JPH0474110A - Hair cosmetic - Google Patents

Abstract

PURPOSE:To provide the subject hair cosmetic containing a specified amine oxide such as a dimethylalkylamine oxide and excellent in imparting gentleness and smoothness to hair, prevention of falling-out of hair and hair-restoring properties. CONSTITUTION:One or more amine oxides selected from a dimethylalkylamine oxide, a dihydroxyethylamine oxide and a dimethylalkylpolyoxyethyleneamine oxide represented by formulae I-III (R is 26-36C straight or branched alkyl or alkenyl; n is integer of 1-5) are mixed as effective components in a hair cosmetic preferably in an amount of 0.0001-20 wt.%, furthermore preferably 0.005-10 wt.% to obtain the objective hair cosmetic having an excellent effect of imparting gentleness and smoothness to hair and remarkably excellent in hair-restoring effect and prevention of falling-out of hair due to reduction of ratio of hair root-resting period.

Description

[Detailed Description of the Invention] [Industrial Field of Application] The present invention provides a hair cosmetic that contains amine oxide and has an excellent effect of imparting moisture and smoothness to hair, and is also excellent in hair loss prevention and hair growth effects. Regarding fees.

[Prior Art] Traditionally, the causes of baldness and hair loss are (1) activation of male hormones in organs such as hair roots and sebaceous glands, (2) decreased blood flow to hair follicles, and (3) excessive secretion of sebum. , scalp abnormalities due to the production of peroxide, etc.

For this reason, conventional hair nourishing products generally contain compounds that have the effect of eliminating or alleviating the above-mentioned causes.

For example, it contains vitamins such as vitamin E, vasodilators such as Aspergillus japonica extract, anti-inflammatory agents such as hinokitiol, female hormones such as estradiol, skin function enhancers such as cephalanthine, etc., and is effective in preventing and treating alopecia. It is used.

However, the mechanism of hair loss and hair growth is extremely complex.
Conventional methods of hair growth, such as inhibiting the activation of male hormones and increasing blood flow to the hair follicles, have not been sufficient to prevent hair loss or to restore hair.

The present applicant discovered that a hair cosmetic containing an amine oxide having an alkyl group or an alkenyl group having 8 to 24 carbon atoms was found to have anti-hair loss and hair-nourishing effects.
-249132.

[Problems to be Solved by the Invention] However, although the above-mentioned hair cosmetics have excellent anti-hair loss and hair-nourishing effects, they lack the effect of imparting moisture and smoothness to the hair, and therefore cannot be used as hair cosmetics. It was unsatisfactory.

In view of the above-mentioned circumstances, the inventors of the present invention have devised a method that prevents hair loss while having the effect of imparting moisture and smoothness to hair.
As a result of searching for hair cosmetics that have an effective effect on hair growth, it was discovered that a hair cosmetic containing a specific amine oxide satisfies the above requirements, and the present invention was completed.

[Means for Solving the Problems] That is, the present invention provides a hair cosmetic that is characterized by containing a specific amine oxide.

Hereinafter, the configuration of the present invention will be explained in detail.

The amine oxides used in the present invention include the following.

(1) - Dimethylalkylamine oxide represented by (A) H3 R-N-)0 (A) H3 (wherein R is a straight or branched alkyl group or alkenyl having 26 to 36 carbon atoms) represents a group.)(?)−
Dihydroxyethylalkylamine oxide CH2CH2OH R-N-+0 (B) CH2CH2 that can be completely drained in shipyard (B)
OH (In the formula, R represents a linear or branched alkyl group or alkenyl group having 26 to 36 carbon atoms) (3) - Dimethylalkyl polyoxyethylene amine oxide represented by Funazura (C) H3 R-(OCH2CH2 )n-N+O(C)CH.

(In the formula, R represents a straight or branched alkyl group or alkenyl group having 26 to 36 carbon atoms.

represents an integer from 1 to 5. ) One or more of the above amine oxides (i), (fi) and (iii) are used.

Specific examples of the amine oxide of the present invention are as follows:
For example, N,N-dimethyl-2-dodecylhexadecylamine oxide, N,tonmethyl-2-tetradecylstearylamine oxide, N,N-dihydroxyethyl-2-dodecylhexadecylamine oxide, dimethyloftacosylpolyoxyethylene (3 moles) amine oxide, dimethyl hexacosyl polyoxyethylene (1
, amine oxide, etc.

The blending amount of the above amine oxide is 0 in the hair cosmetic of the present invention.
．． The range is preferably from 0.001 to 20% by weight, and more preferably from 0.005 to 10% by weight. The amount added is 0.0
If it is less than 0.001% by weight, it will not be possible to obtain sufficient hair loss prevention, hair nourishing effects, and usability such as moisturizing and smoothing of the hair. I also don't like it.

In addition to one or more of the amine oxides of the present invention, the hair cosmetic according to the present invention includes vitamins such as zara, vitamin B6, vitamin E and its derivatives, biotin, pantothenic acid and its derivatives, and glycyrrhetinic acid. and derivatives thereof, nicotinic acid esters such as benzyl nicotinate, cyclosporins, carpronium chloride, cephalanthine, oxendrone, diazoxide, minoxidil, ethinyl estradiol, etc. may be simultaneously blended. Furthermore, additives commonly used in hair cosmetics, such as hinokitiol, hexachlorophene, phenol,
Antibacterial agents such as benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, trichlorocarbanilide and bithionol, cooling agents such as menthol, drugs such as salicylic acid, zinc and its derivatives, lactic acid and its alkyl esters, and organics such as citric acid. Acids, amino acids such as arginine, chelating agents such as edetic acid or its salts, oils such as olive oil, squalane, liquid paraffin, isopropyl myristate, higher fatty acids, higher alcohols, polyhydric alcohols such as glycerin and propylene glycol, non- ionic surfactants, cationic surfactants,
Anionic surfactants, fragrances, antioxidants, ultraviolet absorbers, pigments, ethanol, water, humectants, thickeners, chelating agents, buffering agents, etc. may be appropriately blended within the range that does not impair the effects of the present invention. I can do it.

The hair cosmetic of the present invention may be in any form as long as it can be applied to the outer skin, such as liquid, milky lotion, or ointment.

(The following is a blank space) [Example] Next, the present invention will be described in further detail by giving examples. The present invention is not limited thereby. The blending amount is in weight%.

S　　　　1-destination A lotion having the composition shown in Table 1 was prepared.

(Production method) Hydrogenated castor oil ethylene oxide (
After dissolving the adduct (40 moles) and perfume, and then adding purified water, the amine oxide and pigment shown in Table 1 were added and dissolved with stirring to obtain a transparent liquid hair cosmetic.

(The following is a blank space) (1) Test method In order to evaluate the moistness and smoothness of the hair cosmetics of the present invention, a sensory evaluation was conducted by a panel of experts, and the average score was calculated.

0(2) Fairly moist and smooth.

○(1) Moist and smooth.

X (0) L It doesn't feel smooth.

(2) As is clear from Results Table 2, the hair cosmetics according to the present invention:
It has an excellent effect on making hair moist and smooth.

Effect on hair loss test J (1) Test method Judgment was made based on the change in the number of strands of hair removed during hair washing before and after using the sample. There were 8 subjects in each of the Example and Comparative Example groups. The test period was six months, with the first two months being a period in which no sample was applied, and the latter four months being a period in which samples were applied. During the sample application period, the sample was applied to the scalp twice a day in an amount of 2 to 4 ml per day.

During the test period, the hair was washed and collected every other day, and the number of hairs with a thickness of 50 μm or more was counted. The number of hairs pulled in each period was determined by summing up the data for the two months without sample application and the data on the number of hairs pulled in the latter two months of the hair tonic application period for each period, and the rate of change in the average number of hairs pulled per day for each subject. (Average number of hairs pulled out during the hair tonic application period ÷ Average number of hairs pulled out during the non-application period x 100) was expressed as a percentage.

(2) Results As is clear from Table 3, the hair cosmetic composition according to the present invention containing amine oxide has an extremely excellent hair removal prevention effect.

1) Test method In order to investigate the hair-nourishing effect of the hair cosmetic of the present invention, a tricogram test was conducted. There were 8 subjects in each of the Example and Comparative Example groups. The sample application period was 4 months, during which time the sample was applied to the scalp twice a day, 2 to 4 ml each time. Immediately before application and immediately after the end of the 4-month application, each subject removed 50 hair terminals from the top of their head, observed the removed hair roots under a microscope, and determined the growth, regression, and resting stages of the hair based on the morphology of the hair roots. was determined and the hair root telogen rate was calculated. The hair growth effect of each sample was compared based on the increase/decrease in the telogen rate before and after application of the sample.

(2) As is clear from Results Table 4, the hair cosmetics according to the present invention:
It reduces the hair root telogen rate and has an excellent hair-nourishing effect.

1 What--1 95% ethanol 90. ON, N
-Dimethyl-2-dodecylhexadecylamine oxide 0.0003 Dihydrodiethyl hexadecylamine oxide 0,0002 Sodium lauryl sulfate 0.1 Hydrogenated castor oil ethylene oxide (40 mol) adduct 0.5 Purified water Residual fragrance and pigment Appropriate amount ( Manufacturing method) Hydrogenated castor oil ethylene oxide (
After dissolving the adduct (40 moles) and perfume, and then adding purified water, the above amine oxide and pigment were added and dissolved with stirring to obtain a transparent liquid hair cosmetic.

SJJL-Dan (A phase) N,N-dimethyl-2-hexadecyl eicosylamine oxide 10.0 Liquid paraffin 5.0 Cetostearyl alcohol 5.5 Glyceryl monostearate
3.0 dihydroxyethyl hexacosylamine oxide 0.002 dimethyloctacosylpolyoxyethylene (3 mol) amine oxide 0.00
3 Vitamin E acetate 0.05 Propylparaben 0.3 Fragrance
0.05 (Phase B) Glycerin 7.0 Dipropylene glycol 20.0 Polyethylene glycol 4000 5.0 Sodium hexametaphosphate 0.005 Purified water
Residue (manufacturing method) Phase A and phase B were respectively heated and dissolved and mixed, and emulsified with a homomixer to obtain an ointment-like hair cosmetic.

JL Example-21 (A phase) N,N-dimethyl-2-tetradecylstearylamine oxide 8. ON, N-dimethyl-2-hexadecyl eicosylamine oxide
2. ON, N-dihydrodiethyl-2-dodecylhexadecylamine oxide 2.0 cetanol vaseline polyoxyethylene (10 mole addition) monostearate sorbitan monooleate fragrance 5.5 3.0 2.0 1.0 0.1 ( Phase B) Glycerin 10.020% Chlorhexidine gluconate solution 0.1 Purified water
Residue (manufacturing method) Phase A and phase B were respectively dissolved by heating and mixed and emulsified using a homomixer to obtain a milky hair cosmetic.

[Effects of the Invention] The hair cosmetic according to the present invention has an excellent effect of imparting moisture and smoothness to hair, and also reduces the hair root telogen rate, and has extremely excellent hair growth and hair loss prevention effects. There is.

Claims (1)

[Claims] (1) Hair cosmetics characterized by containing one or more amine oxides represented by the following general formulas (i), (ii) and (iii) (i) A hair cosmetic product represented by the general formula (A) Dimethylalkylamine oxide ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼ (A) (In the formula, R represents a straight or branched alkyl group or alkenyl group having 26 to 36 carbon atoms.) (ii)
Dihydroxyethylalkylamine oxide represented by the general formula (B) ▲ Numerical formulas, chemical formulas, tables, etc. are available ▼ (B) (In the formula, R represents a straight or branched alkyl group or alkenyl group having 26 to 36 carbon atoms. )(iii)
Dimethylalkyl polyoxyethylene amine oxide represented by the general formula (C) ▲ Numerical formulas, chemical formulas, tables, etc. are available ▼ (C) (In the formula, R is a straight or branched alkyl group or alkenyl group having 26 to 36 carbon atoms. and n represents an integer from 1 to 5.)