JPH04503677A - 薬剤学的製剤 - Google Patents

薬剤学的製剤

Info

Publication number: JPH04503677A
Authority: JP; Japan
Prior art keywords: skin diseases; pharmaceutical preparations; pharmaceutical; active substance; skin
Prior art date: 1989-12-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

JP3500922A

Other languages

English (en)

Japanese (ja)

Inventor

レースリング，ゲオルク

ザクセ，アンドレアス

ツァウムザイル，ルードルフ　ペーター

リートル，ユッタ

Original Assignee

シェーリング　アクチェンゲゼルシャフト

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-14

Filing date

1990-12-07

Publication date

1992-07-02

1990-12-07 Application filed by シェーリング　アクチェンゲゼルシャフト filed Critical シェーリング　アクチェンゲゼルシャフト

1992-07-02 Publication of JPH04503677A publication Critical patent/JPH04503677A/ja

Status Withdrawn legal-status Critical Current

Links

239000000825 pharmaceutical preparation Substances 0.000 title claims description 7
239000002502 liposome Substances 0.000 claims description 15
208000017520 skin disease Diseases 0.000 claims description 7
239000002253 acid Substances 0.000 claims description 6
239000006185 dispersion Substances 0.000 claims description 6
150000007513 acids Chemical class 0.000 claims description 4
150000002148 esters Chemical class 0.000 claims description 4
239000000499 gel Substances 0.000 claims description 4
150000003839 salts Chemical class 0.000 claims description 4
125000004432 carbon atom Chemical group C* 0.000 claims description 3
239000006071 cream Substances 0.000 claims description 3
239000006210 lotion Substances 0.000 claims description 2
239000008194 pharmaceutical composition Substances 0.000 claims description 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
229910052760 oxygen Inorganic materials 0.000 claims 1
239000001301 oxygen Substances 0.000 claims 1
239000013543 active substance Substances 0.000 description 15
239000000203 mixture Substances 0.000 description 10
238000000034 method Methods 0.000 description 9
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
239000000243 solution Substances 0.000 description 6
150000002632 lipids Chemical class 0.000 description 5
239000002904 solvent Substances 0.000 description 5
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
238000009472 formulation Methods 0.000 description 4
238000002360 preparation method Methods 0.000 description 4
239000000126 substance Substances 0.000 description 4
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
230000000694 effects Effects 0.000 description 3
238000000265 homogenisation Methods 0.000 description 3
239000012528 membrane Substances 0.000 description 3
239000000725 suspension Substances 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
102000004190 Enzymes Human genes 0.000 description 2
108090000790 Enzymes Proteins 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
239000003963 antioxidant agent Substances 0.000 description 2
230000003078 antioxidant effect Effects 0.000 description 2
239000008346 aqueous phase Substances 0.000 description 2
239000002800 charge carrier Substances 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
235000012000 cholesterol Nutrition 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
238000004821 distillation Methods 0.000 description 2
BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 description 2
239000003883 ointment base Substances 0.000 description 2
230000035515 penetration Effects 0.000 description 2
239000000843 powder Substances 0.000 description 2
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
239000011734 sodium Substances 0.000 description 2
-1 stearylamine Chemical class 0.000 description 2
230000000699 topical effect Effects 0.000 description 2
TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 1
HVYWMOMLDIMFJA-UHFFFAOYSA-N 3-cholesterol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 HVYWMOMLDIMFJA-UHFFFAOYSA-N 0.000 description 1
101150034533 ATIC gene Proteins 0.000 description 1
208000002874 Acne Vulgaris Diseases 0.000 description 1
NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
201000004624 Dermatitis Diseases 0.000 description 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 1
ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 1
229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
REYJJPSVUYRZGE-UHFFFAOYSA-N Octadecylamine Chemical compound CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 description 1
206010040865 Skin hyperpigmentation Diseases 0.000 description 1
DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
229920002125 Sokalan® Polymers 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
206010000496 acne Diseases 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
230000002280 anti-androgenic effect Effects 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
229910052786 argon Inorganic materials 0.000 description 1
239000012298 atmosphere Substances 0.000 description 1
239000003899 bactericide agent Substances 0.000 description 1
239000000872 buffer Substances 0.000 description 1
239000002775 capsule Substances 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
RNPXCFINMKSQPQ-UHFFFAOYSA-N dicetyl hydrogen phosphate Chemical compound CCCCCCCCCCCCCCCCOP(O)(=O)OCCCCCCCCCCCCCCCC RNPXCFINMKSQPQ-UHFFFAOYSA-N 0.000 description 1
229940093541 dicetylphosphate Drugs 0.000 description 1
201000010099 disease Diseases 0.000 description 1
238000005538 encapsulation Methods 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000000945 filler Substances 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
239000011521 glass Substances 0.000 description 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
208000000069 hyperpigmentation Diseases 0.000 description 1
230000003810 hyperpigmentation Effects 0.000 description 1
239000011261 inert gas Substances 0.000 description 1
230000002757 inflammatory effect Effects 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
239000002674 ointment Substances 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
150000003904 phospholipids Chemical class 0.000 description 1
230000035479 physiological effects, processes and functions Effects 0.000 description 1
238000005498 polishing Methods 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
230000001568 sexual effect Effects 0.000 description 1
235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
229960001295 tocopherol Drugs 0.000 description 1
229930003799 tocopherol Natural products 0.000 description 1
235000010384 tocopherol Nutrition 0.000 description 1
239000011732 tocopherol Substances 0.000 description 1
238000009834 vaporization Methods 0.000 description 1
229940099259 vaseline Drugs 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Dermatology (AREA)
Birds (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Emergency Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Gerontology & Geriatric Medicine (AREA)
Dispersion Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

JP3500922A 1989-12-14 1990-12-07 薬剤学的製剤 Withdrawn JPH04503677A (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3941582.1		1989-12-14
DE3941582A DE3941582A1 (de)	1989-12-14	1989-12-14	Pharmazeutische praeparate

Publications (1)

Publication Number	Publication Date
JPH04503677A true JPH04503677A (ja)	1992-07-02

Family

ID=6395592

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP3500922A Withdrawn JPH04503677A (ja)	1989-12-14	1990-12-07	薬剤学的製剤

Country Status (4)

Country	Link
EP (1)	EP0458924A1 (fr)
JP (1)	JPH04503677A (fr)
DE (1)	DE3941582A1 (fr)
WO (1)	WO1991008735A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH07145081A (ja) *	1993-08-20	1995-06-06	Euro Celtique Sa	消毒剤及び／又は創傷治癒促進剤の外用製剤

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10131796A1 (de) *	2001-06-30	2003-01-16	Beiersdorf Ag	Verwendung von Cardiolipin in kosmetischen oder dermatologischen Zubereitungen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3542773A1 (de) *	1985-12-04	1987-06-11	Roehm Pharma Gmbh	Hautwirksame pharmaka mit liposomen als wirkstofftraeger
FR2591105B1 (fr) *	1985-12-11	1989-03-24	Moet Hennessy Rech	Composition pharmaceutique, notamment dermatologique, ou cosmetique, a base de phases lamellaires lipidiques hydratees ou de liposomes contenant un retinoide ou un analogue structural dudit retinoide tel qu'un carotenoide.
FR2627385B3 (fr) *	1988-02-23	1991-08-23	Serobiologiques Lab Sa	Composition notamment utile comme matiere de base pour la preparation de compositions pharmaceutiques, notamment dermatologiques et/ou cosmetiques
DE3811081A1 (de) *	1988-03-30	1989-10-12	Schering Ag	Verwendung von topisch applizierbaren praeparaten zur behandlung der altershaut

1989
- 1989-12-14 DE DE3941582A patent/DE3941582A1/de not_active Withdrawn
1990
- 1990-12-07 WO PCT/DE1990/000950 patent/WO1991008735A1/fr not_active Ceased
- 1990-12-07 JP JP3500922A patent/JPH04503677A/ja not_active Withdrawn
- 1990-12-07 EP EP91900173A patent/EP0458924A1/fr not_active Withdrawn

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH07145081A (ja) *	1993-08-20	1995-06-06	Euro Celtique Sa	消毒剤及び／又は創傷治癒促進剤の外用製剤

Also Published As

Publication number	Publication date
WO1991008735A1 (fr)	1991-06-27
EP0458924A1 (fr)	1991-12-04
DE3941582A1 (de)	1991-06-20

Legal Events

Date	Code	Title	Description
2004-02-24	R250	Receipt of annual fees	Free format text: JAPANESE INTERMEDIATE CODE: R250
2005-02-15	R250	Receipt of annual fees	Free format text: JAPANESE INTERMEDIATE CODE: R250
2006-02-28	R250	Receipt of annual fees	Free format text: JAPANESE INTERMEDIATE CODE: R250
2007-02-20	R250	Receipt of annual fees	Free format text: JAPANESE INTERMEDIATE CODE: R250
2008-02-26	FPAY	Renewal fee payment (event date is renewal date of database)	Free format text: PAYMENT UNTIL: 20090218 Year of fee payment: 9
2009-02-18	LAPS	Cancellation because of no payment of annual fees

Publication	Publication Date	Title
EP0892638B1 (fr)	2002-11-13	Formulation topique de vitamine d a base de liposomes
US5166139A (en)	1992-11-24	Complexes of saponins and their aglycons with phospholipids and pharmaceutical and cosmetic compositions containing them
US5030442A (en)	1991-07-09	Non-crystalline minoxidil composition
KR100612398B1 (ko)	2006-08-16	포스페이트 유도체의 착체
Asbill et al.	2000	Enhancement of transdermal drug delivery: chemical and physical approaches
US5118671A (en)	1992-06-02	Complexes of aescin, β-sitosterol or cholesterol, and phospholipids and pharmaceutical compositions containing them
US4828837A (en)	1989-05-09	Non-crystalline minoxidil composition, its production and application
JP4237446B2 (ja)	2009-03-11	トコフェロール誘導体を用いてナノ乳化粒子を安定化させる方法及びナノ乳化粒子を含有する皮膚外用剤組成物
HU202745B (en)	1991-04-29	Process for producing pharmaceutical compositions acting on the skin or percutaneously on the organism, having increased penetration capacity and comprising liposomes as active ingredient carrier
EP0609963B1 (fr)	2002-03-06	Compositions topiques contenant des dérivés du benzimidazole et du benzotriazole
US20080292688A1 (en)	2008-11-27	Liposome and preparation method of the same
KR20180131876A (ko)	2018-12-11	리포좀 기술을 이용한 안정화된 세라마이드 복합물 및 그 제조 방법 및 이를 함유하는 화장료 조성물
JP3011762B2 (ja)	2000-02-21	医薬品
HUT73531A (en)	1996-08-28	Ketoprofene liposomes
WO1998030215A1 (fr)	1998-07-16	Formulation topique de tretinoine a base de liposomes
JPH04503677A (ja)	1992-07-02	薬剤学的製剤
CN1331592A (zh)	2002-01-16	脂质体尼氟酸新的皮透抗炎药物
CA2222061A1 (fr)	1996-11-28	Medicaments topiques pour le traitement et la prevention de l'alopecie
AU2001276254B2 (en)	2006-07-13	Liposomic formulation of clobetasol propionate
JP2844245B2 (ja)	1999-01-06	癒合助長用組成物
EP0571063A1 (fr)	1993-11-24	Préparations pharmaceutiques
KR20260060142A (ko)	2026-05-04	바이셀 나노입자 및 이의 제조방법
KR20110039069A (ko)	2011-04-15	모발 성장 촉진용 조성물
JPS61260026A (ja)	1986-11-18	経皮吸収性を高めた皮膚外用剤
WO2024058540A1 (fr)	2024-03-21	Composition comprenant des microparticules d'acide hyaluronique de poids moléculaire élevé

JPH04503677A - 薬剤学的製剤 - Google Patents

Info

Links

Classifications

Landscapes

Applications Claiming Priority (2)

Publications (1)

Family

ID=6395592

Family Applications (1)

Country Status (4)

Cited By (1)

Families Citing this family (1)

Family Cites Families (4)

Cited By (1)

Also Published As

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Legal Events