JPH0511908B2 - - Google Patents
Info
- Publication number
- JPH0511908B2 JPH0511908B2 JP62103403A JP10340387A JPH0511908B2 JP H0511908 B2 JPH0511908 B2 JP H0511908B2 JP 62103403 A JP62103403 A JP 62103403A JP 10340387 A JP10340387 A JP 10340387A JP H0511908 B2 JPH0511908 B2 JP H0511908B2
- Authority
- JP
- Japan
- Prior art keywords
- magnesium ions
- magnesium
- cyanoformazane
- elements
- bis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229910001425 magnesium ion Inorganic materials 0.000 claims description 59
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims description 58
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 31
- 229910001424 calcium ion Inorganic materials 0.000 claims description 30
- 238000004458 analytical method Methods 0.000 claims description 24
- 125000001424 substituent group Chemical group 0.000 claims description 21
- 239000002738 chelating agent Substances 0.000 claims description 20
- 239000007788 liquid Substances 0.000 claims description 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 11
- 239000008139 complexing agent Substances 0.000 claims description 10
- 230000001186 cumulative effect Effects 0.000 claims description 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 7
- 230000008859 change Effects 0.000 claims description 6
- 239000000872 buffer Substances 0.000 claims description 5
- AOBOENGQFGWLIJ-UHFFFAOYSA-N 1-cyano-N'-(2-hydroxyanilino)-N-(2-hydroxyphenyl)iminomethanimidamide Chemical compound OC1=CC=CC=C1NN=C(C#N)N=NC1=CC=CC=C1O AOBOENGQFGWLIJ-UHFFFAOYSA-N 0.000 claims description 3
- 230000000536 complexating effect Effects 0.000 claims description 3
- NMSQAWVNRWNLSP-UHFFFAOYSA-N N'-amino-1-cyano-N-iminomethanimidamide Chemical compound NN=C(N=N)C#N NMSQAWVNRWNLSP-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000000691 measurement method Methods 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 description 28
- 108090000623 proteins and genes Proteins 0.000 description 28
- 102000004169 proteins and genes Human genes 0.000 description 28
- OFVKKKJBIUQTNH-UHFFFAOYSA-N N'-amino-N-cyanoiminomethanimidamide Chemical compound NN=CN=NC#N OFVKKKJBIUQTNH-UHFFFAOYSA-N 0.000 description 20
- -1 Hydroxy-substituted cyanoformazane Chemical class 0.000 description 19
- 239000003153 chemical reaction reagent Substances 0.000 description 18
- 238000012360 testing method Methods 0.000 description 15
- 239000012530 fluid Substances 0.000 description 13
- 150000001875 compounds Chemical class 0.000 description 12
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 11
- 239000011777 magnesium Substances 0.000 description 11
- 229910052749 magnesium Inorganic materials 0.000 description 11
- 238000000034 method Methods 0.000 description 10
- 239000010410 layer Substances 0.000 description 9
- 239000000975 dye Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 239000003960 organic solvent Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 6
- 238000010792 warming Methods 0.000 description 6
- 238000003556 assay Methods 0.000 description 5
- 125000004432 carbon atom Chemical group C* 0.000 description 5
- 125000001309 chloro group Chemical group Cl* 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 230000003595 spectral effect Effects 0.000 description 5
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 4
- 238000010668 complexation reaction Methods 0.000 description 4
- 229920002521 macromolecule Polymers 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- 239000002250 absorbent Substances 0.000 description 3
- 230000002745 absorbent Effects 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 239000012876 carrier material Substances 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- CDAWCLOXVUBKRW-UHFFFAOYSA-N 2-aminophenol Chemical group NC1=CC=CC=C1O CDAWCLOXVUBKRW-UHFFFAOYSA-N 0.000 description 2
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 2
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 2
- NXONRGITMLLJDJ-UHFFFAOYSA-N CCCCCCNS(=O)(=O)C1=CC=C(O)C(NN=C(N=NC=2C(=CC=C(C=2)S(=O)(=O)NCCCCCC)O)C#N)=C1 Chemical compound CCCCCCNS(=O)(=O)C1=CC=C(O)C(NN=C(N=NC=2C(=CC=C(C=2)S(=O)(=O)NCCCCCC)O)C#N)=C1 NXONRGITMLLJDJ-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- CWNSVVHTTQBGQB-UHFFFAOYSA-N N,N-Diethyldodecanamide Chemical compound CCCCCCCCCCCC(=O)N(CC)CC CWNSVVHTTQBGQB-UHFFFAOYSA-N 0.000 description 2
- FSVCELGFZIQNCK-UHFFFAOYSA-N N,N-bis(2-hydroxyethyl)glycine Chemical compound OCCN(CCO)CC(O)=O FSVCELGFZIQNCK-UHFFFAOYSA-N 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 239000013060 biological fluid Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 230000023852 carbohydrate metabolic process Effects 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 description 2
- MLIREBYILWEBDM-UHFFFAOYSA-N cyanoacetic acid Chemical compound OC(=O)CC#N MLIREBYILWEBDM-UHFFFAOYSA-N 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 230000005670 electromagnetic radiation Effects 0.000 description 2
- 239000010408 film Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000003365 glass fiber Substances 0.000 description 2
- 239000003673 groundwater Substances 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 230000037356 lipid metabolism Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 239000004745 nonwoven fabric Substances 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 239000013535 sea water Substances 0.000 description 2
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 230000007480 spreading Effects 0.000 description 2
- 125000004964 sulfoalkyl group Chemical group 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000002759 woven fabric Substances 0.000 description 2
- JIVDOFLPGFPRRU-UHFFFAOYSA-N 1-cyano-N'-(3,5-dichloro-2-hydroxyanilino)-N-(3,5-dichloro-2-hydroxyphenyl)iminomethanimidamide Chemical compound OC1=C(Cl)C=C(Cl)C=C1NN=C(C#N)N=NC1=CC(Cl)=CC(Cl)=C1O JIVDOFLPGFPRRU-UHFFFAOYSA-N 0.000 description 1
- JKXYOQDLERSFPT-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-octadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO JKXYOQDLERSFPT-UHFFFAOYSA-N 0.000 description 1
- YJDZXFQBZOLRCX-UHFFFAOYSA-N 5-chloro-3-[2-[[(5-chloro-2-hydroxy-3-sulfophenyl)diazenyl]-cyanomethylidene]hydrazinyl]-2-hydroxybenzenesulfonic acid Chemical compound C1=C(Cl)C=C(S(O)(=O)=O)C(O)=C1NN=C(C#N)N=NC1=CC(Cl)=CC(S(O)(=O)=O)=C1O YJDZXFQBZOLRCX-UHFFFAOYSA-N 0.000 description 1
- SJINHPXZLMIRBX-UHFFFAOYSA-N CCCCCCCCNS(=O)(=O)C1=CC=C(O)C(NN=C(N=NC=2C(=CC=C(C=2)S(=O)(=O)NCCCCCCCC)O)C#N)=C1 Chemical compound CCCCCCCCNS(=O)(=O)C1=CC=C(O)C(NN=C(N=NC=2C(=CC=C(C=2)S(=O)(=O)NCCCCCCCC)O)C#N)=C1 SJINHPXZLMIRBX-UHFFFAOYSA-N 0.000 description 1
- MHXMRYUAUWCQQN-UHFFFAOYSA-N CCCCNS(=O)(=O)C1=CC(Cl)=C(O)C(NN=C(N=NC=2C(=C(Cl)C=C(C=2)S(=O)(=O)NCCCC)O)C#N)=C1 Chemical compound CCCCNS(=O)(=O)C1=CC(Cl)=C(O)C(NN=C(N=NC=2C(=C(Cl)C=C(C=2)S(=O)(=O)NCCCC)O)C#N)=C1 MHXMRYUAUWCQQN-UHFFFAOYSA-N 0.000 description 1
- IUJJDNBEGUFDHI-UHFFFAOYSA-N CCCCNS(=O)(=O)C1=CC=C(O)C(NN=C(N=NC=2C(=CC=C(C=2)S(=O)(=O)NCCCC)O)C#N)=C1 Chemical compound CCCCNS(=O)(=O)C1=CC=C(O)C(NN=C(N=NC=2C(=CC=C(C=2)S(=O)(=O)NCCCC)O)C#N)=C1 IUJJDNBEGUFDHI-UHFFFAOYSA-N 0.000 description 1
- BXOPUGPISHTURA-UHFFFAOYSA-N CCN(CC)S(=O)(=O)C1=CC=C(O)C(NN=C(N=NC=2C(=CC=C(C=2)S(=O)(=O)N(CC)CC)O)C#N)=C1 Chemical compound CCN(CC)S(=O)(=O)C1=CC=C(O)C(NN=C(N=NC=2C(=CC=C(C=2)S(=O)(=O)N(CC)CC)O)C#N)=C1 BXOPUGPISHTURA-UHFFFAOYSA-N 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- PJWWRFATQTVXHA-UHFFFAOYSA-N Cyclohexylaminopropanesulfonic acid Chemical compound OS(=O)(=O)CCCNC1CCCCC1 PJWWRFATQTVXHA-UHFFFAOYSA-N 0.000 description 1
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000010496 Heart Arrest Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
- 229930064664 L-arginine Natural products 0.000 description 1
- 235000014852 L-arginine Nutrition 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 description 1
- MKWKNSIESPFAQN-UHFFFAOYSA-N N-cyclohexyl-2-aminoethanesulfonic acid Chemical compound OS(=O)(=O)CCNC1CCCCC1 MKWKNSIESPFAQN-UHFFFAOYSA-N 0.000 description 1
- YJPSAZIZSRRLKI-UHFFFAOYSA-N NS(=O)(=O)C1=CC=C(O)C(NN=C(N=NC=2C(=CC=C(C=2)S(N)(=O)=O)O)C#N)=C1 Chemical compound NS(=O)(=O)C1=CC=C(O)C(NN=C(N=NC=2C(=CC=C(C=2)S(N)(=O)=O)O)C#N)=C1 YJPSAZIZSRRLKI-UHFFFAOYSA-N 0.000 description 1
- RWVBYOKQVXXAGE-UHFFFAOYSA-N OC1=CC([N+]([O-])=O)=CC=C1NN=C(C#N)N=NC1=CC=C([N+]([O-])=O)C=C1O Chemical compound OC1=CC([N+]([O-])=O)=CC=C1NN=C(C#N)N=NC1=CC=C([N+]([O-])=O)C=C1O RWVBYOKQVXXAGE-UHFFFAOYSA-N 0.000 description 1
- LBSBGQSPFYZNKX-UHFFFAOYSA-N OC1=CC=C(C#N)C=C1NN=C(C#N)N=NC1=CC(C#N)=CC=C1O Chemical compound OC1=CC=C(C#N)C=C1NN=C(C#N)N=NC1=CC(C#N)=CC=C1O LBSBGQSPFYZNKX-UHFFFAOYSA-N 0.000 description 1
- RKYLRPCANWSOQS-UHFFFAOYSA-N OC1=CC=C(Cl)C=C1NN=C(C#N)N=NC1=CC(Cl)=CC=C1O Chemical compound OC1=CC=C(Cl)C=C1NN=C(C#N)N=NC1=CC(Cl)=CC=C1O RKYLRPCANWSOQS-UHFFFAOYSA-N 0.000 description 1
- MEYDFWXBJDNZTQ-UHFFFAOYSA-N OC1=CC=C([N+]([O-])=O)C=C1NN=C(C#N)N=NC1=CC([N+]([O-])=O)=CC=C1O Chemical compound OC1=CC=C([N+]([O-])=O)C=C1NN=C(C#N)N=NC1=CC([N+]([O-])=O)=CC=C1O MEYDFWXBJDNZTQ-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 229920004896 Triton X-405 Polymers 0.000 description 1
- DVQCYCUWIYIYCF-UHFFFAOYSA-N [Mg].NN=CN=NC#N Chemical compound [Mg].NN=CN=NC#N DVQCYCUWIYIYCF-UHFFFAOYSA-N 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 238000006149 azo coupling reaction Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 239000007998 bicine buffer Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 125000001246 bromo group Chemical group Br* 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 150000003857 carboxamides Chemical class 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 239000011247 coating layer Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 125000002993 cycloalkylene group Chemical group 0.000 description 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 229940039227 diagnostic agent Drugs 0.000 description 1
- QHGRPTNUHWYCEN-UHFFFAOYSA-N dioctyl phenyl phosphate Chemical compound CCCCCCCCOP(=O)(OCCCCCCCC)OC1=CC=CC=C1 QHGRPTNUHWYCEN-UHFFFAOYSA-N 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000010840 domestic wastewater Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 230000002550 fecal effect Effects 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 238000001506 fluorescence spectroscopy Methods 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 125000001188 haloalkyl group Chemical group 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000002232 neuromuscular Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000037324 pain perception Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229920003172 poly (isopropyl acrylamide) Polymers 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920005749 polyurethane resin Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 230000022558 protein metabolic process Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000001055 reflectance spectroscopy Methods 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 201000004193 respiratory failure Diseases 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical group [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
- 235000010288 sodium nitrite Nutrition 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000003335 steric effect Effects 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000002235 transmission spectroscopy Methods 0.000 description 1
- 125000004385 trihaloalkyl group Chemical group 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/525—Multi-layer analytical elements
- G01N33/526—Multi-layer analytical elements the element being adapted for a specific analyte
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Description
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US857219 | 1986-04-29 | ||
| US06/857,219 US4753890A (en) | 1986-04-29 | 1986-04-29 | Analytical element and method for determination of magnesium ions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62261064A JPS62261064A (ja) | 1987-11-13 |
| JPH0511908B2 true JPH0511908B2 (ja) | 1993-02-16 |
Family
ID=25325486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62103403A Granted JPS62261064A (ja) | 1986-04-29 | 1987-04-28 | ãã°ãã·ãŠã ã€ãªã³æž¬å®çšåæèŠçŽ ããã³æ¹æ³ |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4753890A (ja) |
| EP (1) | EP0244197B1 (ja) |
| JP (1) | JPS62261064A (ja) |
| CA (1) | CA1290659C (ja) |
| DE (1) | DE3776395D1 (ja) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008537144A (ja) * | 2005-04-19 | 2008-09-11 | ã¹ãã·ã£ã«ãã£ãŒ ã¢ãã»ã€ãºïŒã€ã³ã³ãŒãã¬ãŒããã | åæè©Šæäžã®ã«ã«ã·ãŠã ããã°ãã·ãŠã ããã³ãããªãŠã ã®å®éã«ãã¹ãããŸïœïœïœãçšããæ¹æ³ |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4647525A (en) * | 1984-10-01 | 1987-03-03 | Minnesota Mining And Manufacturing Company | Stabilized leuco phenazine dyes and their use in an imaging system |
| US5215925A (en) * | 1986-04-29 | 1993-06-01 | Eastman Kodak Company | Method and composition for magnesium ion detection using hydroxy-substituted cyanoformazans |
| US5126271A (en) * | 1991-07-16 | 1992-06-30 | James W Harasymiw | Method for determining the consumption rate of alcohol by a human subject |
| WO1993008684A1 (en) * | 1991-10-28 | 1993-05-13 | Steinman Gary D | Process and device for measuring magnesium in biological fluids and method of preparing the device |
| US5340804A (en) * | 1991-11-14 | 1994-08-23 | Eli Lilly And Company | 1,5-diphenyl-3-formazancarbonitril parasiticides |
| US5914271A (en) * | 1996-04-19 | 1999-06-22 | Actimed Laboratories, Inc. | Fertility test |
| FR2801596B1 (fr) | 1999-11-26 | 2004-12-03 | Atofina | Polyesters thermoplastiques a proprietes choc ameliorees et compositions de modifiants choc |
| FR2801597B1 (fr) | 1999-11-26 | 2005-03-11 | Atofina | Compositions de polyesters thermoplastiques a proprietes choc ameliorees |
| FR2801598B1 (fr) | 1999-11-26 | 2005-03-11 | Atofina | Compositions de polyesters thermoplastiques a proprietes choc ameliorees |
| US6736420B2 (en) | 2000-03-03 | 2004-05-18 | Jost International Corporation | Carrier assembly for a fifth wheel |
| US6790666B2 (en) * | 2001-12-28 | 2004-09-14 | Nalco Company | Method to ascertain whether soluble hardness is calcium or magnesium based |
| EP2553469B1 (en) * | 2010-03-30 | 2015-01-14 | Roche Diagniostics GmbH | Method for measurement of calcium ions |
| US9284448B2 (en) | 2011-04-14 | 2016-03-15 | Ticona Llc | Molded reflectors for light-emitting diode assemblies |
| US9062198B2 (en) | 2011-04-14 | 2015-06-23 | Ticona Llc | Reflectors for light-emitting diode assemblies containing a white pigment |
| US9453119B2 (en) | 2011-04-14 | 2016-09-27 | Ticona Llc | Polymer composition for producing articles with light reflective properties |
| JP5923183B2 (ja) | 2011-12-30 | 2016-05-24 | ãã£ã³ãã»ãšã«ãšã«ã·ãŒ | çºå ããã€ã¹çšã®åå°æ¿ |
| WO2014099745A1 (en) | 2012-12-18 | 2014-06-26 | Ticona Llc | Molded reflectors for light-emitting diode assemblies |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3663525A (en) * | 1968-11-06 | 1972-05-16 | Du Pont | Preparation of copper formazyl dyes |
| US4132528A (en) * | 1978-01-03 | 1979-01-02 | Eastman Kodak Company | Analytical element for the analysis of liquids under high pH conditions |
| US4383043A (en) * | 1981-07-13 | 1983-05-10 | American Monitor Corporation | Magnesium assay with calmagite or eriochrome black T reagents |
| JPS5853758A (ja) * | 1981-09-28 | 1983-03-30 | Wako Pure Chem Ind Ltd | ãã°ãã·ãŠã 枬å®è©Šè¬ |
-
1986
- 1986-04-29 US US06/857,219 patent/US4753890A/en not_active Expired - Lifetime
- 1986-11-26 CA CA000523820A patent/CA1290659C/en not_active Expired - Lifetime
-
1987
- 1987-04-28 JP JP62103403A patent/JPS62261064A/ja active Granted
- 1987-04-28 DE DE8787303729T patent/DE3776395D1/de not_active Expired - Lifetime
- 1987-04-28 EP EP87303729A patent/EP0244197B1/en not_active Expired - Lifetime
Non-Patent Citations (1)
| Title |
|---|
| CHEMICAL ABSTRACTS=1983 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008537144A (ja) * | 2005-04-19 | 2008-09-11 | ã¹ãã·ã£ã«ãã£ãŒ ã¢ãã»ã€ãºïŒã€ã³ã³ãŒãã¬ãŒããã | åæè©Šæäžã®ã«ã«ã·ãŠã ããã°ãã·ãŠã ããã³ãããªãŠã ã®å®éã«ãã¹ãããŸïœïœïœãçšããæ¹æ³ |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0244197B1 (en) | 1992-01-29 |
| US4753890A (en) | 1988-06-28 |
| JPS62261064A (ja) | 1987-11-13 |
| CA1290659C (en) | 1991-10-15 |
| DE3776395D1 (de) | 1992-03-12 |
| EP0244197A1 (en) | 1987-11-04 |
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