JPH04334308A - Skin cosmetic - Google Patents

Abstract

PURPOSE:To provide the subject skin cosmetic exhibiting excellent effects for preventing chapping and aging of skin, improving cuticle property and developing beautiful skin. CONSTITUTION:The objective skin cosmetic having remarkably improved effects explained above is produced by using (A) one or more components having blood circulation promoting action or cytotonic action and selected preferably from extract of SENBURI (Swertia japonica), extract of Panax ginseng, vitamin E orotate, diisopropylamine dichloroacetate, gamma-aminobutyric acid, D-pantothenyl ethyl ether, D-pantothenyl ethyl alcohol, vitamin E nicotinate and biotin and (B) 8-beta-glucopyranosyl-7-hydroxy-3-(3',4'-dihydroxyphenyl)-4H-1-benzopy ran-4-one as essential components. The amount of the component A is preferably 0.01-30wt.% (especially 0.1-10wt.%) and that of the component B is preferably 0-0001-2.0wt.% (especially 0.001-1.0wt.%) based on the total prescription components of the cosmetic.

Description

[Detailed description of the invention]

0001

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to skin cosmetics that can exhibit excellent effects on preventing rough skin, improving keratin, preventing aging, and beautifying the skin.

0002

[Prior art and problems to be solved by the invention] Conventionally,
Skin cosmetics aimed at preventing and improving rough skin include crude drug extracts, vitamin E orotate, vitamin E nicotinate, D-pantothenyl ethyl ether, D
- Blood circulation promoters and cell activators such as pantothenyl ethyl alcohol, diisopropylamine dichloroacetate, γ-aminobutyric acid, and biotin have been formulated, but the effects of preventing rough skin, improving keratin, and beautifying the skin are not necessarily sufficient, and the effects are not necessarily sufficient. The development of superior skin cosmetics has been long awaited.

[0003] As a result of intensive studies aimed at developing such skin cosmetics, the present inventors found that the following compounds were found: Jasperum japonica extract, Korean ginseng extract, vitamin E orotate, vitamin E nicotinate, D-pantothenyl ethyl ether, D-pantothenyl. One or more blood circulation promoters selected from ethyl alcohol, diisopropylamine dichloroacetate, γ-aminobutyric acid, and biotin, a cell activator, and 8-
β-glucopyranosyl-7-hydroxy-3-(3',
Skin cosmetics containing 4'-dihydroxyphenyl)-4H-1-benzopyran-4-one (hereinafter abbreviated as PG1) not only exhibit excellent skin roughness prevention effects, keratin improvement effects, and skin beautification effects. It was discovered that the anti-aging effect was significantly enhanced, and the present invention was completed.

[0004] The purpose of the present invention is to provide excellent skin roughness prevention effect,
The object of the present invention is to provide a skin cosmetic that can have a keratin-improving effect, a skin beautifying effect, and an anti-aging effect.

[0005]

[Means for Solving the Problems] The present invention achieves the above object by combining an ingredient having a blood circulation promoting effect or a cell activating effect, and P.
This is a skin cosmetic characterized by containing G1.

[0006] Among the above-mentioned specific blood circulation promoters or cell activators, the manufacturing method of the natural product extracts such as Jasmine japonica extract and Korean ginseng extract is not specified, but the outline of each manufacturing method is as follows. It is as follows.

[Production method of Aspergillus japonica extract] Aspergillus japonica (S.
wertia Japonica Makino)
This is an extract obtained by digesting the dried and pulverized whole plant during flowering period in ethanol or hydrous ethanol and filtering it. In the Examples, an extract obtained by the following method was used.

[0008] 50g of crushed Oriental japonica was added to water-containing ethanol (
Add 250 ml of ethanol (90 wt%) to a temperature of 40 to 50°C.
After digesting and filtering, the residue was digested in the same manner several times to obtain 1.5 liters of extract. 100 ml of purified water was added to the residue obtained by concentrating this under reduced pressure, and after aging for 1 week, the insoluble portion was filtered off and the obtained extract was concentrated under reduced pressure. Ethanol was then added to reduce the ethanol content of the extract to 40 ml.
The amount was adjusted to % by weight, and 100 ml of Oriental japonica extract was obtained.

[Production method of Korean ginseng extract] Panax ginseng C.A.M.
This is an extract obtained by cold soaking a 5- to 6-year-old dried and pulverized root of P. elegans in ethanol or water-containing ethanol and filtering it. In the Examples, an extract obtained by the following method was used.

[0010] 50 g of crushed Panax ginseng was cold soaked in 200 ml of aqueous ethanol (90 wt% ethanol) for 1 week, and the ethanol obtained by filtering was distilled off, and purified water was added until the ethanol content of the extract was 50 wt%. After further aging this in a cold place for 7 to 10 weeks, it was filtered to obtain 100 ml of Korean carrot extract.

[0011] The amount of the blood circulation promoter or cell activator to be blended into the cosmetic of the present invention is appropriately adjusted depending on its effect or the dosage form of the cosmetic, but it is usually as specified in Table 1 below. The blending amount shown in is suitable. The blending amount was based on the total weight of the cosmetic composition.

0012

[Table 1]

One or more of these may be blended into the skin cosmetic of the present invention. Its content is preferably 0.01 to 30% by weight, more preferably 0.1 to 10% by weight, based on the total amount of prescription ingredients of the cosmetic. If it is less than 0.01% by weight, it is difficult to obtain an effect, and if it exceeds 30% by weight, the storage stability of the product will be poor, which is not preferable.

PG1 used in the skin cosmetic of the present invention is a known glycoside [Planta Medica (Planta Medica)
medica), p. 250, 1988] and kudzu root by a known method (described in the above-mentioned document).

The content thereof is preferably 0.0001 to 2.0% by weight, more preferably 0.001 to 1.0% by weight, based on the total amount of prescription ingredients of the cosmetic.

That is, if the content is less than 0.0001% by weight, it is difficult to obtain an effect, and if it exceeds 2.0% by weight, the storage stability of the product will be poor, which is not preferable.

[0017] In addition to the above-mentioned raw materials, the skin cosmetics of the present invention may contain pigments, fragrances, preservatives, surfactants, pigments, antioxidants, etc. as appropriate within the range that achieves the purpose of the present invention. Can be done.

[0018] The dosage forms of the skin cosmetics of the present invention include creams, milky lotions, lotions, packs, powders, and the like. In the case of a milky lotion, for example, this skin cosmetic can be produced by a conventional method of heating and dissolving an oil phase and an aqueous phase, emulsifying and dispersing the mixture, and cooling the mixture.

[0019]

[Examples] The present invention will be described in detail below based on Examples and Comparative Examples. Note that the percentages shown in the examples are percentages by weight. In addition, the methods for measuring the turnover rate of the stratum corneum (antiaging effect), the test method for measuring the rough skin improving effect, the test method for measuring the keratin improving effect, and the sensory test (skin beautifying effect) described in the Examples are as follows.

(1) Method for measuring the turnover rate of the stratum corneum An ointment containing 5% by weight of the fluorescent dye dansyl chloride in white petrolatum was prepared and applied to the skin of the subject's forearm for 24 hours.
Apply the mask with the lid closed for a period of time to allow dansyl chloride to penetrate and bind to the stratum corneum. Thereafter, the test sample was applied to the same area twice a day (morning and evening), the fluorescence of dansyl chloride was checked every day, and the number of days until the fluorescence disappeared was defined as the turnover rate of the skin stratum corneum. Note that the normal turnover rate of the stratum corneum of the skin is 14 to 16 days, but in aged skin it increases to about 18 days, but when anti-aging effects appear, it shortens to about 12 days.

(2) Test method for measuring the effect of improving rough skin The effect of continuous application for 4 weeks was investigated on 20 middle-aged and elderly subjects who had rough skin on their lower legs. 1 on the subject's left lower leg test site.
Approximately 1 g of the sample was applied twice a day, and the condition of the skin before and after the test was evaluated according to the following criteria. No sample was applied to the right lower leg, which served as a control. Judgment criteria for skin dryness -: Normal ±: Slight dryness, no scaling +: Mild dryness, scaling ++: Moderate dryness, scaling +++: Significant dryness, scaling The judgment results of the test site and control site before and after the test were compared, If the skin dryness has improved by two or more levels (e.g. +→-,
++ → ±) was considered “effective,” one level of improvement was considered “slightly effective,” and no change was considered “ineffective.” The test results are shown in terms of the number of subjects who found the test to be "effective" or "slightly effective."

(3) Test method for measuring keratin improving effect (increasing the anti-peeling property of keratinocytes) Scotch tape (Nichiban Mending Tape) is adhered to the skin of the test area before and after the start and end of the rough skin improvement measurement test described above. When the tape was peeled off, the state of the corneocytes adhering to the tape was examined in detail using a scanning electron microscope, and the anti-peeling properties of the skin corneocytes were judged according to the following criteria. Judgment criteria for keratin improving effect (increased anti-exfoliation property of corneocytes) Evaluation score 1: No scale observed Evaluation point 2: Small scale scattered evaluation point 3: Small to medium scale noticeable evaluation point 4: Large scale noticeable evaluation is 4 When the difference between the evaluation score of the test site and that of the control site after weekly continuous application was 2 points or more, it was considered "effective," when it was 1 point, "somewhat effective," and when it was 0 points, "ineffective." The test results are shown as the number of subjects who found the test to be "effective" or "slightly effective."

(4) Sensory test (skin beautification effect test) The sample was applied twice a day (morning and evening) for 3 consecutive months to 20 female subjects (35 to 55 years old) who complained of rough skin, fine wrinkles, dry skin, etc. The effects were evaluated after 1, 2, and 3 months. The test results were ``skin moisture'', smoothness, and elasticity.
``My skin became moisturized'', ``My skin became smoother'', ``My skin became smoother''
The number of people who answered "My skin became taut" was shown.

■ Examples 1 to 10, Comparative Examples 1 to 12 Jasmine japonica extract, Korean ginseng extract, vitamin E orotate, vitamin E nicotinate, D-pantothenyl ethyl ether, D-pantothenyl ethyl alcohol, diisopropylamine dichloroacetate, γ - One selected from aminobutyric acid and biotin and PG1 were blended in the composition shown in Table 2, and a skin cream was prepared based on the following preparation method. The various tests described above were carried out for each, and the results are shown in Tables 3 and 4.

[0025]

[Table 2]

[0026]

[Table 3]

[0027]

[Table 4]

■ Preparation method Dissolve (A) uniformly at 70°C and (B) at 50°C, and (
It is prepared by pouring (B) into (A) while stirring A) to emulsify and disperse it, and then cooling it to a temperature of 30° C. while stirring.

■Characteristics The skin creams of Examples 1 to 10 of the present invention were found to have remarkable effects in various properties. On the other hand, Comparative Examples 1 to 12
The skin creams were inferior in various properties compared to the examples of the present invention.

[0030]

EFFECTS OF THE INVENTION As described above, it is clear that the present invention provides a skin cosmetic that can exhibit excellent skin roughness prevention effects, keratin improvement effects, anti-aging effects, and skin beautification effects.

Claims (2)

[Claims] Claim 1: A component having a blood circulation promoting effect or a cell activating effect and 8-β-glucopyranosyl-7-hydroxy-
3(3',4'-dihydroxyphenyl)-4H-1-
A skin cosmetic containing benzopyran-4-one. [Claim 2] The ingredients having a blood circulation promoting effect or a cell activating effect are Jasmine japonica extract, Korean ginseng extract, vitamin E-orotate, diisopropylamine dichloroacetate, γ-aminobutyric acid, D-pantothenyl ethyl ether, D-pantothenyl. The skin cosmetic according to claim 1, which is at least one selected from the group consisting of ethyl alcohol, vitamin E-nicotinate, and biotin.