JPH0566149B2 - - Google Patents

Description

[Detailed description of the invention]

[Industrial Application Field] The present invention is a novel medical covering material, more specifically, it is characterized by surface-treating medical gauze or medical nonwoven fabric with hyaluronic acid or its salts, or tryptophan, histidine, uric acid, or its salts. This invention relates to a new medical dressing material. [Prior art] Conventional medical gauze, medical non-woven fabrics, etc. are used for bandages, treatment masks, etc., and often come into direct contact with wounds, inflamed areas, or skin, and are intended to improve flame resistance and water absorption. Consideration has also been given to improving conventional gauze, and various nonwoven fabrics have been investigated, and synthetic polymers such as polyvinyl chloride, polystyrene, polypropylene, polyester, polyamide, and polyurethane have been used as materials. However, fibers and nonwoven fabrics made of such materials not only have poor biocompatibility but also have no heat retention properties.Recently, highly water-absorbing materials such as rayon have been used, but after absorbing water and absorbing the liquid, It oozes and becomes sticky, which also poses a hygiene problem. Furthermore, in the case of dressings, surgical coverings, etc. that are applied directly to the affected area, the liquid exuding from the affected area will solidify, significantly reducing the removability of the wound, and may worsen the wound that is about to heal completely. Furthermore, dryness of the affected area increases the damage due to the tension of the skin, which is not always satisfactory. Furthermore, it is difficult to prevent dryness of inflamed areas even with various types of gauze intended for sterilization and wound protection, such as emergency bandage patch gauze, patch gauze with acrinol, acrinol wet gauze, eye patch gauze, and eye patch gauze with acrinol. Therefore, it was difficult to maintain breathability and prevent drying. [Problems to be Solved by the Invention] The present invention solves the problem that when conventionally used gauze, adhesive bandages, surgical coverings, etc. are applied directly to the affected area, they stick tightly to the inflamed area or wound and cannot be removed. In some cases, complete healing may be delayed or the wound may be reinjured. In order to solve these problems, various types of covering materials made by laminating aluminum sheets have been considered, and efforts are being made to improve the releasability of the covering material and the inflamed area. However, in the case of aluminum sheets, the aluminum sheet supplies oxygen to the affected area, retains moisture, and has an insulating effect due to the aluminum sheet, which prevents heat radiation from the inflamed area and is not necessarily considered to be effective in curing the disease. In addition, in either method, it is difficult to prevent dryness while maintaining the air permeability of the affected area, and the dryness causes pain and itchiness in the affected area, so these methods are not necessarily satisfactory. Therefore, as a result of intensive studies to solve these problems, the inventors of the present invention have added moisturizing ingredients to materials that come into direct contact with the affected area, such as medical gauze and surgical coverings, such as gauze, absorbent cotton, acrinol wet gauze, and non-woven fabrics. By immersing it in an aqueous solution or spraying it with an aqueous moisturizing component solution, it is intended to improve the removability of the dressing and the healing effect of the affected area. [Means for solving the problem] The dressing of the present invention is intended to prevent dryness of the affected area, improve breathability, and promote healing of inflammation or wounds. It is treated with hyaluronic acid, a skin component, or its sodium salt, potassium salt, ammonium salt, amino acid salt, calcium salt, or amine salt, and the adhesion rate to gauze, absorbent cotton, and nonwoven fabric is 0.01 ~
The amount is 2% by weight, preferably 0.01 to 1% by weight, and immersion or spraying treatment is desirable. If it is less than 0.01% by weight, it is ineffective, and if it is more than 2% by weight, it is not necessary from the viewpoint of effectiveness and economy. The combined addition of tryptophan, histidine, uric acid, or their salts prevents the oxidative degradation of hyaluronic acid into low molecular weight molecules, maintains the moisturizing properties of hyaluronic acid, and promotes curing. In the present invention, tryptophan, histidine, uric acid, or salts thereof refer to DL-tryptophan, L-tryptophan, and their hydrochlorides, acetates, and sulfates; - Refers to histidine and its hydrochloride, acetate, and sulfate; uric acid or its salts refer to uric acid, sodium urate, potassium urate, calcium urate, sodium hydrogen urate, potassium hydrogen urate, calcium hydrogen urate, and ammonium hydrogen urate. , uric acid amino acid salt,
Refers to uric acid amine salts, etc., and the adhesion rate to gauze, nonwoven fabrics, etc. is 0.005 to 1.5% by weight, preferably 0.01 to 1.5% by weight.
It is 1% by weight. If it is less than 0.005% by weight, the desired effect cannot be obtained, and if it is more than 1.5% by weight, it is not necessary in terms of solubility and effectiveness. The medical dressing of the present invention can be applied to medical bandages, medical gauze, eye patches, etc. Medical hygiene products include absorbent cotton, napkins, tampons, clean cotton, bandages, disposable diapers, artificial skin, sutures, etc. It is. Materials used for these include synthetic polymer nonwoven fabrics such as cotton and rayon, polyvinyl chloride, polyacrylic ester, polyester, nylon, polyethylene, polypropylene, polyolefin, and cellulose ester, chitin fibers and chitin nonwoven fabrics, sheep intestinal thread, and chitin. suture,
Pork skin, cow skin, etc. can be used. The method of attaching hyaluronic acid or its salts, tryptophan, histidine, uric acid or its salts to gauze, nonwoven fabric, etc. in the present invention is to dissolve them in a solvent such as water or alcohol, apply them by dipping or spraying, and use them as they are. Or,
Remove water, solvent, etc. and dry before use. [Example] The present invention will be explained below with reference to Examples. Example 1 Sodium hyaluronate (purity 95% or more) 0.3
Dissolve g in 100 ml of purified water, cut medical gauze (Japanese) (cotton), rayon non-woven fabric, nylon non-woven fabric, polypropylene non-woven fabric, pigskin into 5 cm x 5 cm and soak for 5 minutes to determine the moisture content under the following conditions. I looked into it.
Note that the numbers in the table are expressed as water retention rates relative to the original fabric.

【table】

[Table] Example 2 A patient with burns on both the left and right insteps was treated for 2 days from 7 days after the burn, that is, when the formation of thin skin was observed.
Collodion-treated gauze was applied to the affected areas of the left and right insteps, and cotton gauze treated with sodium hyaluronate and then collodion-treated gauze was applied to the affected areas of the left and right insteps for treatment for 2 days. It was replaced with a new one after 12 hours had passed. The severity of burns on the affected areas was the same in both cases, but the area on the right leg was about 30 ^cm2, and the area on the left leg was about 1/3 of the same size.

[Table] Treatment for the affected area of the right leg was discontinued after 30 hours, and treatment was performed using the usual method. As a result, since the area of the right foot was large, it was difficult to say anything about the tearing of the thin skin from a single test, but the itching that appeared was due to excessive dryness and would worsen if continued. There was no itching in the affected area of the left leg, and the healing effect was good. Example 3 A mixed aqueous solution of 0.1% sodium hyaluronate and 0.03% sodium urate was sprayed onto ribanol-impregnated gauze and ribanol-impregnated gauze for a patient who had undergone four-stitch eyelid suturing, and the affected area was covered with ophthalmia. The present inventors used the drugs alternately every 6 hours so as not to affect the healing of the affected area. As a result, in the case of using Rivanol-impregnated gauze, after about 3 hours, there was a feeling of tightening towards the sutured area and a slight pain was felt. On the other hand, the product of the present invention had no abnormalities at all, and no abnormalities were observed even after repeated testing three times.

Claims (1)

[Scope of Claims] 1. A novel medical covering material, characterized in that medical gauze or medical nonwoven fabric is surface-treated with hyaluronic acid or its salt in an amount of 0.01 to 2.0% by weight. 2 Medical gauze or medical nonwoven fabric containing 0.01 to 2.0% by weight of hyaluronic acid or its salt and 0.005 to 1.5% by weight of one or more types selected from tryptophan, histidine, uric acid, or its salts.
A novel medical dressing material characterized by surface treatment to make it look like this.