JPH05277155A - Kit for dissolving dry pharmaceutical preparation - Google Patents

Abstract

(57) [Summary] [Purpose] To provide a kit for dissolving a dry preparation, which is easy and quick to dissolve and can be performed aseptically. [Structure] An ampoule 1 filled with a dissolving solution and a communication device 4 of a tubular member, and a transfusion needle 6 having puncture parts at both ends is fixed to one end of the cylinder part of the communication device 4. On the inner circumference of the tubular portion of the communication device 4, an ampoule holding portion 7 that holds the mouth portion of the ampule 1 slidably in the axial direction and a syringe holding portion 8 that fits the tip portion of the syringe.
Are formed.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a kit for dissolving a dry preparation. More specifically, the present invention relates to a dry preparation dissolving kit capable of aseptically preparing dry preparations such as powder preparations, solid preparations and freeze-dried preparations in hospitals and the like.

[0002]

2. Description of the Related Art Conventionally, dry preparations have been dissolved as follows. First, place the ampoule containing the solution and the small vial containing the dried preparation on the desk, aspirate the solution from the ampoule with a syringe, and then inject the solution into the vial and transfer it. The dry formulation is dissolved in the solution. After that, the drug solution in the vial is again sucked with a syringe and used for injection into the human body.

[0003]

However, according to the above-mentioned conventional method, since the suction and injection operation with the syringe has to be repeated, the operation is complicated, and the operation is performed with the ampoule open, so that aseptic operation cannot be performed. There is a problem. In view of such circumstances, an object of the present invention is to provide a kit for dissolving a dry preparation, which is easy and quick to dissolve and can be performed aseptically.

[0004]

The dry preparation dissolving kit of the present invention comprises an ampoule filled with a dissolving solution and a communication device of a tubular member, and one end of the tubular portion of the communication device has: An infusion needle having puncture parts at both ends is fixed, and an ampoule holding part for axially slidably holding the mouth part of the ampoule and a tip of a syringe are provided on the inner circumference of the tubular part of the communication device. It is characterized in that a syringe holding part for fitting the parts is formed.

[0005]

In the present invention, the ampoule holding portion of the communication device is inserted deeply into the mouth of the ampoule, one end of the infusion needle is inserted into the amplifier, and then the other end of the infusion needle contains the dry preparation. Puncture the mouth of the vial. In this state, the solution in the ampoule is transferred into the vial via the transfer needle to dissolve the dry preparation in the vial. Then, the ampoule is taken out, and the tip portion of the syringe is fitted into the syringe holding portion of the communication device. In this state, the dissolved drug solution in the vial is transferred into the syringe through the transfer needle. After filling the syringe with the drug solution, the syringe can be immediately used for injection into the human body or the like by removing the syringe from the communication device. As described above, according to the present invention, the dry preparation can be dissolved by a series of simple operations, and furthermore, the ampoule and the vial can be aseptically carried out in the closed space in which the ampoule and the vial are communicated with each other via the transfer needle.

[0006]

EXAMPLES Next, examples of the present invention will be described. In FIG. 1, reference numeral 1 denotes a plastic ampoule, which is filled with a solution such as physiological saline. This ampoule 1
The mouth portion 2 has a cylindrical shape, and the tip portion 3 thereof is formed as a thin film. Reference numeral 4 denotes a communication device, which is a substantially cylindrical member. One end of the communication device 4 is closed by a wall 5, and a transfusion needle 6 is fixed to the wall 5. The transfusion needle 6 has puncture parts 6a and 6b at both ends.
Is a double-ended needle. The inner circumference of the communication device 4 on the closed side is an ampoule holding part 7, which is a cylindrical surface having an inner diameter into which the mouth part 2 of the ampoule 1 can be slidably inserted. Further, the inner circumference on the opening side is a syringe holding portion 8, which is formed into a tapered cylindrical surface for fitting a tip portion of a known syringe used for injection or the like. Reference numeral 9 is a flange, and 10 is a cap for protecting the infusion needle 6 in an aseptic state.

In the above embodiment, in order to prevent the mouth portion 2 of the ampoule 1 from being contaminated, the diameter of the base side of the ampoule 1 is tapered, and the ampoule 1 is sealed by an O-ring separately provided in the communication device 4. Good. Ampoule 1 for the above dissolution kit
The communication device 4 is shallowly inserted into the mouth of the device, and can be stored and transported without the thin film 3 being punctured by the transfusing needle 6.

Next, a method of using the above dissolution kit will be described. First, as shown in FIG. 2 (I), the communication device 4 is deeply inserted into the mouth 2 of the ampoule 1 as shown by an arrow a, and the thin film 3 at the tip of the mouth 2 is pierced by the transfusing needle 6. Then, the cap 10 is removed as shown in FIG. Next, FIG.
As shown in (III), the rubber stopper 12 at the mouth of the well-known vial 11 containing the dried preparation is punctured by the transfusing needle 6 to connect the ampoule 1 and the vial 11. In this case, vial 11
Is a vacuum bottle, the solution in ampoule 1 will naturally flow into vial 11. When the vial 11 is not a vacuum bottle, the solution can be transferred by pumping the ampoule 1. In this way, when the solution is placed in the vial 11, the dry formulation inside is dissolved and a drug solution is prepared. Next, the ampoule 1 is removed from the communication device 4, and the tip portion 22 of the known syringe 21 for injection is fitted into the syringe holding portion 8 as shown in FIG. Inject the drug solution. After the injection is completed, the communication device 4 is removed from the tip portion 22, and an injection needle or the like for human body injection is fitted into the tip portion 22 and used for injection into the human body or the like.

In the present embodiment, since the dry preparation can be dissolved and injected into the syringe by the above series of operations, the operation is very simple, and the solution or drug solution can be transferred only through the transfer needle 6. Since it is transferred and exposed to the atmosphere, there is an advantage that the dissolution operation can be performed aseptically.

Next, another embodiment of the present invention will be described. In the above embodiment, the space from the flange 9 of the communication device 4 to the transfusing needle 6 was covered with the cap 10, but instead of this, a large cap 31 was used to communicate from the mouth of the ampoule 1 as shown in FIG. The entire device 4 may be covered. In this case, a shoulder 32 may be formed near the root of the mouth 2 of the ampoule 1 so that the cap 31 is fitted slightly tightly so as not to come off unexpectedly. Also, shoulder 32 and cap 31
You may make it insert a sealing material, such as an O-ring, between the inner peripheral surface. Furthermore, in the above-described embodiment, as shown in FIG.
), The rubber stopper 1 of the vial 11 with the transfer needle 6
The puncture to 2 was performed directly, but a known vial guide may be attached to the mouth portion 13 of the vial 11 so that the puncture is performed while guiding the puncturing operation.

[0011]

According to the present invention, the dry preparation can be dissolved and injected into a syringe by a series of operations, so that the operation is very simple and the aseptic dissolution operation can be performed.

[Brief description of drawings]

FIG. 1 is a cross-sectional view of essential parts of a dry preparation dissolving kit according to an embodiment of the present invention.

FIG. 2 (I) is an explanatory diagram of an operation of puncturing the ampoule 1,
(II) is an explanatory view of an operation of removing the cap 10.

FIG. 3 (III) is an explanatory view of the communication operation between the ampoule 1 and the vial 11, and (IV) is an explanatory view of the operation of transferring the dissolved drug solution to the syringe 21.

FIG. 4 is a cross-sectional view of essential parts of a dry preparation dissolving kit according to another embodiment of the present invention.

[Explanation of symbols]

1 ampoule 2 mouth
4 Communication device 6 Transfer needle 7 Ampoule holder
8 Syringe holder

Claims (1)

[Claims] 1. An ampoule filled with a dissolving solution and a communication device of a tubular member, wherein a transfer needle having a puncture part at both ends is fixed to one end of the communication device. ,
On the inner circumference of the tubular portion of the communication device, an ampoule holding portion that slidably holds the mouth portion of the ampoule and a syringe holding portion that fits the tip portion of the syringe are formed. A characteristic kit for dissolving a dry preparation.