JPH0645530B2 - External skin preparation - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial field of application] The present invention blends liquid polyhydric ester of polyhydric alcohol and fatty acid together with 4- (1,1-dimethylethyl) -4′-methoxydibenzoylmethane. The present invention relates to a skin external preparation having excellent UV protection effect and excellent quality.

[Prior Art] It is known that sun rays not only cause sunburn but also promote skin aging due to the sunburn.

There are not a few skin external preparations designed to prevent the sun's rays, but all of them are powdered and mainly reflected,
It was dealt with by scattering, or was compounded with substances called UV-B such as salicylic acid derivatives and aminobenzoic acid derivatives that absorb only ultraviolet rays having a relatively short wavelength.

[Problems to be Solved by the Invention] 4- (1,1-Dimethylethyl) -4′-methoxydibenzoylmethane is a harmful U to sun rays, especially to the skin.
Recently, it has been spotlighted as a substance called VA that absorbs ultraviolet rays having a relatively long wavelength, but its compatibility with the skin external preparation base is poor, and it is relatively short even if it is mixed with the skin external preparation in a dissolved state. It often precipitates as crystals over time.

Needless to say, when the crystals are deposited as crystals, the quality of the external preparation for skin is significantly impaired, and even the UV absorption ability for the original purpose cannot be exhibited.

[Means for Solving Problems] As a result of earnest research in view of such circumstances, the present inventor has found that 4- (1,
By blending 1-dimethylethyl) -4'-methoxydibenzoylmethane with a liquid polyhydric ester of a polyhydric alcohol and a fatty acid, not only the UV absorption effect is excellent, but also the long-term stability is excellent and quality deterioration occurs. The inventors have found that a topical skin external preparation can be obtained, and completed the present invention.

That is, the present invention provides a skin external preparation having an excellent ultraviolet absorbing effect and an excellent quality.

Hereinafter, the configuration of the present invention will be described in detail.

4- (1,1-dimethylethyl) -used in the present invention
4'-methoxydibenzoylmethane is disclosed in JP-A-55-6.
It is manufactured by the method shown in 6535, and is supplied by Givaudan Co., Ltd. under the trade name of "Pulsol 1789".

The amount to be added to the external preparation for skin is optional depending on the expected UV absorption effect, but if the amount is extremely large, the amount of the base for external preparation for skin becomes too small, which is not preferable. It is preferably 0.01 to 10%. If it is less than 0.01%, the ultraviolet absorbing effect is small and the intended purpose cannot be achieved. If it exceeds 10%, the amount of the base agent for external preparation for skin is reduced and the quality of the external preparation for skin itself is impaired.

Examples of the polyhydric alcohol constituting the liquid polyhydric ester of a polyhydric alcohol and a fatty acid to be blended for the purpose of exerting the effect of the present invention include, for example, ethylene glycol, propylene glycol, neopentyl glycol, glycerin,
Diglycerin, polyglycerin, trimethylolpropane, pentaerythritol, sorbitan, and the like, and fatty acids having 8 to 22 carbon atoms, such as straight chain, branched, and unsaturated fatty acids, for example, n-decanoic acid, 2-ethylhexanoic acid,
Isostearic acid, oleic acid, linoleic acid, etc. are famous.

Examples of the liquid polyhydric ester of polyhydric alcohol and fatty acid include glyceryl tri (2-ethylhexanoate), glyceryl triisostearate, glyceryl diisostearate, glyceryl di (2-ethylhexanoate), pentaerythritol- Tetra (2-ethylhexanoate), propylene glycol-diolate, ethylene glycol di (2-ethylhexanoate), neopentyl glycol di (n-decanoate), diglycerin diisostearate, sorbitan sesquioleate, etc. are available. It's easy to do.

These esters are blended in one kind or two or more kinds, but as an amount to be mixed for the purpose of exerting the effect of the present invention, 4-
The amount of (1,1-dimethylethyl) -4'-methoxydibenzoylmethane is required to be 1/2 or more, and even if it is added in excess, the effect of the present invention is not impaired.

In the present invention, 4- (1,1-dimethylethyl) -4 '
Any conventional skin external preparation base can be used as the skin external preparation base in which the liquid polyvalent ester of -methoxydibenzoylmethane, polyhydric alcohol and fatty acid is blended.

That is, liquids, gels, pastes, creams and the like, as a component for modifying the skin external preparation, moisturizers, oils, surfactants, thickeners, sequestering agents, other ultraviolet absorbers, drugs, It goes without saying that dyes and fragrances can be used in combination.

[Examples] <Example 1> Sunscreen oil 4- (1,1-dimethylethyl) 2 wt% -4'-methoxydibenzoyl methane glyceryl tri (2-ethylhexa 10 noate) (trade name: RA-G-308) ) Liquid paraffin 88 [Effect of the invention] Example 1 is an external preparation for skin containing 4- (1,1-dimethylethyl) -4'-methoxydibenzoylmethane and a liquid polyhydric alcohol fatty acid ester in accordance with the present invention. Is.

On the other hand, the case where 4- (1,1-dimethylethyl) -4'-methoxydibenzoylmethane is not mixed and the case where liquid polyhydric alcohol fatty acid ester is not mixed are shown below as control examples.

<Comparative Example 1> 4- (1,1-dimethylethyl) 2 wt% -4'-methoxydibenzoyl methane squawan 10 liquid paraffin 88 <Comparative example 2> Glyceryl tri (2-ethylhexa 10 wt% noate) (trade name: RA -G-308) Liquid paraffin 90 Table 1 shows the storage stability and UV protection effect.

The external preparations for skin of Example 1 and Comparative Examples 1 and 2 are all used as sunscreen oils.

Although Comparative Example 1 was a uniform liquid immediately after the production, 4-
(1,1-Dimethylethyl) -4'-methoxydibenzoylmethane is gradually deposited, and the quality of the external skin preparation is deteriorated, and even the ultraviolet protection effect is reduced.

In Comparative Example 2, crystals are not precipitated, but the UV protection effect cannot be expected.

On the other hand, in Example 1, the crystals are not precipitated immediately after the production and also after the storage for a long period of time, the ultraviolet protection effect is excellent, and the quality is stable.

This is a result of applying the technique according to the present invention.

The present invention will now be described in more detail with reference to more examples, but the present invention is not limited thereto.

Example 2 A. Cetanol 3 wt% Stearic acid 3 Vaseline 3 Neopentyl glycol 3 Di (n-decanoate) Glyceryl monostearate 2 Sorbitan sesquioleate 2 Squalane 5 4- (1,1-Dimethylethyl) 2-4'-methoxydibenzoyl methane fragrance Suitable amount B. Propylene glycol 3 Potassium hydroxide 0.2 Purified water based on the total amount of 100 An oil phase portion of A and an aqueous phase portion of B are dissolved by heating at 70 ° C., and A is added to B to emulsify. Then, it is cooled to obtain a cream.

Example 3 4- (1,1-dimethylethyl) 5 wt% -4'-methoxydibenzoyl methane Solid paraffin 20 Vaseline 20 Castor oil 40 Glyceryl triisostearate 5 Diglycerin diisostearate 3 Formulation colorant (red color) 7) Perfume proper amount Each of the above raw materials is heated and melted at 80 ° C., and then poured into a predetermined container to obtain a lipstick.

Example 4 A. Stearyl alcohol 2 wt% Stearic acid 2 Purified lanolin 2 Pentaerythritol-tetra 5 (2-ethylhexanoate) Glyceryl monolinoleate 1 Glyceryl monostearate 2 4- (1,1-Dimethylethyl) 2-4'-methoxydi Benzoyl methane Preservative Amount Perfume Amount B. Glycerin 5 Potassium hydroxide 0.2 Purified water 100 as a whole C.I. Formulated powder 10 A oil phase raw material and B aqueous phase raw material are heated and melted at 70 ° C., respectively, and then A is added to B and emulsified. A powdery portion of C is dispersed therein and then cooled to obtain a cream foundation.

Example 5 Ethylene glycol di 50 wt% (2-ethylhexanoate) Glyceryl tri (2-ethyl 10 hexanoate) Trimethylolpropane tri 15 isostearate Liquid paraffin 10 4- (1,1-Dimethylethyl) 10 -4 ' -Methoxydibenzoyl methane dye Appropriate amount Perfume Appropriate amount Each of the above components is dissolved by heating at 50 ° C and then stirred and cooled to obtain a body oil.

Example 6 Solid paraffin 10 wt% Liquid paraffin Total amount of 100 Vaseline 20 Glyceryl monostearate 5 Diglycerin 0.05 Diisostearate 4- (1,1-Dimethylethyl) 0.1 -4'-Methoxydi Benzoyl methane fragrance Appropriate amount Each of the above components is dissolved by heating at 50 ° C., followed by stirring and cooling to obtain a body gel.

The external preparations for skin of Examples 2 to 6 were excellent in the effect of absorbing ultraviolet rays, and there was no deterioration in quality due to precipitation of crystals even after 3 months from the production.

This is a result of applying the technique according to the present invention.

Claims (1)

[Claims] 1. 4- (1,1-Dimethylethyl) -4'-
A skin external preparation characterized in that a liquid polyvalent ester of a polyhydric alcohol and a fatty acid is blended together with methoxydibenzoylmethane.