JPH05232123A - Automatic analyzer for clinical inspection - Google Patents

Abstract

(57) [Summary] [Purpose] A single analysis is performed for multiple types of data measurement and comprehensive determination, and abnormal data caused by a patient's disease is detected separately from abnormal data caused by a device abnormality. [Structure] A cross-check logic between items of a plurality of types is input from a keyboard 9 of an operation unit. A plurality of types of samples of the same patient are set at a predetermined position of one sample rack with a bar code label of a patient ID number, and the rack is set in the rack storage section 2A,
Have the barcode read during transportation. After that, the data measured in the analysis unit is transferred to the memory in the operation unit 5CPU 8 and temporarily stored, and the patient from the specimen in which all the measurement data of plural types of items necessary for the check by the above-mentioned logic are gathered Call measurement data by number and perform check.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to an automatic analyzer for clinical examination.

[0002]

2. Description of the Related Art Conventionally, in clinical tests of biochemistry, all data measured by an automatic analyzer have been manually checked. However, today, with the rapid improvement in processing capacity of automatic analyzers, it has become possible to measure the data of a large amount of specimens, and it has become impossible for humans to perform all the data check processing. Therefore, it has become an indispensable problem to reduce the load of the data check work of the inspection engineer and to automate the process.

In the conventional automatic analyzer, Japanese Unexamined Patent Application Publication No. 2-24056
As shown in No. 9, the following three-step data check is performed.

1. Device alarm check according to the alarm generated and detected by the automatic analyzer.

2. Reaction process check, which is checked by the change in absorbance data during the reaction for each item.

3. Cross-check between items using the correlation between multiple items.

This three-step check was performed to detect an abnormality in the data, and a reinspection instruction was sent to the analysis section. As a result, detection of abnormality, determination of re-examination, and instruction are performed in real time.

[0008]

In the above-mentioned prior art, although the abnormal data due to the abnormality of the device can be detected, the abnormal data due to the disease of the patient is regarded as the abnormal data due to the abnormality of the device. It was impossible to detect them separately. Moreover, it was difficult to detect abnormalities in the data by using only the analysis result of the serum or the analysis result of the urine alone. Humans such as inspection technicians check a plurality of types of data and comprehensively judge the data.

An object of the present invention is to measure multiple types of data,
Another object of the present invention is to provide an automatic analyzer for clinical examination, which has a function of performing comprehensive determination and detecting abnormal data caused by a patient's disease by distinguishing it from abnormal data caused by the abnormality of the device. ..

[0010]

In order to solve the above-mentioned object, a plurality of types of samples, for example, serum, urine, etc.
Can be set in the same rack 1 to identify multiple types,
Also, a sample number identification mechanism is provided. Further, a sample transfer section 2B for transferring the rack to the analysis section is provided.

The operation unit 5 CPU 8 is provided with a memory for storing a plurality of types of data and a logical operation unit for checking the data according to a specified logical expression, and a plurality of types of data are combined and checked externally. A logic input unit 9 is provided for inputting a logical expression. The features of the present invention are, in an automatic analyzer for clinical examination, a sampling mechanism capable of setting a plurality of types of samples at one time, measuring a plurality of types of samples for one patient, and combining the data. By having a computer that determines device abnormality and patient abnormality, and the input function of the logic that combines and checks items, cross-checks between items across multiple sample types can be performed, and abnormalities caused by diseases can be performed. Data
It is possible to detect the abnormal data caused by the device separately.

[0012]

[Function] The rack 31 for setting the sample,
The holes 32 for a plurality of sample sets are provided so that a plurality of sample containers can be set. This rack has a bar code label 3 for identifying patient specimens.
3 or a hole for identifying the number is set.

Further, the sample rack 1 is connected to a sampler which is transported to the analysis section and a transport section 2B of the sampler,
It is provided with a patient ID number detection mechanism 3 for detecting a patient number of a rack passing therethrough, and a memory in the operation unit 5CPU 8 in which data for each patient measured by the analysis unit is sequentially stored. A plurality of types of measurement data of the same patient can be collectively called from this memory by designating a patient number.

In the operation unit 5, logic for checking data is input from the keyboard 9. These logics can be entered by the operator. In the arithmetic processing, when the data of a certain patient is extracted, various types of data of the patient are collected and ordered at once. This data is checked according to the input logic. This check logic is composed of a check logic formula that extends over each type, and performs a check on a sample for which all measurement data for each type is complete. As a result of the check, a judgment is made on the sample in which a contradiction is found, and the instruction for the retest is issued by the analysis unit CPU.
4. Request the re-inspection to the rack transport system 2B.

[0015]

Embodiments of the present invention will be described below with reference to the drawings.

FIG. 1 shows the internal structure of the automatic analyzer.
FIG. 2 shows the overall flow.

The automatic analyzer comprises an analysis section and a rack storage section 2.
A, sample transport unit 2B, bar code reader 3,
The operation unit 5 includes a CRT 6, a printer 7, a CPU 8, and a keyboard 9.

First, when executing the data check, the cross-check logic between items that is divided into a plurality of types is input from the keyboard 9 of the operation unit 5 and the data check execution mode is set.

Next, a plurality of types of samples for one patient are placed in respective sample containers and set in the same rack 31 at predetermined positions as shown in FIG. At this time, a bar code label 33 showing the patient's ID number is attached to the rack.
Then, they are collectively set in the rack storage section 2A and the analysis is started. The rack is transported to the sample transport unit 2B, and in the process, the barcode reader 3 reads the patient ID number.

After that, the rack is automatically positioned at the sampling position and the measurement is started. After the measured data is sent to the CPU 4 of the analysis unit and analyzed, the data of the operation unit
It is sent to the memory in the CPU 8 and temporarily stored.

For a sample in which the measurement data of a plurality of types of items required for data check are all collected, the measurement data is called from the memory by the patient number, and the data check is sequentially executed according to the above logic. The result is a CRT,
And output to a printer. It is also stored in the memory.

Next, an example of the determination process will be shown.

The data analyzed by the CPU of the analysis unit 4 and stored in the memory of the operation unit 5 CPU 8 is
It is checked by the logic input to the arithmetic processing unit in 8. The measurement data for one patient is called by using the patient ID number as an index, and the data of the plurality of types is checked by the following method.

First, FIG. 4 shows an embodiment of the present invention. This is a method of checking and determining a plurality of types of data collected from the same patient according to a cross-check logic between items across a plurality of types. A specific example is shown in FIG.

FIG. 5 shows a combination of serum CRE (creatinine) concentration, BUN (urea nitrogen) concentration, and urine CRE concentration, and the data is checked according to a logic using an algorithm. The judgment is made in the following cases.

When both CRE concentrations in serum and urine are abnormal, it is determined that the CRE concentration is abnormal due to renal disease.

When only one of the data of serum and urine is abnormal, it is considered to be an error in measurement, and CR in the serum sample is considered.
Retest is determined to be required for CRE in E, BUN and urine samples.

When the serum and urine CRE levels are both normal, the serum BUN level is confirmed, and when the levels are also normal, the patient is regarded as normal. Also, in serum
If the BUN concentration is abnormal, it is considered to be an error during measurement, and it is determined that CRE and BUN in the serum sample and CRE in the urine sample need to be retested.

FIG. 6 shows another embodiment of the present invention. In this method, the analysis results of a plurality of types collected from the same patient are individually checked according to the cross-check logic input for each type, and further the respective determination results are comprehensively determined according to the final logic. A specific example is shown in FIG.

FIG. 7 shows creatinine, uric acid, urea, and sodium ions in blood when performing a functional test of the kidney.
Not only the concentration of potassium ion and chloride ion, but also creatinine, uric acid, urea and sodium ion in urine,
Compare potassium ion and chloride ion concentrations. First,
Cross-check between items separately for serum and urine according to an algorithm that uses the correlation between items. The serum check algorithm in this case is shown in FIG. 8 as an example. Next, the respective determination results thus obtained are collated to determine the data. When both the serum and urine renal function check results are normal, the patient is normal, and when both are abnormal, the patient is judged to be abnormal due to a disease. However, when it is determined that the check result in either serum or urine is abnormal,
It is considered that some kind of error occurred in the process from collecting the sample from the patient to obtaining the measurement data, and re-examination is required for all items related to the data check regardless of the patient's presence or absence of disease.

[0031]

As described above in detail, according to the present invention, it becomes possible to directly detect the abnormality of the patient by distinguishing the abnormality of the patient and the abnormality of the device.

[Brief description of drawings]

FIG. 1 is a diagram showing an internal configuration of an automatic analyzer.

FIG. 2 is a diagram schematically showing a series of flows of the present invention.

FIG. 3 is a diagram showing a rack in which a plurality of types of samples for one sample are set.

FIG. 4 is a diagram showing an example of a determination algorithm of measurement data.

5 is a flowchart of the specific example of FIG. 4. FIG.

FIG. 6 is a diagram showing an example of a determination algorithm of measurement data.

FIG. 7 is a flowchart of the specific example of FIG.

8 is a flowchart showing cross-check between items of renal function in a serum sample in the flowchart of the example of FIG.

[Explanation of symbols]

DESCRIPTION OF SYMBOLS 1 ... Sample rack, 2A ... Rack storage part, 2B ... Sample conveyance part, 3 ... Bar code reading device, 4 ... Analysis part CPU, 5 ... Operation part, 6 ... CRT, 7 ... Printer, 8 ...
Operation unit CPU, 9 ... Keyboard, 31 ... Sample rack, 32 ... Sample container insertion unit, 33 ... Bar code label.

Claims (4)

[Claims] 1. An automatic analyzer for clinical examination, which is capable of measuring concentration data of a plurality of items requested to be analyzed for a sample collected from a patient, sets a plurality of types of samples at once. A sampler mechanism capable of measuring, a sample of a plurality of sample types of the same patient, a result is checked according to a specified check logic, a device abnormality and a patient's pathological condition abnormality are determined, and a check logic. An automatic analyzer for clinical tests, which has the input function of. 2. The method according to claim 1, wherein the analysis result of the serum of the same patient and the analysis result of the urine are checked in accordance with the designated check logics, thereby determining the normality / abnormality of the data and determining the serum determination result. An automatic analyzer for clinical examination, which is characterized by further performing a check according to a specified check logic based on a result of urine determination to detect / determine a pathological condition abnormality of a patient. 3. The automatic analyzer for clinical examination according to claim 1, which has a function of generating a comment on the judged result. 4. The automatic analyzer for clinical examination according to claim 1, wherein a re-examination is instructed to the analysis unit according to the determination result.