JPH0640858A - Hair tonic - Google Patents

Abstract

PURPOSE:To obtain a hair tonic having excellent hair tonic effect such as hair- falling preventing effect and hair restoration effect by using a fibroblast growth factor as an active component. CONSTITUTION:A fibroblast growth factor, preferably a base-type fibroblast growth factor is used as an active component and compounded in an amount of 0.000001-0.1wt.% based on the total hair tonic. The hair tonic is properly compounded with other components such as vasodilator, amino acid, vitamin, dermatic function promoting agent, female hormone preparation, antibacterial agent, refreshing agent, oil, polyhydric alcohol, surfactant, perfumery and antioxidant. The agent is formed in a form applicable to the skin such as liquid, milky lotion or ointment and directly applied or scattered to the skin at a daily rate of 0.01-1,000mug/1kg body weight in 1-4 divided doses. It is applicable in the fields of pharmaceuticals, quasi-drugs and cosmetics.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a fibroblast growth factor (Fibroblast Growth Factor).
Hereinafter referred to as FGF) as an active ingredient.
The present invention relates to a hair nourishing agent having excellent hair loss prevention and hair growth effects. The present invention is particularly used in the fields of medicines, quasi drugs, and cosmetics.

[0002]

2. Description of the Related Art Conventionally, the causes of baldness and hair loss are activation of male hormones in organs such as hair roots and sebaceous glands, decrease in blood flow to hair follicles, excessive secretion of sebum, and generation of peroxides. Abnormalities of the scalp are considered. For this reason, conventional hair nourishing agents are generally blended with compounds having the action of removing or reducing the above causes. For example, vitamins such as vitamin B and vitamin E, amino acids such as serine and methionine, vasodilators such as cembly extract and acetylcholine derivative, purple root extract, anti-inflammatory agents such as hinokitiol, female hormone agents such as estradiol, cepharanthin, etc. , A skin function-enhancing agent, etc. are mixed and used for the prevention and treatment of alopecia.

[0003]

However, in spite of various attempts as described above, conventional hair nourishing agents do not always have sufficient hair nourishing effects such as hair loss prevention and hair growth effect. There wasn't. It is believed that these are probably due to various causes of hair loss and the mechanism of hair growth is also very complicated.

In view of the insufficient hair-feeding effect as described above, the present inventors are effective for hair loss and have excellent hair-preventing effects such as hair loss prevention and hair growth effects. As a result of the search, the inventors have found that FGF has an excellent hair-feeding effect, and have completed the present invention.

[0005]

That is, the present invention provides FG
The present invention provides a hair nourishing agent containing F as an active ingredient. Hereinafter, the configuration of the present invention will be described in detail. The FGF used in the present invention is generally acid type (hereinafter referred to as a-FGF) and basic type (hereinafter referred to as b-F).
(Described as GF). In the present invention, either of these may be used, but b-
FGF is preferred. The FGF used in the present invention is already available on the market as a reagent derived from bovine. The FGF used in the present invention may be the one described above, or a horse,
Any animal-derived animal such as sheep, rabbit and rat may be used.

[0006] The amount of FGF of the present invention is
0.01-1000ppm (0.000001-0.1wt%), preferably
It is 0.1 to 100 ppm (0.00001 to 0.01% by weight). 0.01pp
If it is less than m, the effect of the present invention cannot be sufficiently obtained, and 1000 pp
When it exceeds m, it is not preferable in terms of formulation.

The hair nourishing agent according to the present invention includes, in addition to the above-mentioned FGF, vasodilators such as carpronium chloride, cembly extract and acetylcholine derivative, amino acids such as serine and methionine, vitamin B6, vitamin E and its derivatives,
Vitamins such as biotin, pantothenic acid and its derivatives, glycyrrhetinic acid and its derivatives, nicotinic acid esters such as benzyl nicotinate, skin function enhancers such as cepharanthin, and female hormone preparations such as estradiol may be mixed at the same time. . Furthermore, additives usually used for hair nourishing agents, for example, hinokitiol, hexachlorophene, benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, trichlorocarbanilide and antibacterial agents such as biothionol, a refreshing agent such as menthol, salicylic acid, Zinc and its derivatives, drugs such as lactic acid and its alkyl esters, organic acids such as citric acid, amino acids such as arginine, olive oil, squalane, liquid paraffin, isopropyl myristate, oils such as higher fatty acids and higher alcohols, glycerin, propylene Polyhydric alcohol such as glycol, other surfactants, fragrances, antioxidants, ultraviolet absorbers, dyes, ethanol, water, humectants, thickeners and the like may be appropriately blended within a range that does not impair the effects of the present invention. it can.

The hair nourishing agent of the present invention may be in any form as long as it has properties applicable to the outer skin such as liquid, emulsion and ointment. The hair nourishing agent of the present invention is administered by percutaneous administration by directly applying or spraying on the skin. Further, the dose of the hair nourishing agent of the present invention cannot be definitely determined because it varies depending on age, individual difference, medical condition, etc. However, in general, the dose for administration to humans is 1 kg of body weight and 0.01 to 1000 μg per day, preferably. Is 0.1 to 100 μg, and this amount can be administered once a day or in 2 to 4 divided doses.

[0009]

EXAMPLES Next, the production method and the hair-retaining action of the hair nourishing agent of the present invention will be described in more detail with reference to examples. The present invention is not limited to this. The blending amount is% by weight.

(Manufacturing method) 100% of b-FGF was prepared in advance.
An aqueous solution of μg / ml (ppm) was prepared. B in 95% ethanol
-FGF and hydrogenated castor oil ethylene oxide (40 mol) adduct were added, dissolved by stirring, and then ion-exchanged water was added and mixed to obtain a liquid hair nourishing agent of Example 1. Examples 2 to 5 and Comparative Example 1 were also obtained in the same manner as in Example 1.

[0011]

[Table 1]

[Hair Growth Test] Examples 1 to 5 and Comparative Example 1
Hair growth test with C3H / HeNCr in the resting period of hair cycle
Using the J mouse, the method of Ogawa et al. (Normal and Abnormal Epidermal Differentiation
[Normal and Abnormal Epidermal Differentiation],
Edited by M. Seiji and IA Bernstein, pp. 159-170, 1982, University of Tokyo. That is, the number of mice was 10 per group, and there was no application, and the mice were divided into 7 groups of Examples 1 to 5 and Comparative Example 1, the backs of the mice were shaved with a clipper and a shaver, and each sample was treated with 0.1 times a day.
Each ml was applied. The hair-growth effect of each sample was measured by measuring the hair-growth part on the back of the mouse and compared by the area ratio. Table 2 shows the number of days required for 50% hair growth rate for each sample.

[0013]

[Table 2]

As is clear from Table 2, the hair nourishing agent according to the present invention has an excellent hair growth effect.

[Hair nourishing test] Next, in order to examine the hair nourishing effects such as hair loss prevention and hair growth effects of the hair nourishing agent of the present invention, a trichogram test was conducted on humans. The hair nourishing agents of Examples 1 to 5 and Comparative Example 1 were used.

[Trichogram test] The hair roots of the removed hair before and after the use of the hair nourishing agent are observed under a microscope, and the number of resting hair roots is counted from the morphology of the hair nourishing agent. The effects were compared. Resting hair roots are hair roots that have stopped growing, and it has been recognized that people who complain of hair loss have a higher proportion of resting hair roots than normal people. Each hair nourishment of Examples 1 to 5 and Comparative Example 1 was applied to the scalp of 10 male subjects twice a day, 2 ml each, continuously for 6 months, immediately before and immediately after the application for 6 months. 100 hairs were removed from each subject, and each hair root was examined. The results are shown in Table 3.

[0017]

[Table 3]

As is clear from Table 3, the hair nourishing agent according to the present invention has an excellent hair nourishing action.

[0019]

The hair nourishing agent of the present invention has excellent hair nourishing effects such as hair loss prevention and hair growth effects.

Example 6 O / W emulsion type hair nourishing agent (phase A) wt% b-FGF aqueous solution 100 μg / ml (ppm) 1.0 polyoxyethylene (60 mol) addition-hardened castor oil 2.0 glycerin 10.0 dipropylene glycol 10.0 1 , 3-Butylene glycol 5.0 Polyethylene glycol 1500 5.0 (Phase B) Cetyl isooctanate 10.0 Squalane 5.0 Vaseline 2.0 Propylparaben 2.0 (Phase C) Carboxyvinyl polymer 1% aqueous solution 30.0 Sodium hexametaphosphate 0.03 Ion-exchanged water 8.35 (Phase D) ion Exchanged water 4.5 (Phase E) Causticari 0.12 Ion exchanged water 5.0 (Production method) Phases A and B are melted by heating at 60 ° C, mixed and treated with a homomixer to form a gel. Phase D is gradually added to this and dispersed by a homomixer. Next, dissolved C phase was added thereto, and finally dissolved E phase was added and emulsified with a homomixer to obtain an O / W emulsion type hair nourishing agent. When this hair nourishing agent was subjected to a practical use test to humans as in Example 1, it was confirmed that the hair nourishing action was excellent.

Example 7 Creamy hair nourishing agent (phase A) wt% b-FGF aqueous solution 100 μg / ml (ppm) 5.0 liquid paraffin 5.0 cetostearyl alcohol 5.5 glyceryl monostearate 3.0 EO (20 mol) -2-octyldodecyl ether 3.0 Propylparaben 0.3 Perfume 0.1 (Phase B) Glycerin 8.0 Dipropylene glycol 20.0 Polyethylene glycol 4000 5.0 Sodium hexametaphosphate 0.005 Ion-exchanged water 45.095 (Production method) Phases A and B are dissolved by heating and mixed,
The mixture was emulsified with a homomixer to obtain a creamy hair nourishing agent. When this hair nourishing agent was subjected to a practical use test on humans as in Example 1, it was confirmed that the hair nourishing effect was excellent.

Example 8 Cream hair nourishing agent (Phase A) wt% b-FGF aqueous solution 100 μg / ml (ppm) 0.5 liquid paraffin 10.5 glyceryl monostearate 3.0 EO (20 mol) -2-octyldodecyl ether 3.0 propylparaben 0.3 Fragrance 0.1 (Phase B) Glycerin 10.0 Dipropylene glycol 18.0 Polyethylene glycol 4000 5.0 Sodium hexametaphosphate 0.005 Ion-exchanged water 54.595 (Manufacturing method) Phases A and B are melted by heating and mixed,
The mixture was emulsified with a homomixer to obtain a creamy hair nourishing agent. When this hair nourishing agent was subjected to a practical use test on humans as in Example 1, it was confirmed that the hair nourishing effect was excellent.

Example 9 O / W emulsion type hair nourishing agent (Phase A) wt% b-FGF aqueous solution 100 μg / ml (ppm) 10.0 Polyoxyethylene (60 mol) Addition hydrogenated castor oil 2.0 Glycerin 10.0 1,3-butylene Glycol 5.0 Polyethylene glycol 1500 5.0 (Phase B) Cetyl isooctanate 10.0 Vaseline 8.0 Propylparaben 2.0 (Phase C) 1% aqueous solution of carboxyvinyl polymer 30.0 Sodium hexametaphosphate 0.03 Ion exchanged water 8.35 (D phase) Ion exchanged water 4.5 (E phase) ) KASEIKARI 0.12 Ion-exchanged water 5.0 (Production method) Phases A and B are dissolved by heating at 60 ° C, mixed, and homogenized to form a gel. Phase D is gradually added to this and dispersed by a homomixer. Next, dissolved C phase was added thereto, and finally dissolved E phase was added and emulsified with a homomixer to obtain an O / W emulsion type hair nourishing agent. When this hair nourishing agent was subjected to a practical use test to humans as in Example 1, it was confirmed that the hair nourishing action was excellent.

Example 10 O / W emulsion type hair nourishing agent (A phase) wt% a-FGF aqueous solution 100 μg / ml (ppm) 1.0 polyoxyethylene (60 mol) addition-hardened castor oil 2.0 glycerin 10.0 dipropylene glycol 10.0 1 , 3-Butylene glycol 5.0 Polyethylene glycol 1500 5.0 (Phase B) Cetyl isooctanate 10.0 Squalane 5.0 Vaseline 2.0 Propylparaben 2.0 (Phase C) Carboxyvinyl polymer 1% aqueous solution 30.0 Sodium hexametaphosphate 0.03 Ion-exchanged water 8.35 (Phase D) ion Exchanged water 4.5 (Phase E) Causticari 0.12 Ion exchanged water 5.0 (Production method) Phases A and B are melted by heating at 60 ° C, mixed and treated with a homomixer to form a gel. Phase D is gradually added to this and dispersed by a homomixer. Next, dissolved C phase was added thereto, and finally dissolved E phase was added and emulsified with a homomixer to obtain an O / W emulsion type hair nourishing agent.

Claims (2)

[Claims] 1. A fibroblast growth factor (Fibroblas)
t Growth Factor) as an active ingredient. 2. The fibroblast growth factor is a basic fibroblast growth factor (basic type-Fibroblast Gro).
The hair nourishing agent according to claim 1, which is a Wth Factor).