JPH06271402A - Vermin-repelling composition - Google Patents

Abstract

(57) [Summary] [Purpose] When applied to the skin surface of the human body, there is little stickiness or skin irritation, and it excels in usability. Even when sprayed with an aerosol and atomized, it causes irritation to the nasal mucosa. Provided is a pest repellent composition which is relieved, has good redispersibility by shaking upon use of a powder that has settled and accumulated, and has excellent persistence of pest repellent efficacy. [Structure] A pest-repellent active ingredient is mixed with a porous organic powder so that the pest-repellent active ingredient is at least partially impregnated into the micropores or voids of the porous organic powder. As the porous organic powder, primary particles having powder particles themselves have fine pores or voids inside and porous particles and secondary particles obtained by aggregating primary particles to form secondary aggregates having fine pores or voids between particles. Any of the porous powders can be used.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a pest repellent composition, and more particularly to a human pest repellent composition having improved irritation, ease of use, and sustained release.

[0002]

2. Description of the Related Art Blood-sucking insects such as mosquitoes, flies, flies, fleas, etc. inhabit a large amount in tropical regions to warm regions, but depending on the species, they are often found in cold regions as well, and camping, hiking, fishing, golf, gardens. Attacks or blood-sucks the exposed skin surface when playing, outdoor recreation such as yachting, or when working on farms, fields, or power development areas in the mountains, and it is uncomfortable and sometimes infectious diseases and climate. It may also be a vector for the disease. Many studies have been conducted on pest repellents for repelling insect damage from such blood-sucking insects, and N, N-diethyl-m-toluamide, dimethylphthalate, dibutylphthalate,
Substances having a repellent effect such as 2,3,4,5-bis (Δ ₂ -butylene) -tetrahydrofurfural, di-n-propylisocinchomeronate and di-m-butylsassinate have been found and practically used. Have been used for.

Conventionally used dosage forms include one or more of these pest repellent substances, an liquefied gas such as LPG or Freon, or an aerosol agent using a compressed gas such as CO ₂ , N ₂ or air. A typical example is an aerosol agent using a pressure pump, and other examples include an emulsified cream and a lotion diluted with ethyl alcohol or isopropyl alcohol. However, some pest repellents have an irritation to the human body when applied to the skin surface of the human body, and particularly, N, N-diethyl-m-toluamide (hereinafter, D), which is the most typical and widely used, is used.
(ET) has a very significant irritation to the nasal mucosa when atomized by the above-mentioned aerosol agent and made into fine particles.

As a method for reducing the irritation of the nasal mucosa by such a finely divided drug, Japanese Patent Publication No. 47-43.
Japanese Patent Publication No. 745 discloses a method of adding glycerol acetate, isopropyl myristate, lauryl methacrylate, etc., and Japanese Patent Publication No. 48-939 discloses a method of adding oleyl alcohol and hexadecyl alcohol. It is difficult to say that the aerosol agent using the agent has a sufficient effect, and when it adheres to the skin, it has a sticky feeling and impairs the feeling of use. Further, the pest repellent active ingredient itself also often feels an oily and unpleasant sticky feeling when applied to the skin surface, and in general, the feeling of use when using the human body pest repellent composition is not preferable. . Furthermore, since the main period of use of the pest repellent is the hot summer months and the discomfort tends to increase, there is a demand for a pest repellent composition that does not give a sticky feeling.

Another problem with pest repellents is that they lack efficacy persistence, and various improvements have been invented in this regard as well. For example, Japanese Patent Laid-Open No. 4-24
4001 describes a composition in which DET and hydrophobic silicone are blended, but the problem of irritation to the nasal mucosa when atomized with an aerosol agent has not been solved, and as a compatibilizer Although a composition in which a fatty acid ester is used in a relatively large amount is also described, these compatibilizers are not preferable because they give an unpleasant sticky feeling when attached to the skin.

Further, Japanese Patent Laid-Open No. 59-199602 and Japanese Patent Publication No. 4-65802 describe a method of reducing percutaneous absorption of a pest repellent by using various powders. Since the agent is adsorbed on the powder surface, it easily migrates to the skin, and it is hard to say that it has a sufficient effect. Furthermore, for the purpose of reducing disappearance of the pest repellent due to evaporation, many methods of forming inclusion compounds or microcapsules of the pest repellent active ingredient have been invented, but these lead to cost increase due to complicated manufacturing process. Therefore, it is not practical. Further, for the same purpose, many methods of adding a raw material having a film forming ability have been invented,
These are not preferable because they give the skin an unpleasant feeling of adhesion and a soft feeling.

[0007]

Therefore, an object of the present invention is to provide an excellent feeling in use, such as less sticky feeling or skin irritation when applied to the human skin surface, and to be atomized by spraying with an aerosol agent. Even in the case of the above, the object is to provide a pest repellent composition in which irritation to the nasal mucosa is significantly alleviated. A further object of the present invention is to provide a pest repellent composition which is excellent in the persistence of the pest repellent effect when applied, and which is also excellent in the redispersibility by shaking when the precipitated and deposited powder is used. .

[0008]

According to the present invention, in order to achieve the above-mentioned object, a pest repellent active ingredient is mixed with a porous organic powder, and the pest repellent active ingredient is at least partially porous porous powder. Provided is a pest repellent composition, which is in a state of being impregnated into micropores or voids. As the above-mentioned porous organic powder, the powder particles themselves are primary particles having micropores or voids inside, and / or the primary particles are aggregated into a secondary aggregate having micropores or voids between the particles. Secondary particle porous powder is used. Preferably, the porous organic powder used is a synthetic polymer.

[0009]

The present inventor has conducted extensive studies on the form and composition of a pest repellent composition, and as a result, combines a pest repellent active ingredient with a porous organic powder to form a micropore or a void in the porous organic powder. It was found that the above object can be achieved by impregnating the pest repellent active ingredient, and completed the present invention. That is, in the pest repellent composition of the present invention, since most of the pest repellent active ingredient is impregnated inside the porous organic powder at the time of use, even when atomized by spraying with an aerosol agent, The irritation is significantly reduced as compared with the case where the active ingredient acts directly on the nasal mucosa. Further, even when it adheres to the skin, most of the pest repellent active ingredient adheres through the porous organic powder, so that it does not cause an unpleasant sticky feeling.
Furthermore, the migration of the pest repellent active ingredient impregnated inside the powder to the skin is less than when not using the powder or in the state of being adsorbed on the powder surface, and since the disappearance of the active ingredient due to evaporation is reduced, It is also excellent in the persistence of pest repellent effect.

As the porous powder, one in which the powder particles themselves have fine pores or voids (referred to as primary particle porous powder) and one in which the primary particles agglomerate and have secondary pores or voids between the particles Although it can be mentioned as a product (referred to as secondary particle porous powder), both of them can be used in the present invention. Further, as the powder used in the present invention,
It is preferably an organic powder. The reason is that the true specific gravity of the organic powder is about 0.7 to 1.8,
This is because the true specific gravity of the inorganic powder is about 2.0 or more, and the specific gravity of the organic powder is relatively lighter than that of the inorganic powder, so that the redispersibility of the precipitated and deposited powder by shaking during use is good. .

In recent years, in order to avoid ozone layer depletion due to freon-based compounds, conventionally freon-based solvents have been used as diluents for active ingredients, but they have been changed to alcohol-based solvents and the like. Further, for the same purpose, the propellant used for the aerosol agent has been changed from chlorofluorocarbon gas to liquefied petroleum gas, dimethyl ether or the like. These alternatives have a lower specific gravity than chlorofluorocarbon solvents and chlorofluorocarbons. That is, the liquid specific gravity of the CFC-based solvent or CFC gas is about 1.2 to
Whereas 1.6, the liquid specific gravity of the alternative diluent and propellant, which has become the mainstream in recent years, is about 0.5 to 0.8.

The pest repellent needs to be uniformly sprayed or applied to a relatively wide range of both arms, both feet, neck lines, etc., and it is desired that the powder dispersed by shaking slowly sediments. For this purpose, a small difference between the liquid specific gravity of the diluent or propellant and the true specific gravity of the powder is an important factor. Therefore, it is desirable to use an organic powder having a relatively low true specific gravity in a formulation using a diluent or a propellant, which has become mainstream in recent years. Furthermore, in order to redisperse the precipitated and accumulated powder by shaking, it is important that the true specific gravity of the powder is as small as possible and the difference in specific gravity between the diluent and the propellant is as small as possible. Is. As typical raw materials, synthetic polymers can be mentioned, and examples thereof include polyamide-based and acrylic-based materials.

The powder used in the present invention is not particularly limited as long as it is a porous organic powder as described above, but the following factors can be mentioned as factors for obtaining more preferable performance. First, the particle shape of the powder may be indefinite, but it is more preferable that it is substantially spherical. This property is important in order to obtain a good feel when contacting the skin and to avoid problems such as sedimentation and agglomeration of deposited powder in the preparation. To avoid agglomeration of powder components in the formulation, various additives such as surfactants and esters are often used, but some of these compounds have an unpleasant sticky feeling when attached to the skin. It often causes skin irritation and it is desirable to suppress the amount added as much as possible.
For this reason, it is significant to make the powder substantially spherical. Plate-like or needle-like powders should be avoided because they tend to become entangled when settling and accumulating, resulting in poor redispersibility.

The average particle diameter of the porous organic powder is 1 to 50 μm.
The thickness is preferably about m, more preferably about 5 to 40 μm. If the particle size of the powder is too small, there is a high possibility that the powder will be inhaled into the lung by breathing, which is not preferable. On the other hand, if the powder particle size is too large, the settling speed of the powder in the formulation will be high, there is a risk that the injection port may be clogged with the aerosol agent, and many dropouts after it adheres to the skin, etc. Yes, it is not preferable. The amount of porous organic powder added is
Type of powder, amount of pest repellent active ingredient, amount of various additives,
Although it is not limited in nature because it may change depending on the type and amount of diluent, it is psychologically or psychologically difficult to confirm that powder components are attached to the skin due to too much powder being added. It is considered to be unfavorable in appearance. Therefore, the amount of porous organic powder added is 10
It is preferably less than wt%. Further, in order to reduce irritation to the nasal mucosa, it is desired to add about 0.1% by weight or more.

The pest repellent composition of the present invention can be prepared by mixing the respective raw materials with a stirrer such as a mixer or a homogenizer, and does not require special steps or consideration in production. Therefore, there are great manufacturing advantages as compared to inclusion compound formation, microencapsulation, and the like. Since the pest repellent composition of the present invention is characterized by reducing irritation to the nasal mucosa when it is made into fine particles, it is the most typical dosage form for use as an aerosol. However, the pest repellent composition of the present invention is excellent in sedimentation, redispersibility of deposited powder components, slow sedimentation speed of the redispersed powder, excellent persistence of effect, and reduction of unpleasant sticky feeling. In addition, it has many advantages such as easy smoothness and smoothness due to the powder component, so it can be used not only for aerosols but for other dosage forms such as lotions and creams. Is.

The pest repellent active ingredient of the present invention includes N,
N-diethyl-m-toluamide (hereinafter referred to as DET), di-n-butyl-succinate (hereinafter referred to as DNBS)
,), Di-n-propyl-isocinchomeronate (hereinafter referred to as DPIC), tetramethylthiuram disulfite, guanidine, naphthalene cresol, cycloheximide, zinc dimethyldithiocarbamate, cyclohexylamine, N, N-dimethylsulfenyl. Dithiocarbamate, 2,6-dimethyl-octadiene-
(2,6) -αl (8) (hereinafter referred to as citral),
0,0-diethyl S-2-ethylthioethyldithiophosphate (hereinafter referred to as ETP), 0,0-dimethyl S-2-isopropylthioethyldithiophosphate,
γ-chloralose, 4- (methylthio) -3,5-xylyl-N-methylcarbamate, 4-aminopyridine anthraquinone, tetramethylthylium disulfide,
Diallyl disulfide, dimethyl phthalate, dibutyl phthalate (hereinafter referred to as DBP), 2,3,4,5-
Examples thereof include substances having a repellent effect such as bis (Δ ₂ -butylene) -tetrahydrofurfural. The addition amount of the pest repellent active ingredient is not particularly limited because the repellent effect peculiar to each active ingredient is different, but by setting it to about 1 to 20% by weight in the formulation, the purpose is to obtain a suitable effect, a good feeling of use, etc. Can be achieved.

In addition, the pest repellent composition of the present invention may contain any conventionally known component within a range that does not impair the effects of the present invention. Such compounding ingredients include, for example, water: jojoba oil, avocado oil, almond oil, olive oil, grape seed oil, sesame oil, sasanqua oil, safflower oil, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil. Oils such as, castor oil, sunflower oil, cottonseed oil, peanut oil, cocoa oil, palm oil, coconut oil, beef oil, fish fat, hydrogenated oil, turtle oil, pork oil, mink oil, egg yolk oil: whale wax, shellac , Beeswax, lanolin, liquid lanolin, carnauba wax, candelilla wax and other waxes:
Liquid paraffin, liquid polyisobutylene, squalane,
Hydrocarbons such as pristane, petrolatum, paraffin, cesylene, pentane and hexane: dimethyl polysiloxane,
Silicone oils such as methylphenylpolysiloxane, methylhydrogenpolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane: succinic acid, tartaric acid, citric acid, undecylenic acid, lauric acid, myristic acid, palmitic acid, stearic acid, Fatty acids such as isostearic acid, oleic acid, linoleic acid, ricinoleic acid and behenic acid: ethanol, isopropanol, lauryl alcohol, cetanol, 2-hexyldecanol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, alcohols such as lanolin alcohol: ethylene glycol, Diethylene glycol monoethyl ether, triethylene glycol, polyethylene glycol, propylene glycol,
Polyhydric alcohols such as 1,3-butylene glycol, glycerin and batyl alcohol: glucose, sucrose, lactose,
Sugars such as xylitol, sorbitol, mannitol and maltitol: diisopropyl adipate, hexyldecyl isostearate, cetyl isooctanoate, oleyl oleate, decyl oleate, lanolin acetate, butyl stearate, isopropyl myristate, diethyl phthalate, laurate Esters such as hexyl: aluminum stearate, calcium stearate, magnesium stearate, zinc stearate, aluminum myristate, calcium myristate, magnesium myristate, zinc myristate, aluminum palmitate, calcium palmitate, magnesium palmitate, palmitate Metal soaps such as zinc, zinc laurate, zinc undecylenate, and calcium acetate: gum arabic, sodium alginate Potassium, casein, carrageenan,
Natural water-soluble polymer compounds such as karaya gum, agar, quince seed, gelatin, dextrin, starch, tragacanth and pectin: Natural pigments such as chlorophyll and β-carotene: sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate , Sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate,
Penta-2-ethylhexylate diglycerol sorbitan, tetra-2-ethylhexylate diglycerol sorbitan, and other sorbitan fatty acid esters, monocotton oil fatty acid glycerin, glyceryl monoerucate, glycerin sesquioleate, glyceryl monostearate, α,
α'-Oleic acid glycerin pyroglutamate, glycerin monostearate Glycerin polyglycerin fatty acids such as malic acid, propylene glycol fatty acid esters such as propylene glycol monostearate, hydrogenated castor oil derivative, lipophilic non-ion such as glycerin alkyl ether Surfactants: POE sorbitan monooleate, POE sorbitan monostearate, POE sorbitan monooleate, POE sorbitan tetraoleate, and other POE sorbitan fatty acid esters, POE sorbit monolaurate, POE sorbit monooleate, POE sorbit pentaoleate , POE sorbit monostearate, POE sorbit fatty acid ester, POE glycerin monostearate, POE glycerin monoisostearate Rate, POE glycerin fatty acid esters such as POE glycerin triisostearate, POE monooleate, POE distearate, P
POE fatty acid esters such as OE monodioleate and ethylene glycol distearate, POE lauryl ether, POE oleyl ether, POE stearyl ether, POE behenyl ether, POE 2-octyldodecyl ether, POE cholestanol ether and other P
POE alkyl phenyl ethers such as OE alkyl ethers, POE octyl phenyl ether, POE nonyl phenyl ether, POE dinonyl phenyl ether, Pluronic type surfactants such as Pluronic, P
OE / POP cetyl ether, POE / POP 2-decyl tetradecyl ether, POE / POP monobutyl ether, POE / POP hydrogenated lanolin, POE / POP
POE / POP alkyl ethers such as glycerin ether, tetra-POE / tetra-POP ethylenediamine condensates such as Tetronic, POE castor oil, POE hydrogenated castor oil, POE hydrogenated castor oil monoisostearate,
POE hydrogenated castor oil towisostearate, POE hydrogenated castor oil monopyroglutamic acid monoisostearate diester, POE hydrogenated castor oil POE castor oil such as maleic acid, hydrogenated castor oil derivative, POE beeswax lanolin derivative such as POE sorbit beeswax, coconut oil Fatty acid diethanolamide, lauric acid monoethanolamide,
Alkanol amides such as fatty acid isopropanolamide, POE propylene glycol fatty acid ester, PO
E Alkylamine, POE fatty acid amide, sucrose fatty acid ester, POE nonylphenylformaldehyde condensate, alkylethoxydimethylamine oxide, trioleylphosphoric acid and other hydrophilic nonionic surfactants: soap base, sodium laurate, palmitic acid Fatty acid soap such as sodium, higher alkyl sulfate ester salt such as sodium lauryl sulfate and potassium lauryl sulfate, P
OE lauryl sulfate triethanolamine, POE sodium lauryl sulfate and other alkyl ether sulfate salts, N-acyl sarcosinic acid such as lauroyl sarcosine sodium, N-myristoyl-N-methyl taurine sodium, coconut oil fatty acid methyl tauride sodium,
Higher fatty acid amide sulfonate such as sodium lauryl methyl tauride, POE oleyl ether sodium phosphate, phosphate ester salt such as POE stearic ether phosphate, sodium di-2-ethylhexyl sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene Sodium sulfosuccinate, lauryl polypropylene glycol sulfosuccinates such as sodium sulfosuccinate, sodium linear dodecylbenzene sulfonate, triethanolamine linear dodecylbenzene sulfonate, alkylbenzene sulfonates such as linear dodecylbenzene sulfonate, monosodium N-lauroyl glutamate , N-stearoyl glutamate disodium, N-myristoyl-L-glutamate monosodium, etc. Acyl glutamate, hardened coconut oil fatty acid glycerin sodium sulfate and other higher fatty acid ester sulfate ester salt, funnel oil and other sulfated oil, POE alkyl ether carboxylic acid, POE alkyl allyl ether carboxylate, α-olefin sulfonate, higher salt Fatty acid ester sulfonate, secondary alcohol sulfate ester salt, higher fatty acid alkylolamide sulfate ester salt,
Lauroyl monoethanolamide sodium succinate,
N-palmitoyl aspartic acid ditriethanolamine, anionic surfactant such as sodium caseinate: polyether-modified silicone, amino-modified silicone, alkyl-modified silicone, alcohol-modified silicone, carboxylic acid-modified silicone, etc. silicone-based surfactant: perfluoro Fluorine-based surfactants such as alkylcarboxylic acid salts, perfluoroalkyl phosphates, perfluoroalkyltrimethylammonium salts, perfluoroalkylpetines, perfluoroalkylamine oxides, perfluoroalkylEO adducts: butyl paraoxybenzoate, Preservatives such as propyl paraoxybenzoate, ethyl paraoxybenzoate and methyl paraoxybenzoate: vitamin A, vitamin D, vitamin E, vitamin K
And other vitamins: estradiol, ethinyl estradiol, cortisone and other hormones: aluminum hydroxy chloride, aluminum chloride, aluminum sulfate, basic aluminum bromide, aluminum phenol sulfonic acid, tannic acid, aluminum naphthalene sulfonic acid, basic aluminum iodide, etc. Antiperspirants: UV absorbers such as urocanic acid and cinoxate: Anti-inflammatory agents such as allantoin, aloe powder and guaizulene: 3,4,4-
Trichlorocarbanilide (TC), triethyl citrate (TEC), benzalkonium chloride,
Benzotonium chloride, alkyltrimethylammonium chloride, resorcin, phenol, sorbic acid, salicylic acid, hexachlorophene and other fungicides: other powders not exemplified in the present invention: lavender, lemon, lime, jasmine, which are natural plant flavors. Essential oils such as mint, peppermint, rose, camphor: musk, civet,
Animal flavors such as castor and other synthetic flavors: propellants such as dimethyl ether, liquefied petroleum gas, compressed nitrogen gas, compressed air, carbon dioxide gas and the like.

[0018]

EXAMPLES The present invention will be specifically described below with reference to Examples, Comparative Examples and various test examples, but it goes without saying that the present invention is not limited to the following Examples.

Table 1 shows the types and properties of each powder component used in the following examples and comparative examples.

[Table 1]

Examples 1 to 7 and Comparative Examples 1 to 6 Pest repellent compositions having the respective formulations shown in Tables 2 and 3 were prepared,
A glass aerosol test bottle was filled to obtain an aerosol agent.

[Table 2]

[0021]

[Table 3]

Test Example 1 (nasal mucosa irritation test) The aerosols of Examples 1 to 7 and Comparative Examples 1 to 6 were sprayed on both hands and both feet, and the stimulus strength to the nasal mucosa felt at that time was as follows. It was evaluated in four stages. ◎ Almost no irritation. ○ Slightly stimulating, but not a problem. × There is irritation. XX Very stimulating. The results of the nasal mucosa stimulation test are shown in Table 4.

[Table 4] As is clear from the results shown in Table 4, the pest repellent aerosol agent using the porous organic powder has less irritation to the nasal mucosa as compared with those using the non-porous powder or those not using the powder. You can see that it is done.

Examples 8 to 12 and Comparative Examples 7 to 9 Pest repellent compositions having the respective formulations shown in Tables 5 and 6 were prepared,
The compositions of Examples 8 to 10 and Comparative Examples 7 and 9 were filled into glass aerosol test bottles to make aerosol agents, while the compositions of Examples 11 and 12 and Comparative Example 8 were filled into PET containers. It was used as a lotion.

[Table 5]

[0024]

[Table 6]

Test Example 2 (Redispersibility Test) Each sample prepared in Examples 8 to 12 and Comparative Examples 7 to 9 was left in an atmosphere of 25 ° C. for 3 months and then shaken by hand to redisperse it. The results of observing the sex were evaluated according to the following four grades. ◎ Disperse uniformly by shaking about 1 to 5 times. ○ Disperse uniformly by shaking about 5 to 10 times. × Aggregation tendency is observed. XX At least partially strong aggregates were formed. The test results are shown in Table 7.

[Table 7] As is clear from the results shown in Table 7, the one using the porous organic powder is superior in redispersibility to the one using the inorganic powder.

Examples 13 and 14 and Comparative Examples 10 to 12 The pest repellent compositions having the respective formulations shown in Table 8 were prepared and filled in a glass aerosol test bottle to prepare an aerosol agent.

[Table 8]

Test Example 3 (Usage test) The aerosols of Examples 13 and 14 and Comparative Examples 10 to 12 were sprayed onto both hands and feet, and the feeling of use was evaluated according to the following three grades. ○ There is almost no unpleasant feeling of use such as stickiness or softness. × The above-mentioned uncomfortable feeling of use. XX The above-mentioned unpleasant feeling of use is very strong. The test results are shown in Table 9.

[Table 9] As is clear from the results shown in Table 9, it can be seen that the aerosol agent using the porous organic powder has an excellent feeling of use as compared with the case where the non-porous aerosol agent is used and the case where the powder is not used. .

Examples 15 and 16 and Comparative Examples 13 and 14 The pest repellent compositions having the respective formulations shown in Table 10 were prepared and filled in a glass aerosol test bottle to prepare an aerosol agent.

[Table 10]

Test Example 4 (Pest Repellent Efficacy Test) The aerosols of Examples 15 and 16 and Comparative Examples 13 and 14 were applied to the upper arm of a healthy adult male in an amount of 0.1 mg of active ingredient per cm ^2. It was sprayed to become. About 6 hours after spraying, about 50 female adults of Aedes albopictus not blood-sucking
The upper arm was inserted for 30 seconds into the gauge where the rat was released, and the number of mosquitoes that sucked blood was observed. The results were evaluated according to the following two grades. ○ Blood is not sucked. × Blood is sucked in at least one place. The test results are shown in Table 11.

[Table 11] From the results shown in Table 11, the pest repellent aerosol agent using the porous organic powder is superior in the pest repellent efficacy and its sustainability as compared with the case of using the non-porous one and the case of not using the powder. I understand.

[0030]

As described above, the pest repellent composition of the present invention comprises a pest repellent active ingredient combined with a porous organic powder,
Most of the pest repellent active ingredients are impregnated into the micropores or voids of the porous organic powder, so there is little sticky feeling or skin irritation when applied to the human skin surface, and a feeling of use In addition, the effect of significantly reducing irritation to the nasal mucosa even when atomized by being sprayed with an aerosol is obtained. Further, since the difference between the true specific gravity of the porous organic powder used in the present invention, particularly the porous organic powder formed of a synthetic polymer and the liquid specific gravity of the diluent or the propellant is small, the precipitated and deposited powder is shaken. Then, it can be easily re-dispersed, and a stable and excellent usability product can be obtained. Furthermore, the migration of the pest repellent active ingredient impregnated inside the porous organic powder to the skin is less than that in the case of not using the powder or being adsorbed on the powder surface, and the disappearance of the active ingredient due to transpiration is reduced. Therefore, the pest repellent efficacy is also excellent in sustainability.

Claims (3)

[Claims] 1. A pest characterized in that a porous organic powder is blended with the pest repellent active ingredient, and the pest repellent active ingredient is at least partially impregnated into the micropores or voids of the porous organic powder. Repellent composition. 2. A porous organic powder is a primary particle in which the powder particles themselves have micropores or voids inside and / or a secondary agglomerate in which the primary particles are aggregated to have micropores or voids between the particles. The pest repellent composition according to claim 1, which is a porous powder of secondary particles. 3. The pest repellent composition according to claim 1, wherein the porous organic powder is formed of a synthetic polymer.