JPH0431066B2 - - Google Patents

Description

Detailed Description of the Invention (Field of Application of the Invention) The present invention is applicable to, for example, flow-in injection analysis (hereinafter simply abbreviated as FIA), in which two or more sample solutions are passed through an eluent. When injecting,
A multi-purpose liquid injection mode that allows the injection form and injection method of multiple samples to be changed simply by changing the flow path to the small opening of the device and the connection method of the sample measuring tube, and the above-mentioned system that allows changing the flow path of one or more sample liquids. The present invention relates to a multi-purpose liquid injection/flow path change modification style that can be changed simply by changing the method, and a liquid injection device that can change the flow path change simply by changing the method.

(Background of the Invention) FIA, which has recently attracted particular attention as a method for analyzing components in a sample liquid, involves injecting a sample assisting liquid (hereinafter simply referred to as a sample) into the flow of an eluent. Since the pressure applied to the system is high, a pressure-resistant liquid injection device is usually used to inject the sample.

Liquid chromatography (hereinafter simply referred to as HLC), which is attracting attention along with FIA, uses a column filled with a resin that has a high affinity for specific components in the sample, and the resin in the column interacts with each component in the sample. Based on the difference in affinity shown between the two, predetermined components are separated and analyzed using a detector. This can be achieved by replacing the FIA reaction tube with a column, but depending on the analytical component, multiple components may be separated. In many cases, it is necessary to select and use the most suitable column for the analysis from among several columns.

FIG. 1 schematically shows a typical liquid injection system in FIA, and a well-known six-way valve 4 is used as the liquid injection device. Further, FIG. 2 schematically shows a typical flow path changing system in HLC, and the two six-way valves 11 and 13 described above are used as the flow path changing device.

To explain the outline of the liquid injection shown in FIG. 1, the eluent sent from the eluent tank 1 to the flow path 3 by the pump 2 is normally delivered to one of the six-way valves 4 in the communication relationship shown by the solid line in the figure. The liquid passes through the flow path, enters the flow path 5, the reaction tube 6, and then the detector 7. On the other hand, the other two passages in the six-way valve 4 are provided with liquid measuring tubes (generally consisting of tubes externally mounted on the buff lever).
In other words, the loop 8 is connected and communicated, and the sample in the sample container 9 is suctioned by the pump 10 to fill the loop 8 with the sample. Then, the passage in the six-way valve 4 is switched as shown by the broken line in the figure, and the sample is injected into the flow of the eluent as a "plug flow", so that the sample and the reagent in the eluent react and are analyzed by the detector 7. It's summery.

The six-way valve 4 has a pair of stator (fixed body) and rotor (rotating body) that have airtight opposing surfaces, the stator has a total of six small openings at each 60° rotation position, and the rotor has a It is well known as having three bridging grooves that connect adjacent small openings, and the communication relationship can be switched as shown in the figure by rotating the rotor by 60 degrees. The mode of injection into the liquid is simple and can be performed by rotating the rotor, so it is now widely used.

Also, if we explain the outline of the flow path change in Fig. 2,
The eluent sent from the eluate tank 1 is normally passed through six-way valves 11 and 13, which are in communication with each other as shown by the solid line in the figure.
The liquid is sent to the detector 7 through the flow path shown in the solid line relationship. Therefore, the sample injected into the eluent usually
It will be separated by column 14. Further, when the flow paths in the six-way valves 11 and 13 are switched as shown by the broken lines in the figure, the sample is now separated by the column 12.

(Prior Art) A twelve-way valve shown in FIG. 3 is known as one that enables these plurality of liquid injection forms by the sliding rotation of one rotor. This is a hexagonal valve with 12 small openings arranged in one stator.
When using two valves in conjunction, it is necessary to connect two small openings with piping, which creates dead volume and the risk of contamination from the piping. Two of the small openings were used for communication piping, making it impossible to connect piping for other functions, and it was essentially a ten-way valve, which had major drawbacks.

(Objective of the Invention) The first object of the present invention is to enable simultaneous injection of multiple types of injection methods and sample injection and flow path changes when multiple liquids such as a sample and a reagent are injected into an eluent as described above. A liquid injection device that enables accurate injection and flow path change in many types of injection and flow path changes by changing only the piping. Our goal is to provide the following.

(Summary of the Invention) In accordance with the above-mentioned objective, the present invention allows multiple types of injection operations to be performed by changing the piping configuration of the liquid system when injecting two or more types of liquid into another steady flow. In particular, the liquid injection device is characterized in that the operation can be performed by rotating only one rotor and stator, and the gist of this liquid injection device is that a pair of The opposing surface slides and rotates 360°/n degrees (n is an integer of 6 or more).
The stator and the rotor, which can be switched to the first and second positions, have m concentric circles (m is an integer of 2 or more) having different radii formed on one opposing surface thereof, and 360 m concentric circles on the concentric circles are formed. Six small apertures are arranged in one circle on the radial line of the angle obtained by dividing ° by n, and the small apertures are communicated with the other opposing surface.
The liquid injection device is characterized in that it has xm bridging grooves and one bridging groove on one of the pair of opposing surfaces for communicating the small openings between the concentric circles.

(Embodiments of the Invention and Effects thereof) Hereinafter, one embodiment of the present invention will be described based on an embodiment shown in the drawings.

Figures 4 to 6 show sample analysis in which at least the following sample injection forms (a) to (c) can be selected and performed only by rotating the rotor and stator by changing the piping form. The figure shows a multifunctional liquid injection device used for.

(b) Inject different samples simultaneously in parallel into the eluent stream.

(b) Different samples are placed in series at the same time into the flow of eluent.

(c) Inject the sample continuously.

FIG. 4 is a sectional view showing the outline of the structure of the liquid injection device of the present invention. In the figure, 21 is a disc-shaped stator, and at its periphery there is a circle of a rotor case 22 having a U-shaped cross section. The ring flange tip is engaged,
These stator 21 and rotor case 22 are firmly connected by bolts 23.

In the hollow area surrounded by the stator and rotor case 22, a rotor 24 is provided which is in air (liquid) tight contact with the inner surface of the stator 21 under a predetermined pressure.
and a drive disk 25 that rotates this rotor 24.
and a spring 2 that applies a pressing force to the stator 21 of the rotor 24 via the drive disk 25.
6 is housed therein, and a rotary drive shaft 27 extends from the back surface of the front drive disk 25 to the outside of the rotor case 22 . Reference numeral 28 denotes an operating handle that projects from the extending end of the rotary drive shaft 27 in the radial direction.

Further, on the hollow inner surface of the stator 21, a fifth
A plurality of small openings a to l are formed as shown in FIG. There is.

In addition, the small openings a to l are arranged such that a to f are located at every 60 degrees on the inner circumference, and g to l are located at a position on the outer circumference.
- f are positioned every 60 degrees in the same direction, and a and g are arranged in the illustrated relationship in which they are communicated by a bridging groove.

In addition, as shown in FIGS. 6A and 6B, on the surface of the rotor 24 facing the stator, the small openings a to f on the stator side are spaced apart in the circumferential direction at positions in the radial direction facing the small openings a to f. A plurality of bridging grooves A to C that selectively communicate the portions and a plurality of bridging grooves D that selectively communicate the circumferentially spaced portions of the small openings g to l.
~F are formed. These bridge grooves A to F
In the present invention, the groove is formed by providing a recess on the surface of the rotor, but the groove may be formed by opening only at both end portions of the rotor surface and drilling inside the groove halfway. Also, for convenience, the grooves are emphasized and drawn thick in the drawings, but in reality, fine line-like grooves are sufficient.

The stator 21 and rotor 24 configured as described above are brought into airtight contact with each other as shown in FIG. rotor 24
The position can be changed by sliding and rotating the .

FIG. 7 shows a flow diagram of FIA in which different types of liquids are simultaneously injected into the flow by the sample injection device by rotation of the rotor and stator.

The eluent is sent to the sample injection device 15 by the pump 1, and then passes through the reaction tube 6 to the detector 7.
The liquid is sent to.

FIG. 8A shows a detailed piping diagram of the sample injection device 15 in the FIA of FIG. This will be explained below based on the drawings.

The small opening a is the inlet of the eluent, and the small openings f and l
are piped so that they meet and serve as an eluent outlet. Further, the small openings b, e and h, k are connected to both ends of the sample loops 8, 8'. Also, the small openings c and d are 2 in the reagent liquid (second liquid) filling circuit.
One point c is connected to the reagent container 32, and the other point d is connected to a suction pump (not shown).
Similarly, small openings i and j are connected to a sample container (not shown) with i connected to a sample container (not shown), and small opening j to a suction pump (not shown). Also, g is occluded.

FIG. 8B shows a state in which the stator and rotor are aligned in one position, which is the liquid filling mode, and this becomes the reference (first) position of the liquid injection device. In this state, small openings a and f,
g and l are determined by bridging grooves C and F on the rotor side. A liquid passage is formed, and a steady flow is maintained by a pump.

In addition, the small openings b, c, d, and e of the sample system are formed by bridging grooves A and B. c → A → b → loop 8 → e → B → d
A liquid passage is formed, and the loop 8 is filled with a sample using a sample container.

Similarly, reagent system liquid path i→D→h→loop 8′→
k→E→g' indicates that the loop 8' is filled with reagents.

From this state, move the rotor 24 to the stator 21.
By sliding and rotating 60 degrees and switching to the second position, the liquid passage is changed as follows.

As each of the bridging grooves A, B, and C rotates, the communication relationship between the small openings a to f of the sample system is changed as follows.

That is, when the other position is set to the liquid filling mode shown in FIG.
Therefore, this liquid path becomes g→a→A→b→loop 8→e→C→f between the inlet and outlet of the eluent, and the sample is injected into the flow of the eluent.

In addition, the alignment of the small openings g to l of the other reagent system and the bridging grooves D, E, and F on the rotor side was changed,
The liquid passage is between the inlet and the outlet of the eluent.
→D→h→loop 8'→k→F→l, and the reagent is injected into the eluent flow.

In short, in the injection mode at the second position, the eluent is divided into two stages at the inlet g, one through the loop 8 and the other through the loop 8', and combined at the exit; Since the passage changes occur in complete cycles and the merging is caused by the flow of one eluent, extremely accurate simultaneous injection of the two liquids can be achieved.

In other words, as shown in FIG. 9, a "merging zone type" injection in which the sample and reagent are injected completely in parallel becomes possible.

(Effect of B) This allows FIA to use expensive reagents as eluents.
In this method, only the required amount of reagent can be injected when needed without directly using a solution containing the reagent as an eluent, making it possible to save a large amount of reagent. We provide a simple pre-labeling device for pre-labeling HLC, which involves reacting, transporting the reaction product to a resin-filled column, and analyzing target components.

Figure 10A shows the flow of an HLC in which the sample injection device has the function of liquid injection and flow path change, in which the eluent and sample are transported to the column by changing the flow path during sample injection due to the rotation of the rotor and stator. A diagram was shown.

The eluent is sent to the injection device 15 by the pump 1, and then to the detector 7 through the reaction tube 6.

FIG. 11A shows a detailed piping diagram of the liquid injection device 15 in the HLC of FIG. 10.

The small opening f is an inlet for the eluent, and the small opening l is an outlet for the eluent. Further, the small openings b, e and h, k are connected to both ends of the sample loop 8 and the resin-filled column 12, respectively. The small openings c and d form two points in the sample liquid (second liquid) filling circuit, one of which is connected to a sample container (not shown), and the other d to a suction pump (not shown).

Small apertures i and j are open. j is connected to a suction pump (not shown). Also, g is occluded.

FIG. 11B shows a state in which the stator and rotor are aligned in the first position, which is the liquid filling mode, and this is the first position of the liquid injection device. In this state, the small openings a and f, g and l are formed by bridging grooves c and F on the rotor side.
A liquid path of C→a→g→F→l is formed, and the pump causes a steady flow of the eluent.

In addition, the small openings b, c, d, and e of the sample system are formed by bridging grooves A and B. c → A → b → loop 8 → e → B → d
A liquid passage is formed, and a loop 8 is formed by the sample container 9.
is filled with the sample.

Similarly, column liquid path i→D→h→column 12→
It is opened by k→E→j.

By slidingly rotating the rotor 24 by 60 degrees with respect to the stator 21 and switching it to the second position, the liquid passage is changed as follows.

As each of the bridging grooves A, B, and C rotates, the communication relationship between the small openings a to f of the sample system is changed as follows. That is, A is a small opening a on the stator side,
b, B are small apertures c, d, and C are small apertures e, f. Furthermore, the communication relationship between the small openings g to l of the reagent system in the bridging grooves D, E, and F is changed as follows. That is, D is the small opening g, h on the stator side, E is the small opening i, j,
F is a small opening k, l, so this liquid passage is between the inlet and outlet of the eluent, f→C→e→loop 8
→b→A→a→g→D→h→Column 12→k→F→
1, and the sample is injected into the eluent flow of normal liquid chromatography.

Thereby, in the injection mode at the second position, sample injection and flow path change are performed simultaneously. That is, the system normally changes from the no-load, no-column flow shown in FIG. 11B to the HLC system only when necessary.

Also, if the column is replaced by a loop, the samples of the two loops will be injected into the flow in series.

That is, as shown in FIG. 12A, the sample and reagent can be injected in series.
Also, if the sample and reagent filling circuits are replaced, the 12th
As shown in Figure 2, it is possible to inject the sample first and then the reagent in series in the direction of the flow of the eluent.

(Effect B) With regard to the liquid injection function, this enables FIA, which uses expensive reagents as eluents, to dispense only the required amount of reagents when they are needed, without directly using a liquid containing reagents as eluents. This makes it possible to save a large amount of reagents, and it is also useful in pre-label HLC, which involves reacting the target substance with a reagent and transporting the reaction product to a resin-filled column to analyze the target component. Therefore, it is possible to provide a spray label liquid injection device that enables the analysis method with simple operations. In addition, in normal HLC, when the resin packed in the column is destroyed due to the properties of the liquid and the separation ability decreases, a reagent that changes the liquid properties of the sample is injected before the sample. is of great help in protecting the resin.

FIG. 13A shows a flow diagram of liquid chromatography in which two columns are selected and used by the sample injection device by rotating a rotor and a stator.

FIG. 14A shows a detailed piping diagram of the sample injection device in the HLC shown in FIG. 13A.

The small opening f is an inlet for the eluent, and the small opening h is an outlet for the eluent. Further, the small openings b, e and i, j are connected to both ends of the separation columns 12, 14. The small openings c, d, j, and k are open, and the small openings a, g are closed.

FIG. 13B shows a state in which the stator and rotor are aligned to the position where the separation column 12 is used, and this is the first position of the liquid injection device. In this state, the small openings e, f, a, b, g, h are formed by the bridging grooves C, A, D on the rotor side, f→C→
A liquid passage of e→column 12→b→A→a→g→D→h is formed, and the separation column 12 is used as a separation column.

By slidingly rotating the rotor 24 by 60 degrees with respect to the stator 21 and switching it to the second position, the liquid passage is changed as follows.

As the bridging grooves A, B, and C rotate, the communication relationships between the small openings a to f of the sample system are changed as follows. That is, A is the small opening b, c, on the stator side.
B is small aperture d, e, C is small aperture af. Furthermore, the communication relationship between the small openings g to l in the bridging grooves D, E, and F is changed as follows. That is, D is the small opening h, i on the stator side, E is the small opening j, k, F is the small opening g,
l. Therefore, between the inlet and outlet of the eluent, the liquid passage is f→C→a→g→F→l→column 14→i→
A liquid path D→h is formed, and the column 14 is used as a separation column.

Also, by replacing the column with a loop, the sample can be injected at both locations.

As a result, in conventional sample injection devices, two positional relationships can be considered when sliding and rotating the stator and rotor, and only one of these positions is in sample injection mode, whereas in this sample injection device, The sample is injected at both of the two positions in sample injection mode. In other words, the sample injection time is reduced to 1/2 of the conventional time.

(Effect of C) Regarding the effect as a liquid injection function, the conventional
With HLC, analysis has become possible in a short period of time due to significant advances in separation capabilities, and since FIA analysis is a flow-type analysis method that does not require separation, it is possible to inject a large number of samples in an extremely short period of time. Therefore, in these fields, it was necessary to inject a large number of samples in an extremely short period of time. However, although conventional sample injection devices had limitations in sample injection due to the above-mentioned conditions, this injection device now makes it possible to accurately inject a large number of samples into the flow of eluent in an extremely short period of time. Ta.

According to the present embodiment described above, there are a wide variety of injection formats when two types of liquids are injected into the eluent flow, and it is difficult to realize these simultaneously with one valve. . On the other hand, although the operation of this liquid injection device is extremely simple, just by changing the connection piping on the stator side, it has an excellent function of being able to select injection modes with many different functions. ,
Furthermore, the structure of the device itself is only a single valve mechanism, and its usefulness is extremely large.

Furthermore, the grooves formed on the stator and rotor are actually fine linear grooves, and the rotor, which is usually made of polyimide, Teflon, etc., is pressed against the stator with a sufficiently large pressing force. Since it maintains sufficient air (liquid) tightness for contact, it is possible and easy to draw various grooves geometrically as long as it does not impede liquid flow. A multifunctional liquid injection device can also be designed with various groove formations and small opening arrangements.

Specifically, as shown in Fig. 15, the stator is the same as in Fig. 5, but the shape of the rotor bridge is different, and Fig. 16 shows two stators in the embodiments shown in Figs. 4 to 6. The bridging groove that connects the small openings on the circumference was placed on the stator side, but in Fig. 16A, it is placed on the rotor side, etc.
Various aspects can be mentioned.

Furthermore, FIGS. 17A and 17B show configuration diagrams of a stator and a rotor of a liquid injection device which is one of the modified examples of the present invention when n=7.

A plurality of small openings a to l are formed in the hollow inner surface of the stator, as shown in FIG. A bridging groove is formed at f and f' at the upper part of the circumference at a distance of 360/7=approximately 51 degrees from f. Similarly, the small openings g to l and the bridging grooves l and l' are also located on the outer circumference and arranged in the relationship shown.

As shown in FIG. 17B, at positions in the radial direction facing the small openings a to l on the surface of the rotor facing the stator, the circumferentially spaced portions of the small openings a to f on the stator side are selectively communicated with each other. Multiple bridging grooves A~
There is no problem even if a plurality of bridging grooves D to F are formed to selectively communicate the spaced apart portions of the small openings g to l in the circumferential direction with the small openings g to l.

As described above, the basic structure of a liquid injection device having these functions is a small cell placed on the circumference of a circle with m folds (m is an integer of 2 or more) at an angle of 360/n degrees (n is an integer of 6 or more). Of the openings, a total of 6 x m small openings inside and outside are required, and one small opening on the inner periphery and one small opening on the outer periphery are always communicated by a bridging groove provided in the rotor or stator. characterized by being present.

The example shown above is a stator (or rotor)
Although the small aperture formed in Figure 18 is for the case where m = 2, the present invention is also possible when m = 3, 4 or more. , FIGS. 19A and 19B show front views of the basic stator and rotor when m=4.

Other structures of the present invention include those that utilize sliding rotation of two stators and one rotor.

In other words, Figure 20 is a cross-sectional view of the configuration of a "Sandermanch type" liquid injection device that injects two types of liquid into another steady flow using two stator surfaces and one rotor (two rotor surfaces). This is shown in the figure.

In the figure, 21 is a disk-shaped first stator;
1' is a second stator, and these two stators 21, 21' are firmly connected by bolts 23. In the hollow area surrounded by the stators 21, 21', there are two stators 21, 21'.
The rotor 24 is connected to the inner surface of the rotor 24 through the rotor 24, which is in air (liquid) tight contact with the inner surface of the
A spring 26 is housed therein, which applies a pressing force to the two stators 21, 21'.

Reference numeral 28 denotes an operating handle that projects from the extending end of the rotary drive shaft 27 in the radial direction.

The stator 21 has a plurality of small openings a to f as shown in FIG.
1' has a plurality of small openings g~ as shown in Fig. 21B.
l are formed, and these small openings are connected to the stators 21 and 2.
It is connected and communicated with various external pipes through a through hole penetrating in the thickness direction of 1'.

Further, on the surface of the rotor 24 facing the stator 21, as shown in FIG. A plurality of bridging grooves A to C selectively communicate with the rotor 2.
On the surface facing the stator 21' of No. 4, as shown in FIG. Multiple bridging grooves D to F
are formed, and one of the grooves formed on both surfaces of the rotor 24 is communicated with each other by grooves m and m' passing through the inside of the rotor.

FIG. 23 shows a piping diagram for injecting two liquids in series.

The small opening a is the inlet of the eluent, and the small opening g is the outlet. The small openings c, f and i, l are at both ends of the sample loops 8, 8', and the small openings d, e, j and k form two points in the sample liquid filling circuit.

In FIG. 23, which is the liquid filling mode, a→
A liquid path m→m'→g is formed, and each sample system is filled with a sample into the loops 8 and 8' by a liquid filling circuit.

In FIG. 23, the rotor 24 is placed on the stator surface 2.
When it is switched to the second position by sliding and rotating 60 degrees clockwise relative to the first position, the liquid passage is changed as follows.

a→C→f→loop 8→c→A→m↓ g←F←l←loop 8'←i←D←m', and the two samples are injected in series into the eluent stream.

In this device as well, as in the above device, various configurations where m>3, small openings in the stator, and various structures in the grooves in the rotor are allowed.

(Scope of application of the present invention) The liquid injection device of the present invention is not only applicable to sample analysis such as flow injection analysis, but also for mixing three or more liquids (or combining three or more liquids) for purposes other than analysis operations. This device is suitably used as a device for mixing two liquids (which may also have a function such as mixing two liquids). For example, it can be used to appropriately supply a necessary reagent in a reaction system that performs a reaction using a delivered reagent.
A specific example is the delivery of reagents to a reaction tank in the usual chemical industry or a fermentation tank in microbial fermentation.

(Effects of the Invention) As described above, the liquid injection device according to the present invention is for injecting a plurality of liquids, and functions can be selected by an extremely simple operation of changing the piping. In order to achieve this function, it is extremely easy to rotate the rotor and stator, the structure is simple, and injection can be performed accurately at the same time.
Its usefulness is extremely great.

[Brief explanation of drawings]

Figure 1 is a diagram showing an example of a liquid injection device using a known six-way valve, Figure 2 is a diagram showing an example of a flow path changing device using two known six-way valves, and Figure 3 is a diagram showing an example of a flow path changing device using two known six-way valves.
The figure shows a known twelve-way valve, FIG. 4 is a schematic sectional view of a liquid injection device according to an embodiment of the present invention, FIG. 5 A is a front view of the stator, B is a sectional view taken along the line Figure 6 A is a front view of the rotor, B is -
7 is a diagram showing an example of the flow using the liquid injection device of the present invention, FIG. FIG. 9 is an explanatory diagram for injecting reagents and samples; FIGS. Figure 11A is a diagram showing an example of the piping of the liquid injection device of the present invention, Figure 11B is a diagram showing the state of liquid passage formation by the stator and rotor,
Figure 2 is an explanatory diagram for injecting reagents and samples.
Figures 3A to 3C are diagrams showing an example of the flow using the liquid injection device of the present invention, Figure 14A is a diagram showing an example of the piping of the liquid injection device of the present invention, and Figure 3A is a diagram showing the liquid passage formed by the rotor and stator. Diagram showing the state of , No. 15, 1
Figure 6 is a front view of the rotor, Figures 17, 18, and 19 A are front views of the stator, Figures 17, 18, and 19 B are front views of the rotor, and Figure 20 is a schematic cross-section of a liquid injection device in an embodiment of the present invention. 21A and 21B are front views of the stator, FIGS. 22A and 22B are front views of the rotor, and FIG. 23 is a diagram showing an example of piping in the embodiment of FIG. 20. 1; Eluent tank, 2; Pump, 3, 5; Channel,
4, 11, 13; Six-way valve, 6; Reaction tube, 7; Detector, 8, 8'; Loop, 9; Sample container, 10; Suction pump, 12, 14; Column, 2
1; Stator, 22; Rotor case, 23; Bolt, 24; Rotor, 25; Rotation drive disk, 2
6; Spring, 27; Rotation drive shaft, 28; Operation handle, 29; Pipe, A, B, C...L; Bridge groove, a,
b, c...x; Small opening.

Claims (1)

[Claims] 1. A stator and a rotor in which a pair of airtight opposing surfaces can be switched to a first and second position by slidingly rotating 360/n degrees (n is an integer of 6 or more). , m concentric circles (m is an integer of 2 or more) with different radii are formed on one opposing surface, and 6 circles are formed in one circle on the radial line of the angle obtained by dividing 360° on the concentric circles by n. 3×m small openings are arranged on the other opposing surface, and 3×m bridging grooves for communicating the small openings are arranged on one side of the opposing surface, and small openings between the concentric circles are arranged on one of the opposing surfaces. A liquid injection device characterized by having one bridging groove for communication. 2. In a stator and a rotor, two pairs of airtight opposing surfaces can be switched to the first and second positions by sliding rotation of 360/n degrees (n is an integer of 6 or more). m concentric circles (m is an integer greater than or equal to 1) with different radii are formed on one of the opposing surfaces, and 6 concentric circles are formed on the radial line of the angle obtained by dividing 360° of each circle by n. A small opening is arranged, and
There are m×3 bridging grooves on the pair of opposing surfaces, and
m'(m' is an integer greater than or equal to 1) concentric circles with different radii are formed on the opposing surface of one of the remaining pairs, and the radius of each circle is calculated by dividing 360° of each circle by n. Six small openings are arranged on the circumference, and m' x 3 bridging grooves are arranged on the other opposing surface, and at least one through groove is provided to communicate the small openings between the concentric circles. Characteristic liquid injection device.