JPH0533153Y2 - - Google Patents

Description

[Detailed Description of the Invention] [Industrial Field of Application] The present invention relates to a pharmaceutical bottle for storing two types of drugs that are used in combination.

[Conventional technology]

Many pharmaceutical products are prepared by mixing two different drugs under sterile conditions.

In this invention, medicines refer to humans or livestock,
It refers to drugs used for the treatment, diagnosis, treatment, or prevention of diseases in poultry, and in that it is not limited to diseases in humans, it has a broader meaning than "medicine" as defined in Article 69 of the Patent Act.

When storing two types of drugs, it has conventionally been common practice to store each drug in a bottle and seal the bottle.

When at least one of the above two types of drugs is a liquid, a flip-off cap (abbreviated as FOC) is known which has sealing properties and a sealing function and into which a syringe needle can be inserted. .

[The problem that the idea aims to solve]

Put each of the two types of drugs in separate bottles,
When stored in a sealed container, a. The operation of aseptically mixing the two types of drugs before use is complicated, and especially when an emergency is required, it is laborious and time-consuming.

b) Management is time-consuming because two medicine bottles must be stored and managed as a set.

In particular, if the wrong combination of drugs (in appearance, it is a combination of two types of bottles) is made, an extremely serious situation may occur, and human life may be at stake. There are also problems with the potential for danger and the psychological burden caused by such potential danger.

FIG. 4 is an explanatory diagram of a conventional technique in which liquid A and liquid B stored in two bottles 1 and 2 are mixed using a syringe 3.

Although this conventional technique seems simple, it has various inconveniences.

Furthermore, in addition to the two bottles 1 and 2, there is also a syringe 3.
It is not possible to mix two types of drugs without using . That is, it is necessary to either dispose of one syringe 3 for the mixing operation, or to wash and disinfect the syringe 3.

Moreover, depending on the type of drug being mixed, 2
Some drugs must be left undisturbed for a predetermined period of time after being mixed.Also, in preparation for medical procedures (for example, surgery), two types of drugs may be mixed in advance and prepared for use at any time. Sometimes you have to. In such a case, mixing two types of drugs outside the bottle as in the prior art shown in FIG. 4 not only wastes a lot of time and effort, but also
It is difficult to temporarily store mixed drugs.

In addition, there are further problems as follows. That is,
In Fig. 4, in order to suck up the liquid A in the bottle 1 into the syringe 3, air must be introduced into the bottle 1. air leaks from). This drug is
If it is desired to avoid exposure to air until the mixing is completed, the conventional mixing operation shown in FIG. 4 is extremely difficult.

Also, when air comes into contact with a drug, it means that it becomes contaminated with airborne bacteria, so
You want to limit contact with air as much as possible.

FIG. 5 shows an example of a conventional technique different from the above.

In this conventional example, bin 1 and bin 2 are connected to tube 4.
Connect it with A and B by shaking Bin 1 and Bin 2.
Both liquids are mixed.

In the prior art shown in FIG. 2, the degree to which the drug solution is exposed to air is significantly reduced, but does not reach zero, and the air inside the tube 4 comes into contact with the drug.

Further, the point that the tube 4 must be disposable or sterilized is similar to the conventional example (using a syringe) shown in FIG.

And, as can be easily understood from Figure 5,
If you try to mix liquids A and B by shaking bottles 1 and 2, the capacity of at least one of the bottles must be larger than the sum of the volumes of liquids A and B, and it will be difficult to use an oversized bottle. This increases costs and makes storage inconvenient.

When storing two types of drugs that are not pharmaceuticals, for example, for photographic developers, one lid 5 is shared and a double bottle consisting of an inner bottle 6 and an outer bottle 7 is stored, as shown in FIG. is publicly known. According to this conventional example, when the lid 5 is screwed off from the mouth of the outer bottle 7, the outer bottle 7 is opened and the inner bottle 6 is opened.
It is taken out of the outer bin 7 in the form that it adheres to.

However, bottles like the one shown in FIG. 6 are unbeatable for storing drugs such as pharmaceuticals that must maintain strict sterility, and the drugs cannot be extracted using aseptic operations.

The present invention was developed in view of the above-mentioned circumstances. (i) 2.
(ii) remains strictly isolated from the atmosphere until mixing is completed; and (iii) is not excessive in overall shape or weight; (iv) To provide a composite pharmaceutical bottle in which the mixed drug can be stored aseptically, and (v) the mixed drug can be extracted from the bottle by aseptic operation. With the goal.

[Means to solve the problem]

In order to achieve the above object, the composite pharmaceutical bottle according to the present invention includes a double bottle consisting of an outer bottle and an inner bottle formed in a double cylindrical shape, and a double bottle that is attached to the mouth of the outer bottle. a rubber cap having flexible rubber-like elasticity that seals the outer bottle and is separated from the mouth of the inner bottle when no external force is applied; and a rubber cap that is crimped to the mouth of the outer bottle while covering the rubber cap , a crimping cap having a half-cut groove; a finger piece fixed to a portion of the crimping cap surrounded by the half-cut groove; It is characterized by having a protrusion that can be brought into close contact with the mouth of the person.

[Action]

According to the above configuration, the finger piece is fixed to the crimped cap,
Cover the rubber cap attached to the mouth of the outer bottle,
When the crimped cap is crimped onto the opening of the outer bottle, the protrusion of the finger piece presses the rubber cap to bring it into close contact with the opening of the inner bottle, thereby sealing the inner bottle.

Then, when the force of the fingertip is applied to the finger piece while the crimping cap remains, the half-cut groove of the crimping cap is cut and the finger piece is removed.

When the finger piece is removed, the pressure on the rubber cap by the protrusion is released, and the rubber cap restores its elasticity to release the opening of the inner bottle.

In this way, the inner bottle is opened inside the outer bottle while the opening of the outer bottle is covered with the rubber cap and the inside is kept sealed (blocked from the atmosphere).

This brings about a state in which the medicine in the outer bottle and the medicine in the inner bottle can be mixed.

〔Example〕

FIG. 2 is an exploded sectional view showing an embodiment of the composite medical bottle according to the present invention.

The outer bottle 8a and the inner bottle 8b are arranged in a double cylinder shape, sharing a bottom part.

A rubber cap 9 made of a synthetic resin having flexible rubber elasticity is attached to cover the mouth portion 8a _-1 of the outer bottle 8a. Reference numeral 9a is a flat plate-shaped portion of the rubber cap 9, which can be pierced with an injection needle. 9b is the leg of the rubber cap.

The caulking cap 10 is made of a plastic material (aluminum in this example), and has a cylindrical part 10b that fits into the mouth part 8a _-1 of the outer bottle 8a, and
A ring-shaped half-cut groove 10a and an opening 10c located inside the ring-shaped half-cut groove 10a are provided on the top surface thereof.

In this example, the finger piece is made of thermoplastic synthetic resin and has a disc shape, and is fixed to the opening 10c of the crimping cap 10 by heat crimping 11a.

A protrusion 11b is provided on the inner surface of the finger piece 11.
is provided, and the opening 10 of the caulking cap 10
It protrudes downward from c.

The half-cut groove 10a is a known component of the FOC described above, and is a shearing cut formed intermittently (in the shape of a broken line).

In this state (FIG. 2, pre-assembly state), the inner bottle 8b and the rubber cap plate-shaped portion 9a are separated by a distance d. Put medicine A liquid into the outer bottle 8a.

Although liquid B may be placed in the inner bottle 8b, powder C is placed in this example.

When the cylindrical portion 10b of the crimping cap 10 is fitted onto the opening 8a _-1 of the outer bottle as shown by the arrow j and crimped by applying a force in the direction of the arrow F, the result is as shown in FIG.

10 _b-1 is a caulked portion of the cylindrical portion 10.

The protrusion 11b of the finger piece 11 presses down the plate-shaped portion 9a of the rubber cap 9, bringing it into close contact with the upper end opening of the inner bottle 8b.

If liquid A and powder C are stored in this state (FIG. 1), there is no risk that the two drugs will get mixed up and be replaced with another drug (not shown).

Therefore, storage management is easy and reliability is high.

In this state (Fig. 1), even if the double bottle 8 is accidentally knocked over, there is no risk of it mixing with liquid A because the opening of the inner bottle containing powder C is covered with the rubber cap 9. None.

To mix both drugs (liquid A, powder C),
Hold the outer bottle 8a of the double bottle 8 in the palm of your hand, place the pad of your thumb on the outer periphery of the finger piece 11, and apply force in the direction of arrow f.

Then, the top surface of the caulking cap 10 is torn along the half-cut groove 10a, as shown in FIG. 3.

As a result, the pressure of the rubber cap plate part 9a by the protrusion 11b is released, and the rubber cap plate part 9a is separated from the upper end opening of the inner bottle 8b by elastic restoring force, creating a gap of dimension d.

In this state (FIG. 3), the periphery of the rubber cap 9 is secured to the opening 8 of the outer bottle 8a by the caulking cap 10.
It is closely attached to _a-1 and is blocked from the atmosphere.

When the double bottle 8 is turned upside down and shaken in this state (FIG. 3), both drugs (liquid A and powder C in this example) are not exposed to the atmosphere and are mixed in a sterile state.

It can be easily seen that this mixing operation does not require any auxiliary equipment such as syringes or tubes.

The amount of shaking required to achieve complete mixing varies depending on the properties of the drug and may be determined experimentally in advance.

For example, if water and ethyl alcohol have good mutual solubility, it is sufficient to invert the double bottle 8 and leave it for a while.Also, if powder C is poorly soluble in liquid A, leave it still. Shake thoroughly until no precipitate forms at the bottom.

When the mixing is completed, the central part of the plate-like part 9a of the rubber cap 9 is exposed, as can be easily understood from FIG. can.

When implementing the present invention, the plate-shaped portion 9 of the rubber cap
It is advantageous to provide a recess 9c (see FIG. 3) for inserting an injection needle in a.

Furthermore, as can be easily understood from Figure 3,
After both drugs (solution A, powder C) are mixed, they can be kept in a sterile state until they are used. It is also convenient to store the remaining liquid after using, for example, half the amount.

[Effect of idea]

As explained above, the composite pharmaceutical bottle according to the present invention includes a double bottle made of an outer bottle and an inner bottle formed in a double cylindrical shape, and an outer bottle attached to the mouth of the outer bottle. a rubber cap with flexible rubber-like elasticity that seals the inner bottle and is spaced apart from between the inner bottle when no external force is applied; a crimping cap having a cut groove; a finger piece fixed to a portion of the crimping cap surrounded by the half cut groove; It is equipped with a protrusion that allows it to come into close contact with the body, and (i) 2.
(ii) remains strictly isolated from the atmosphere until mixing is completed; and (iii) is not excessive in overall shape or weight; (iv) The mixed drug can be stored aseptically as it is, and (v) The mixed drug can be extracted from the bottle using aseptic operations, which is an excellent practical effect.

[Brief explanation of the drawing]

Figures 1 to 3 show an embodiment of a composite pharmaceutical bottle according to the present invention, with Figure 1 being a vertical sectional view depicting the state during assembly and storage, and Figure 2 showing the bottle before assembly is completed. An exploded vertical cross-sectional view depicting the state of the device; FIG. 3 is a vertical cross-sectional view for explaining how to use the device. Fourth
FIG. 5 and FIG. 5 are explanatory diagrams of the prior art in the case of storing and mixing two types of pharmaceuticals, respectively. FIG. 6 is a sectional view showing an example of a bottle that is not suitable for storing medicines. 1, 2... bottle, 3... syringe, 4... tube, 5... lid, 6... inner bottle, 7... outer bottle, 8
...Double bottle, 8a...Outer bottle, 8b...Inner bottle, 9...Rubber cap, 9a...Plate-shaped part, 9b
... Leg, 10 ... Caulking cap, 10a ... Half-cut groove, 11 ... Finger piece, 11b ... Protrusion.

Claims (1)

[Claims for Utility Model Registration] A double bottle consisting of an outer bottle and an inner bottle formed into a double cylindrical shape, which is attached to the opening of the outer bottle to seal the outer bottle, and which is not subject to any external force. a rubber cap with flexible rubber-like elasticity that is spaced apart from the mouth of the inner bottle when not in use; a caulking cap having a half-cut groove that covers the rubber cap and is caulked to the mouth of the outer bottle; A finger piece fixed to a portion surrounded by the half-cut groove; and a protrusion provided on the finger piece to press the rubber cap and bring it into close contact with the mouth of the inner bottle. A compound-shaped pharmaceutical bottle characterized by: