JPH0566927B2 - - Google Patents
Info
- Publication number
- JPH0566927B2 JPH0566927B2 JP25911585A JP25911585A JPH0566927B2 JP H0566927 B2 JPH0566927 B2 JP H0566927B2 JP 25911585 A JP25911585 A JP 25911585A JP 25911585 A JP25911585 A JP 25911585A JP H0566927 B2 JPH0566927 B2 JP H0566927B2
- Authority
- JP
- Japan
- Prior art keywords
- hair
- effect
- piperidinopyrimidine
- diamino
- oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000004209 hair Anatomy 0.000 claims description 13
- 239000002537 cosmetic Substances 0.000 claims description 11
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 8
- ZIMGGGWCDYVHOY-UHFFFAOYSA-N 3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine Chemical compound N=C1N(O)C(N)=CC(N2CCCCC2)=N1 ZIMGGGWCDYVHOY-UHFFFAOYSA-N 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 239000004615 ingredient Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 description 16
- 239000012085 test solution Substances 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- FCKLFGKATYPJPG-SSTBVEFVSA-N Oxendolone Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1C[C@H](CC)[C@H](O)[C@@]1(C)CC2 FCKLFGKATYPJPG-SSTBVEFVSA-N 0.000 description 5
- 230000003779 hair growth Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 2
- 230000002280 anti-androgenic effect Effects 0.000 description 2
- 239000000051 antiandrogen Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Description
【発明の詳細な説明】
産業上の利用分野
本発明は、公知の化合物３種類を組み合わせる
ことによつて、結果的に有効な毛髪の成長促進作
用を示す養毛化粧品に関するものである。DETAILED DESCRIPTION OF THE INVENTION Field of Industrial Application The present invention relates to a hair nourishing cosmetic product that exhibits an effective hair growth promoting effect by combining three types of known compounds.
従来技術及び問題点
本発明者は、先に抗アンドロジエン剤
（antiandrogen）と２，４−ジアミノ−６−ピペ
リジノピリミジン−３−オキサイド（２，４−
diamino−６−piperidinopyrimidine−３−
oxide）との組み合わせによる有効な毛髪の成長
促進作用を見出だし、特願60−4625にこれらの化
合物を有効成分として含む養毛化粧料を開示し
た。本発明者は、上記養毛化粧料の改善を志し、
様々な検討を試みていたが、通常の溶媒に溶けに
くい抗アンドロジエン剤が１−ドデシルアザシク
ロヘプタン−２−オン（１−
dodecylazacycloheptan−２−one）に溶解する
ことを見出だし、本発明を完成するに至つた。Prior Art and Problems The present inventor has previously discovered that antiandrogen and 2,4-diamino-6-piperidinopyrimidine-3-oxide (2,4-diamino-6-piperidinopyrimidine-3-oxide)
diamino−6−piperidinopyrimidine−3−
discovered an effective hair growth promoting effect in combination with oxide), and disclosed a hair-growth cosmetic containing these compounds as active ingredients in Japanese Patent Application No. 60-4625. The present inventor aims to improve the above-mentioned hair nourishing cosmetics,
Various studies have been carried out, but an antiandrodiene agent that is difficult to dissolve in ordinary solvents is 1-dodecyl azacycloheptan-2-one (1-
dodecylazacycloheptan-2-one), leading to the completion of the present invention.
解決手段
本発明の要旨は抗アンドロジエン剤
（antiandrogen）を１−ドデシルアザシクロヘプ
タン−２−オンに溶解せしめて、２，４−ジアミ
ノ−６−ピペリジノピリミジン−３−オキサイド
とともに有効成分として化粧品基剤中に配合する
ことにより、抗アンドロジエン剤と２，４−ジア
ミノ−６−ピペリジノピリミジン−３−オキサイ
ドの両者のみを配合した化粧品に比べて、さらに
養毛効果にすぐれた化粧品を得ることが出来るこ
とにある。以下詳細に説明する。Solution The gist of the present invention is to dissolve an antiandrogen in 1-dodecyl azacycloheptan-2-one and use it together with 2,4-diamino-6-piperidinopyrimidine-3-oxide as an active ingredient. Cosmetics that have even better hair-nourishing effects than cosmetics that only contain both an anti-androgien agent and 2,4-diamino-6-piperidinopyrimidine-3-oxide by blending them into the cosmetic base. The goal is to be able to obtain the following. This will be explained in detail below.
化粧品基剤中への抗アンドロジエン剤の配合量
は、凡そ、化粧品基剤の0.25〜2.5重量％、２，
４−ジアミノ−６−ピペリジノピリミジン−３−
オキサイドのそれは、0.1〜１％、１−ドデシル
アザシクロヘプタン−２−オンは、１〜10％の範
囲で夫々用いることにより十分に目的を達成する
ことができる。抗アンドロジエン剤としては、
16β−エチル−17β−ヒドロキシ−４−エストレ
ン−３−オンなどを挙げることができる。以下に
本願化粧品の養毛効果を示す試験例と製造実施例
とを掲げる。 The amount of anti-androgien agent added to the cosmetic base is approximately 0.25 to 2.5% by weight of the cosmetic base.
4-diamino-6-piperidinopyrimidine-3-
The purpose can be sufficiently achieved by using 0.1 to 1% of the oxide and 1 to 10% of 1-dodecyl azacycloheptan-2-one. As an anti-androgien agent,
Examples include 16β-ethyl-17β-hydroxy-4-estren-3-one. Test examples and manufacturing examples showing the hair-nurturing effect of the cosmetics of the present invention are listed below.
［試験例］
本願化粧品の養毛効果の検定の為、下記のよう
なＡ，B2種の供試液を準備し、これらの供試液
使用前後の洗髪時の抜毛本数の変化で、効果の判
定をした。被試験者は、総じて男性で、供試液の
各について５名ずつ２群に分けて、１週間に１度
の割合で、４ケ月間計16回抜毛を回収した、最初
の２ケ月間は自然抜毛回収期間とし、後半の２ケ
月間を後記供試液Ａ，Ｂの塗布による効果を見る
期間とした。効果は、供試液使用前の期間（無塗
布期間）と該液使用中の期間（塗布期間）のそれ
ぞれ８回の平均で比較した。尚、１回の洗髪間隔
は２日とした。[Test Example] In order to test the hair-growth effect of the cosmetics of this application, two types of test solutions A and B as shown below were prepared, and the effect was determined by the change in the number of hairs pulled out when hair was washed before and after using these test solutions. did. The test subjects were generally male, and they were divided into 2 groups of 5 people for each test solution, and hair was collected once a week for a total of 16 times over 4 months.The first 2 months were natural. The hair removal period was used as a recovery period, and the latter two months were used as a period to observe the effects of applying test solutions A and B described later. The effects were compared using the average of eight times each during the period before the test solution was used (non-application period) and during the period during which the test solution was used (application period). The interval between each hair wash was 2 days.
供試液 Ａ：
16β−エチル−17β−ヒドロキシ
−４−エストレン−３−オン ……0.5ｇ
２，４−ジアミノ−６−ピペリジノピ
リミジン−３−オキサイド ……0.5ｇ
95％エタノール ……50ｇ
蒸留水 ……49ｇ
供試液 Ｂ：
16β−エチル−17β−ヒドロキシ
−４−エストレン−３−オン ……0.5ｇ
１−ドデシルアザシクロヘプタン−２
−オン ……5.0ｇ
２，４−ジアミノ−６−ピペリジノピ
リミジン−３−オキサイド ……0.5ｇ
95％エタノール ……50ｇ
蒸留水 ……44ｇ
結 果
下表に示すように、供試液Ａでは、５名中著し
い効果（＋＋＋）１名、かなりの効果（＋＋）２
名、やや効果（＋）２名という結果であつたが、
供試液Ｂでは、著しい効果３名かなりの効果２名
という結果を得た。Test solution A: 16β-ethyl-17β-hydroxy-4-estren-3-one …0.5g 2,4-diamino-6-piperidinopyrimidine-3-oxide …0.5g 95% ethanol …50g Distilled water … ...49g Test solution B: 16β-ethyl-17β-hydroxy-4-estren-3-one ...0.5g 1-dodecyl azacycloheptan-2-one ...5.0g 2,4-diamino-6-piperidinopyrimidine- 3-Oxide...0.5g 95% ethanol...50g Distilled water...44g Results As shown in the table below, with test solution A, 1 out of 5 people had a significant effect (+++) and 2 had a significant effect (++).
The result was a slight effect (+) for 2 people.
For sample solution B, three people had a significant effect and two people had a fair effect.
Ａ 群 パネルNO 無塗布期間 塗布期間 効果 １ 261±34 233±42 ＋ ２ 313±52 222±38 ３ 196±26 138±51 ４ 296±41 264±25 ＋ ５ 352±53 309±33 Ｂ 群 パネルNO 無塗布期間 塗布期間 効果 １ 397±43 336±27 ２ 184±27 101±56 ３ 224±39 128±53 ４ 324±44 212±48 ５ 289±28 226±31 尚上表において、判定基準は次の通りである。Group A Panel NO No application period Application period Effect 1 261±34 233±42 + 2 313±52 222±38 3 196±26 138±51 4 296±41 264±25 + 5 352±53 309±33 Group B Panel NO No application period Application period Effect 1 397±43 336±27 2 184±27 101±56 3 224±39 128±53 ４ 324±44 212±48 5 289±28 226±31 In the above table, the judgment criteria are as follows.
抜毛本数の減少数 効果基準
70本以上 著しい効果
40〜69 かなりの効果
11〜39 やや効果あり＋
10本以下 効果なし −
上記から明らかなように、16β−エチル−17β
−ヒドロキシ−４−エストレン−３−オンと２，
４−ジアミノ−６−ピペリジノピリミジン−３−
オキサイドの併用よりも、この二者に、更に１−
ドデシルアザシクロヘプタン−２−オンを添加す
ることによる相乗効果がみられる。 Reduction in number of hairs pulled Effectiveness criteria 70 or more Significant effect 40-69 Considerable effect 11-39 Somewhat effective + 10 or less No effect - As is clear from the above, 16β-ethyl-17β
-hydroxy-4-estren-3-one and 2,
4-diamino-6-piperidinopyrimidine-3-
Compared to the combination of oxide, these two have an additional 1-
A synergistic effect is seen with the addition of dodecylazacycloheptan-2-one.
［実施例］ ヘアローシヨンの製造
16β−エチル−17β−ヒドロキシ−４−エスト
レン−３−オン0.5ｇを、１−ドデシルアザシク
ロヘプタン−２−オン５ｇに溶解せしめる。一
方、２，４−ジアミノ−６−ピペリジノピリミジ
ン−３−オキサイド0.5ｇを、95％エタノール50
mlに溶解せしめ、得られた両液を混合後、香料、
養毛料を適量加え、さらに精製水を加えて全体を
100ｇとして、ヘアローシヨンを得る。[Example] Production of hair lotion 0.5 g of 16β-ethyl-17β-hydroxy-4-estren-3-one is dissolved in 5 g of 1-dodecyl azacycloheptan-2-one. On the other hand, add 0.5 g of 2,4-diamino-6-piperidinopyrimidine-3-oxide to 50% of 95% ethanol.
ml, and after mixing both the obtained liquids, add the fragrance,
Add an appropriate amount of hair tonic, then add purified water and mix
Obtain hair lotion as 100g.
Claims (1)
ロヘプタン−２−オンとおよび２，４−ジアミノ
−６−ピペリジノピリミジン−３−オキサイドと
を養毛成分として含有する養毛化粧品。1. A hair nourishing cosmetic containing an anti-androgien agent, 1-dodecyl azacycloheptan-2-one, and 2,4-diamino-6-piperidinopyrimidine-3-oxide as hair nourishing ingredients.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25911585A JPS62120311A (en) | 1985-11-19 | 1985-11-19 | Hair nourishing cosmetic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25911585A JPS62120311A (en) | 1985-11-19 | 1985-11-19 | Hair nourishing cosmetic |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62120311A JPS62120311A (en) | 1987-06-01 |
| JPH0566927B2 true JPH0566927B2 (en) | 1993-09-22 |
Family
ID=17329522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP25911585A Granted JPS62120311A (en) | 1985-11-19 | 1985-11-19 | Hair nourishing cosmetic |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62120311A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH072628B2 (en) * | 1986-03-31 | 1995-01-18 | 日東電工株式会社 | Hair nourishing composition |
| JPS63290814A (en) * | 1987-05-25 | 1988-11-28 | Kayoko Kaneko | Hair-nourishing and hair-dressing agent |
| US6958672B1 (en) * | 2004-06-30 | 2005-10-25 | General Electric Company | System and method for magnetizing blocks on a magnet assembly of an MRI device |
-
1985
- 1985-11-19 JP JP25911585A patent/JPS62120311A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS62120311A (en) | 1987-06-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0356583B1 (en) | Scalp treatment method | |
| JPH0368004B2 (en) | ||
| JP2915931B2 (en) | Anti-irritant and desensitizing compositions and methods of use | |
| JPH08507044A (en) | Hair treatment composition | |
| JPS61165311A (en) | Hair tonic cosmetic | |
| JPH0521085B2 (en) | ||
| JPH0566927B2 (en) | ||
| JPH04193821A (en) | Hair nourishing cosmetic | |
| JPS63264513A (en) | cosmetics | |
| JP2891727B2 (en) | Hair restoration | |
| JPH0853327A (en) | Hair nourishing and hair-restoring agents using allantoin or its derivatives | |
| JP2001288046A (en) | Composition for scalp and hair | |
| JPH0615462B2 (en) | Hair composition | |
| JP2546813B2 (en) | Hair nourishing cosmetics | |
| RU2033146C1 (en) | After-shampooing hair conditioner | |
| JP3205601B2 (en) | Hair restorer | |
| JPH11302133A (en) | Cosmetic for scalp and hair | |
| JP2774071B2 (en) | Hair restoration cosmetics | |
| JPS61165312A (en) | Hair tonic cosmetic | |
| JP3193544B2 (en) | Hair restoration cosmetics | |
| JPS61165310A (en) | Gray hair-preventing cosmetic | |
| JPH0552802B2 (en) | ||
| JP3014215B2 (en) | Hair restoration cosmetics | |
| DE3877199T2 (en) | METHOD FOR TREATING THE SCALP. | |
| JPH1077216A (en) | Hair-restoring cosmetic material |