywords
- soft capsule
- agent
- capsule agent
- coating
- film
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007901 soft capsule Substances 0.000 claims abstract description 29
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims abstract description 10
- 239000002253 acid Substances 0.000 claims description 8
- 239000011248 coating agent Substances 0.000 abstract description 11
- 238000000576 coating method Methods 0.000 abstract description 10
- 238000000034 method Methods 0.000 abstract description 7
- 239000007788 liquid Substances 0.000 abstract description 5
- 150000004665 fatty acids Chemical group 0.000 abstract description 3
- 239000000194 fatty acid Substances 0.000 abstract description 2
- 235000013305 food Nutrition 0.000 abstract description 2
- 231100000053 low toxicity Toxicity 0.000 abstract description 2
- 238000005507 spraying Methods 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 abstract 12
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000004321 preservation Methods 0.000 abstract 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 239000004203 carnauba wax Substances 0.000 description 2
- 235000013869 carnauba wax Nutrition 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 238000004381 surface treatment Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- RPONPMMNRVSJAT-UHFFFAOYSA-N C(C)(=O)OCC(O)CO.C(C)(=O)OCCCCCCCCCCCC Chemical compound C(C)(=O)OCC(O)CO.C(C)(=O)OCCCCCCCCCCCC RPONPMMNRVSJAT-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 235000019645 odor Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000010079 rubber tapping Methods 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- -1 sucrose fatty ester Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 238000009849 vacuum degassing Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
Description
【０００１】0001
【産業上の利用分野】本発明は軟カプセル剤の剤皮表面
をグリセリルモノ脂肪酸ジアセテートで被覆することに
より、軟カプセル剤同士の付着及び容器等との付着を防
止した軟カプセル剤に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a soft capsule whose shell surface is coated with glyceryl monofatty acid diacetate to prevent the soft capsules from adhering to each other and to containers and the like.
【０００２】0002
【従来の技術】軟カプセル剤は、ゼラチンにグリセリン
、Ｄ−ソルビトール等の可塑剤を添加して製した殻の中
に油性液、懸濁液等の内容物を充填したもので、吸収性
がよい、含量の均一性に優れている、内容物の酸化防止
能がよい、不快臭、味のマスキングが容易である等の理
由から、近年急速にのびつつある剤形の一つである。[Prior Art] Soft capsules are made by adding a plasticizer such as glycerin or D-sorbitol to gelatin and filling the shell with contents such as an oily liquid or suspension. It is one of the dosage forms that has been rapidly gaining popularity in recent years due to its excellent content uniformity, good anti-oxidation ability, and ease of masking unpleasant odors and tastes.
【０００３】軟カプセル剤に皮膜水分は通常６〜１０％
程度であるが、皮膜水分含量が多い場合、あるいは高温
に保管されると、剤皮が軟化し、ガラスビン等の容器の
壁に付着したり、軟カプセル剤同士が相互に付着して、
容器から取り出すことが困難となるという問題点があっ
た。[0003] Soft capsules usually have a film moisture content of 6 to 10%.
However, if the film has a high water content or is stored at high temperatures, the shell will soften and may stick to the walls of containers such as glass bottles, or soft capsules may stick to each other.
There was a problem in that it was difficult to take out the container.
【０００４】従来、このような軟カプセル剤の付着を防
止する方法として、軟カプセル剤の剤皮表面をカルナウ
バロウ（特開昭５６−１５６２１２ 号）又は硬化植物
油もしくはショ糖脂肪エステル（特開昭６４−７９１１
０号）で表面処理する方法が知られている。しかしなが
ら、これらの方法も充分に満足し得るものではなかった
。[0004] Conventionally, as a method for preventing such adhesion of soft capsules, the surface of the shell of soft capsules was coated with carnauba wax (Japanese Patent Application Laid-Open No. 156212/1982), hydrogenated vegetable oil, or sucrose fatty ester (Japanese Patent Application Laid-open No. 156212/1983). -7911
A method of surface treatment with No. 0) is known. However, these methods were not fully satisfactory.
【０００５】[0005]
【発明が解決しようとする課題】従って、本発明は、高
温、高湿下に保存しても、軟カプセル剤同士が付着した
り、容器に付着することのない軟カプセル剤を提供する
ことを目的とするものである。SUMMARY OF THE INVENTION Therefore, it is an object of the present invention to provide soft capsules that do not stick to each other or to containers even when stored at high temperatures and high humidity. This is the purpose.
【０００６】[0006]
【課題を解決するための手段】斯かる実情において、本
発明者は鋭意研究を行った結果、グリセリルモノ脂肪酸
ジアセテートで表面処理すれば上記目的が達成されるこ
とを見出し、本発明を完成した。[Means for Solving the Problems] Under these circumstances, the present inventor conducted extensive research and found that the above object can be achieved by surface treatment with glyceryl monofatty acid diacetate, and has completed the present invention. .
【０００７】すなわち、本発明は、剤皮表面をグリセリ
ルモノ脂肪酸ジアセテートで被覆した軟カプセル剤を提
供するものである。That is, the present invention provides a soft capsule whose shell surface is coated with glyceryl monofatty acid diacetate.
【０００８】本発明において使用されるグリセリルモノ
脂肪酸ジアセテートとしては、脂肪酸部が炭素数８〜２
０、特に１２〜１８のものが好ましい。これらのグリセ
リルモノ脂肪酸ジアセテートは食品用の基剤として使用
されている極めて毒性の低いものである。[0008] The glyceryl monofatty acid diacetate used in the present invention has a fatty acid moiety having 8 to 2 carbon atoms.
0, particularly preferably 12 to 18. These glyceryl monofatty acid diacetates are used as food bases and have extremely low toxicity.
【０００９】本発明において、軟カプセル剤の剤皮表面
の被覆は、自体公知の方法によって行いうるが、例えば
、コーティングパン中に軟カプセル剤を入れ、回転させ
ながら、これに液体状のグリセリルモノ脂肪酸ジアセテ
ートを噴霧する方法を好ましい方法としてあげることが
できる。グリセリルモノ脂肪酸ジアセテートの被覆量は
特に制限されないが、一般には剤皮重量に対し０．０３
％程度が好ましい。[0009] In the present invention, the surface of the soft capsule can be coated by a method known per se. For example, the soft capsule is placed in a coating pan, and while it is being rotated, liquid glyceryl monomer is added to the soft capsule. A preferred method is a method of spraying fatty acid diacetate. The amount of glyceryl monofatty acid diacetate coated is not particularly limited, but is generally 0.03% of the weight of the coating.
% is preferable.
【００１０】0010
【実施例】次に実施例を挙げて説明する。[Example] Next, an example will be given and explained.
【００１１】実施例１
（１） ゼラチン１０ｋｇ、グリセリン４．５ｋｇ及
び精製水６ｋｇを８０℃で３時間加熱攪拌してゼラチン
のゾル溶液とし、真空脱気したのち、５０℃の恒温槽に
貯留して軟カプセル皮膜剤とした。酢酸トコフェロール
１ｋｇ及びゴマ油０．５ｋｇ を撹拌して均一な混合液
とし、この液を内容液として、ライナー社製ロータリー
充填機を用いて、常法により上記の軟カプセル皮膜で被
包成形し、通常の乾燥工程を経て、内容量１５０ｍｇの
球状の軟カプセル剤を製造した。
（２） このカプセル１０，０００カプセルをコーテ
ィングパン中に投入し、回転させながら、グリセリルモ
ノラウリルジアセテートを皮膜重量に対して０．０２重
量％程度噴霧し、被覆を施した。Example 1 (1) 10 kg of gelatin, 4.5 kg of glycerin, and 6 kg of purified water were heated and stirred at 80°C for 3 hours to form a gelatin sol solution. After vacuum degassing, the solution was stored in a constant temperature bath at 50°C. It was made into a soft capsule coating agent. 1 kg of tocopherol acetate and 0.5 kg of sesame oil are stirred to form a uniform mixture, and this liquid is used as the content liquid to be encapsulated with the above-mentioned soft capsule film using a Reiner rotary filling machine in a conventional manner. Through the drying process, spherical soft capsules with a content of 150 mg were manufactured. (2) 10,000 capsules were placed in a coating pan, and while rotating, glyceryl monolauryl diacetate was sprayed in an amount of about 0.02% by weight based on the weight of the coating, thereby coating the pan.
【００１２】比較例１
実施例１の（１）で製造した軟カプセル剤１０，０００
カプセルをコーティングパン中に投入し、回転させなが
ら２００メッシュ以下の粒度に篩過したカルナウバロウ
を皮膜重量に対して０．０３重量％ふりかけ被覆を施し
た。Comparative Example 1 Soft capsule prepared in Example 1 (1) 10,000
The capsules were placed in a coating pan and coated with carnauba wax, which had been sieved to a particle size of 200 mesh or less, in an amount of 0.03% by weight based on the weight of the coating while rotating.
【００１３】実施例１及び比較例１で被覆を施した軟カ
プセル剤及び実施例１の（１）で製造した被覆無しの軟
カプセル剤１００カプセルを、各々ガラスビンに入れ、
密栓して、３５℃及び４０℃の恒温槽中に８週間放置し
、相互付着の程度を調べた。その結果を表１に示す。[0013] 100 capsules of the coated soft capsules of Example 1 and Comparative Example 1 and the uncoated soft capsules produced in Example 1 (1) were placed in glass bottles.
The tubes were sealed tightly and left in a constant temperature bath at 35° C. and 40° C. for 8 weeks, and the degree of mutual adhesion was examined. The results are shown in Table 1.
【００１４】[0014]
【表１】[Table 1]
【００１５】−；相互付着は無く自由にビンから排出で
きる。
±；ビンを逆さにして軽く振る程度でビンから排出でき
る。
＋；ビンを逆さにして軽く手でたたくとビンから排出で
きる。
＋＋；ビンを逆さにして強く手でたたくとビンから排出
できる。-: There is no mutual adhesion and the bottles can be freely discharged. ±; It can be discharged from the bottle by turning the bottle upside down and shaking it gently. +: It can be discharged from the bottle by turning the bottle upside down and tapping it lightly with your hand. ++; You can eject it from the bottle by turning it upside down and hitting it strongly with your hand.
【００１６】[0016]
【発明の効果】本発明の軟カプセルはグリセリルモノ脂
肪酸ジアセテートで表面処理されているので、高温、高
湿下に保存しても、軟カプセル剤同士が付着したり、容
器に付着することがない。[Effects of the Invention] Since the soft capsules of the present invention are surface-treated with glyceryl monofatty acid diacetate, the soft capsules do not stick to each other or to the container even when stored at high temperatures and high humidity. do not have.
Claims (1)
セテートで被覆した軟カプセル剤。1. A soft capsule whose shell surface is coated with glyceryl monofatty acid diacetate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4962091A JPH04288011A (en) | 1991-03-14 | 1991-03-14 | Soft capsule agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4962091A JPH04288011A (en) | 1991-03-14 | 1991-03-14 | Soft capsule agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH04288011A true JPH04288011A (en) | 1992-10-13 |
Family
ID=12836279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4962091A Pending JPH04288011A (en) | 1991-03-14 | 1991-03-14 | Soft capsule agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH04288011A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004331510A (en) * | 2003-04-30 | 2004-11-25 | Sansho Pharmaceutical Co Ltd | Capsule |
| JPWO2005120490A1 (en) * | 2004-06-11 | 2008-04-03 | 小野薬品工業株式会社 | Capsule stable against chewing |
| US7867513B2 (en) | 2004-02-17 | 2011-01-11 | Eisai R&D Management Co., Ltd. | Soft capsule |
-
1991
- 1991-03-14 JP JP4962091A patent/JPH04288011A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004331510A (en) * | 2003-04-30 | 2004-11-25 | Sansho Pharmaceutical Co Ltd | Capsule |
| US7867513B2 (en) | 2004-02-17 | 2011-01-11 | Eisai R&D Management Co., Ltd. | Soft capsule |
| JPWO2005120490A1 (en) * | 2004-06-11 | 2008-04-03 | 小野薬品工業株式会社 | Capsule stable against chewing |
| JP5615478B2 (en) * | 2004-06-11 | 2014-10-29 | 小野薬品工業株式会社 | Stable capsule against chewing |
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