JPH05170603A - Dermatic external preparation composition - Google Patents

Abstract

(57) [Summary] [Object] An object of the present invention is to provide a skin external preparation composition having excellent durability of pest repellent effect. [Structure] Mixing and blending diethyltoluamide with one or more compounds selected from a benzophenone derivative, a cinnamic acid derivative, a paraaminobenzoic acid derivative, a salicylic acid derivative, a dibenzoylmethane derivative, and a benzimidazole derivative. A characteristic external preparation composition for skin.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin external preparation composition having excellent persistence of the pest repellent effect of diethyltoluamide.

[0002]

BACKGROUND OF THE INVENTION Diethyltoluamide is widely used as a pest repellent for protecting oneself from pests such as mosquitoes. However, although this diethyltoluamide has a high repellent effect,
The effect was lacking in sustainability and further improvement was required. Therefore, an object of the present invention is to provide a skin external preparation composition having excellent sustainability of repellent effect.

[0003]

SUMMARY OF THE INVENTION In view of the above circumstances, the inventors of the present invention have conducted extensive studies to improve the durability of diethyltoluamide, and as a result, diethyltoluamide, and further benzophenone derivatives, cinnamic acid derivatives, and paraaminobenzoic acid derivatives have been developed. The present invention has been completed by discovering that the sustainability of the effect is enhanced by combining and combining one or more compounds selected from salicylic acid derivatives, dibenzoylmethane derivatives and benzimidazole derivatives, and completed the present invention.

That is, the present invention relates to diethyltoluamide and
A skin external preparation composition comprising a combination of one or more compounds selected from benzophenone derivatives, cinnamic acid derivatives, paraaminobenzoic acid derivatives, salicylic acid derivatives, dibenzoylmethane derivatives, and benzimidazole derivatives. Is.

The diethyltoluamide used in the present invention has been conventionally used as a pest repellent, and is widely used as a reagent or an industrial raw material. The blending amount varies depending on the formulation of the final composition and the use conditions, but is 0.01 to 9 based on the total amount of the final composition.
It is used in an amount of 0.0% by weight, preferably 1 to 20% by weight.

The benzophenone derivative used in the present invention includes 2-hydroxy-4-methoxybenzophenone and 2-hydroxy-4-methoxybenzophenone-5.
-Sulfonic acid and its salts, 2,2'-dihydroxy-
4-methoxybenzophenone, 2,4-dihydroxybenzophenone, 2,2 ', 4,4'-tetrahydroxybenzophenone, 2,2'-dihydroxy-4,4'-
Examples thereof include dimethoxybenzophenone and 2-hydroxy-4-octoxybenzophenone.

As the cinnamic acid derivative used in the present invention, p-methoxycinnamic acid 2-ethylhexyl ester, p-methoxycinnamic acid diethanolamine salt, di-
P-methoxycinnamic acid-glyceryl mono-2-ethylhexanoate and the like can be mentioned.

The para-aminobenzoic acid derivative used in the present invention is 4-bis- (2-hydroxypropyl).
-Aminobenzoic acid ethyl ester, p-aminobenzoic acid 1,2,3-propanetriol ester, p-dimethylaminobenzoic acid octyl ester, p-aminobenzoic acid and the like can be mentioned.

The salicylic acid derivative used in the present invention includes salicylic acid 2-ethylhexyl ester, salicylic acid 3,3,5-trimethylcyclohexyl ester,
Examples include salicylic acid triethanolamide.

Examples of the dibenzoylmethane derivative used in the present invention include 1-p-cumenyl-3-phenylpropane-1,3-dione and 4-t-butyl-4'-methoxydibenzoylmethane.

The benzimidazole derivative used in the present invention is 2-phenyl-benzimidazole-5.
-Sulfonic acid and its salts are mentioned.

The benzophenone derivative, the cinnamic acid derivative, the paraaminobenzoic acid derivative, the salicylic acid derivative, the dibenzoylmethane derivative and the benzimidazole derivative used in the present invention may be blended in one or two or more types depending on the formulation and use of the final composition. Although it depends on the conditions, it is in the range of 0.001 to 20.0% by weight, preferably 1 to 15% by weight, based on the total amount of the final composition.

The external preparation for skin of the present invention is used in the form of ointments, creams, emulsions, lotions, perfumes, colognes, sprays and the like.

The external preparation for skin of the present invention may contain other bases and additives depending on the dosage form within the range in which the object of the present invention is achieved.

[0015]

EXAMPLES The present invention will be described in detail below with reference to examples.
In the examples, wt% means wt%.

Prior to the examples, the test method for pest repellent effect and its persistence will be described. (Blood-feeding repellent test for adult Aedes albopictus) In order to investigate the repellent effect of Aedes albopictus on adults, the following test was conducted in a thermostatic chamber at room temperature of 30 ° C. and humidity of 70%.
After applying 10 g of each sample to the left and right forearms, 5-7 after emergence
Each arm was inserted into a 20 cm × 15 cm wire net containing 50 adult male and female Aedes albopictus for 15 minutes to allow blood feeding. 30 minutes for this enforcement, 1
The test was performed after 2 hours, 4 hours, and 6 hours, and the number of blood-sucking traces within the time of blood-sucking was counted, and the repellency rate was calculated from Equation 1.

[Equation 1] X: Number of blood-sucking traces when test liquid was not applied Y: Number of blood-sucking traces when test liquid was applied

Example 1 The cream of the present invention was prepared according to a conventional method according to the formulation shown in Table 1, and a blood-sucking repellent test against adult Aedes albopictus was conducted. The results are shown in Table 4.

[0018]

[Table 1]

Comparative Example 1 A cream for comparison having the formulation shown in Table 2 was prepared by a conventional method, and a blood-sucking repellent test against adult Aedes albopictus was carried out. The results are shown in Table 4.

[0020]

[Table 2]

Comparative Example 2 A cream for comparison having the formulation shown in Table 3 was prepared according to a conventional method, and a blood-sucking repellent test against adult Aedes albopictus was conducted. The results are shown in Table 4.

[0022]

[Table 3]

[0023]

[Table 4]

As shown in Table 4, the first embodiment of the present invention is
Even after 6 hours from application, the repellent effect did not decrease, and it was excellent. On the other hand, Comparative Example 1 containing only diethyltoluamide
Had a remarkable effect up to 30 minutes, but the effect was lost over time. In addition, Comparative Example 2 in which diethyltoluamide was not added did not show any repellent effect.

Example 2 A lotion was prepared according to the conventional method according to the formulation shown in Table 5, and a blood-sucking repellent test was conducted on adults of Aedes albopictus.

[0026]

[Table 5]

Example 3 Colons were prepared according to the conventional method according to the formulations shown in Table 6, and a blood-sucking repellent test was conducted on adults of Aedes albopictus.

[0028]

[Table 6]

Example 4 A milky lotion was prepared according to a conventional method according to the formulation shown in Table 7, and a blood-sucking repellent test against adult Aedes albopictus was conducted.

[0030]

[Table 7]

Example 5 Ointments having the formulations shown in Table 8 were prepared by a conventional method, and a blood-sucking repellent test against adult Aedes albopictus was conducted.

[0032]

[Table 8]

Example 6 A cream was prepared according to the conventional method according to the formulation in Table 9, and a blood-sucking repellent test against adult Aedes albopictus was conducted.

[0034]

[Table 9]

Table 10 shows the results of the blood-sucking repellent test for adults of Aedes albopictus of Examples 2 to 6. As shown in the table,
Examples 2 to 6 of the present invention were excellent in repellent effect even 6 hours after application.

[0036]

[Table 10]

[0037]

INDUSTRIAL APPLICABILITY As described above, according to the present invention, diethyltoluamide, a benzophenone derivative, a cinnamic acid derivative,
A skin external preparation composition having excellent persistence of pest repellent effect by blending in combination with one or more compounds selected from para-aminobenzoic acid derivative, salicylic acid derivative, dibenzoylmethane derivative and benzimidazole derivative. It is clear to provide.

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Claims (1)

[Claims] 1. Diethyltoluamide, a benzophenone derivative, a cinnamic acid derivative, a paraaminobenzoic acid derivative,
A skin external preparation composition comprising a combination of one or more compounds selected from salicylic acid derivatives, dibenzoylmethane derivatives and benzimidazole derivatives.