JPH0564129B2 - - Google Patents

Description

Claim 1 (a) biotin, (b) vitamin B ₁ , (c) vitamin B ₂ ,
(d) Nicotinamide, (e) Vitamin B ₆ , (f) Vitamin
B ₁₂ , and (g) a rheumatic disease therapeutic agent containing a vitamin group consisting of pantothenic acid, pantothenyl alcohol, or a salt thereof as active ingredients. 2. The rheumatic disease therapeutic agent according to claim 1, further containing minerals and/or trace elements. 3. The therapeutic agent for rheumatic diseases according to claim 1 or 2, further comprising a carrier substance, an antioxidant, and an antibacterial agent. 4 15mg Vitamin B ₁ 15mg Vitamin B ₂ 50mg Nicotinamide 10mg Vitamin B ₆ 25mg Calcium pantothenate 0.15mg Biotin, and 10 μg Vitamin B ₁₂ as described in any one of claims 1 to 3. A treatment agent for rheumatic diseases. Claims 1 to 3 contain 5 15mg vitamin B ₁ 15mg vitamin B ₂ 50mg nicotinamide (PP-factor) 10mg vitamin B ₆ 25mg calcium pantothenate 0.15mg biotin 10μg vitamin B ₁₂ and 500mg vitamin C The rheumatic disease therapeutic agent according to any one of the above. 6 25000I.E. Vitamin A 20mg Vitamin B ₁ 5mg Vitamin B ₂ 50mg Nicotinamide 10mg Vitamin B ₆ 10mg Panthenol 0.25mg Biotin (vitamin H) 5μg Vitamin B ₁₂ 1mg Folic acid 150mg Vitamin C 1000I.E. Vitamin D 10mg Vitamin E 435mg CaHPO ₄・2H ₂ O 10mg Reduced Fe 35.5mg MgHPO ₄・3H ₂ O 2.05mg MnSO ₄・4H ₂ O 3.9mg CuSO ₄・5H ₂ O 2.3mg ZnSO ₄・7H ₂ O 0.25mg Na ₂ MoO ₄・2H ₂ O, and 83.9 mg PO ₄ type phosphorous substance, the therapeutic agent for rheumatic diseases according to any one of claims 1 to 3. Description The present invention relates to a new method of using various vitamins individually or in combination for the long-term treatment and/or prevention of rheumatism, and to a method for the long-term treatment and/or prevention of rheumatism. Rheumatoid arthritis is a widespread disease. In the United States alone, approximately 30 million patients suffer from arthritis. Magazine "Time" No. 33, page 41,
See publication August 16, 1982. Known treatments for rheumatoid arthritis are described in “Rheumatology Bulletin,” Volume 32, No. 1 (1982), page 1, published by the Arthritis Association, 3400 Peachtree Road, NE Atlanta, Georgia 30326. . Drugs that are summarized under the collective concept of vitamins are well known. Professor Hermann Lemp's book “Hemi.
See "Lexicon" by Frank Hetzsier Books, Stawatgart. This book describes how to improve the condition of rheumatoid arthritis by short-term administration of vitamins, as well as by high unit doses and/or so-called large doses of vitamins. “Arthritis and Related Symptoms, Textbook of Rheumatology” Author: Joseph Lee Hollander, MD, 7th edition,
(In Europe) Published by Henry Kimpton, London, 1966, see especially chapter 37, “Diet and Vitamins in Rheumatoid Arthritis” by Ronald W. Lamont Herbers, MD. Surprisingly, however, it has been found that long-term administration of a specific group of vitamins can very effectively treat rheumatic diseases by preventing, reversing, and/or curing them over a long period of time. That is, the present invention provides (a) biotin, (b) vitamin B ₁ , (c) vitamin B ₂ ,
(d) Nicotinamide, (e) Vitamin B ₆ , (f) Vitamin
B ₁₂ , and (g) a group of vitamins consisting of pantothenic acid, pantothenyl alcohol, or salts thereof, as active ingredients. The present invention is useful for the long-term treatment and/or prevention of rheumatic diseases, especially when these are of the inflammatory and degenerative type and occur in the joints, muscles, tendons and other parts of the motor organs. A new method for use in or in combination with the present invention.
Examples of such diseases include arthritis, chronic polyarthritis, primary polyarthritis and general arthritis, especially chronic and/or acute arthritis.The term "polyarthritis" includes these diseases. The collective concept of all possible forms of pathogenesis corresponds here to rheumatoid arthritis, early chronic polyarthritis, osteoarthritis or other types and variants of these diseases, symptoms and syndromes.
Target one of the 100 species. In the following, we will use the general and collective concepts of polyarthritis. Long-term treatment can be carried out in any of the following ways: The main ones are systematic methods, injections, and topical treatments, and the most commonly used of these is oral administration. Drugs that act as rheumatism therapeutics can be administered orally and/or by injection at approximately 0.25 to 2 mg/Kg/body weight per day.
Preferably, 0.5 to 1 mg/Kg/day is prepared and administered, but it is also possible to administer a larger or smaller amount, and the amount can be easily determined by a specialist such as a doctor. When combining vitamins, the amount of each vitamin can be adjusted. Thus, the medicament can be administered as individual doses or in several subpackages. For preferred oral administration, the usual usage forms, such as capsules, sugar-coated tablets or tablets, are conceivable. The manufacture of such dosage forms can be carried out in a conventional manner. In carrying out the use according to the invention, it is necessary to treat the patient according to the invention over a long period of time. The meaning of "long-term" here generally depends on the severity of the disease being treated, the general condition of the patient, and the weight and age of the patient. A specialist can easily determine how long treatment will need to continue until the condition improves or is completely cured. In some cases, daily administration of the drug or combination of drugs can be interrupted for a week or month or more, and then continued at lower doses. It has been found that, depending on the particularities of the individual to be treated, a preferred long-term treatment period is at least 5 months, sometimes at least 6 months, preferably 1 year, and more preferably at least 2 years. It has also been shown that in some cases it is highly advantageous to continue long-term treatment for the entire life of the patient being treated. rheumatic diseases in general, polyarthritis in particular;
Furthermore, in order to cure and/or suppress and/or prevent (prevent) patients with chronic polyarthritis in their early stages, the drug used according to the present invention or the combination of drugs used according to the present invention may be administered over a long period of time. Regular, continuous, daily administration without interruption is highly advantageous. The vitamins or vitamins referred to herein mainly belong to the vitamin B complex, and for the definition of this concept, see, for example, the "hemi-lexicon" mentioned at the beginning. For use according to the invention, the vitamin or combination of vitamins may be supplemented with at least one mineral and/or at least one trace element and/or at least one additive, in particular carrier substances, antioxidants, antioxidants, etc. Combine bacterial agents. Below we list the individual compounds that can be newly used according to the invention, as well as their synonyms, biological precursors (if any) and their chemical symbols. Vitamin A Synonyms: Retinol Axerophthol Antixerophthalmic vitamin Anti-infectious vitamin Epithelial tissue protective vitamin Growth vitamin Biological precursors: α-, β-, γ-carotene Cryptoxanthin (3-hydroxy-β-carotene) Echinenone (4-oxo-β-carotene) Titroxanthin (mutatochrome; β-carotene oxide) Myxoxanthin Torralhodine Afuanine Chemical symbol: All-trans β-carotene All-trans vitamin A ₁ = all-trans-3,
7-dimethyl-9-(2',6',6'-trimethyl-
1'-cyclohexane-1'-yl)-2, 4, -6,
8-nonatetraen-1-ol All-trans vitamin A ₂ = 3′, 4′-dehydrovitamin A ₁ vitamin B ₁ Synonyms: thiamine aneurin anti-neuritis vitamin anti-beriberi vitamin beriberi antibody torline Chemical symbol: 3-(4-amino-2-methylpyrimidyl-5
-methyl)-4-methyl-5-β-hydroxy
Ethylthiazole vitamin B ₂ Synonyms: Riboflavin Lactoflavin Chemical symbol: 6,7-dimethyl-9-(D-1'-ribityl)-
Isoalloxazine Nicotinamide Synonyms: Nicotinamide Nicotylamide Niacinamide Vitamin PP Pellagra Preventive Agent PP-Factor Pellagra Preventive Factor Chemical Symbol: Pyridine-3-carboxylic acid amide vitamin B ₆ Synonyms: Pyridoxine Adermine Anti-acrodini factor Anti-dermatitis factor Murine pellagra antibody Chemical symbol: 2-Methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine (pyridoxol) 2-methyl-3-hydroxy-4-formyl-5
-Hydroxymethyl pyridine 2-Methyl-3-hydroxy-4-aminomethyl-5-hydroxy (pyridoxal) methyl pyridine (pyridoxamine) Three groups of active substances, pyridoxol, pyridoxal and pyridoxamine, exert all the vitamin _B6 effects. Matches the chemical symbol for pyridoxine. Pantothenic acid Synonyms: Filtrate factor Bios a Bios Kuken anti-dermatitis factor anti-whitening factor Chemical symbol: D(+)-α, γ-hydroxy-β, β-dimethylbutyryl-β′-alanine Pantothenyl alcohol (panthenol) Salt: Calcium pantothenate (calcium-D-
pantonato) biotin Synonyms: vitamin H bios bios b coenzyme R skin factor anti-seborrheic vitamin chemical symbol: 3,4-(2'-ketoimidazolide)-2(ω-carboxybutyl)-thiophene (β-biotin) Folic acid Synonyms: Pteroylglutamic acid Vitamin B _C Vitamin M Elato factor (liver) Lactobacillus casei factor Chemical symbol: N-[4-([2-amino-4-hydroxy-6
-pteridyl)methyl]amino)benzoyl]-
Glutamate Vitamin B ₁₂ Synonyms: Cyanocobalamine Erythrotin Animal Protein Factor (APF) Antiperniciosa Factor Extrinsic Factor (CASTL E) Up to now, a considerable number of vitamin B ₁₂ -factors (cobalamines) have been isolated and presented. They are distinguished according to their various proportions of nucleotides, and their biological activities differ accordingly.
Vitamin _B12 is mostly obtained from cultures of Streptomyces griseus and similar organisms. Vitamin C Synonyms: Ascorbic acid Antiscurvy vitamin Antiscorbutein Hexuronic acid Chemical symbol: Ascorbic acid Dehydroascorbic acid = L-threo-2,3,4, =2,3-diketo-5, 6-pentaoxy-he -L-gulonolactone xaone-2-carboxylic acid lactone = L-threo-3 -Ketohexaonic acid enol lactone vitamin D Synonym: Calciferol Anti-depressant vitamin Chemical symbol: Vitamin _D2 : Ergocalciferol (irradiation product of ergosterin) Vitamin D ₃ : Cholecalciferol (irradiation product of 7,8-dihydrocholesterin) Besides vitamins D ₂ and D ₃ (which alone have therapeutic uses), a series of homologous compounds are well known. Together with the two vitamins mentioned above, they constitute the so-called vitamin-D group. Vitamin _D1 : Molecular compound of vitamin _D2 and lumisterine (irradiation product of ergosterine), not naturally occurring. Vitamin _D4 : irradiation product of 22,23-dihydroergosterin. Vitamin _D5 : Irradiation product of 7-dihydrocitosterin. Vitamin _D6 : Irradiation product of 7-dihydrostigmamasterin. Vitamin D ₇ : Irradiation product of 7-dihydrocamposterin (isomer with 22,23-dihydroergosterin) Vitamin E Synonyms: Tocopherols Anti-malnutrition vitamins Anti-infertility vitamins Fertility vitamin Vitamin E is the group name for all tocopherols Tocopherols are distinguished by the number and position of methyl groups in the hydroxychroman ring, and in part by the presence of double bonds in the phytyl side chains. However, in general, α-tocopherol or its acetate salt exists under the name of vitamin E, which possesses the greatest biological effectiveness of all tocopherols. Chemical symbol: α-Tocopherol; 2,5,7,8-tetramethyl-2-(4',8',12'-trimethyl dodecyl)-chroman-6-ol or 5,7,
8-trimethyltocol β-tocopherol; 5,8-dimethyltocol γ-tocopherol; 7,8-dimethyltocol δ-tocopherol; 8-monomethyltocol ε-tocopherol; 2-furnesyl-2,
5,8-trimethylchroman-6-ol ζ-tocopherol: 2-falnesyl-2,
5,7,8-tetramethylchroman-6-ol η-tocopherol: 7-monomethyltocol Below are some examples of combinations of preparations preferentially used according to the invention and methods of use according to the invention. show. It should be emphasized here that the invention is not restricted to the combinations described here. This drug is manufactured according to the usual method. 1 Vitamin-B-Complex-Factor Preparation Active Substances: The essential factors in the pure form of Vitamin-B-Complex and the clinically determined quantitative relationships are as follows:

[Table] 1ml droplet contains 1.14g of carbohydrates, which is
Equivalent to 4.7Kcal. One strong sugar-coated tablet is 270 mg.
Equivalent to 1.1Kcal, 4.02g of 5ml syrup is
Equivalent to 16.5Kcal. *This formulation will be referred to as a “combination” hereafter. 2 Vitamin C (tablets) or Vitamin C
Vitamin B-complex preparation with calcium and calcium (foaming tablets)

[Table] One effervescent tablet contains 704 mg of carbohydrates.
This is equivalent to 2.9Kcal. Each effervescent tablet also contains 230mg of Na (equivalent to approximately 0.6g of NaCl)
including. In a patient's diet with minimal NaCl,
Recommended use of tablets instead of foam tablets. **) This formulation will be designated as a “combination” hereafter. 3. Polyvitane formulation combination

【table】

[Table] One effervescent tablet contains 891 mg of hydrocarbons,
This is equivalent to 3.6Kcal. Furthermore, 300mgNa (approximately 0.7
g of NaCl). One sugar-coated tablet is 350mg,
Equivalent to 1.4Kcal. For patients on a diet reduced in NaCl, the use of capsules or dragees instead of effervescent capsules is recommended. ***) This composition will hereinafter be designated as a "combination". Long-term treatment of rheumatic diseases and/or
Alternatively, the method of the present invention for prophylaxis is characterized by administering to the patient individual vitamins or a combination of various vitamins in variable amounts. In the method according to the invention, it is advantageous to administer the above-mentioned drug combination primarily by oral drops and/or injection. The new uses of the invention, as well as the new methods of the invention, have applications in human and veterinary medicine. It is also used, for example, in humans and warm-blooded animals such as horses, cows, dairy cows, dogs, cats, and others. The two patients to be treated will be described below. Example A Married woman A was born on September 30, 1890 in St. Petersburg (now Leningrad), a territory of the Soviet Union, is of mixed Russian-Finrid descent, and has lived in Zyuritsch (Switzerland) since 1924. Her parents and siblings are unknown as they have not been allowed contact with Leningrad since 1934.
As of 1982, A is unaware of any illnesses that have or have not occurred in her family. A remained strong at heart until he reached old age.
In 1964, at the age of 74, he underwent appendectomy, but
He survived with such remarkable ease that his doctor did not allow him to be discharged from the hospital until a week later, but he did allow him to go on a vacation directly from the hospital. Until early 1982, A had all his own teeth. A was approximately 153 cm tall and had a lovely appearance. Although she never smoked in her life, she was always a ``gourmet lover,'' preferring to eat meat, and drank alcohol in moderation, only consuming a glass of wine with meals. Her weight in 1972 was approximately 47Kg.
It is estimated that it was. Ten years ago, in 1972, he began complaining of ``rheumatic pain'' in his right shoulder and right knee joint. A became a widow in 1948, but she had a habit of indulging in her attachment to her town, and during that time she traveled a considerable distance (approximately 10 to 12 hours) every day.
Km) on foot. The pain that began in my right knee naturally resulted in my very long daily walk around town being cut short. The disease gradually subsided and increased slowly over several years. Over a long period of time (probably 1973-1975) she consulted her family doctor and was subsequently treated with various NSAIDs.
- You took rheumatoid arthritis medication. For example, aspirin, irgapirin, butazolidine, voltaren, and many other drugs prescribed by doctors did not produce positive results. Then, around 1975, when doctors started giving patients a series of numerous injections (so many that it's hard to remember) directly into the knee (a kind of golden formula), she was still very nervous. So, after a certain period of time (I don't know how long or how long after the injections) I could no longer tolerate this painful treatment, so I started treatment for polyarthritis. I simply gave up on suffering any more pain and decided to live out the rest of my life with the severe pain of rheumatism, or even die because of it. This can be said to have been an extremely important decision in A's life, as long as she always had in mind that she would live to be at least 100 years old, possessing an extremely strong ability to live. As mentioned above, the progression of her polyarthritis was gradual but progressive, and this was explained by the fact that A was being seen at regular intervals (once a week). It was well observed. Since about 1976, the patient has been noted to have a state of weakness, which at first was easily interpreted as age and not polyarthritis, but when she first complained of stiffness in her fingers in the morning, she went into more detail. Reaching,
Polyarthritis was initially considered. When this "stiffness of my fingers in the morning" started, I was unable to put on my clothes right after I woke up, wash my face in the morning, and prepare breakfast. A lived alone in a one-room house and took care of all the household chores by himself. She said she thought she would have to spend at least half an hour, if not a full hour, trying to keep her fingers soft through training. In addition, there was a marked tendency for fatigue and pain to develop quickly in the joints of the hands and fingertips (with the exception of the thumb joint). The skin on the painful limb (the leading edge) of the finger swelled up and turned red to purple, swollen as if inflamed, and the whole body was in severe pain, so no one touched A's finger. I thought it would be better if I didn't have it. My fingernails, including my thumb, became increasingly brittle and somewhat ``scaly,'' making it easier to remove them from the nail bed, and they began to take on unusual shapes.
In particular, the nails on both thumbs showed a tendency to curl up (scleroderma). A large, extremely painful, not very hard tumor (is it movable?) has started to grow on the top of the big toe, right next to my right wrist joint. I didn't have a fever. Nor did he allow the patient to rest before taking his true temperature. Her right shoulder and right knee undoubtedly hurt her a lot, so she, for example, started eating with her left hand so she wouldn't have to move her right shoulder. Despite several years of illness, the old woman remained stubborn and refused to take any medication, taking only ``mild'' painkillers. She did nothing about this condition except to take tonics (such as old age insurance drugs) for the increasingly frequent debilitation and great signs of fatigue. She seemed to understand this as well, and was instructed to take the ``combination'' listed above, but she persevered and accepted it. From around 1976/77, A. took the "combination" capsules daily without interruption and on a regular basis. Immediately after the start of administration of the COMBINATION, the first positive sign was that the debilitating state began to gradually but clearly disappear. Meanwhile, the pain from the arthritis continued, varying from severe to unbearable depending on the weather and mood. The pain did not abate, and the difficulty in moving the hands, fingers, right knee, and right shoulder remained, but the rest of the patient's general condition, as far as the patient's condition was concerned, was old. Despite his age, he seemed to be doing well. And she continued to resist attempts to somehow induce her to take good medicine for her ``rheumatic'' pains. After a few months of administering the "combination" (Patient A had to take the "combination" daily for at least 8-12 months), he reported feeling much better and the pain in his shoulders and knees had subsided. The pain was becoming intermittent, and the pain in both hands and fingers began to show subtle signs of getting worse. It was also observed that many of the symptoms described above often began to disappear in this patient. The most notable part of the fingernails was the distal limb of the finger, where the inflammation gradually decreased. A said that the stiffness in his fingers that occurred in the morning, when his movements were severely restricted, gradually became shorter. The stiffness that lasted two hours back then is now
It started to disappear in 30 minutes. Fingernails slowly began to regain a somewhat healthy appearance (scleroderma). Moreover, in November 1982, the nails on both of his thumbs, which were the most affected, showed signs of the dramatic changes seen during recovery from the disease. A few years ago and in the years that followed, A's hands were extremely sensitive to pain and pressure, so they were highly sensitive, but they were typical of the hands of an elderly person and showed no signs of polyarthritis. Ta. Today, no matter where I press the patient, there is no pain, and the patient is fine. Original pain that was constantly felt in the right shoulder and right knee (A
(who blamed this pain on the impending sudden change in weather) was probably a debilitating phenomenon, but it was not inflamed. Further noteworthy facts are as follows. In other words, after it appeared that he had overcome polyarthritis thanks to the "combination," in 1981, despite his advanced age, he was clearly gaining weight, albeit slightly, and his food intake was decreasing. This is what happened in a situation where the number of cases is gradually decreasing in comparison. The increase will probably be around 2.5-3Kg. The course of polyarthritis and the course of overcoming it through "combination" have been explained above for A. Case of B Male B was born on May 24, 1920 in the Soviet territory of Atkarsk (on the banks of the Volga River) into a poor family. B's family was expelled from the Soviet Union in 1924 as unwanted foreigners (because they were Swiss). Since then B has lived in Switzerland. B's father died of lung cancer at the age of 59 (1948). Her two older sisters died of breast cancer at the ages of 45 and 58, respectively. Polyarthritis did not appear in my father or two older sisters. B's mother developed polyarthritis for the first time when she was middle-aged, not a young woman. In the case of B, about 9 years ago
The first signs suggestive of polyarthritis appeared in 1973. Namely, a peculiar, medium-hard, extremely painful swelling that developed in the middle joint of the right index finger was completely difficult to heal (the difficulty in healing has now been reduced to only a small area with ``combination'' treatment).
And it's painless). No one paid attention to this phenomenon. However, about three years ago, in 1979, B.
When I woke up every morning, I started noticing that my fingers were stiff. After a few months, red, painful, bulging swellings appeared in all the most advanced knuckles (except the thumb), which by early 1981 had become an extremely unpleasant disorder, so B was written or typed. It was so bad that I feared I would lose all ability to operate it. The leading edge of my knuckles became extremely thick, and I began to feel a severe tingling sensation at the tips of my fingers. B's hands became sensitive and hurt so badly that he refrained from offering his hands to greet others. B was suffering from severe pain in his hands and fingers and was adamant against all attempts, but in the end he was prescribed a ``combination''. The first 30 capsules of the "combination" did not yet produce the expected results, and moreover, an anomaly occurred that was specific to this preparation. In other words, certain areas of the face became patchy and unhealthy red in color, starting to look like they had just bloomed, and the combination had to be discontinued. The allergy quickly disappeared. I also alternately avoided using the words “combination” and “combination.” In July 1975, he broke his right little finger and underwent surgery to correct the fracture. After removing the “screw”,
I still felt slight pain in the injured joint for a while. About three years later, the first knuckle, the joint that underwent surgery, began to show signs of inflammation and stiffness. The inflammation of this knuckle of the right little finger had a purely traumatic cause, but it continued for a long time and
Even his fingers began to show similar inflammation and pain. In order to overcome unpleasant phenomena, in this case we must consciously use “combinations”/“combinations”.
(One tablet a day, B is “experience” with kidney stones)
When administering foam tablets (which I was discouraged from administering because they contain calcium), the following was observed: In other words, after about 8 to 12 months, the joint and the most distal limb of the right little finger, which had suffered the trauma, had healed, and the remaining joint nodule no longer hurt at all even when pressed hard. It is. After another 8 to 10 months, the signs of arthritis and inflammation in the 8 knuckles (the leading edge) also disappeared. However, when administration of the "combination"/"combination" was discontinued for a while (approximately 10-14 days), joint pain immediately developed in the seven fingers where the primary inflammatory process had occurred, but this was severe. It should be noted that no acute symptoms appeared, while the traumatized right little finger did not respond to this withdrawal. There were 10 discontinuation tests of this drug conducted several times.
I always had to stop after ~14 days, but I didn't want to risk new inflammation and pain. A few years ago, B often felt polyarthritis pain in his left shoulder and left ankle, but the pain didn't last long, so he didn't pay much attention to it.
However, the pain caused by this spontaneous polyarthritis (as a side effect, so to speak) completely disappeared, and this pain caused B to develop a painless, or perhaps ossified swelling that no longer hurts. It was confirmed that the wound had been left in the middle bone of the left leg. Furthermore, another phenomenon was observed in connection with the disappearance of the polyarthritis in B's fingers. In other words, nodules were clearly left on the most advanced joints of some fingers, and as long as the intake of "combinations"/"combinations" continued, these nodules remained.
Today it remains completely pain-free. This distinct nodule forms gradually, very gradually. Since there are no X-ray images for comparison, it is not possible to tentatively prove this phenomenon, but the above-mentioned peculiar swelling on Delenck's right index finger had clearly diminished, but gradually In other words, it was determined only several months after the intake of the "combination"/"combination". Other: B has not smoked for 20 years, and other than the “combination”/combination, he takes a headache medication (Tonopan) sporadically only when it is unavoidable, and is completely healthy, at least after overcoming the polyarthritis he had. B.'s life so far has been marked by two health events: in 1949 he contracted closed TBC (joint X-ray), which was completely cured, and in 1968 he suffered a major traffic As a result of being a victim of a disaster, I ended up with complex bone fragments from my left arm inside my body.These fragments of the radius and ulna were removed using osteosynthesis (two titanium plates with 13 screws). ) was artificially and skillfully repaired. B is the total of two boards.
I used 13 screws to attach it to the bone in 1982, but I didn't experience any problems. It can be seen from both of these cases that by long-term use of the exemplified "combinations", "combinations" and "combinations", polyarthritis, which can be seen at a glance, can be rendered painless and painless, that is, insidious. However, it has been found that administering large doses during the so-called first month of treatment, strangely, does not produce either positive or negative effects.
With the use of this group's preparations in the short and medium term, positive results never appear with respect to polyarthritis. On this basis, great value is placed on special emphasis on several months of treatment (prophylaxis) using the above preparations and the whole group of preparations. The following table provides a more detailed explanation of the reports regarding both A and B listed above. Tablet treatment: Rheumatism (early chronic polyarthritis) Treatment period: 18 months and 60 months

[Table] Table symbols The following symbols were used to represent treatment effects. 0 = No improvement effect 1 = Very effective 2 = Good effect 3 = Very effective 4 = No symptoms - = No symptoms appear. Married woman A received 1 capsule containing the “combination”
I take one tablet a day. Man B alternated between taking one sugar-coated tablet containing the ``combination'' and one tablet containing the ``combination'' every day.