JPH06172150A - Skin cosmetics - Google Patents

Abstract

(57) [Summary] [Structure] A skin makeup containing at least one selected from the group consisting of glycyrrhetinic acid and its ester, and at least one selected from the group consisting of ascorbic acid phosphoric acid ester and its salts. Fee. [Effect] The skin cosmetic of the present invention has an excellent pigmentation-improving effect. By locally applying it to spots on the skin, freckles, and pigmented areas after sunburn, the area is treated / improved, and normal skin is treated. In addition to being able to return to color, no irritation to the skin, expression of allergies, etc. are not observed, and it is highly safe.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin cosmetic, and more particularly to a skin cosmetic for recovering a pigmented pigmentation state to a normal skin color.

[0002]

2. Description of the Related Art Skin color is determined by the amount and distribution of melanin synthesized in epidermal melanocytes. The amount of melanin synthesis itself is determined by the intensity of action of sunlight (especially ultraviolet rays) and melanocyte stimulating hormone. Yes, if melanin synthesis is enhanced, stains, freckles, sunburn, etc. occur. Then, with age, the occurrence of spots, freckles, and sunburn disappearance is reduced, which is a major problem in women.

[0003] So far, for example, vitamin C derivatives have been developed for cosmetics to restore the normal state of skin color by restoring the accelerated state of melanin synthesis. However, there is a problem that the vitamin C derivative is unstable as a compound and has a very weak effect as a cosmetic for external use. Therefore, it has been proposed that cosmetics contain ascorbic acid phosphoric acid ester and glycyrrhizinic acid for the purpose of improving the stability and the whitening effect (Japanese Patent Laid-Open Publication No. 6-58242).
2-298508). On the other hand, JP-A-1-186809
In the publication, it is proposed to combine a specific fatty acid or its derivative with an anti-inflammatory agent such as glycyrrhizic acid or glycyrrhetinic acid in order to improve the whitening effect. However, a sufficient effect of improving pigmentation has not been obtained. On the other hand, as a highly effective agent, hydroquinone derivatives are used in the United States for the treatment of spots and whitening black skin, but this has problems with safety such as skin irritation and allergies, as well as white spots. There are some reports that it may occur, and there was a problem in using it as a cosmetic.

[0004]

SUMMARY OF THE INVENTION Therefore, an object of the present invention is to provide a skin cosmetic which is effective in restoring a normal skin color and has no problem in stability and safety.

[0005]

In view of such circumstances, the inventors of the present invention have studied the mechanism of melanin synthesis from various angles and have broadly searched for substances that control melanin synthesis. Glycyrrhetinic acid or its esters, which are known to have substances, have the effect of promoting the elimination of pigment spots by themselves, and when this is used in combination with ascorbic acid phosphoric acid ester or its salts, this whitening effect is enhanced. Find out that
The present invention has been completed.

Therefore, the present invention is a skin cosmetic containing at least one selected from the group consisting of glycyrrhetinic acid and its ester and at least one selected from the group consisting of ascorbic acid phosphoric acid ester and its salts. .

Examples of the glycyrrhetinic acid ester used in the skin cosmetics of the present invention include glyceryl glycyrrhetinic acid, stearyl glycyrrhetinic acid, pyridoxine glycyrrhetinic acid, and the like. As salts of ascorbic acid phosphoric acid ester, potassium salt, Examples thereof include sodium salt and magnesium salt.

In the skin cosmetic of the present invention, the blending amount of glycyrrhetinic acid and / or its ester is preferably 0.01 to 30% by weight, particularly preferably 0.1 to 20% by weight in the composition, and phosphorus ascorbate. Acid ester and /
Alternatively, the blending amount of the salts is preferably 0.01 to 20% by weight, particularly preferably 0.1 to 10% by weight. Further, the mixing ratio of the glycyrrhetinic acid (A) and the ascorbic acid phosphoric acid ester (B) is preferably in the range of (A) :( B) = 1: 20 to 10: 1.

In the skin cosmetic of the present invention, in addition to the above-mentioned essential components, optional components which are usually added to cosmetics depending on the dosage form, such as purified water, as long as the effects of the present invention are not impaired.
Ethanol, oily substances, humectants, thickeners, preservatives, emulsifiers, medicinal ingredients, powders, fragrances, emulsion stabilizers, pH adjusters and the like can be added.

Oily ingredients include liquid paraffin, petrolatum, paraffin wax, squalane, beeswax, carnauba wax, olive oil, lanolin, higher alcohols,
Fatty acids, synthetic ester oils of higher alcohols and fatty acids, silicone oils, etc .; as humectants, sorbitol, xylitol, glycerin, maltitol, propylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, sodium pyrrolidone carboxylate , Lactic acid,
Sodium lactate, polyoxypropylene fatty acid ester, polyethylene glycol, etc .; carboxyvinyl polymer, carboxymethyl cellulose, as thickener
Water-soluble polymers such as polyvinyl alcohol, carrageenan, and gelatin; electrolytes such as sodium chloride and potassium chloride; preservatives such as urea, methylparaben, ethylparaben, propylparaben, butylparaben, and sodium benzoate; emulsifiers Polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester,
Polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester,
Nonionic surfactants such as polyoxyethylene glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitol fatty acid ester; powders of talc, sericite, mica, kaolin, silica, bentonite, vermiculite, zinc white ,mica,
Mica titanium, titanium oxide, magnesium oxide, zirconium oxide, barium sulfate, red iron oxide, iron oxide, ultramarine blue and the like; PH adjusting agents include buffers such as lactic acid-sodium lactate and citric acid-sodium citrate.

Further, by adding allantoin, vitamin E acetate, yoquinin and various plant extracts as various active ingredients, the effect of suppressing melanin can be improved. Further, by adding various ultraviolet absorbing substances, it is possible to obtain a cosmetic having both a sunburn preventing effect and a sunburn preventing effect.

Further, the skin cosmetic of the present invention can be made into cosmetics of various dosage forms. Generally, the dose is 1 cm ² of the skin surface in the case of, for example, a cream or ointment preparation.
1 to 20 mg per liquid, 1 to 10 mg for liquid formulations
It is preferable that

[0013]

EFFECTS OF THE INVENTION The skin cosmetic of the present invention has an excellent effect of improving pigmentation, and by locally applying it to spots on the skin, freckles, and the pigmented area after sunburn, the area is treated / improved, and is normally treated. It is possible to return to a different skin color, and the irritation to the skin, the development of allergies, etc. are not recognized, and the safety is high.

[0014]

EXAMPLES Next, the present invention will be described with reference to test examples and examples, but the present invention is not limited thereto.

Test Example 1 A brown guinea pig having an acquired ability to form melanin pigment spots was used as an experimental animal, and after pigmentation was formed, the effect of improving fading on pigmentation was examined. Test method: Brown guinea pig (skin color is similar to that of yellow race, and like humans, guinea pigs that start to develop pigment spots in about 4 days after irradiation with ultraviolet rays and have the darkest skin color in about 8 days. ) Was shaved with a hair clipper and further shaved with an electric razor. This guinea pig was intraperitoneally administered with 8-methoxypsoralen (PUVA) and then irradiated with UVA (BLB lamp, 3.1 mW / cm ² ) for 5 minutes. From 15 days after irradiation, a 5% solution (80% ethanol, 20% water) of the evaluation sample was applied to the generated PUVA pigment spot formation site twice a day continuously for a total of 30 days. The degree of blackening of the skin color was visually evaluated according to the following criteria, and the evaluation points were averaged to measure the effect. The results are shown in Table 1. Criteria 0: No pigmentation is observed. 1: A slight pigmentation with unclear boundaries is observed. 2: Medium pigmentation with clear boundaries is recognized. 3: Clearly marked strong pigmentation is observed. result:

[0016]

[Table 1]

Example 1 Lotion type cosmetics:

[Table 2] (Composition) (% by weight) (1) Glycyrrhetinic acid 2.0 (2) Ascorbic acid phosphate magnesium salt 3.0 (3) Glycerin 4.0 (4) Polyoxyethylene hydrogenated castor oil 1. 5 (5) Ethanol 10.0 (6) Sodium pyrrolidonecarboxylate 2.0 (7) Fragrance slight amount (8) Purified water Total residual amount 100.0

Example 2 Oil essence type cosmetics:

[Table 3] (Composition) (% by weight) (1) Stearyl glycyrrhetinate 2.0 (2) Ascorbic acid phosphate potassium salt 3.0 (3) Mink oil 55.0 (4) Wheat germ oil 40.0 Total 100.0

Example 3 W / O type moisturizing cream type cosmetics:

[Table 4] (Composition) (% by weight) (1) Glycyrrhetinic acid 2.0 (2) Ascorbic acid phosphate magnesium salt 3.0 (3) Vaseline 6.0 (4) Cholesterol 0.6 (5) Cetanol 0.5 (6) Sorbitan sesquioleate 2.0 (7) Liquid lanolin 4.0 (8) Isopropyl palmitate 8.0 (9) Squalane 10.0 (10) Solid paraffin 4.0 (11) Butyl paraben 0.1 (12) Methylparaben 0.1 (13) Glycerin 3.0 (14) Perfume 0.2 (15) Purified water Balance total 100.0

Example 4 O / W type moisture cream type cosmetics:

[Table 5] (Composition) (% by weight) (1) Glycyrrhetinic acid 2.0 (2) Ascorbic acid phosphate sodium salt 3.0 (3) Stearic acid 2.0 (4) Cetanol 4.0 (5) Vaseline 5.0 (6) Squalane 8.0 (7) Hardened palm oil 4.0 (8) Polyoxyethylene sorbitan monostearate (20E.O.) 1.4 (9) Lipophilic glyceryl monostearate 2 .4 (10) butylparaben 0.1 (11) methylparaben 0.1 (12) glycerin 3.0 (13) dipropylene glycol 3.0 (14) L-arginine (10.0%) potassium hydroxide 0. 2 (15) Perfume 0.2 (16) Purified water Balance total 100.0

Example 5 Emulsion type cosmetic composition:

(Table 6) (Composition) (% by weight) (1) Glycyrrhetinic acid 2.0 (2) Ascorbic acid phosphate magnesium salt 3.0 (3) Stearic acid 1.0 (4) Cetanol 2.0 (5) Vaseline 2.5 (6) Squalane 4.0 (7) Hardened palm oil 2.0 (8) Polyoxyethylene sorbitan monostearate (20E.O.) 1.4 (9) Lipophilic glyceryl monostearate 1 .2 (10) Butylparaben 0.1 (11) Methylparaben 0.1 (12) Glycerin 3.0 (13) Dipropylene glycol 3.0 (14) Potassium hydroxide 0.2 (15) Carboxyvinyl polymer 0. 2 (16) Perfume 0.2 (17) Purified water Balance total 100.0

Example 6 Pack-type cosmetics (paste peel-off type):

[Table 7] (Composition) (wt%) (1) Stearyl glycyrrhetinate 5.0 (2) Ascorbic acid phosphate magnesium salt 5.0 (3) Polyvinyl alcohol 12.0 (4) Sodium carboxymethyl cellulose 3.0 (5) Dipropylene glycol 2.0 (6) Glycerin 2.0 (7) Ethanol 5.0 (8) Olive oil 3.0 (9) Polyoxyethylene hydrogenated castor oil (30E.O.) 0.5 (10 ) Titanium oxide 8.0 (11) Kaolin 6.0 (12) Perfume 0.1 (13) Methylparaben 0.1 (14) Purified water Balance total 100.0

Example 7 Ointment type cosmetics:

[Table 8] (Composition) (% by weight) (1) Glyceryl glycerinate 5.0 (2) Ascorbic acid phosphate magnesium salt 5.0 (3) White petrolatum 90.0 Total 100.0

Example 8 Liquid formulation cosmetics:

[Table 9] (Composition) (% by weight) (1) Pyridoxine glycyrrhetinate 4.0 (2) Ascorbic acid phosphate magnesium salt 1.0 (3) Ethanol 95.0 Total 100.0

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Yukihiro Yada 1-1-1 Kushimodani, Ninomiya-cho, Haga-gun, Tochigi Prefecture 12-1 (72) Genji Imagawa 1022-89 Himuro-cho, Utsunomiya-shi, Tochigi Prefecture

Claims (1)

[Claims] 1. A skin cosmetic comprising at least one selected from the group consisting of glycyrrhetinic acid and its ester, and at least one selected from the group consisting of ascorbic acid phosphoric acid ester and its salts.