JPH0597648A - Cosmetic - Google Patents

Abstract

PURPOSE:To provide a cosmetic safe for skins when applied to the skins, smoothening the skins, having a high whitening activity and holding the skins in the young states, from an easily available raw material. CONSTITUTION:A cosmetic contains a solvent extract usually in an amount of 0.0001-5wt.%, the solvent extract being obtained by extracting all grass of a Rosaceae Agrimunia plant with a hydrophilic organic solvent, generally ethanol, or further methanol, butanol, acetone or their mixture (one part of these organic solvents may be replaced with water). The cosmetic has a whitening action on skins and an activity for preventing the aging, fine wrinkles and roughness of the skins and for increasing a wet touch because of having an active enzyme-inhibiting activity. Since the dried grass of the raw material is called SENKAKUSO which has been utilized as a galenical drug, the safety of the grass is guaranteed. The raw material is easily available, because the dried all grass of the raw material is sold as a galenical drug and further because the grass naturally growing in the fields and mountains of Japan is gathered.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic product which has a whitening effect and which makes the skin smooth and keeps youthful.

[0002]

2. Description of the Related Art It belongs to the family of dicotyledonous plants of the genus Astragalus, the subdivided flower subweb and the family Rosaceae. In Japan, Agrimony (Agrimon)
ia eupatoria) is a perennial that grows naturally in Honshu, Shikoku, Kyushu, and Ryukyu and grows in the mountains and on the roadside. Korea outside Japan,
It is distributed in the temperate to temperate zones of Taiwan, Siberia and the Himalayas.

This grass is called Senzuru grass, and the whole grass is used. Its purpose is to be used as a hemostasis, antidiarrheal, anti-inflammatory, tonic medicine, and for various bleeding symptoms such as hematemesis, bloody stool, hematuria, under the cleft leak zone, and Shigellosis. However, as a cosmetic, it is merely used as a head cosmetic in JP-A-1-313414 and as a bactericidal composition in JP-A-60-184024.

[0004]

SUMMARY OF THE INVENTION An object of the present invention is to provide a cosmetic material which is easy to obtain, is safe to apply to the skin, smoothes the skin, has a whitening effect, and keeps youthful skin from easily available raw materials. To provide.

[0005]

Means for Solving the Problems The inventors of the present invention have tested a large number of plant extracts that are easily available, and as a result, Senzuru-kusa is very effective as a cosmetic in terms of its whitening effect, skin anti-aging effect and the like. The present invention has been completed by finding out that it is effective. That is, the present invention is a cosmetic containing a solvent extract of the whole plant of the genus Astragalus.

[0006] The genus Astragalus has already been sold as a herbal medicine in which the whole plant is dried and used as a raw material for medicines, and it can be easily collected from the wild areas of Japan. To make a cosmetic raw material, this is extracted with a hydrophilic organic solvent, but generally, it is extracted with ethanol, further with methanol, butanol, acetone, or a mixture thereof. It is also possible to replace part of these organic solvents with water. The amount of water greatly varies depending on the type of hydrophilic organic solvent, but in the case of ethanol, whitening components decrease when extracted with a solvent containing 50% or more water. In addition,
In the case of water alone or ethanol, even if the water content is 50% or more, the whitening components are reduced, and there is no point in using such an extraction method, but there is no effect on the active oxygen suppression effect, and such an extraction method may also be used depending on the purpose. You can choose.

This extract is used as a raw material for other cosmetics, for example, liquid oils such as squalane and jojoba oil, solid oils such as beeswax and cetyl alcohol, various activators, moisturizing agents such as glycerin and 1,3 butylene glycol, and various drugs. Etc.,
Cosmetics of various dosage forms can be prepared. For example, a lotion, a cream, a milky lotion, a pack or the like may be used depending on the purpose.

The concentration of the extract of the present invention to be used is naturally influenced by the purpose of use and other ingredients and is not particularly limited, but it is usually 0.0001 to 5%. is there.

[0009]

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples. A production example of the extract (dry solid matter) used in Examples and Comparative Examples will be described first.

(Production Example 1) 200 g of methanol was added to 20 g of dried Senzuru grass and the mixture was refluxed and cooled for 3 hours. This was filtered and lyophilized. The yield was 1.98g.

(Manufacturing Example 2) 300 g of ethanol was added to 10 g of dried Sendakusa grass and the mixture was extracted with a Soxhlet extractor. The extract was freeze-dried. The yield was 1.87g.

(Example 1) Lotion (parts by weight) Methanolic extract of dried cypress plant of Production Example 1 (dried product) 1.0 Ethanol 80.0 Purified water19.0  100.0

(Example 2) Cream (parts by weight) A. Squalane 20.0 Jojoba oil 5.0 Beeswax 5.0 Cetostearyl alcohol 2.0 Glycerin monostearate 1.0 Sorbitan monostearate 2.0 Ethanol extract of dried citrus grass of Production Example 2 (dry matter)1.0  36.0 B. Purified water 55.9 Polyoxyethylene (20E.O.) sorbitan monostearate 2.0 Polyoxyethylene (60E.O.) Hydrogenated castor oil 1.0 Glycerin 5.0 Methyl paraoxybenzoate0.1  64.0 Weigh A and B respectively, heat to 70 ° C, and add A to B
Slowly add with stirring, then slowly with stirring 3
Cooled to 0 ° C.

(Comparative Example 1) Comparative Example 1 is obtained by replacing the dried extract of Example 1 with water.

(Comparative Example 2) Comparative Example 2 is one in which the dried extract of Example 2 was replaced with water and used as component B.

As an evaluation method, a 1.0% by weight ethanol solution of the dried extract of Production Example 2 was used to measure the tyrosinase activity inhibition rate and the active oxygen suppressing effect, and Examples 1 and 2 and Comparative Examples 1 and 1 were used. The 2 lotions and creams were evaluated by a sensory test by a panel.

(Inhibition rate of tyrosinase activity) 0.9 ml of Mcllvaln buffer, 1.66 mM tyrosine (Tyr)
osine) solution 1.0 ml, the dried extract of Preparation Example 1 or 2 was dissolved in ethanol, water was added, and ethanol was removed by an evaporator, and then adjusted to 0.1% by weight (dry matter) / volume%. 1.0 ml of the prepared solution (sample solution) was placed in a screw vial and heated in a 37 ° C. constant temperature water tank for 5 minutes or more. Tyrosinase solution (Sigma, mushroom-derived, 9
0.1 unit (14 units / ml) was added, and the mixture was kept warm in a 37 ° C. constant temperature water bath, and after 10 minutes, the absorbance was measured at 475 nm. As a control, pure water was added instead of the above sample solution, and the same measurement was performed. (Calculation formula) Tyrosinase activity inhibition rate (%) = {B- (A
-P)} / B × 100 where A: absorbance of sample specimen B: absorbance of control P: absorbance of sample specimen due to coloration (3-fold dilution) The results are shown in Table 1.

[0018]

[Table 1]

(Active oxygen suppressing concentration) There is 21% oxygen in the atmosphere, and without this, living things (excluding anaerobic ones)
Cannot exist. However, oxygen becomes active oxygen under the influence of ultraviolet rays and enzymes. Active oxygen oxidizes fatty acids and produces peroxides. It also oxidizes and damages the phospholipids of biological membranes in the body. Moreover, it is said that the generated peroxide and active oxygen damage DNA and accelerate aging. It also affects the mechanism of melanin production from tyrosine and is involved in skin darkening. Suppressing this active oxygen is one of the important factors required for the skin, in other words, for cosmetics. There are various methods for measuring the effect of suppressing active oxygen, but the following method was used this time. pH 7.8, 50mM Potassium phosphate buffer (containing 1.3mM DETAPAC) 133ml 40 uint / ml Catalase above potassium phosphate buffer 5ml 2mM Nitroblue Tetrazolium above potassium phosphate buffer 5ml 1.8mM Xanthine above phosphorus Potassium acid buffer 17 ml 160 ml 2.4 ml of the mixture of the above reagents, the lyophilized product of the extract of Preparation Example 1 or 2 was dissolved in ethanol, water was added, and the ethanol was removed by an evaporator. 0.3 ml of liquid (sample) adjusted to 1 weight (dry matter) / volume%
In addition, xanthine oxidase (use water as the sample beforehand,
At the time of experiment, 0.3 ml of the above-mentioned potassium phosphate buffer is adjusted so that the absorbance increases about 0.02 per minute) and the absorbance (560 nm) is immediately measured. (Measurement is performed for 2 minutes and linearity is confirmed.) (Calculation formula) Inhibition rate = (A−B) / A × 100 A: Change in absorbance per minute when the sample is water B: Sample Change in absorbance per minute of the results are shown in Table 2.

[0020]

[Table 2]

(Use test) Faces of 12 women were divided into right and left sides, one of which was used as an example and the other of which was used as a comparative example once or more daily, and a questionnaire was conducted three months later. Example 1 and Comparative Example 1 were used in combination with each other. The criteria are as follows, and the results of the questionnaire are summarized in the table below. Example is very good 3 Example is considerably good 2 Example is slightly good 1 No difference 0 Comparative example is good −1 Comparative example is good −2 Comparative example Table 3 shows the result of the total value of -3 judgment points.

[0022]

[Table 3]

[0023]

EFFECTS OF THE INVENTION The cosmetic composition of the present invention has a whitening effect on the skin and has an active oxygen-suppressing effect to prevent aging of the skin, to prevent wrinkles and rough skin, and to give a moist feeling by containing the extract of Sengakurusakusa. Has the effect of increasing. Since it has been used as a crude drug, its safety is guaranteed.

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[Procedure amendment]

[Submission date] December 10, 1991

[Procedure Amendment 1]

[Document name to be amended] Statement

[Correction target item name] 0018

[Correction method] Change

[Correction content]

[0018]

[Table 1]

[Procedure Amendment 2]

[Document name to be amended] Statement

[Name of item to be corrected] 0020

[Correction method] Change

[Correction content]

[0020]

[Table 2]

Front Page Continuation (72) Inventor Masao Hattori 2556-4-2 2-203 Gofuku Suehiro-cho, Toyama City, Toyama Prefecture (72) Inventor Kenji Shimomura 3-16-32 Funae, Ise City, Mie Prefecture 72 Inventor Masami Nakamura Mie Prefecture 6-32 Ikegami Town, Toba City

Claims (1)

[Claims] 1. A cosmetic comprising a solvent extract of the whole plant of the genus Astragalus in the family Rosaceae.