JPH0525846B2 - - Google Patents

Description

[Detailed description of the invention]

[Industrial Application Field] The present invention relates to a novel hair nourishing agent containing a hyaluronic acid-protein complex and a placenta extract as essential components. That is, the object of the present invention is to provide a hair nourishing agent that has excellent hair nourishing and hair growth effects that enhance and normalize the functions of the hair and scalp, and also provides moisturizing properties to the hair and scalp, making them healthy. It's about doing. [Prior Art] Various hair tonics have been conventionally used for the prevention and treatment of alopecia. There are various symptoms of alopecia, and the causes and mechanisms of hair loss are still largely unknown. When alopecia is viewed comprehensively, some kind of abnormality is recognized in the area. Therefore, hair tonics include various drugs that have the effect of preventing or suppressing these, such as keratolytic disinfectants that act on the keratin and epidermis, anti-inflammatory agents such as salicylic acid, resorcinol, and glycyrrhizic acid, as well as hair matrix and Mononitroguaiacol, a cell activator that acts on the surrounding environment, pantothenic acid derivatives, female hormones, amino acids, etc.
It also contains peripheral vasodilation and blood circulation promoters such as carpronium chloride, Jasperia japonica extract, raysogen, and vitamin E. Hair tonics are effective when applied externally by preventing or suppressing dandruff, itching, and hair loss, and by promoting hair growth and growth, but they have not yet been fully satisfactory. do not have. By the way, placenta extract has an activating effect on the skin, and is used as a skin treatment agent for cuts, burns, etc. because of its ability to promote wound repair.
It is used for cosmetic purposes such as treating pigmentation such as spots and freckles, preventing skin aging, and preventing rough skin. In addition, when applied to the hair and scalp, it activates the cell functions of the scalp and hair roots and harmonizes the functions, correcting the flow of keratin on the scalp and promoting hair growth [Dr.Kurt Richter GmbH: Kosm-Parf ---
Drog-Rundschau Nr.7-8, 115-116 (1959)]
It is also known that On the other hand, hyaluronic acid has been researched to be incorporated into cosmetics from the viewpoint of skin protection by taking advantage of its excellent water-retaining ability, and also has the ability to penetrate the skin, stably revitalize tissues, and dilate peripheral blood vessels. It improves blood circulation, stimulates intermediate metabolism, enhances the supply of nutrients and excretion of waste products, makes skin tissues healthy, improves complexion, and improves texture (Tokuko Sho 33)
-500) has become publicly known. However, there are not many known examples of the effective use of hyaluronic acid in hair nourishing products based on its cell activating effect and water retention properties. [Problems to be Solved by the Invention] Various conventional hair nourishing agents are known as described above, but none have been found to be fully satisfactory as they are inferior in substantial hair nourishing and hair growing effects. Furthermore, placenta extract is also known as an important hair nourishing agent, but when used alone in makeup, it does not have sufficient hair nourishing and hair growth effects, and when added in large amounts, it causes stickiness, making it undesirable for use. . In view of the above-mentioned problems, the present invention takes into consideration the fact that the effects of conventional hair tonics are not satisfactory, and significantly solves the problem. [Means for Solving the Problems] In order to obtain a hair nourishing agent that has an unprecedented hair nourishing effect, the present inventors conducted intensive research on various hair nourishing agents, and as a result, they discovered that a hyaluronic acid-protein complex and a placenta extract were combined into a hair nourishing agent. They discovered that an extremely excellent hair-nourishing effect can be obtained by using them together, and based on this knowledge, they completed the present invention. That is, an object of the present invention is to provide a hair nourishment that is characterized by essentially containing a hyaluronic acid-protein complex and a placenta extract, and is excellent in hair nourishing and hair growth effects. The configuration of the present invention will be explained below. The placenta extract essential to the present invention is human,
Those obtained from the placenta of cows, pigs, sheep, etc. by conventional methods can be used, and the extraction method, purification method, and processing method are not limited. The amount of the placenta extract used in the present invention is 0.01 to 10 parts by weight, and is effective within this range. The hyaluronic acid-protein complex essential to the present invention is obtained by extracting and purifying the umbilical cord, chicken crest, animal skin, eyeball vitreous body, etc. after washing with water and crushing it at low temperature without enzymatic decomposition. It is an extract or powder, and contains a hyaluronic acid-protein complex as the main component. The amount of the hyaluronic acid-protein complex used in the present invention is 0.001 to 3% by weight, and is effective within this range. Incidentally, although the hyaluronic acid-protein complex is particularly effective in the hair nourishment of the present invention, prior to the present invention, the effectiveness of various hyaluronic acid-related substances was also studied at the same time. Hyaluronic acid-related substances are derived from natural products [for example, those disclosed in Japanese Patent Publication No. 33-500, Japanese Patent Publication No. 51-11178, and Japanese Patent Publication No. 56-158706], those extracted by culturing microorganisms, synthetic products, That is, there are different sources, extraction methods, purification methods, etc., as well as hyaluronic acid salts such as sodium, potassium, and basic amino acid salts. It has also been found that these also exhibit good hair-nourishing effects when used in combination with placenta extract. However, in the present invention, when the hyaluronic acid-protein complex is used in combination with placenta extract, it has a more excellent hair-nourishing effect than the hyaluronic acid-free one, and is the most suitable one. Ta. The hair nourishing agent of the present invention has hyaluronic acid-
By using the protein complex and placenta extract together, the excellent cell activating effects and moisturizing properties of these ingredients work together synergistically to promote hair growth and hair growth on the hair and scalp. This is a significant promotion. The hair nourishment base material according to the present invention may be of various types, such as milky lotions, creams, lotions, etc., such as hair tonics, hair liquids, hair lotions, hair creams, hair rinses, shampoos, setting lotions, hair sprays, hair packs, etc. Examples include products for Also, as a hair nourishing base, purified water, alcohols, polyhydric alcohols, oils and fats, surfactants, moisturizers, ultraviolet absorbers, thickeners, pigments, preservatives, fragrances, etc. are usually added to cosmetics. Components can be selected and used as appropriate. Furthermore, in general, resorcinol, which is a medicinal ingredient of hair tonics, keratolytic agents such as salicylic acid, hormones, vitamins such as vitamin E, vitamin E ₂ , etc.
Amino acids, crude drug extracts such as Oriental japonica extract, photosensitive pigments, bactericides, cooling stimulants such as menthol, etc. can be added as appropriate. [Example] Next, the present invention will be further explained by giving examples. These do not limit the present invention in any way. Example 1, Comparative Examples 1 to 3 Hair nourishing agent (hair lotion type) Table 1 shows the formulations of Examples and Comparative Examples. still,
The blending amount is in weight%.

[Table] (Production method) In Example 1, after dissolving (1) to (2) in (3), (4) to (6) were sequentially added and mixed with stirring to obtain a hair nourishing agent. Comparative Examples 1 to 3 were manufactured according to Example 1. Using the hair nourishing agents of Example 1 and Comparative Examples 1 to 3, the hair nourishing effects were measured. The test method is as shown below. Hair growth effect test method Hartley guinea pig (♀), weight 500±11.3
The right and left backs of each guinea pig were dehaired, and the right side was used as a control side without application, and the left side was used as a test side, and 0.1 ml of each of Example 1 and Comparative Examples 1 to 3 was applied.
After applying twice a day for 21 days, 20% of the hair on both sides
The book was removed and the difference in average hair length between the control side and the test side was examined to examine the effect on the growth of the guinea pigs' body length in Example 1. The results are shown in Table 2.

[Table] Total number of animals As is clear from the above results, the hair nourishing agent of Example 1 according to the present invention exhibited an extremely superior hair nourishing effect than that of Comparative Example 1. In particular, although Comparative Examples 1 and 2, in which the hyaluronic acid-protein complex and placenta extract were combined alone in the base, were more effective than Comparative Example 3, the combination of the hyaluronic acid-protein complex and placenta extract was more effective. In Example 1, it is observed that it has a significant effect. Example 2 Hair nourishing agent (hair cream type) (Formulation) (% by weight) (1) Beeswax 1.0 (2) Liquid paraffin 50.0 (3) Stearin 3.0 (4) Sorbitan sesquioleate 2.2 (5) Polyoxyethylene monolaurate Bitane (23E.0.) 1.8 (6) Hyaluronic acid-protein complex 0.2 (7) Placenta extract 0.2 (8) Fragrance 0.2 (9) Methyl paraoxybenzoate 0.1 (10) Purified water Remaining amount (manufacturing method) (6) ~(7) and (9)~(10) are mixed and dissolved, and (1)~
After mixing (5), heat and dissolve and add to emulsify.
After cooling, add (8) to obtain a hair nourishing agent. The hair nourishing agent of Example 2 obtained as above was as follows:
It had an extremely excellent hair-nourishing effect. Example 3 Hair nourishing agent (hair solid type) (Formulation) (% by weight) (1) Liquid paraffin 15.0 (2) Lanolin alcohol 2.1 (3) Polyoxyethylene lauryl ether phosphorus (12E.0) 7.0 (4) Lauric acid Diethanolamide 3.0 (5) Hyaluronic acid-protein complex 0.5 (6) Placenta extract 1.0 (7) Fragrance Appropriate amount (8) Preservative Appropriate amount (9) Purified water Remaining amount (manufacturing method) (5) to (6) and (8) ) to (9) are dissolved, and after mixing (1) to (4), the heated and dissolved mixture is added and emulsified. After cooling, add (7) to obtain a hair nourishing agent. The hair nourishment of Example 3 obtained as above was as follows:
It had an extremely excellent hair-nourishing effect. Example 4 Hair nourishing agent (hair liquid type) (Formulation) (% by weight) (1) Polyoxypropylene butyl ether phosphate (35P.0.) 9.0 (2) Polyoxypropylene monobutyl ether (60P.0.) 10.0 ( 3) Triethanolamine 1.0 (4) Hyaluronic acid-protein complex 0.5 (5) Placenta extract 2.0 (6) Ethanol 30.0 (7) Fragrance appropriate amount (8) Preservative appropriate amount (9) Purified water Remaining amount (manufacturing method) (4 ) ~ (5) is dissolved in (9), then (1) ~ (3) and (6) ~
Add the mixed and dissolved solution of (8), stir and mix to obtain a hair nourishing agent. The hair nourishing agent of Example 4 obtained as above was as follows:
It had an extremely excellent hair-nourishing effect. [Effect] The present invention uses a hyaluronic acid-protein complex and placenta extract as active ingredients in the hair growth material base material, so that the effects of these ingredients, including cell activation and moisturizing properties, are synergistic. Together, hair,
Improves scalp function and normalizes hair growth,
Promotion of hair growth, prevention of hair loss, prevention of dandruff, itching, scalp hair,
The present invention is based on the fact that a hair nourishing agent that has extremely excellent hair nourishing effects such as keeping the scalp healthy has been obtained. That is, the present invention has made it possible to provide a hair nourishing agent that has excellent hair nourishing and hair growing effects that have not been seen before.

Claims (1)

[Claims] 1. A hair nourishing agent containing a hyaluronic acid-protein complex and placenta extract as essential ingredients.