JPH04500368A - solid toothpaste composition - Google Patents
solid toothpaste compositionInfo
- Publication number
- JPH04500368A JPH04500368A JP2509394A JP50939490A JPH04500368A JP H04500368 A JPH04500368 A JP H04500368A JP 2509394 A JP2509394 A JP 2509394A JP 50939490 A JP50939490 A JP 50939490A JP H04500368 A JPH04500368 A JP H04500368A
- Authority
- JP
- Japan
- Prior art keywords
- sodium
- lysozyme
- composition
- xylitol
- lactoferrin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims description 21
- 239000007787 solid Substances 0.000 title claims description 5
- 239000000606 toothpaste Substances 0.000 title description 4
- 229940034610 toothpaste Drugs 0.000 title description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 14
- 239000004615 ingredient Substances 0.000 claims description 9
- 108090000790 Enzymes Proteins 0.000 claims description 8
- 102000004190 Enzymes Human genes 0.000 claims description 8
- 229940088598 enzyme Drugs 0.000 claims description 8
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 7
- 239000000377 silicon dioxide Substances 0.000 claims description 7
- 239000000600 sorbitol Substances 0.000 claims description 7
- 208000006558 Dental Calculus Diseases 0.000 claims description 6
- 102000016943 Muramidase Human genes 0.000 claims description 6
- 108010014251 Muramidase Proteins 0.000 claims description 6
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims description 6
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 6
- 239000000796 flavoring agent Substances 0.000 claims description 6
- 229960000274 lysozyme Drugs 0.000 claims description 6
- 235000010335 lysozyme Nutrition 0.000 claims description 6
- 239000004325 lysozyme Substances 0.000 claims description 6
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 6
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 6
- 239000000811 xylitol Substances 0.000 claims description 6
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 6
- 229960002675 xylitol Drugs 0.000 claims description 6
- 235000010447 xylitol Nutrition 0.000 claims description 6
- 102000010445 Lactoferrin Human genes 0.000 claims description 5
- 108010063045 Lactoferrin Proteins 0.000 claims description 5
- 241001465754 Metazoa Species 0.000 claims description 5
- 150000001412 amines Chemical class 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 5
- 235000013355 food flavoring agent Nutrition 0.000 claims description 5
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims description 5
- 235000021242 lactoferrin Nutrition 0.000 claims description 5
- 229940078795 lactoferrin Drugs 0.000 claims description 5
- 235000010234 sodium benzoate Nutrition 0.000 claims description 5
- 239000004299 sodium benzoate Substances 0.000 claims description 5
- 241000282472 Canis lupus familiaris Species 0.000 claims description 4
- 230000000844 anti-bacterial effect Effects 0.000 claims description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 3
- 230000002421 anti-septic effect Effects 0.000 claims description 3
- 239000002948 appetite stimulant Substances 0.000 claims description 3
- 239000003086 colorant Substances 0.000 claims description 3
- 230000008021 deposition Effects 0.000 claims description 3
- IDAGXRIGDWCIET-SDFKWCIISA-L disodium;(2s,3s,4s,5r)-2,3,4,5-tetrahydroxyhexanedioate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O IDAGXRIGDWCIET-SDFKWCIISA-L 0.000 claims description 3
- TYBHZVUFOINFDV-UHFFFAOYSA-N 2-bromo-6-[(3-bromo-5-chloro-2-hydroxyphenyl)methyl]-4-chlorophenol Chemical compound OC1=C(Br)C=C(Cl)C=C1CC1=CC(Cl)=CC(Br)=C1O TYBHZVUFOINFDV-UHFFFAOYSA-N 0.000 claims description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 2
- 235000016623 Fragaria vesca Nutrition 0.000 claims description 2
- 235000011363 Fragaria x ananassa Nutrition 0.000 claims description 2
- 240000004670 Glycyrrhiza echinata Species 0.000 claims description 2
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims description 2
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 2
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
- 239000000551 dentifrice Substances 0.000 claims description 2
- 208000007565 gingivitis Diseases 0.000 claims description 2
- 229940010454 licorice Drugs 0.000 claims description 2
- 235000019359 magnesium stearate Nutrition 0.000 claims description 2
- 239000004033 plastic Substances 0.000 claims description 2
- 230000000979 retarding effect Effects 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 2
- 239000011734 sodium Substances 0.000 claims 2
- 229910052708 sodium Inorganic materials 0.000 claims 2
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims 1
- 244000307700 Fragaria vesca Species 0.000 claims 1
- 101710132682 Lysozyme 1 Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000000845 anti-microbial effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- -1 amines Monocetylamine Hydrofluoride Chemical class 0.000 description 3
- 230000001680 brushing effect Effects 0.000 description 3
- 210000004268 dentin Anatomy 0.000 description 3
- 210000003127 knee Anatomy 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 241000269821 Scombridae Species 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 229940125716 antipyretic agent Drugs 0.000 description 1
- 229940029995 appetite stimulants Drugs 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 229930002875 chlorophyll Natural products 0.000 description 1
- 235000019804 chlorophyll Nutrition 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000010436 fluorite Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 235000020640 mackerel Nutrition 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるため要約のデータは記録されません。 (57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】 本発明は、口腔衛生製品及び練り歯磨きとして用いられる組成物についての新規 なガーレン型剤型並びに該剤型に適合された新規な組成物に関する。[Detailed description of the invention] The present invention relates to novel compositions for use as oral hygiene products and toothpastes. The present invention relates to a gallen-type dosage form and a novel composition adapted to the dosage form.
歯磨組成物が現在殆んどゲル又は粉末のペーストの剤型（形態）であることは知 られている。それらの使用は、上記組成物の所定量を集めてそれらをブラシを用 いて歯に適用することからなる。It is well known that most toothpaste compositions are currently in the form of gel or powder pastes. It is being Their use involves collecting a predetermined amount of the above composition and applying them using a brush. It consists of applying it to the teeth.
このようなブラシの使用は、多くの理由のためそれ自体欠点であり、なかんずく なぜ子供違が彼らの歯を定期的に磨くのをいやがるのかがその一つの理由である 。外出したときには、食事後あるいは訪問前に歯を磨くことが困難である。また 、犬などの動物の歯を首尾よくきれいにすることも極めて困難である。The use of such brushes is a disadvantage in itself for many reasons, among others This is one reason why children are reluctant to brush their teeth regularly. . When you go out, it is difficult to brush your teeth after meals or before visits. Also It is also extremely difficult to successfully clean the teeth of animals such as dogs.
上記限界を逃れるために、ブラシを使用する必要のないエーロゾルとして適用さ れる溶液形態の組成物を提供することが提案された。この提示はなるほど有利で はあるが、その適用に当っては、超微粉砕されたとしても固形成分特に不可欠の 研磨粒子を極めて低い含量にせざるを得ない。To escape the above limitations, it can be applied as an aerosol without the need to use a brush. It has been proposed to provide a composition in the form of a solution in which: This suggestion is very advantageous. However, in its application, even if it is ultra-finely pulverized, solid components, especially the essential This necessitates a very low content of abrasive particles.
さらに、このような有効成分の溶解は、その不可避的な希釈の結果、その効率が 低下してしまう。Moreover, the dissolution of such active ingredients reduces their efficiency as a result of their unavoidable dilution. It will drop.
本発明は、歯磨組成物として噛み砕くべき錠剤の形態の固型組成物を用いること によってこれら全ての欠点を解消するものである。The present invention uses a solid composition in the form of a tablet to be chewed as a dentifrice composition. This eliminates all these drawbacks.
この適用に適合された本発明に係るこのような組成物は、 １、防腐及び／又は抗菌性活性を有する少なくとも１つの成分、 ２、研磨作用を有する少なくとも１つの成分、３、歯石析着遅延作用を有する少 なくとも１つの成分、４、ムチン斑を攻撃しまた恐らくは抗菌作用も有する少な くとも１つの成分、 ５、フッ素源として作用する少なくとも１つの成分、Ｂ、及び補助的に歯肉炎に 対する局部抗炎症剤、及び食欲増進剤及び／又は香味料、着色剤及び／又は悪臭 息に対これら全ての成分は錠剤又はコロッケ中に固溶体として混合される。この ような組成物はそれ自体全く新規なものであり、多くの全く新しい重要な作用を 有する。Such a composition according to the invention adapted for this application is 1. at least one component having antiseptic and/or antibacterial activity; 2. At least one component that has an abrasive action; 3. A small amount of component that has a tartar deposition retarding action. At least one ingredient, 4, which attacks mucin plaques and perhaps also has antibacterial properties. At least one ingredient, 5. At least one component that acts as a fluoride source, B, and supplementary for gingivitis. topical anti-inflammatory agents, and appetite stimulants and/or flavorants, colorants and/or malodors against For breath All these ingredients are mixed as a solid solution in tablets or croquettes. this Such compositions are entirely new in themselves and have many entirely new and important effects. have
−そのムチン斑との接触を通してその出現次いで頑強な斑への変換を遅らせる。- through contact with mucinous plaques, delaying their appearance and subsequent transformation into robust plaques;
−その防腐作用が歯を被覆する中性膜の軟質斑への変換を遅らせる。- Its antiseptic action slows down the transformation of the neutral membrane covering the teeth into soft plaques.
−その幾つかの成分を象牙質上に固着することにより鯖歯に対する象牙質の保護 を強化する。- Protection of dentin against mackerel teeth by fixing some of its components on dentin strengthen.
−その膜形成作用が喫煙者のうちニコチンがら生じる歯石析着に対し歯を保護す る。- Its film-forming action protects teeth from tartar deposits caused by nicotine in smokers. Ru.
これらの効果は長く続き、いかなる歯磨をせずとも歯を保護することは留意すべ きである。These effects are long-lasting and it is important to keep in mind that you will protect your teeth even without brushing your teeth in any way. It is possible.
さらに、噛んでいる間にマイルドな研磨剤が清掃及び磨き作用を行う。Additionally, mild abrasives provide cleaning and polishing action while chewing.
これらの要素の組合せ効果は、ムチン斑及び歯石析着の出現の生理病理学を攻撃 するという両画生学の観点から興味があり、滑らかで輝いた歯になるという視覚 的な結果と共に予防的な抗鯖歯作用並びに象牙質の保護を有する。The combined effect of these factors attacks the physiopathology of the appearance of mucin plaques and tartar deposits. I am interested from the perspective of bioscience, and the vision of having smooth and shiny teeth. It has preventive anti-dental effects as well as protective effects on dentin.
人及び子供達の間では、この組成物は歯磨き（ブラッシング）と組み合わせるこ とができ、２回の歯磨きの間に歯を保護しまた息をされやかにすることが可能と なる。Among humans and children, this composition can be combined with tooth brushing. It can protect your teeth and make your breath fresher between two brushings. Become.
犬の間では、この組成物は、歯石析着を低減しまた息をされやかにするという解 決困難な問題に対する新しい解答となる。Among dogs, this composition has been shown to reduce tartar buildup and freshen breath. It provides new answers to difficult problems.
人が用いる場合、組成物は歯の作用で噛み砕くことができる錠剤の形態である。When used by humans, the composition is in the form of a tablet that can be chewed with the aid of the teeth.
以上の２つの実施例はそれぞれ成人及び子供に適合した組成物の例示であるが、 限定的なものではない。While the above two examples are illustrative of compositions suitable for adults and children, respectively, It is not limited.
実施例１：成人用固形歯磨組成物 （代表的範囲） フッ素化アミン類 一セチルアミン ヒドロフルオライド（ＣＦ） ０．１〜０．３−ビス（ヒドロ キシエチル）−アミノプロピル−Ｎ−（ヒドロキシエチル）−オクタデシルアミ ンジヒドロフルオライド（ＢＦ） １．２〜】、６ジメチルボリシロキサン 安息香酸ナトリウム ０〜０．５ 糖酸ナトリウム ０〜０．５ デンタチウム（酵素錯体） １〜Ｂ リゾチーム □〜３ ラクトフェリン ○〜１．５ 香味料（クロロフィル）０．１〜０．５粉末シリカ ２〜７ ソルビトール ８０〜９゜ キシリトール １−〇 （代表的節ＦＭ） フッ素化アミン類 −ＣＦ ０．１〜０．３ − Ｂ Ｆ ０．２〜１．２ −ジメチルポリシロキサン １〜５ 安息香酸ナトリウム □〜Ｑ、２ 糖酸ナトリウム ０〜０．１ デンタチウム（酵素錯体）０．５〜４ リゾチーム ０〜２ 香味料（ストロベリー）０．１〜０．５粉末シリカ １〜６ 粉末ソルビトール ６０〜９゜ キシリトール １〜６ 同様な組成物は動物（犬、猫等）に用いることができ、以下の例はこの適用の例 示であり、組成物は錠剤、リオクス（ｌｙｏｅｓ）、活性組成物を被覆したプラ スチックもしくはゴム片（例えば擬似骨）の形態で噛み砕かれた後に歯に適用さ れる。Example 1: Solid toothpaste composition for adults (Representative range) Fluorinated amines Monocetylamine Hydrofluoride (CF) 0.1-0.3-bis(hydrofluoride) xyethyl)-aminopropyl-N-(hydroxyethyl)-octadecylamide dihydrofluoride (BF) 1.2~], 6 dimethylborisiloxane Sodium benzoate 0-0.5 Sodium saccharate 0-0.5 Dentatum (enzyme complex) 1-B Lysozyme □～3 Lactoferrin ○～1.5 Flavoring agent (chlorophyll) 0.1-0.5 Powdered silica 2-7 Sorbitol 80~9° Xylitol 1-〇 (Representative FM) Fluorinated amines -CF 0.1~0.3 - B F 0.2～1.2 -Dimethylpolysiloxane 1-5 Sodium benzoate □～Q, 2 Sodium saccharate 0-0.1 Dentatum (enzyme complex) 0.5-4 Lysozyme 0-2 Flavoring agent (strawberry) 0.1-0.5 Powdered silica 1-6 Powdered sorbitol 60~9° Xylitol 1-6 Similar compositions can be used for animals (dogs, cats, etc.) and the examples below are examples of this application. The composition is available in tablets, lyoes, plastic coated with the active composition. Applied to the teeth after being chewed in the form of a stick or piece of rubber (e.g. pseudo-bone) It will be done.
１１ゼ［コ週旦！１１１國ｊ （代表的範囲） フッ素化アミン類 一ジメチルポリシロキサン ２〜Ｂ 安息香酸ナトリウム □〜０．２ ブロモクロロフェン ０．０５〜０．２５食欲増進剤 ０．１０−０．２０ 香味料（甘草）０．１〜０．５ デンタチウム（酵素錯体） １〜５ リゾチーム ０〜２ ラクトフエリン ０〜２ 超微粉砕シリカ ２〜７ 粉末ソルビトール ６０〜９゜ キシリトール ０〜３ ステアリン酸マグネシウム １〜４ １８−β−グリセルへチン酸 ０．１〜３荊記実記実施おいて、引用した“デン タチウム（Ｄｅｎｔａｚｉｕｍ）’は本出願人のフランス特許第８９１１８６８ 号に記載のように酵素錯体である。11ze [ko weekday! 111 country j (Representative range) Fluorinated amines Monodimethylpolysiloxane 2-B Sodium benzoate □～0.2 Bromochlorophene 0.05-0.25 Appetite stimulant 0.10-0.20 Flavoring agent (licorice) 0.1-0.5 Dentatum (enzyme complex) 1-5 Lysozyme 0-2 Lactoferrin 0-2 Ultra-finely ground silica 2-7 Powdered sorbitol 60~9° Xylitol 0-3 Magnesium stearate 1-4 18-β-glycerohetinate 0.1 to 3 Dentazium’ is patented in French Patent No. 8911868 by the applicant. It is an enzyme complex as described in the issue.
前記成分の作用は次のとおりである。The effects of the above components are as follows.
＊酵素錯体ニー抗ムチン斑 一生物学的抗菌 ＊リゾチームニーマイルドな抗生物質 −解熱剤 一消炎剤 ＊ジメチルポリシロキサンニー膜成形剤−抗歯石析着 一染色防止にコチン） ＊フッ素アミン類（ＢＦ及びＣＦ）ニー有機螢石をもたらす 一抗ｔＩＡ歯 一防腐及び再ミネ ラル化 ＊超微粉砕シリカニーマイルドな研磨剤＊佐薬ニーソルビトール 一キシリトール 一糖酸ナトリウム 一香味料 一着色剤 一安息香酸ナトリウム 国際調査報告 国際調査報告 ＦＲ９０００４４４ ＳＡ ３８４１*Enzyme complex knee anti-mucin plaque A biological antibacterial *Lysozyme knee mild antibiotic -Antipyretics - Anti-inflammatory agent *Dimethylpolysiloxane knee film forming agent - anti-tartar deposition (To prevent staining) *Fluoramines (BF and CF) yield organic fluorite One anti-tIA tooth - Preservation and remineralization Ralization *Ultra-finely ground silica mild abrasive *Adjuvant sorbitol monoxylitol Sodium monosaccharide A flavoring agent one colorant Sodium monobenzoate international search report international search report FR9000444 SA 3841
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8908356A FR2648346B1 (en) | 1989-06-20 | 1989-06-20 | SOLID TOOTHPASTE COMPOSITIONS |
| FR8908356 | 1989-06-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH04500368A true JPH04500368A (en) | 1992-01-23 |
Family
ID=9383040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2509394A Pending JPH04500368A (en) | 1989-06-20 | 1990-06-20 | solid toothpaste composition |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0429635A1 (en) |
| JP (1) | JPH04500368A (en) |
| AU (1) | AU5931590A (en) |
| CA (1) | CA2034498A1 (en) |
| FR (1) | FR2648346B1 (en) |
| WO (1) | WO1990015591A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999056762A1 (en) * | 1998-04-30 | 1999-11-11 | Snow Brand Milk Products Co., Ltd. | Preventives and ameliorating agents for periodontosis |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4341139C1 (en) * | 1993-12-02 | 1995-04-13 | Upmeyer Hans Juergen | Dimethicone for the treatment of aphthae |
| TW414713B (en) | 1994-05-12 | 2000-12-11 | Dentsply Gmbh | Fluoride releasing liquid dental primer product and method |
| ES2079325B1 (en) * | 1994-08-18 | 1996-10-16 | Bio Cosmetics S L | LOW ABRASIVITY DENTRIFY, WHITENING, ANTI-PLATE AND ANTI-TARE PASTA. |
| ES2134738B1 (en) * | 1994-08-18 | 2000-05-01 | Biocosmetics Sl | LOW ABRASIVITY WHITE, ANTI-PLATE AND ANTI-TARE DENTIPHRICANE LEG ". |
| US5665333A (en) * | 1995-01-17 | 1997-09-09 | Homola; Andrew M. | Methods, compositions, and dental delivery systems for the protection of the surfaces of teeth |
| US5961958A (en) * | 1996-07-16 | 1999-10-05 | Four Star Partners | Methods, compositions, and dental delivery systems for the protection of the surfaces of teeth |
| US6432388B1 (en) * | 1997-11-14 | 2002-08-13 | Biocosmetics, S.L. | Whitening anti-plaque and anti-tartar low abrasivity tooth paste |
| US20030003059A1 (en) * | 2001-04-03 | 2003-01-02 | Frederic Dana | Dentifrice compositions |
| FR3106059B1 (en) | 2020-01-14 | 2023-11-17 | Dana Jean Dominque | EDIBLE TOOTHPASTE COMPOSITION TO SUCK OR CHEW, METHOD FOR PREPARING SAID TOOTHPASTE COMPOSITION |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1293516A (en) * | 1958-10-31 | 1962-05-18 | Unilever Nv | Dental preparations for cleaning teeth |
| DE2523940A1 (en) * | 1975-05-30 | 1976-12-09 | Gerhard Fischer | Liq for tooth and oral care to replace use of tooth brush - contains particulate material and film loosening agent |
| DE2712161C2 (en) * | 1977-03-19 | 1983-01-05 | Blendax-Werke R. Schneider Gmbh & Co, 6500 Mainz | Dental and oral care products |
| DE2804093C3 (en) * | 1978-01-31 | 1980-12-04 | Ferrero Ohg, 3570 Stadtallendorf | Tooth-friendly, low-water, sugar-containing foods and tooth-friendly, low-water pharmaceutical preparations |
| US4308252A (en) * | 1979-10-31 | 1981-12-29 | Young Dental Mfg. Co. | Dentifrice composition |
| GB8421226D0 (en) * | 1984-08-21 | 1984-09-26 | Int Conferences Ab | Tooth cleaning tablet |
| FR2607704B1 (en) * | 1986-12-05 | 1990-05-04 | Boyer Danielle | HYGIENE PRODUCT, PARTICULARLY FOR THE DENTURE CARE OF DOGS |
-
1989
- 1989-06-20 FR FR8908356A patent/FR2648346B1/en not_active Expired - Lifetime
-
1990
- 1990-06-20 WO PCT/FR1990/000444 patent/WO1990015591A1/en not_active Ceased
- 1990-06-20 CA CA002034498A patent/CA2034498A1/en not_active Abandoned
- 1990-06-20 AU AU59315/90A patent/AU5931590A/en not_active Abandoned
- 1990-06-20 EP EP19900910124 patent/EP0429635A1/en not_active Ceased
- 1990-06-20 JP JP2509394A patent/JPH04500368A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999056762A1 (en) * | 1998-04-30 | 1999-11-11 | Snow Brand Milk Products Co., Ltd. | Preventives and ameliorating agents for periodontosis |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0429635A1 (en) | 1991-06-05 |
| FR2648346B1 (en) | 1993-10-08 |
| CA2034498A1 (en) | 1990-12-21 |
| WO1990015591A1 (en) | 1990-12-27 |
| AU5931590A (en) | 1991-01-08 |
| FR2648346A1 (en) | 1990-12-21 |
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