JPH04301564A - Sample injector for two-channel injection - Google Patents

Abstract

PURPOSE:To obtain a sample injecting device which enables simultaneous injection of the same sample into two measuring systems by one injecting operation without contamination. CONSTITUTION:A disk-shaped rotor 8 and first and second disk-shaped stators 7 and 9 so disposed oppositely as to hold the rotor 8 therebetween are provided. First to sixth holes 7a to 7f made in the first stator 7, first to fourth grooves 8b, 8c, 8b' and 8c' formed in the shapes of circular arcs in the rotor 8 on its side coming into contact with the first stator 7, seventh to twelfth holes 9a to 9f made in the second stator 9, a thirteenth hole 8a so made as to pierce the rotor 8 through, and a fourteenth hole 8d so made in the rotor 8 as to communicate with the thirteenth hole 8a from the lateral side, are provided. First and second sample loops are provided outside the first stator 7, and switching of internal flow passages is conducted with the rotor 8 rotated by 60 deg..

Description

[Detailed description of the invention]

0001

[Industrial Application Field] The present invention is installed in a liquid chromatograph or an ion chromatograph, and simultaneously injects a sample into two chromatography systems with a single sample injection operation to separate components with different physical properties into two separation models. -Relates to a sample injection device that allows measurements to be made on a board.

0002

2. Description of the Related Art FIG. 3 is an explanatory diagram of the configuration of an ion chromatograph equipped with a general sample injection device. In this figure, 1a is a tank in which a mobile phase made of, for example, a carbonate solvent is stored, 1b is a tank in which a scavenger liquid is stored,
2a and 2b are liquid sending pumps, 3 is a sample injection device, 4 is a separation column filled with, for example, an anion exchange resin with a low ion exchange capacity, and 5 is an ion exchange membrane 5a, for example, which divides the inside into an inner chamber 5b and an outer chamber 5c. The sectioned suppressor 6 is a detector, for example a conductivity detector.

In the ion chromatograph having the configuration shown in FIG. 3, the sample injection device 3 is initially off and its internal flow path is in a solid line connection state. Also, pump 2
When a is driven, the mobile phase in the tank 1a is transferred to the sample injection device 3.
The first port 3a → the second port 3b → the separation column 4 → the inner chamber 5b of the suppressor 5 → the detector 6 and then is discharged from an outlet (not shown). Moreover, when the pump 2b is driven,
The scavenger liquid in the tank 1b is transferred to the outer chamber 5 of the suppressor 5.
c and is discharged from an outlet (not shown). Therefore, the cations contained in the mobile phase flowing in the inner chamber 5b are ion-exchanged via the ion exchange membrane 5a, and the conductivity background of the eluent is reduced.

On the other hand, when a sample to be measured is injected from the fourth port 3d of the sample injection device 3 using the syringe 3h, the sample is transferred from the fourth port 3d of the sample injection device 3 to the groove 3l' to the groove 3l'. 3 port 3c → measuring tube 3g → 6th port 3f → groove 3m →
It flows through the fifth port 3e and fills the metering tube 3g. In this state, when the sample injection device 3 is turned on and its internal flow path is switched to the broken line connection state, the sample to be measured in the measuring tube 3g is transported to the separation column 4 by the mobile phase.
It is chromatographically separated in the separation column. The sample to be measured thus separated is detected by the detector 6 via the inner chamber 5b of the suppressor 5.

[0005]

[Problems to be Solved by the Invention] However, in the conventional example described above, in order to measure components with different properties (for example, anions and cations) contained in the same sample, it is necessary to measure only one component. After completing the measurement, the mobile phase and separation column were changed and the other component was measured. For this reason, measurement requires a long time, and if the components in the sample are likely to denature or change in composition, this poses a major problem in terms of measurement accuracy and reproducibility.

On the other hand, attempts have been made to prepare two ion chromatograph apparatuses and inject the same sample into each measurement system for measurement. However, in order to automate the process, it was necessary to prepare two automatic injection devices, and there were also disadvantages in that two samples to be measured had to be prepared for the two autosamplers. The present invention has been made in view of the drawbacks of the conventional example, and its purpose is to provide a sample injection device that can simultaneously inject the same sample into two measurement systems without contaminating it in a single injection operation. It's about doing.

[0007]

[Means for Solving the Problems] The present invention provides a two-channel injection sample injector that includes a disc-shaped rotor and a rotor.
disc-shaped first and second stators arranged opposite to each other so as to sandwich the stator; and first to sixth holes bored at equal intervals along the circumference in the first stator. and,
first and second grooves formed in an arc shape on a surface of the rotor in contact with the first stator; and arc-shaped grooves in a surface of the rotor in contact with the second stator. The third and fourth grooves formed, and the seventh to fourth holes bored in the second stator at positions corresponding to the first to sixth holes, respectively.
a 12th hole, a 13th hole provided to pass through the rotor, and a 13th hole drilled in the rotor so as to communicate with the 13th hole from the side surface. 14
The hole communicates with a first sample loop provided on the outside of the first stator such that the first hole and the fourth hole communicate with each other, and the seventh hole and the tenth hole communicate with each other. The second stage
This problem has been solved by providing a second sample loop provided outside the rotor and configuring the rotor to be rotated by 60 degrees to switch the internal flow path.

[0008]

[Operation] The present invention operates as follows. That is, first, the sample injector of the embodiment of the present invention is turned off, and the first and second sample loops are filled with the liquid to be measured. Next, the sample injector of the embodiment of the present invention is turned on, and the first mobile phase introduced from the first mobile phase introduction channel is transferred from the third hole of the first stator to the rotor.
2nd groove of the stator → 4th hole of the 1st stator → 1st sample loop →
1st hole of 1st stator → 1st groove of rotor → 1st stator
The mobile phase is discharged from the mobile phase outlet channel through the second hole of the filter. At the same time, the second mobile phase introduced from the second mobile phase introduction flow path is transferred from the third hole of the second stator to the fourth groove of the rotor to the second
Derivation of the mobile phase via the 4th hole of the stator → 2nd sample loop → 1st hole of the 2nd stator → 3rd groove of the rotor → 2nd hole of the 2nd stator is discharged from the flow path. In this way,
The liquid to be measured filled in the first sample loop is transported by the mobile phase and guided from the first mobile phase outlet channel to the first separation column (or first chromatography system), and then to the second sample loop. The liquid to be measured filled in the tube is transported by the mobile phase and guided to the second separation column (or second chromatography system) from the second mobile phase outlet channel.

[0009]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be explained in detail below with reference to the drawings. FIG. 1 is an exploded perspective view showing the main parts of an embodiment of the present invention. 1 stator 7
, (b) shows a disc-shaped rotor 8 made of ceramic, for example, and (c) shows a disc-shaped second stay facing the other surface of the rotor 7. 9 is shown.

Further, 7a to 7f are first to sixth holes provided so as to pass through the first stator 7, and 8a are provided so as to pass through the rotor 8. hole, 8
b, 8c are first and second grooves provided in the surface of the rotor 8 in contact with the first stator 7 and formed in an arc shape;
8b', 8c' are provided on the surface of the rotor 8 that is in contact with the second stator 9, and are formed in a circular arc shape.
8d is a hole drilled in the rotor 8 so as to communicate with the hole 8a from the side surface, and 9a to 9f are seventh to seventh grooves provided to pass through the second stator 9. There are 12 holes.

FIG. 2 is a diagram for explaining the operation of the embodiment of the present invention, in which (a) shows the state in which the sample collecting device is off, and (b) shows the state in which the sample collecting device is in the on state. It shows. In addition, in FIG. 2, 10a and 10b are first and second measuring tubes each having a certain internal volume, A is a measurement liquid introduction flow path, B and B' are measurement liquid outlet flow paths, and C and E. indicates a mobile phase introduction channel, and D and F indicate a mobile phase derivation channel. Incidentally, in FIG. 2, the same symbols as in FIG. 1 are used with the same meaning, and repeated explanation here will be omitted.

The operation of the embodiment of the present invention will be explained below with reference to FIGS. 1 and 2. Initially, the sample injector of the embodiment of the present invention is turned off and is in the state shown in FIG. 2(a). In this state, the mobile phase introduced from the mobile phase introduction channel C is transferred from the third hole 7c of the first stator 7 to the first hole 7c of the rotor 8.
The mobile phase passes through the groove 8b and the second hole 7b of the first stator 7, and is discharged from the mobile phase outlet channel D. In addition, the mobile phase introduction channel E
The mobile phase introduced from the third hole 9c of the second stator 9
→The third groove 8b' of the rotor 8→The second hole 9b of the second stator 9, and is discharged from the mobile phase outlet flow path F.

On the other hand, use a syringe or the like to insert the hole 8d in the rotor 8.
(In other words, the liquid to be measured is introduced from the introduction channel A of the liquid to be measured) from the hole 8a of the rotor 8→the hole 7a of the first stator 7→
Sample loop 10a → hole 7d of first stator 7 → rotor
The measured liquid passes through the second groove 8c of No. 8 and the hole 7e of the first stator 7, and is discharged from the outlet flow path B of the liquid to be measured. At the same time, the rotor
The liquid to be measured is introduced from the hole 8d of the rotor 8 (that is, the introduction channel A of the liquid to be measured) from the hole 8a of the rotor 8 to the second stator 9.
hole 9a→sample loop 10b→hole 9d of second stator 9
→ 4th groove 8c' of rotor 8 → hole 9e of 2nd stator 9
The liquid to be measured is discharged from the outlet channel B'. In this way, the sample loops 10a and 10b are filled with the liquid to be measured.

Now, when the sample injector according to the embodiment of the present invention is turned on, the state shown in FIG. 1 (b) occurs. In this state, the mobile phase introduced from the mobile phase introduction channel C is
First hole 7c of stator 7 → second groove 8c of rotor → hole 7d of first stator 7 → sample loop 10a → first stator 7
The mobile phase is discharged from the mobile phase outlet channel D through the hole 7a of the rotor 8, the first groove 8b of the rotor 8, and the hole 7b of the first stator 7. At the same time, the mobile phase introduced from the mobile phase introduction channel E is
First hole 9c of second stator 9 → Fourth groove 8c' of rotor →
Via hole 9d of second stator 9 → sample loop 10b → hole 9a of second stator 9 → third groove 8b' of rotor 9 → hole 9b of second stator 9, It is discharged from the mobile phase outlet channel F.

In this way, the liquid to be measured filled in the sample loop 10a is transported by the mobile phase and sent from the mobile phase outlet channel D to the first separation column (or first separation column (not shown)).
chromatographic system), sample loop 10b
The liquid to be measured filled in the chamber is transported by the mobile phase and led to a second separation column (or second chromatography system) (not shown) from a mobile phase outlet channel F. Further, by repeating the above-described on/off operation with the sample injector of the embodiment of the present invention, it becomes possible to inject the sample to be measured into two chromatography systems such as an ion chromatograph with good reproducibility. Note that the present invention is not limited to the above-described embodiments, and can be modified in various ways.

[0016]

According to the present invention as described in detail above, a sample injected from one sample injection port in one injection operation is simultaneously injected into two sample loops, and two A sample injector for two-channel injection with a simple configuration that can simultaneously inject the same sample into two measurement systems without contaminating it and has excellent injection reproducibility is realized.

[Brief explanation of drawings]

FIG. 1 is an exploded perspective view of essential parts of an embodiment of the present invention.

FIG. 2 is an explanatory diagram of main parts of an embodiment of the present invention.

FIG. 3 is an explanatory diagram of a usage example of a conventional example. 1a, 1b tank 2a, 2b Liquid pump 3 Sample injector 4 Separation column 5 Suppressor 6 Detector 7 First stator 8 Rotor 9 Second stator

Claims (1)

[Claims] 1. A disc-shaped rotor, disc-shaped first and second stators arranged opposite to each other so as to sandwich the rotor, and a circumference of the first stator. first to sixth holes drilled at equal intervals along the row;
first and second grooves formed in an arc shape on a surface of the rotor in contact with the first stator; and arc-shaped grooves formed in a surface of the rotor in contact with the second stator. The third and fourth grooves, the seventh to twelfth holes drilled in the second stator at positions corresponding to the first to sixth holes, and the rotor. A 13th hole provided in this way, a 14th hole drilled in the rotor so as to communicate with the 13th hole from the side, and a 14th hole that communicates with the 1st hole and the 4th hole. The first stage is
a first sample loop provided on the outside of the stator; and a second sample loop provided on the outside of the second stator so as to communicate with the seventh hole and the tenth hole. And the rotor
A sample injector characterized in that the internal flow path is switched by rotating by 60 degrees.