JPH06321705A - Insect repellent - Google Patents

Abstract

PURPOSE:To obtain a worm repellent free from unnecessary dispersion of the drug, easy to coat on the application spot and convenient for carrying. CONSTITUTION:This worm repellent is produced by immersing a composition consisting of a worm repellent component of diethyltoluamide, at least one of ethanol and propylene glycol and water on a carrier.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a wet tissue type insect repellent.

[0002]

BACKGROUND OF THE INVENTION Insect repellents are available in the form of aerosols, lotions, creams, napkins, etc., which are used by direct application or sticking to the skin surface [Yoshikatsu Sayama, Fragrance Journal NO. 71, P88
(1985)]. Among the above-mentioned dosage forms, the aerosol type is very convenient because it can easily apply the chemical liquid to a wide range without soiling the hands.

However, since the aerosol type sprays a drug, it is difficult to control the application range of the drug,
There is a problem that the clothes are scattered to the part that does not need to be applied and the clothes are contaminated. Furthermore, there is a possibility that the drug may cause inflammation when it enters a hypersensitive site such as the mucous membrane of the eye, or may cause respiratory system disorders due to the drug inhaled by respiration.

In order to solve the problem of such drug scattering, an aerosol agent capable of spraying the drug in a mousse shape has been proposed (Japanese Patent Laid-Open No. 2-264703). However, since the range that can be applied by one injection becomes extremely narrow, it is necessary to once take the drug on the palm and spread it on the application site, which causes problems such as soiling the hands and fingers. Further, since the aerosol agent container is equipped with a spraying mechanism for spraying the drug in a mist or mousse shape, there is a problem that the container becomes large and it is inconvenient to carry.

[0005]

SUMMARY OF THE INVENTION The present invention has been made in view of the above problems, and an object thereof is to prevent the drug from being unnecessarily scattered and to easily apply the drug to an application site. To provide a convenient insect repellent.

[0006]

The insect repellent of the present invention is a support in which a drug is impregnated.

The support is not particularly limited as long as it has a drug impregnating property, and for example, woven cloth, non-woven cloth,
A resin foam or the like is preferably used. As the woven cloth,
For example, those made of flannel, cotton, silk, polyester, nylon and the like can be mentioned.

Examples of the non-woven fabric include those made of polyester, polyolefin, nylon, cotton, rayon, vinylon and cellulose.

The thickness of the above-mentioned non-woven fabric is preferably 0.3 to 10 mm, more preferably 0.5 to 8 mm, because the thinner the amount of drug that can be impregnated becomes smaller, and the thicker it becomes, the poorer the feeling of use and the lower the portability. Is. Also, the basis weight is 5
It is preferably from 0 to 200 g / m ² .

If the support is thin, the area is increased, and if the support is thick, the area is reduced to make it a puff type, so that the support can be more easily used.

The above-mentioned resin foam is preferably open-celled. For example, polyethylene, polypropylene, ethylene-vinyl acetate copolymer, polyvinyl chloride, etc. are used alone or in combination of two or more resins to form a sheet. A foam may be mentioned. Examples of commercially available resin foams include urethane, styrene foam, and polyethylene foam.

[0012] The thickness of the resin foam is preferably 0.5 to 10 mm, more preferably 1 to 10 mm in order to make the impregnated drug feel on the skin and to be easily applied.
It is 5 mm.

A drug impermeable layer may be provided on one surface of the support. Such a drug-impermeable layer is provided by bonding a drug-impermeable film to one surface of the support with an adhesive or heat-sealing.

Examples of the drug-impermeable layer include:
A polyolefin film such as a polyethylene film is preferably used. The thickness of the polyolefin film is preferably 10 to 30 μm, and may be creased to maintain the flexibility of the polyolefin film.

When the support is a resin foam, the surface of the foam may be heat-treated to melt the air bubbles to form a drug impermeable layer.

The above-mentioned drug is composed of diethyltoluamide, an insect repellent component, at least one of ethanol and propylene glycol, and water.

If ethanol is used as a solvent for the above-mentioned chemicals, the drying property after application can be improved, but if the amount of ethanol increases, damage to the skin and the risk of flammability occur, so water is added. Further, if the amount of water is large, it takes time to dry, so 60% by weight or less is preferable.

Moisturizers, detergents, bactericides, fragrances, etc. may be added to the above-mentioned chemicals, if necessary. Examples of the moisturizer include glycerin, ethylene glycol, propylene glycol, polyethylene glycol and the like. Examples of the cleaning agent include various kinds of surfactants, and examples of the sterilizing agent include quaternary ammonium salts such as benzalkonium chloride. Examples of the cleaning and sterilizing agent include chlorhexidine gluconate and the like.

The amount of the drug impregnated into the above-mentioned support varies depending on the thickness and area of the support.
When a cellulose nonwoven fabric of m ² (size 15 × 16 cm ² ) is used as the support, the amount is preferably 2.7 to 5.1 g. When a polyester non-woven fabric having a basis weight of 190 g / m ² (size 5 × 7 cm ² ) is used as the support, 3.5 to 5 g is preferable.

The insect repellent of the present invention is packaged for the purpose of stability and portability, but it may be packaged for each preparation,
Multiple formulations may be packaged together. Further, when a drug impermeable layer is provided on one surface of the support, the packaging may cover only the other surface.

Since the above insect repellent is a wet tissue type in which a support is impregnated with a drug, the drug is applied by rubbing it against the skin by hand.

[0022]

EXAMPLES Examples of the present invention will be described below. (Example 1) Diethyltoluamide (7 g) Ethanol (50 parts by weight) and water (50 parts by weight) were mixed well, and 4.5 parts by weight of a drug was impregnated into a cellulose fiber non-woven fabric (size 15 × 16 cm ² ) support having a basis weight of 29 g / m ^2. Then, an insect repellent was prepared. One sheet of this insect repellent was laminated with a polyethylene terephthalate (hereinafter referred to as PET) / aluminum foil / polyethylene three-layer film laminate in a polyethylene bag facing each other and heat-sealed on three sides to form an opening. Was heat-sealed to obtain a hermetically-sealed insect repellent.

Example 2 A hermetically-sealed insect repellent was obtained in the same manner as in Example 1 except that 2.5 parts by weight of the drug was impregnated.

Example 3 A hermetically-sealed insect repellent was obtained in the same manner as in Example 1 except that 5.5 parts by weight of the drug was impregnated.

(Example 4) 4.0 parts by weight of the chemical agent was weighted 1
90g / m ² polyester non-woven fabric (size 5 × 7cm
² ) except that it was impregnated in the same manner as in Example 1,
A hermetically sealed insect repellent was obtained.

Example 5 4.0 parts by weight of a chemical agent was heat-bonded to a polyethylene film on one side to obtain a basis weight of 190 g / m 2.
^A hermetically-sealed insect repellent was obtained in the same manner as in Example 1 except that the ^second polyester nonwoven fabric (size 5 × 7 cm ² ) was impregnated.

(Embodiment 6) A polyester non-woven fabric having a basis weight of 190 g / m ² (size 5 × 7 cm ² ) is coated on one side with PET.
3. A support prepared by heat-sealing the polyethylene side of a three-layer film laminate of aluminum foil / aluminum foil / polyethylene in the packaging bag used in Example 1 and the drug prepared in Example 1 through the opening of the bag. After injecting 0 part by weight, the opening was heat-sealed to obtain a hermetically-sealed insect repellent.

(Example 7) Example 7 except that 4.5 parts by weight of a drug, which was prepared by adding 8 parts by weight of diethyltoluamide, 5 parts by weight of propylene glycol, 50 parts by weight of ethanol and 50 parts by weight of water and mixing them well, was used. A sealed package insect repellent was prepared in the same manner as in 1.

Example 8 Example 8 was repeated except that 8 parts by weight of diethyltoluamide, 1 part by weight of chlorhexidine gluconate, 50 parts by weight of ethanol and 50 parts by weight of water were added, and 4.5 parts by weight of a well-mixed drug was used. After preparing the insect repellent in the same manner as in Example 1, 20 pieces of the insect repellent were put together, put in the bag used in Example 1 and hermetically sealed.

Comparative Example 1 A commercially available aerosol type insect repellent (“Skinguard” manufactured by Johnson & Johnson).

[Evaluation of Insect Repellent] With respect to the insect repellents obtained in the above Examples and Comparative Examples, 20 adults evaluated the feeling of use and the contamination at the time of use. (1) Feeling of use After opening the sealed insect repellent, and applying the drug by wiping with a hand on the upper arm, the feeler is evaluated organoleptically according to the following evaluation criteria ~ Table 1 shows the number of respondents to (for multiple answers). The face was also evaluated by the same method, and the results are shown in Table 2. <Evaluation Criteria> The required amount could be freely applied to the required site. The amount of drug was small and the drug was faint. There was a large amount of drug, and there was drug leakage during use. The drug was attached to the area other than the required area. The aerosol of Comparative Example 1 was not directly sprayed onto the face but was once received by the palm and applied to the face.

(2) Contamination at the time of use The sealed insect repellent was opened, and the drug was applied by wiping the upper arm with a hand. Then, after thoroughly washing the used hand with 15 ml of a 40 wt% ethanol aqueous solution, the methanol aqueous solution is recovered to quantify the drug amount,
The relative value of the drug amount (the remaining amount of the drug of the insect repellent of Example 1 was 10
0) is shown in Table 1. Further, the amount of the drug was quantified after applying on the face by the same method, and the results are shown in Table 2.

[0033]

[Table 1]

[0034]

[Table 2]

[0035]

As described above, the insect repellent of the present invention is convenient for carrying since it does not cause unnecessary scattering of the drug and can be easily applied to any site. Further, the insect repellent having the drug impermeable layer provided on one surface of the support can be applied without contaminating the hands or fingers.

Claims (1)

[Claims] 1. An insect repellent component, diethyltoluamide, and either ethanol or propylene glycol as a support.
An insect repellent characterized by being impregnated with a chemical consisting of at least one species and water.