JPH0592905A - Repellent for biting/stinging pest - Google Patents

Abstract

PURPOSE:To obtain the title repellent enhanced in its preservability on the pests' skin leading to sustained repelling effect, also high in color and odor stability with time, by incorporating N,N-diethyl-m-toluamide with an ester oil from a saturated fatty acid and alcohol. CONSTITUTION:The objective repellent can be obtained by incorporating (A) N,N-diethyl-m-toluamide (abbreviated as DEET) excellent in repelling effect, nonirritant to the skin, free from offensive odor, thus widely used as a repelling ingredient for sucking insects such as mosquitoes, lice, fleas and mite, with (B) pref. 0.01-10 (esp. 0.05-5) pts.wt. per pt.wt. of DEET of an ester oil from a saturated fatty acid and alcohol (pref. from tri-2-ethylhexanoic acid and glycerin, tetra-2-ethylhexanoic acid and pentaerythritol, or myristic acid and isopropyl alcohol).

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a repellent for biting pests, and more specifically, N, N-diethyl-
The present invention relates to a biting pest repellent that maintains the effect of m-toluamide (hereinafter referred to as DEET).

[0002]

2. Description of the Related Art Dimethyl phthalate, 2-ethyl-1,3-hexanediol and the like have long been known as repellent components for biting insects, especially blood-sucking insects such as mosquitoes, lice, fleas and mites. In recent years, 2,3,4,5-bis (△ ^2-
Butylene) tetrahydrofurfural, DEET and the like are known. These repellent components are put to practical use as spray solutions or aerosols in the form of alcohol, or in the form of cream or liniment. In particular, DEET is widely used as a repellent component because it has an excellent repellent effect, does not irritate the skin, and has no unpleasant odor.

[0003]

However, when the repellent component is applied to the skin, the repellent component is lost from the skin surface due to volatilization from the skin surface, percutaneous absorption, flow of skin perspiration, friction from clothes, etc. It is difficult to maintain the repellent effect for a long time because it is easy to get rid of. In particular, liquid agents often use alcohol as a base, and the alcohol volatilizes quickly, so the repellent effect is short-lived. A technique for sustaining the repellent effect is a method by powder addition (Japanese Patent Laid-Open No. Sho 5
No. 9-199602) is known, but the powder agent is not preferable because it stains the skin white, the liquid agent requires shaking before use, and the spray agent causes clogging of the nozzle. In addition, castor oil was added to DEE as a technique for sustaining the repellent effect.
Composition blended with T (JP-A-1-172303)
However, this liquid agent is not satisfactory as a preparation for external use because it changes from transparent to brown with time and its odor is not good and it deteriorates with time.

[0004]

Means for Solving the Problems As a result of intensive studies to solve the above problems, the present inventors have found that a liquid agent in which DEET and an ester oil of a saturated fatty acid and an alcohol coexist is
The inventors have found that the retention of DEET on the skin surface is enhanced, and as a result, the repellent effect is long-lasting and the color stability and odor stability with time are also high, and the present invention was completed. That is, the present invention is a biting pest repellent characterized by blending DEET with ester oil of saturated fatty acid and alcohol.

The ester oil used in the present invention is di-2.
-Glycerin heptylundecanoate, tri-2-glycerin heptylundecanoate, glycerin tri-2-ethylhexanoate, glyceryl tri-isostearate, glycerin esters such as diglycerin diisostearate, di-2- Ethyl hexanoic acid ethylene glycol, dicapric acid neopentyl glycol, distearic acid ethylene glycol and other glycol esters, tri-2-ethylhexanoic acid trimethylolpropane, triisostearic acid trimethylol-
Trimethylolpropane esters such as propane, pentaerythritol esters such as tetra-2-ethylhexanoic acid pentaerythritol, isopropyl myristate, 2-hexyldecyl myristate, diisostearyl malate, 2- Monovalent alcohols such as cetyl ethylhexanoate, 2-ethylhexyl palmitate, 2-hexyldecyl palmitate, myristyl myristate, diisobutyl adipate, di-2-heptylundecyl adipate, di-2-hexyldecyl adipate, etc. -Esters with carboxylic acid, and the like. These can be used alone or in combination of two or more. Of these ester oils, glycerin tri-2-ethylhexanoate, pentaerythritol tetra-2-ethylhexanoate, and isopropyl myristate are particularly preferable.

In the present invention, ester oil is DEET.
0.01 to 10 parts by weight, preferably 1 part by weight,
Add from 0.05 to 5 parts by weight. If it is less than 0.01 part by weight, satisfactory results cannot be obtained for the durability of the DEET repellent effect, and if it exceeds 10 parts by weight, stickiness occurs and satisfactory usability cannot be obtained.

In the present invention, if necessary,
3,4,5-bis (△ ² - butylene) tetrahydrofurfuryl hula - le, Jimechirufutare - DOO, 2-ethyl-1,3
Pest repellents such as hexanediol can also be used in combination with DEET. In addition, emulsifier, efficacy enhancer,
Spreading agents, stabilizers, fragrances and the like can also be added as appropriate. The preparation of the present invention can be used as a liquid agent, a liniment agent, an aerosol agent, and a non-azoe type spray agent.

The formulation of the present invention can be produced, for example, as follows. That is, ester oil is added to DEET and dissolved in an organic solvent to prepare a solution, or thereafter an emulsion is prepared by a conventional method. This is filled in a container with a coating stopper to prepare a liquid agent, or in a liniment container to prepare a liniment agent. In addition, this is filled in a non-azoe type spray container to prepare a spray agent, or in an aerosol container together with a liquefied gas to prepare an aerosol agent. As the organic solvent, alcohols (methyl alcohol, ethyl alcohol, isopropyl alcohol, ethylene glycol
, Propylene glycol, etc.), ketones (diisobutyl ketone, 2-octanone, etc.), ether agents (tetrahydrofuran, methyl cellosolve, dipropylene glycol)
Ruethyl ether, etc.) and hydrocarbons (kerosene, solvent naphtha, turpentine oil, etc.) can be used. Of these, the use of alcohols, especially ethyl alcohol, is most desirable. As the liquefied gas, chlorofluorocarbon
Bonn (CFC 11, CFC 12, CFC F-22, etc.),
Liquefied petroleum gas, dimethyl ether and the like can be used.

[0009]

EXAMPLES The present invention will be specifically described below with reference to examples and test examples. Examples 1 to 3 and Comparative Example 1 A biting pest repellent was prepared with the compounding ingredients and the compounding amounts as shown in Table 1 below.

[0010]

[Table 1] ──────────────────────────────────── Comparative Examples Examples ────── ──────────── 1 2 1 2 3 4 ──────────────────────────────── --Ethanol 54 48 53.7 48 24 48 DEET 6 6 6 6 6 6 Tetra-2-ethylhexa --- 0.36 30-pentaerythritol tri-2-ethyl ------ 6 Hexane Acid glycerin Castor oil-6 ----- Freon 12 40 40 40 40 40 40 ───────────────────────────────── ────

Test Example (1) 3 g of each of the above samples was applied to the upper arm, and the amount of DEET remaining on the skin after each lapse of time was quantified. The result is shown in FIG. In the figure, A is a comparative example 1, B is an example 1, C is an example 2, and D is an example 3. Also,
In FIG. 1, the quantitative value after 10 minutes was set to 100, and the quantitative value after each time elapsed was relatively evaluated. From the figure, it can be seen that the repellent effect of the present invention is more durable than the comparative example containing no ester oil, and that the higher the ester oil content is, the more excellent the durability is. (2) In addition, the duration of the repellent effect was evaluated by the following method using mosquitoes. Test method Five healthy adults were set as one group, and one group was applied to each sample. The subjects of each group were evenly coated with the corresponding samples so that the amount of DEET applied was 250 μg / cm ^{2 on} the forearm 12 cm × 5 cm, and 100 wire-feeding Aedes albopictus (female) humans having a blood-sucking ability were released beforehand. -A repellent time was measured by inserting it into a sheet (30 cm x 30 cm x 30 cm). The repelling time was the time required for the mosquito to start sucking blood by exposing the DEET-coated surface every 2 hours in a wire mesh cage for 3 minutes. The results are shown in the table below.

[0012]

[Table 2] ────────────────────────────────── DEET / Evasion time Stability Feeling Smell Ester oil ─ ───────────────────────────────── Comparative Example 1-8 ― 〇 〇 Comparative Example 2 1/1 16 Very good × × Example 1 1 / 0.05 14 Very good ○ ○ Example 2 1/1 16 Very good ○ ○ Example 3 1/5 20 Good ○ ○ Example 4 1/1 16 Very good ○ ○ ────── ─────────────────────────────

The stability in the table was evaluated as follows. Each sample was allowed to stand in a constant temperature bath at 0 ° C. and 50 ° C. for 1 month, and then the product left at 50 ° C. was evaluated for the color of its appearance. The evaluation criteria are as follows. ◯: No discoloration at 0 ° C. X: Discolored at 0 ° C. The feeling of use and the smell were evaluated by sensory evaluation. Among these, the feeling of use is mainly evaluated by the presence or absence of stickiness. Regarding the odor, 0 ° C
The 50 ° C standing product was evaluated with respect to the standing product. The evaluation criteria are as follows. ◯: No odor at 0 ° C. X: Smelling at 0 ° C.

[0014]

As described above, according to the present invention,
It is possible to provide a repellent for biting pests, which has a long-lasting repellent effect and is stable over time.

[Brief description of drawings]

FIG. 1 is a characteristic diagram showing the relationship between the elapsed time and the amount of residual DEET when the repellent according to the present invention is applied to the skin.

Claims (1)

[Claims] 1. N, N-diethyl-m-toluamide,
A biting pest repellent comprising an ester oil of saturated fatty acid and alcohol.