JPH0522865B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION (Technical Field) The present invention relates to an electrolyte measuring device that measures the concentration of a predetermined ion contained in, for example, serum using an ion selective electrode.

(Prior art) In an electrolyte measuring device, a calibration curve is created in advance using multiple standard solutions with known concentrations, and the concentration of the test solution is measured based on the calibration curve. Since the value varies due to changes in temperature, etc., it is necessary to calibrate the calibration curve as necessary.
For calibration of this calibration curve, one standard solution is used and the previously created calibration curve is shifted in parallel according to its output, and the other is to create a new calibration curve using multiple standard solutions. There is. Usually, the former is performed during the measurement of a series of test solutions, and the latter is performed prior to starting the measurement of the series of test solutions.

Therefore, an electrolyte measuring device has been proposed in which one standard solution is built-in and selectively supplied to a measuring section including an ion selection electrode and a reference electrode. In this electrolyte measuring device, another standard solution is manually injected into the measuring section, a calibration curve is created from that standard solution and the built-in standard solution, and the calibration curve created in this way is used as the built-in standard solution. Proofread it.

However, in this conventional electrolyte measurement device, when creating a calibration curve, it is necessary to manually inject other standard solutions into the measurement section.
The operation is troublesome and time-consuming, and if there is a temperature difference between the other standard solutions to be injected and the built-in standard solution, the slope of the calibration curve will change, making accurate measurements impossible.

(Objective of the Invention) The object of the present invention is to eliminate the above-mentioned drawbacks, to be able to always obtain an accurate calibration curve in a short time, and to appropriately measure the desired ion concentration of a test solution with high precision. The purpose of the present invention is to provide an electrolyte measuring device constructed as described above.

(Summary of the Invention) The electrolyte measuring device of the present invention includes a measurement section including an electrode for measuring ion concentration on a flow path of a fluid to be measured, a common introduction path connected to this measurement section, and a common introduction path connected to the measurement section. a plurality of standard fluid flow channels connected to the measuring section via a means for selectively introducing a plurality of standard fluids from the plurality of standard fluid flow channels into the common introduction channel; the measuring section; It is characterized by comprising a common thermostatic case that accommodates a common introduction path and a plurality of standard fluid flow channels, and a means for controlling the temperature inside this thermostatic case.

(Example) Hereinafter, an example of the present invention will be described with reference to the drawings.

FIG. 1 shows the configuration of an example of the electrolyte measuring device of the present invention. The test liquid is injected into an injection port 2 constituting a common introduction path through a sample nozzle 1, and discharged into a waste liquid tank 5 through the common introduction path and a flow cell 4 by operation of a rolling pump 3. The flow cell 4 includes three ion selection electrodes 6a, 6b,
6c, and these ion selection electrodes 6
An electrolytic solution reservoir 8 equipped with a reference electrode 7 is provided in communication with the channels through which the ion-sensitive parts a, 6b, and 6c are exposed, and an electrolytic solution is provided in a flow path connected to the electrolytic solution reservoir 8 through a porous material. Electrolyte 1 stored in tank 9
0 is supplied by operating the rolling pump 11. In this manner, when measuring the test liquid, the test liquid and the electrolytic solution are brought into contact with each other, and the concentrations of three types of ions are measured in the measurement circuit 12 from the outputs of the ion selection electrodes 6a, 6b, and 6c.

On the other hand, the first tank accommodated in the first standard tank 13
The standard solution 14 is temporarily stored in a first standard solution cell 15, and the first standard solution stored in this cell 15 is transferred to the injection port 2 by the operation of the rolling pump 16.
The structure is such that it can be selectively injected. Similarly, the second standard solution 18 contained in the second standard solution tank 17 is temporarily stored in a second standard solution cell 19, and the second standard solution stored in this cell 19 is rolled. It is configured so that it can be selectively injected into the injection port 2 by operating the pump 20.

In this example, the components except for the waste liquid tank 5, electrolyte tank 9, first standard liquid tank 13, and second standard liquid tank 17 are arranged in a common case 21, and the inside of this case 21 is controlled at a constant temperature. . For this purpose, a fan 22 connected to the case 21 and equipped with a heater for supplying hot air into the case 21 is provided, and a temperature sensor 23 is provided inside the case 21, and the output of this temperature sensor 23 is predetermined. The control circuit 24 controls the fan 2 so that it reaches a predetermined value.
Controls the drive of 3.

In this way, in this example, the first standard solution 14 and second standard solution 18 temporarily stored simultaneously are poured into the first standard solution cell 15 and second standard solution cell 19 as needed. The calibration curve is calibrated by selectively supplying it to the flow cell 4 via the inlet and common introduction path.

FIGS. 2, 3, and 4 show Na ions in serum measured by the electrolyte measuring device according to the present invention shown in FIG. 1 and the conventional electrolyte measuring device.
This figure shows a comparison of changes in K ion and Cl ion concentrations due to changes in environmental temperature for three types of serum, each with a high value, a medium value, and a bottom value. As is clear from Figures 2 to 4, in any case, the values measured by the electrolyte measuring device shown in Figure 1, indicated by the solid line, are higher than the values measured by the conventional electrolyte measuring device, indicated by the broken line. Also, the fluctuations due to environmental temperature changes are very small!

In addition, although two types of standard solutions were used in the above-mentioned example, three or more types of standard solutions can also be used in the same manner. Further, the measurement circuit 12, the rolling pumps 3, 11, 16, 20, etc. may be arranged outside the case 21. Further, the temperature control method is not limited to the hot air method, and the temperature of the cell blocks 15 and 19 may be directly controlled by a heater or hot water circulation.

(Effects of the Invention) As described above, according to the present invention, there is provided a measurement section including an electrode for measuring ion concentration, a common introduction path connected to this measurement section, and a common introduction path connected to this measurement section. Since multiple standard fluid flow paths connected to the measuring section are housed in a common constant temperature case and constant temperature control is performed, the standard fluid at a constant temperature is almost unaffected by changes in the environmental temperature. can be selectively and quickly supplied to the measuring section, and can be measured immediately. Therefore, an accurate calibration curve can always be obtained quickly, and the desired ion concentration can always be measured with high precision. be able to.

Furthermore, since a plurality of standard solutions are kept at a constant temperature at the same time in a plurality of standard solution cells, they can be sequentially supplied to the measuring section in a short time.

[Brief explanation of the drawing]

FIG. 1 is a diagram showing the configuration of an example of the electrolyte measuring device of the present invention, and FIGS. 2, 3, and 4 are diagrams for explaining the effects of the present invention. 1... Sample nozzle, 2... Inlet, 3,1
1, 16, 20... Rolling pump, 4... Flow cell, 5... Waste liquid tank, 6a, 6b, 6c
... Ion selection electrode, 7 ... Reference electrode, 8 ... Electrolyte reservoir, 9 ... Electrolyte tank, 10 ... Electrolyte, 12 ... Measurement circuit, 13 ... First standard solution tank, 14 ... ...first standard solution, 15...first standard solution cell, 17...second standard solution tank, 18...
...Second standard solution, 19...Second standard solution cell, 2
1... Case, 22... Fan, 23... Temperature sensor, 24... Control circuit.

Claims (1)

[Claims] 1. A measuring section equipped with an electrode for measuring ion concentration on the flow path of the test fluid, a common introduction path connected to this measuring section, and a plurality of standards connected to the measuring section via this introduction path. a fluid channel, a means for selectively introducing a plurality of standard fluids from the plurality of standard fluid channels into the common introduction channel, the measuring section, the common introduction channel, and a plurality of standard fluid channels. 1. An electrolyte measuring device comprising: a common constant-temperature case that houses the constant-temperature case; and means for controlling the temperature inside the constant-temperature case.