JPH0439862B2 - - Google Patents
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- Publication number
- JPH0439862B2 JPH0439862B2 JP62196644A JP19664487A JPH0439862B2 JP H0439862 B2 JPH0439862 B2 JP H0439862B2 JP 62196644 A JP62196644 A JP 62196644A JP 19664487 A JP19664487 A JP 19664487A JP H0439862 B2 JPH0439862 B2 JP H0439862B2
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- Prior art keywords
- blood
- inner cylinder
- hollow fiber
- cylinder
- outer cylinder
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Description
【発明の詳細な説明】
［産業上の利用分野］
本発明は中空糸外側に血液を流し、酸素は中空
糸内に導入する方式であつて、その中に熱交換器
を内蔵したタイプの人工肺に係り、更に詳しく
は、血液と酸素が中空糸を介して良好に接触で
き、しかも装置を極めてコンパクトにすることが
できる熱交換器内蔵型人工肺に関する。[Detailed Description of the Invention] [Industrial Application Field] The present invention is an artificial type in which blood is passed outside the hollow fiber and oxygen is introduced into the hollow fiber, and a heat exchanger is built into the hollow fiber. The present invention relates to lungs, and more particularly to an artificial lung with a built-in heat exchanger that allows good contact between blood and oxygen via hollow fibers and that allows the device to be made extremely compact.
［従来の技術］
人工肺には大別して気泡型と膜型とがあるが、
ガス交換膜を用いる膜型人工肺は気泡型と比べ、
ガス交換方式がより生理的であり、血液への悪影
響が少ないという利点がある。[Prior art] Artificial lungs can be roughly divided into bubble type and membrane type.
Membrane oxygenators that use a gas exchange membrane have different characteristics compared to bubble oxygenators.
It has the advantage that the gas exchange method is more physiological and has less adverse effects on blood.
ガス交換方式には、中空糸の中空部に血液を流
し、中空糸外部に気体を流す方式と、その逆に、
中空糸の中空部に気体を流し、中空糸外部には血
液を流す方式がある。 There are two gas exchange methods: blood flows into the hollow part of the hollow fiber and gas flows outside the hollow fiber, and vice versa.
There is a method in which gas is allowed to flow through the hollow part of the hollow fiber, and blood is allowed to flow outside the hollow fiber.
［発明が解決をしようとする問題点］
しかしながら、中空部に血液を流す方式におい
ては、血液入口、出口間の圧力損失が大きくな
り、人工肺に流入する側の血液回路内圧が上昇
し、過度の場合、ローラーポンプのラテツクスゴ
ムチユーブが大きく膨らみ破裂の危険がある。更
に、回路内圧が高い場合、赤血球破壊が多いこと
も知られている。[Problems that the invention seeks to solve] However, in the method of flowing blood into a hollow part, the pressure loss between the blood inlet and outlet increases, and the internal pressure of the blood circuit on the side flowing into the oxygenator increases, causing excessive In this case, there is a risk that the latex rubber tube of the roller pump will swell to a large extent and burst. Furthermore, it is known that when the internal pressure of the circuit is high, red blood cells are often destroyed.
また、中空糸外側に血液を流す方式にあつて
は、一般に血液を均一に分散することが困難で、
その結果、血液と酸素を充分に接触させることが
困難であるという問題がある。 In addition, in the method of flowing blood outside the hollow fiber, it is generally difficult to uniformly disperse the blood.
As a result, there is a problem in that it is difficult to bring blood and oxygen into sufficient contact.
さらに、このような人工肺においては、体内に
返血する際、血液温度を36〜37℃程度の所定温度
に保持する必要があるが、上記従来の人工肺にあ
つては、人工肺の外部に熱交換器を配置し、それ
により血液温度を所定に保持されており、装置全
体が大型になつていた。 Furthermore, in such an oxygenator, it is necessary to maintain the blood temperature at a predetermined temperature of about 36 to 37 degrees Celsius when blood is returned to the body. A heat exchanger was placed in the blood to maintain the blood temperature at a predetermined level, making the entire device large.
［問題点を解決するための手段］
そこで、本発明者は前記問題点を解決し、良好
なガス交換を行なうことができ、さらに全体とし
てコンパクトな人工肺を提供するため鋭意研究し
た結果、本発明に到達したのである。[Means for Solving the Problems] Therefore, the inventor of the present invention has conducted extensive research to solve the above-mentioned problems and provide an oxygenator that can perform good gas exchange and is compact overall, and has developed the present invention. The invention has been achieved.
即ち、本発明によれば、内筒と、両端部より中
心部の径を小さくした外筒を設け、該内筒と外筒
の間に内筒と外筒の長手軸方向に沿つて多孔質中
空糸を配置し、内筒、外筒ならびに中空糸の両端
開口部にて該内筒外面、外筒内面及び中空糸外面
を支持部材により気密に支持してなる人工肺であ
つて、外筒端部に設けた血液導入口より中空糸外
側に血液を流し、酸素は中空糸の中空部に導入す
るとともに、内筒内側には熱交換用チユーブを配
し、中空糸外側を流れてくる血液は前記血液導入
口の反対側である内筒端部の円周方向に設けるれ
た通過口より内筒内側に入り、前記熱交換用チユ
ーブの外側部を通過しながら熱交換された上部よ
り排出されることを特徴とする熱交換器内蔵型人
工肺、が提供される。 That is, according to the present invention, an inner cylinder and an outer cylinder having a diameter smaller at the center than at both ends are provided, and a porous material is provided between the inner cylinder and the outer cylinder along the longitudinal axis direction of the inner cylinder and the outer cylinder. An oxygenator in which hollow fibers are arranged, and the outer surface of the inner cylinder, the inner surface of the outer cylinder, and the outer surface of the hollow fibers are airtightly supported by supporting members at the openings at both ends of the inner cylinder, the outer cylinder, and the hollow fibers, the outer cylinder Blood flows to the outside of the hollow fiber from the blood inlet provided at the end, and oxygen is introduced into the hollow part of the hollow fiber, and a heat exchange tube is arranged inside the inner tube to prevent blood flowing outside the hollow fiber. The blood enters the inside of the inner cylinder through a passage hole provided in the circumferential direction at the end of the inner cylinder, which is opposite to the blood inlet, and is discharged from the upper part where heat is exchanged while passing through the outside of the heat exchange tube. An oxygenator with a built-in heat exchanger is provided.
［作用］
中空糸外側を流れてきた血液は、内筒の血液導
出口付近に設けられた通過口を通して内筒内側に
一旦に貯留される。内筒内側には熱交換用チユー
ブが内蔵されており、その外側を血液が流れる。[Operation] The blood flowing outside the hollow fiber passes through the passage hole provided near the blood outlet of the inner cylinder and is temporarily stored inside the inner cylinder. A heat exchange tube is built inside the inner tube, and blood flows around the outside of the tube.
このように内筒内側に血液を一旦貯留すると、
外筒端部に設けた血液導入口より導入された血液
は、中空糸外側を流れるに際し、中心に向つて流
れることになるため、血液と酸素ガスとの接触が
良好に行なわれる。 Once blood is stored inside the inner cylinder in this way,
Blood introduced from the blood inlet provided at the end of the outer cylinder flows toward the center when flowing outside the hollow fiber, so that good contact between the blood and oxygen gas is achieved.
また、血液は内筒内側に設けられている熱交換
用チユーブの外側をゆつくりと流れるため、熱交
換が充分に行われ、血液は所定温度に保たれる。 Furthermore, since the blood slowly flows outside the heat exchange tube provided inside the inner cylinder, heat exchange is sufficiently performed and the blood is maintained at a predetermined temperature.
本発明では、血液はまず中空糸と接触してガス
交換した後に熱交換されるため、例えば、手術開
始の際において、人体から取り出した血液をその
まま中空糸と接触させてガス交換することから、
熱交換して低温とした後にガス交換することに比
し、ガス交換効率が高くなる。さらに、本発明で
は、両端部より中心部の径を小さくした外筒を設
けたので、チヤネリングが防止され、ガスと血液
との接触面積が大きくなつて接触効率が高くな
る。 In the present invention, blood first comes into contact with the hollow fibers and undergoes gas exchange and then undergoes heat exchange.
The gas exchange efficiency is higher than when the gas is exchanged after the temperature is lowered by heat exchange. Furthermore, in the present invention, since the outer cylinder is provided with a diameter smaller at the center than at both ends, channeling is prevented, the contact area between gas and blood is increased, and the contact efficiency is increased.
［実施例］
以下、図面に示す実施例に基き、本発明を説明
する。[Examples] The present invention will be described below based on examples shown in the drawings.
第１図は、本発明の熱交換器内蔵型人工肺の一
実施例を示す断面図である。 FIG. 1 is a sectional view showing an embodiment of an oxygenator with a built-in heat exchanger according to the present invention.
１は血液Ａを導入するための血液導入口であ
り、外筒２の上部に設けられている。外筒２と内
筒３の間には、多数の多孔質中空糸４が配設され
ており、外筒２、内筒３ならびに多孔質中空糸４
の両端部においては、外筒２の内面、内筒３の外
面ならびに多孔質中空糸４の外面が接着剤５によ
り気密に支持されている。また。多孔質中空糸４
の上端部には酸素ガスＢの導入口６が設けられ、
又多孔質中空糸４の下端部には交換されたガスの
出口７が設けられている。 Reference numeral 1 denotes a blood introduction port for introducing blood A, which is provided at the upper part of the outer cylinder 2. A large number of porous hollow fibers 4 are arranged between the outer cylinder 2 and the inner cylinder 3, and the outer cylinder 2, the inner cylinder 3 and the porous hollow fibers 4
At both ends, the inner surface of the outer tube 2, the outer surface of the inner tube 3, and the outer surface of the porous hollow fibers 4 are airtightly supported by an adhesive 5. Also. Porous hollow fiber 4
An inlet 6 for oxygen gas B is provided at the upper end of the
Further, an outlet 7 for the exchanged gas is provided at the lower end of the porous hollow fiber 4.
ここで、外筒２はその中央部の径を両端部の径
より小さく、即ち中央部を絞つた形状をなしてお
り、従つて、外筒２と内筒３の間に配設される多
孔質中空糸４の充填密度は端部にゆくにつれ低く
なるものである。 Here, the outer cylinder 2 has a smaller diameter at the center than the diameter at both ends, that is, it has a narrowed central part. The packing density of the hollow fibers 4 decreases toward the ends.
そして内筒３の内側には血液を所定温度に保持
させるための熱交換用チユーブ８が設けられてい
る。 A heat exchange tube 8 is provided inside the inner cylinder 3 to maintain the blood at a predetermined temperature.
以上の構成において、血液Ａは血液導入口１よ
り人工肺内部に入り、次いで外筒２と内筒３の間
に配設された多孔質中空糸４の外側部を下方に流
れる。この際、血液Ａは、酸素ガス導入口６より
多孔質中空糸４の中空部に送入された酸素ガスと
該多孔質中空糸４に形成された細孔を介して接触
してガス交換を行なう。血液は、次いで内筒３の
下部の円周方向に所定数設けられた通過口９より
内筒３の内側に導かれ、ここで血液は一旦貯留さ
れる。このように血液は血液導入口１より中心に
向つて流下しながら通過口９を介して内筒３の内
側に導かれ、一旦貯留されるようになつているた
め、血液Ａが多孔質中空糸４の外側部と万遍なく
接続し、該中空糸４の中空部を通つている酸素ガ
スとのガス交換が充分且つ良好に行なわれること
となる。なお、内筒３の円周方向に設ける通過口
９の口径、数は、内筒、外筒の径、長さ等によつ
て異なるが、少なくとも血液が多孔質中空糸と万
遍なく接続し得るように設けることが必要であ
る。通常、その口径は１〜15mm（φ）、ピツチは
２〜90mmで形成される。 In the above configuration, blood A enters the oxygenator through the blood inlet 1 and then flows downward through the outer side of the porous hollow fiber 4 disposed between the outer tube 2 and the inner tube 3. At this time, the blood A comes into contact with the oxygen gas fed into the hollow part of the porous hollow fiber 4 from the oxygen gas inlet 6 through the pores formed in the porous hollow fiber 4, thereby performing gas exchange. Let's do it. The blood is then guided inside the inner cylinder 3 through a predetermined number of passage ports 9 provided in the circumferential direction at the lower part of the inner cylinder 3, where the blood is temporarily stored. In this way, the blood flows down from the blood introduction port 1 toward the center while being led to the inside of the inner cylinder 3 via the passage port 9 and is temporarily stored, so that the blood A flows through the porous hollow fibers. The hollow fibers 4 are evenly connected to the outside portions of the hollow fibers 4, and gas exchange with the oxygen gas passing through the hollow portions of the hollow fibers 4 can be carried out sufficiently and favorably. The diameter and number of passage holes 9 provided in the circumferential direction of the inner tube 3 vary depending on the diameter, length, etc. of the inner tube and outer tube, but at least blood can be evenly connected to the porous hollow fiber. It is necessary to provide it so that it can be obtained. Usually, the diameter is 1 to 15 mm (φ) and the pitch is 2 to 90 mm.
内筒３の内側に流入した血液は、内筒３の内側
に設けられた熱交換用チユーブ８の外側を上方に
流れ、熱交換用チユーブ８内を流れる媒体Ｃと熱
交換されてその温度を所定にされて血液排出口１
０より排出される。 The blood that has flowed into the inner tube 3 flows upward on the outside of the heat exchange tube 8 provided inside the inner tube 3, and is heat exchanged with the medium C flowing inside the heat exchange tube 8 to lower its temperature. Blood outlet 1 in place
Ejected from 0.
内筒３の内側に設ける熱交換用チユーブ８の配
設形状は特に限定されるものではないが、螺旋
状、渦巻状が接触面積が増加でき、熱交換効率が
向上することから好ましいものである。また、こ
のチユーブ８の外周面には、第２図に示すような
螺旋状に凸部１１を設けることは同じく接触面積
が増加できることから好ましい。 The arrangement shape of the heat exchange tube 8 provided inside the inner cylinder 3 is not particularly limited, but a spiral shape or a spiral shape is preferable because the contact area can be increased and the heat exchange efficiency can be improved. . Further, it is preferable to provide a spiral convex portion 11 on the outer circumferential surface of the tube 8 as shown in FIG. 2, since this also increases the contact area.
熱交換用チユーブ８の材質も特に限定はされ
ず、伝熱係数の大きい材料であれば使用すること
ができるが、例えばステンレス鋼、アルミニウム
などにエポキシ樹脂、シリコン樹脂、フツ素樹脂
あるいはアルミナ（Al2O3）などをコーテイング
した材料が好ましい。 The material of the heat exchange tube 8 is not particularly limited, and any material with a large heat transfer coefficient can be used. For example, stainless steel, aluminum, epoxy resin, silicone resin, fluororesin, or alumina (Al 2 O 3 ) or the like is preferable.
また、外筒２と内筒３の間に配設される多孔質
中空糸４としては、ポリプロピレン、ポリエチレ
ンなどのポリオレフイン系樹脂、ポリフツ化ビニ
リデン、エチレンテトラフルオロエチレン共重合
体などのフツ素樹脂、シリコーン樹脂等の疎水性
樹脂が好ましく用いられる。また、疎水性樹脂以
外の材料を用いる場合であつても、その血液との
接触面をシリコーン樹脂等で処理し、疎水性とし
たものも用いることができる。 The porous hollow fibers 4 disposed between the outer cylinder 2 and the inner cylinder 3 include polyolefin resins such as polypropylene and polyethylene, fluorocarbon resins such as polyvinylidene fluoride, and ethylenetetrafluoroethylene copolymer; Hydrophobic resins such as silicone resins are preferably used. Furthermore, even when using a material other than a hydrophobic resin, it is also possible to use a material whose contact surface with blood is treated with a silicone resin or the like to make it hydrophobic.
多孔質中空糸４は、その周壁部に多数の微小細
孔を有しており、そこでガス交換が行われる。微
小細孔の平均細孔径は一般に0.10〜1μｍが好まし
い。さらに、中空糸４の空隙率は一般に20〜80％
程度であることが好ましい。 The porous hollow fiber 4 has a large number of micropores in its peripheral wall, and gas exchange takes place there. The average pore diameter of the micropores is generally preferably 0.10 to 1 μm. Furthermore, the porosity of the hollow fibers 4 is generally 20 to 80%.
It is preferable that the degree of
また、多孔質中空糸４の膜面積は通常２m2以下
でよく、従来の市販品に比し小さくすることがで
きる。これは上記したように本中空糸の空隙率が
大きく、且つ血液と酸素ガスとの接触が充分に行
われる故であり、本発明の大きな利点といえる。 Further, the membrane area of the porous hollow fibers 4 may be usually 2 m 2 or less, which can be smaller than that of conventional commercially available products. This is because, as mentioned above, the porosity of the hollow fiber is large and the blood and oxygen gas are brought into sufficient contact with each other, which is a great advantage of the present invention.
なお、前記したように、外筒２はその中央部の
径を両端部の径より小さくしているため、外筒２
と内筒３の間に配設される多孔質中空糸４の充填
密度は端部にゆくにつれ低くなり、通常、両端部
においてはその充填密度は0.3〜0.5で、中央部で
0.4〜0.7となる。 In addition, as mentioned above, since the outer cylinder 2 has a diameter smaller at the center than the diameter at both ends, the outer cylinder 2
The packing density of the porous hollow fibers 4 disposed between the inner cylinder 3 and the inner cylinder 3 decreases toward the ends, and usually the packing density is 0.3 to 0.5 at both ends, and the packing density is 0.3 to 0.5 at the center.
It becomes 0.4 to 0.7.
尚、以上の実施例においては、縦型の熱交換器
内蔵型人工肺の例を示したが、その他横置型でも
よく、また血液導入口、ガス導入口の配置を逆に
する形態であつても使用することができる。 In the above embodiments, an example of a vertical oxygenator with a built-in heat exchanger was shown, but a horizontal type oxygenator may also be used, or the blood inlet port and gas inlet port may be arranged in reverse. can also be used.
以下、具体的に本発明に係る熱交換器内蔵型人
工肺の一例を用いたガス交換の実施結果について
説明する。 Hereinafter, the results of gas exchange using an example of an oxygenator with a built-in heat exchanger according to the present invention will be specifically described.
（実施例）
第１図に示す構成の熱交換器内蔵型人工肺であ
つて、下記の寸法、条件のものを用いた。(Example) An oxygenator with a built-in heat exchanger having the configuration shown in FIG. 1 and having the following dimensions and conditions was used.
外筒……直径〔両端部：78mm（φ）、中央部：70
mm（φ）〕
内筒……直径50mm
全長……220mm
多孔質中空糸……膜面積２m2
中空糸数8841本
充填密度（両端部：0.4、中央部：0.6）
内径300μｍ
外径400μｍ
周壁部厚さ50μｍ
平均細孔径0.22μｍ
空隙率68％
支持部材（ポツテイング材）……ポリウレタン樹
脂
熱交換用チユーブ……厚さ１mm、直径10mm（φ）
のステンレス鋼にエポキシコーテイングを施し
てなるもので、内筒内側に螺旋状に配されてい
る。チユーブの外周面には第２図のごとき凸部
が形成されている。Outer cylinder...Diameter [both ends: 78mm (φ), center: 70
mm (φ)] Inner tube...Diameter 50mm Total length...220mm Porous hollow fiber...Membrane area 2m 2Number of hollow fibers 8841 Packing density (both ends: 0.4, center: 0.6) Inner diameter 300μm Outer diameter 400μm Peripheral wall thickness Size 50μm Average pore diameter 0.22μm Porosity 68% Support member (potting material)...Polyurethane resin heat exchange tube...Thickness 1mm, diameter 10mm (φ)
It is made of stainless steel coated with epoxy and is arranged in a spiral shape inside the inner cylinder. A convex portion as shown in FIG. 2 is formed on the outer peripheral surface of the tube.
以上において、牛血（ヘマトクリツト値40％、
ヘモグロビン量12±１ｇ／dl）に対する酸素ガス
添加能と炭酸ガス交換能を測定したところ、第３
図および第４図に示すように、血液量1.0、2.0、
3.0（／min）における酸素ガス添加量は各々
58、84、102（ml／min）であり、また炭酸ガス除
去量は、ガス流量を1.0、0.2、0.3（／min）と
した場合、血流量１（／min）では各々50、80、
95（ml／min）、血流量２（／min）では、各々
70、100、120（ml／min）となり、十分なガス交
換性能を示した。 In the above, bovine blood (hematocrit value 40%,
When measuring the oxygen gas addition ability and carbon dioxide exchange ability for a hemoglobin amount of 12 ± 1 g/dl), the third
As shown in the figure and Fig. 4, blood volume 1.0, 2.0,
The amount of oxygen gas added at 3.0 (/min) is
58, 84, and 102 (ml/min), and when the gas flow rate is 1.0, 0.2, and 0.3 (/min), the amount of carbon dioxide removed is 50, 80, and 80, respectively, at a blood flow rate of 1 (/min).
95 (ml/min) and blood flow rate 2 (/min), respectively.
70, 100, and 120 (ml/min), indicating sufficient gas exchange performance.
［発明の効果］
以上説明したように、本発明の熱交換器内蔵型
人工肺によれば、血液が多孔質中空糸の外側部と
万遍なく接触するため、血液と酸素ガスとが充分
且つ良好に接触するから、良好なガス交換を行な
うことができるとともに、装置内に熱交換器を内
蔵し一体化したので、人工肺全体として極めてコ
ンパクトな構造とすることができる。[Effects of the Invention] As explained above, according to the oxygenator with a built-in heat exchanger of the present invention, blood comes into contact with the outer part of the porous hollow fibers evenly, so that the blood and oxygen gas are sufficiently exchanged. Since there is good contact, good gas exchange can be performed, and since the heat exchanger is built into the device and integrated, the entire oxygenator can have an extremely compact structure.
第１図は本発明の熱交換器内蔵型人工肺の一実
施例を示す断面図、第２図は熱交換用チユーブの
一部を示す部分説明図、第３図及び第４図は各々
酸素ガス添加能および炭酸ガス交換能を示すグラ
フである。
１……血液導入口、２……外筒、３……内筒、
４……多孔質中空糸、５……接着剤、６……酸素
ガス導入口、７……交換ガス出口、８……熱交換
用チユーブ、９……通過口、１０……血液排出
口、１１……凸部。
Fig. 1 is a sectional view showing an embodiment of an oxygenator with a built-in heat exchanger of the present invention, Fig. 2 is a partial explanatory view showing a part of a heat exchange tube, and Figs. It is a graph showing gas addition ability and carbon dioxide exchange ability. 1...Blood introduction port, 2...Outer cylinder, 3...Inner cylinder,
4... Porous hollow fiber, 5... Adhesive, 6... Oxygen gas inlet, 7... Exchange gas outlet, 8... Heat exchange tube, 9... Passing port, 10... Blood outlet, 11...Protrusion.
Claims (1)
外筒を設け、該内筒と外筒の間に内筒と外筒の長
手軸方向に沿つて多孔質中空糸を配置し、内筒、
外筒ならびに中空糸の両端開口部にて該内筒外
面、外筒内面及び中空糸外面を支持部材により気
密に支持してなる人工肺であつて、外筒端部に設
けた血液導入口より中空糸外側に血液を流し、酸
素は中空糸の中空部に導入するとともに、内筒内
側には熱交換用チユーブを配し、中空糸外側を流
れてくる血液は前記血液導入口の反対側である内
筒端部の円周方向に設けられた通過口より内筒内
側に入り、前記熱交換用チユーブの外側部を通過
しながら熱交換された上部より排出されることを
特徴とする熱交換器内蔵型人工肺。1. An inner cylinder and an outer cylinder with a diameter smaller at the center than at both ends are provided, and a porous hollow fiber is arranged between the inner cylinder and the outer cylinder along the longitudinal axis direction of the inner cylinder and the outer cylinder. tube,
An artificial lung in which the outer surface of the inner cylinder, the inner surface of the outer cylinder, and the outer surface of the hollow fibers are airtightly supported by supporting members at the openings at both ends of the outer cylinder and the hollow fibers, and the blood inlet port provided at the end of the outer cylinder is used. Blood flows outside the hollow fiber, oxygen is introduced into the hollow part of the hollow fiber, and a heat exchange tube is arranged inside the inner cylinder, and the blood flowing outside the hollow fiber is introduced into the hollow part of the hollow fiber on the opposite side of the blood inlet. A heat exchanger characterized in that the heat exchanger enters the inside of the inner cylinder through a passage hole provided in the circumferential direction of an end of the inner cylinder, passes through the outer part of the heat exchange tube, and is discharged from the upper part where the heat is exchanged. Built-in artificial lung.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62196644A JPS6440060A (en) | 1987-08-06 | 1987-08-06 | Artificial lung provided with built-in heat exchanger |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62196644A JPS6440060A (en) | 1987-08-06 | 1987-08-06 | Artificial lung provided with built-in heat exchanger |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6440060A JPS6440060A (en) | 1989-02-10 |
| JPH0439862B2 true JPH0439862B2 (en) | 1992-06-30 |
Family
ID=16361202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62196644A Granted JPS6440060A (en) | 1987-08-06 | 1987-08-06 | Artificial lung provided with built-in heat exchanger |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6440060A (en) |
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|---|---|---|---|---|
| JP2015144857A (en) * | 2011-05-17 | 2015-08-13 | ソリン・グループ・イタリア・ソシエタ・ア・レスポンサビリタ・リミタータ | Blood processing unit having blood cross flow |
| US9402943B2 (en) | 2010-08-19 | 2016-08-02 | Sorin Group Italia S.R.L. | Blood processing unit with modified flow path |
| US10098994B2 (en) | 2014-01-09 | 2018-10-16 | Sorin Group Italia S.R.L. | Blood processing unit with heat exchanger core for providing modified flow path |
| US10369262B2 (en) | 2014-02-28 | 2019-08-06 | Sorin Group Italia S.R.L. | System for providing an integrated arterial filter into an oxygenator, minimizing added priming volume |
| US10661004B2 (en) | 2015-05-12 | 2020-05-26 | Sorin Group Italia S.R.L. | Blood gas exchanger with restriction element or elements to reduce gas exchange |
| US10814056B2 (en) | 2014-11-12 | 2020-10-27 | Sorin Group Italia S.R.L. | Elastic protection tube for a hollow fiber blood processing apparatus |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5762868A (en) * | 1995-11-30 | 1998-06-09 | Minnesota Mining And Manufacturing Company | Blood oxygenator and heat exchanger |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63139562A (en) * | 1986-12-01 | 1988-06-11 | 株式会社 日本メデイカル・サプライ | Hollow yarn type artificial lung |
| JPS6417651A (en) * | 1987-07-10 | 1989-01-20 | Kuraray Co | Hollow yarn type oxygenator |
-
1987
- 1987-08-06 JP JP62196644A patent/JPS6440060A/en active Granted
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|---|---|---|---|---|
| US9402943B2 (en) | 2010-08-19 | 2016-08-02 | Sorin Group Italia S.R.L. | Blood processing unit with modified flow path |
| US10159777B2 (en) | 2010-08-19 | 2018-12-25 | Sorin Group Italia S.R.L. | Blood processing unit with modified flow path |
| US11160912B2 (en) | 2010-08-19 | 2021-11-02 | Sorin Group Italia S.R.L. | Blood processing unit with modified flow path |
| US12171923B2 (en) | 2010-08-19 | 2024-12-24 | Sorin Group Italia S.R.L. | Blood processing unit with modified flow path |
| JP2015144857A (en) * | 2011-05-17 | 2015-08-13 | ソリン・グループ・イタリア・ソシエタ・ア・レスポンサビリタ・リミタータ | Blood processing unit having blood cross flow |
| US10098994B2 (en) | 2014-01-09 | 2018-10-16 | Sorin Group Italia S.R.L. | Blood processing unit with heat exchanger core for providing modified flow path |
| USRE49759E1 (en) | 2014-01-09 | 2023-12-19 | Sorin Group Italia S.R.L. | Blood processing unit with heat exchanger core for providing modified flow path |
| US10369262B2 (en) | 2014-02-28 | 2019-08-06 | Sorin Group Italia S.R.L. | System for providing an integrated arterial filter into an oxygenator, minimizing added priming volume |
| US11471577B2 (en) | 2014-02-28 | 2022-10-18 | Sorin Group S.r.l. | System for providing an integrated arterial filter into an oxygenator, minimizing added priming volume |
| US10814056B2 (en) | 2014-11-12 | 2020-10-27 | Sorin Group Italia S.R.L. | Elastic protection tube for a hollow fiber blood processing apparatus |
| US10661004B2 (en) | 2015-05-12 | 2020-05-26 | Sorin Group Italia S.R.L. | Blood gas exchanger with restriction element or elements to reduce gas exchange |
| US12053565B2 (en) | 2015-05-12 | 2024-08-06 | Sorin Group Italia S.R.L. | Blood gas exchanger with restriction element or elements to reduce gas exchange |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6440060A (en) | 1989-02-10 |
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