JPH045645B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a hair growth and hair growth agent that causes the hair on bald areas to grow into normal terminal hair. Baldness is a state in which terminal hair becomes thinner and smaller each time it grows back, and it does not mean that the function of the hair follicle has completely disappeared, but various explanations have been given for the cause. A typical theory is that sebum secretion from the sebaceous glands increases and mixes with scalp grime, resulting in seborrhea, which clogs the pores and causes nutritional and circulation disorders for the hair roots. The theory that this is due to excessive production of the male hormone (testosterone), creating an imbalance in the top of the head, which was previously controlled by the balance of both sex hormones (hormone theory), and others. There are theories that it is related to genetics and nutrition. but,
Neither could be considered a definitive cause. This is because the above-mentioned theories are based on the conventional erroneous dermatological dogma regarding hair development, that is, when a hair bulb is formed on the skin, hair matrix cells are formed inside it.
This is because the established theory was that these cells begin to differentiate and gradually keratinize and become hair. Under these circumstances, conventionally used hair growth or hair growth agents have focused on improving blood circulation in the hair bulb. For example, an aqueous solution such as hinokiol, menthol, or chili pepper tincture is used as a main ingredient, and this is applied to the scalp to maintain good blood circulation in the scalp.Secondly, it improves blood circulation in the hair bulb and nourishes the hair. Although it is waiting for hair or regeneration,
The current situation is that sufficient effects cannot be achieved. The present invention was completed based on a new theory of hair development that was discovered as a result of many years of research by the present inventor, which differs from the conventional theory regarding hair development as described above. Since this generation theory is essential for understanding the present invention,
The outline is explained below. FIG. 1 is an explanatory diagram of the hair cycle according to this theory.
That is, the hair follicle and the sebaceous gland 1 attached thereto become one set, and during the growth phase, hair is formed from the hair matrix cells 5 of the hair bulb 4. However, instead of continuing to grow forever, the hair goes through a transitional period, enters a resting period, falls out, and the next stage of regeneration begins. This is the hair cycle. According to the conventional theory, regeneration begins from the lower end of the hair follicle in the resting phase, but according to the theory of new hair generation according to the present invention, hair regeneration begins from the isthmic hair sheath 2, which is the outlet of the excretory duct of the sebaceous gland 1. A hair bud is formed (hair bud stage), hair is formed from the epithelial germ cell layer at the bottom of the hair follicle 3, descends while forming hair (hair pile stage), and then a hair bulb is formed. However, until the hair matrix cells 5 are formed in the hair bulb 4, it continues to descend (the hair bulb stage), and when the hair matrix cells 5 reach their full function, the descent stops and the skin Hair only appears on the outside (finished hair). In this way, hair is formed not only from the hair matrix cells 5 of the hair bulb 4, but also from the epithelial cells of the hair follicle, similar to the epidermis, and that the formation of hair involves the sebaceous glands 1. This is an important basis for a new theory regarding hair development (sebaceous gland theory or Inaba theory).
It has been recognized both domestically and internationally. On the other hand, testosterone, a male hormone involved in hair growth, is formed in the testicles 8 and has traditionally been found in the second testicle.
As shown by the chain line a in the figure, it was thought to act directly on the hair matrix cells 5 from the dermal papilla 7 of the hair bulb 4. In contrast, the present inventors believe that this testosterone is transported not only to the hair bulb 4 but also directly to the sebaceous gland 1 by blood circulation (solid line b), and is reduced by the reductase 5α reductase present in the sebaceous gland 1. ,
It is converted into 5α day hydrotestosterone (hereinafter referred to as “5αDHT”), which is a powerful sex hormone, and then this 5αDHT is transported to the blood papilla 7 and hair matrix cells 5 by blood vessels around the hair follicle, c. We have discovered a completely new theory that suppresses the cell division of mother cells 5. Therefore, when the sebaceous glands enlarge due to the influence of nutrition and hormones, the amount of 5α-reductase increases, and testosterone becomes a powerful sex hormone.
It is converted to 5αDHT, and the hair follicles gradually shrink, causing the hair to become bald and bald. Thus, testosterone itself or small amounts of
5αDHT promotes the production of hair, but the effect of 5αDHT that has been converted into a large amount is too strong, so in the same way that giving too much fertilizer to a plant inhibits its growth. It has a suppressive effect on hair matrix cells. In view of the above-mentioned baldness formation process, the present invention suppresses the enzymatic action of 5α reductase present in the sebaceous glands, thereby reducing the conversion of testosterone into the powerful sex hormone 5αDHT. Therefore, focusing on the fact that the inhibitory effect on hair matrix cells diminishes or disappears, hair growth and hair growth agents contain substances that suppress or eliminate the action of 5α reductase present in the sebaceous glands. The gist is that. Up to now, attempts have been made to use competitive resistance agents such as progestin and other male hormones for the purpose of suppressing the activity of 5α-reductase, but these have many side effects and are not suitable as developmental agents. Since 5α-reductase is a reducing enzyme, one way to reduce or eliminate this activity is to use a substance that has a strong oxidizing effect, is harmless to the human body, and does not cause side effects. be. Such substances include, for example, sodium perborate, sodium bromate, and the like. Note that other oxidizing substances can also be used as long as the above two conditions are satisfied. These oxidants have a composition and concentration that is sufficient to suppress or eliminate the action of 5α-reductase and do not affect the human body, and are applied to the bald scalp several times a day, along with other ingredients as necessary. Apply to the skin, apply a light pine surge, and use this continuously for a long period of time. As a result, various oxidizing substances penetrate into the sebaceous glands through the pores of the scalp, and reduce or eliminate the activities of reduced coenzymes (NADH, NADPH (TPNH)) and 5α-reductase present in the sebaceous glands. For this reason, testosterone transported from the testicles is rarely converted to 5aDHT, and only testosterone or a small amount of 5αDHT acts on hair matrix cells. It has been reported that this 5α-reductase exists in large amounts in the sebaceous glands, and only in small amounts in the hair bulb. Therefore, testosterone is directly transported from the testicles to the hair matrix via route a, and a small amount of 5αDHT is formed to promote hair growth, so the effects of the present invention are not impaired. This testosterone or a small amount of 5αDHT
Similar to the development of beards and chest hair after puberty in men, it has good results for hair on the scalp, and as shown in the hair regeneration process diagram above, hair follicles grow and form.
Vigorous cell division occurs in the hair matrix cells and terminal hair develops. (Example) Two types of sodium bromate and sodium perborate were subjected to clinical tests in the following manner. This clinical trial was conducted in the United States on five male subjects between the ages of 30 and 50 for each test, and the drug was used three times a day approximately every 5 hours. The results are shown in the table.Although the effects shown in the table varied from person to person, the judgment was made based on the overall results.

[Table] From the above results, it was confirmed that the theory of the present invention is correct. As mentioned above, the present invention is based on new research results on the hair development process, and conventional hair growth and hair growth agents simply remove and improve factors such as nutritional disorders and circulatory disorders in the hair bulb. In contrast, the present invention uses reductase 5 present in sebaceous glands.
It suppresses and eliminates the action of α-reductase, making it a powerful
It blocks the conversion to 5αDHT, secondarily removes factors that suppress cell division of hair matrix cells, and allows normal testosterone to act on hair matrix cells to promote their division. It has an effect that has not existed in the past in turning naive hair into hard hair.

[Brief explanation of drawings]

Figure 1 is an explanatory diagram of the hair cycle on which the present invention is based;
FIG. 2 is an explanatory diagram of the action pathway of the male hormone testosterone. In the figure, 1... sebaceous gland, 2... hair sheath, 2... hair follicle, 4... hair bulb, 5... hair matrix cell, 7... dermal papilla, 8... testicle.

Claims (1)

[Scope of Claims] 1. A hair growth and hair growth agent characterized by containing a hair growth and hair growth effective amount of at least one selected from sodium bromate and sodium perborate as an active ingredient. 2 The content of sodium bromate is 50,000 or more
The hair growth and hair growth agent according to claim 1, which contains 120000 ppm. 3. The hair growth and hair growth agent according to claim 1, wherein the content of sodium perborate is 5%.