JPH06501857A - double layer dressing - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed description of the invention] double layer dressing The present invention is suitable for wound dressings, typically small cuts, burns, postoperative incision sites and It relates to a type of adhesive used on wounds. In particular, covering such wounds Adhesive bandages or adhesive bandages used at home to protect and protect the wound itself. It relates to things that are used by adhering to or around them. The best of such bandages Another well-known example is Band-Aid (trademark, Johnson & Jo hnson, Inc), Elasto Blast (trademark, Sm1th & Nep Hew Limlted) and Hansaplast (trademark, Belersdor) f　Company A, G).

These well-known long strip bandages consist of a long strip of plastic or woven fabric and a Consists of a sterile gauze bandage with a coat of adhesive for application to the skin. It is equipped with By covering the gauze with a perforated plasti long piece, It is possible to prevent gauze from adhering to the surface of the wound. Also, Kizukura Kiyoshi's It is also known to impregnate gauze with chemicals such as preservatives.

These usually hand-made Nagakata Kizuna Kurakiyo are easy and convenient for home and family use. Although generally effective, there are certain disadvantages. For example, to check the healing process. The bandage must be changed frequently in order to use medication or to use medication. , which is painful in some cases. In many cases, moisture cannot escape sufficiently. This causes the tissue to swell, slowing healing. Washing the wound area will remove the bandage, It becomes loose. The moisture layer that remains on the fibers when wet, or the growth of microorganisms and tissue swelling. Promotes moisture. In addition, it is difficult to use it on areas with large undulations of the body.

An important factor in the wound healing process is maintaining an appropriate moisture environment around the wound area. It is to be. The dressing may protect one area from contamination or It promotes dryness and scab formation, but is not completely satisfactory. The healing process Wounds are protected from contamination and come into contact with a properly moisture-controlled environment. This will be further promoted by

U.S. Pat. No. 4,750,482 (Sieverding) describes A water-insoluble, hydrophilic, pressure-sensitive adhesive useful for attaching tissue to mammalian tissue. is disclosed.

The composition of the adhesive is a synthetic organic polymer without cross-linking that results in a gel of at least - Contains radiation cross-linked synthetic organic polymers obtained from dissolved plasticizer solutions in the body. radiation Cross-linking forms a gel that holds the dissolved plasticizer in a three-dimensional network of bonds. . An example of a synthetic organic polymer without cross-linking that is suitable for radiation cross-linking is polyacrylate. Mention may be made of a mixture of lylic acid and polyethylene oxide in a weight ratio of 14:1. Ru. Dissolved plasticizers include non-volatile elastic agents that are normally liquid at room temperature.

Canadian Patent No. 1.180.244 (Muchin) describes a pharmaceutical coating that adheres to objects. material, made of polyurethane or other copolymer that holds the adhesive on one side Stretchable film sheet and non-stretchable film sheet on the opposite side (11 notes) disclosed that the invention consists of a carrier. This assembly was adhesively applied to the patient. Afterwards, the film sheet carrier is removed from the extensible sheet. The adhesive is It is of the previous form.

U.S. Pat. No. 3,419,006 (King) discloses polyethylene oxide polymers. A composite dressing 'II' is disclosed. Disclosed polymer The complex has a very high water content.

The object of the present invention is to use polymer composites (polymer composites) as materials that come into contact with the skin and wounds. To provide a novel skin/wound dressing using rcoarplexes) .

The present invention is intended to treat skin disorders (this term is defined as cuts, burns, abrasions, skin infections or skin diseases). lesions caused by the disease, postoperative incisions, and other damaged skin or skin. skin (used to include areas of mourning) and contusions or injuries. Use on skin over injured or inflamed tissue, bruised bone or muscle. new connections that can be used at household level, where appropriate. Provides an adherent covering. The adhesive coating material of the present invention allows water vapor to A self-supporting external backing that is permeable ( The backing layer can adhere to one side of the body supported by the backing layer. It has a wound contact layer comprised of a conformable, high moisture content polymeric composite.

According to the present invention, the biologically compatible filJf'! described herein!・Skin contact Coated polymer composites can be used to treat skin disorders when combined with an appropriate backing layer. Create a highly satisfying, moisture-controlled environment suitable for promoting healing. It turns out that it can be provided.

The polymer composite used as the skin injury contact layer of the product of the invention is a sticky solid. Or it is a semi-solid material. For it to adhere to the skin, typically 20 It has a moisture content of ~70% by weight. This complex can be swollen by water, but Essentially water insoluble. This composite consists of a mixture of at least two hydrophilic polymers. coprecipitating from a solution (preferably an aqueous solution) and then removing the coprecipitate from the medium; It is then produced by adjusting the residual moisture content of the coprecipitate, if desired. be able to. By exposing this polymer composite to normal indoor environments, the amount of water is lost, but this is essentially reversible and can be increased by immersion in water. can be restored by exposure to very high humidity. Polymer complexes are formed by individual polymerization In the sense that it cannot be physically separated into its components, it is obtained by the interaction of individual polymers. It is a product that is chemically bonded, but is not essentially chemically cross-linked. Its stickiness is Increases when moistened.

Thus, in accordance with one aspect of the invention, adhesively adheres to mammalian tissue for therapeutic treatment. An adhesive dressing suitable for contacting the treatment area is provided, which dressing is: self-supporting; self-supporting and water vapor permeable layer; and consisting of a sticky polymer composite with high water content supported by its outer layer; an inner layer that contacts the treatment area; sk button-ccMpatibla) and sufficient moisture content to adhere to the skin. and mixed solutions of the first and second coprecipitable hydrophilic polymers. By the resulting co-precipitation and by adjusting the moisture content if desired, the production It consists of a tacky polymer composite product.

According to another aspect of the invention, the tissue of the mammal is applied to contact the treatment area of the mammal. A process for manufacturing a coating material suitable for adhesive attachment is provided, which The process consists of: Mix a solution of co-precipitable hydrophilic polymers and make the solid or semi-solid solution compatible with the wound. producing a solid co-precipitated polymer composite; Its polymer composite and water vapor permeability by applying to the surface of a permeable film forming a laminate with the film; and If necessary, the polymer complex may be applied to the film surface before or after application. The water content of the coalesce is adjusted to the amount required to form an adhesive to the skin.

Thus, the coating of the present invention is a simple material that can be easily adjusted to economical large-scale production. It is possible to produce a substance with a desired structure and composition by a suitable procedure. I can do it.

In the attached drawing: Figure IA is a cross-sectional diagram of the basic structure of the adhesive double-layered bandage of the present invention in a package. can be; Figures 4B and IC are similar diagrams for variations of the embodiment of Figure IA; 3A is a similar cross-sectional diagram of another embodiment of the invention; FIG. 3A is a similar cross-sectional diagram of another embodiment of the invention; 3B is a similar cross-sectional diagram of the embodiment; FIG. 3B is a variation of the embodiment of FIG. 3A; FIG. 3C is a similar view of the bottom release seal of the embodiment of FIGS. 3A and 3B; FIG. 4 is a plan view from below with the tip removed for use; FIG. FIGS. 5 and 6 are similar cross-sectional diagrams of yet another embodiment; FIGS. and a similar cross-sectional diagram of the most preferred embodiment in its packaged state.

Note that in the figures, the same reference numbers indicate the same corresponding parts.

Referring to the accompanying FIG. 1, the basic embodiment includes an external package 13; This package 13 encloses a humid environment 20 around the packaged dressing. It has the property of being a barrier to water vapor. The dressing itself (desired A self-supporting layer 22 made of a film (with holes), a film with high water vapor permeability. a polymer composite layer 24 supported by a foam or woven fabric layer 22; and a release sheet 30 that protects the lower surface of the polymer composite layer 24.

The release sheet 30 is provided with a protruding tab 32 at the end, making it easy to remove the release sheet 30 before use. It can be removed easily. In the variant shown in Figure IB, instead of tabs A body lateral extension portion 32b is provided. In the variant shown in Figure IC, the release sheet The toe 30 consists of two parts, and each part is provided with a protrusion 32c - easy to remove. It is being done. The high humidity environment 20 inside the pan cage 13 causes the polymer composite layer 24 to dry. It prevents you from doing it. A release sheet 30 is used to prevent this assembly from adhering to the package. is prevented.

Referring to Figure 2, the embodiment shown therein (packaging omitted) is Qualitatively similar to that shown in FIG. 22 and a polymer composite layer 24, and is sandwiched between Enhances the adhesion of polymer composites. Combination of adhesive layer 26 and self-supporting layer 22 must have sufficient water vapor permeability.

Referring to FIG. 3A, the embodiment shown therein (also omitting the package) ) has a rim 36 of adhesive material surrounding the polymer composite layer 24. Ru. The adhesive rim 36 is located on the underside of the laterally extending periphery of the self-supporting layer 22. I'm being kicked. In the structure of FIG. 3A, the rim 36 is the only one, except for the polymer composite 24. This is the first adhesive part. In FIG. 3B, self-supporting layer 22 is attached to polymer composite layer 24. Rim 3 as a peripheral extension of bonding adhesive layer 26 beyond polymer composite layer 24 6 is formed. In both cases, the adhesive rim 36 is separated from the top layer by a release sheet. 30, and is exposed to the outside when the release sheet 30 is removed. and adhere to the skin. In both embodiments, the lower part of this assembly is shown in FIG. It has a polished appearance. The adhesive 26 in this embodiment is skin compatible.

Referring to FIG. 4, the embodiment shown therein has a cover for ``22; The covering includes a self-supporting film 34 and attaching the film 34 to the top layer 22. It is in the form of a weak adhesive layer 46 for attachment. Release sheet 34 ．． Tabs 42, 32 are provided respectively for easy removal of 30.

In this embodiment, ]22 is protected until the time of use. The weak adhesive layer 46 It is possible to keep the film 34 in position when the release sheet 30 is removed. It must be strong enough to Adhesive 46 is applied to film 34 from this structure. Even after it is removed, it remains attached to the film 34.

Although the embodiment shown in FIGS. 5 and 6 is the most preferred embodiment, the embodiment shown in FIG. As in the case, a release sheet 34 is attached on top of the "22". In the example of FIG. The upper release sheet 34 has lateral extensions forming tabs for easy removal. 43 and is attached to the upper layer 22 by an adhesive layer 46. glue The lower part of the layer 46, the extension 43, is provided with a protective patch 44 of a suitable material. Ru. A release sheet 30 covering polymer composite layer 24 resists its removal. It has tabs 32 to make it easier. As in FIG. 3B, the adhesive layer 26 is a polymer composite. It is provided extending to the outer periphery of the combined layer 24, thereby adhering to the skin. It looks like this. The whole thing is housed in a sealed external lock cage 13. . The package contains a high humidity environment within which the polymer composite 24 is applied prior to use. It is advisable to keep it moist. Package 13 is aluminum Made by foil/thermoplastic laminate or metallized thermoplastic film. It is preferable that the material is made of aluminum, so that it can be heat-sealed. heat seal You can conveniently open the package by tearing off the edge of the package. It should be assumed that Alternatively, make appropriate cuts on the edges of the package to easily You can also make it so that it can be opened. In the embodiment of FIG. 6, the release sheet 34 is adhesive 22 without using any agent. For example, the upper layer 22 can be removed from the surface of the release sheet. Solution casting can be performed on the surface.

In other respects, this embodiment is the same as the embodiment shown in FIG.

The illustrated embodiments are for illustrative purposes only and are not intended to limit the scope of the invention. Please understand that there is no such thing.

For use, the package must be in a sealed outer package or in an opening bag assembly. taken from. The release zone 30 covering the polymer composite layer 24 is removed. The bandage is applied to the wound area so that the polymer composite layer 24 is in contact with the wound. It will be done. The adhesion of Kizuna 61 Sei to wounds is due to the inherent adhesiveness of the polymer composite layer 24. and, in the case of the embodiments of FIGS. 3, 5 and 6, of the surrounding adhesive layer 36. This is accomplished by adhesion to the skin surrounding the wound site. Apply Kiyoshi Kizukura to the wound site. Pressure can be applied to and through the upper layer 22 after approximately the top of the This can slow down bleeding from the wound site. After that, the bandage should be applied properly. A moist environment can be provided to the wound site.

Polymer composite Ifm used as wound contact layer in the dressing of the invention The article is substantially wound compatible and skin compatible.

``The word ``bound c-tible'' Here, it can be used for new wound sites in humans or other animals, and Describes materials that do not harmfully interfere with normal, healthy biological processes that may occur in It is used for this purpose. Compatible with skin (skin com patible) The word J indicates that it is not harmful to normal, healthy skin where it is used. It means yes. The adhesive coating material of the present invention is suitable for filling (33 areas and the environment). It provides excellent water vapor permeability, and is effective against foods containing viruses. Provide an adequate barrier to damage from harmful contamination or physical contact that interferes with the healing process. It works in this way. After removing this adhesive dressing, surround the injured area. The skin is relatively free of swelling and discoloration.

This is primarily due to the adequate water vapor permeability of the assembly.

The polymer composite layer as well as the outer layer and any adhesive layer between them. After the adhesive layer is applied to a wound, it remains on the wound and, if desired, By making them transparent, you can inspect the wound and visually monitor the healing process. You can do something like this. Furthermore, such adhesive coatings may be, for example, colored, non-colored, Manufactured to be cosmetically attractive by being transparent or matte can be used to retain drugs to treat the wound site. Each of the above All layers have the right permeability to water vapor to ensure the best properties for treatment. It is possible to make it into something. Preferably they also have oxygen permeability.

The polymer composite used in the present invention is compatible with scratches and has minimal A sticky product produced by co-precipitation from a solution of at least two water-soluble hydrophilic polymers. It is a created thing. Preferably, the polymer is coprecipitated from an aqueous solution. The choice of two polymers is , when two polymer solutions are mixed together in relation to each other, the resulting When mixing solutions, after standing, during subsequent concentration, during pH adjustment, or when using appropriate solutes. is selected such that upon addition of the two polymers, a coprecipitate of the two polymers is formed.

The coprecipitate is usually semi-solid and has a "rubber-like" consistency, and the supernatant liquid is discarded. , or a suitable solvent (e.g., water-soluble ethanol, water-soluble acetone, or water-soluble solvent). by dissolving it at room temperature or slightly higher temperature in Can be separated. This solution is then applied to the self-supporting outer layer and allowed to dry. I can do it. Alternatively, pour the polymer solution onto a suitable transfer surface. Cast, dry and deposit onto a self-supporting outer layer as a transfer coating. and, if deemed necessary, then some degree of refinement prior to final assembly of the product. to increase adhesion to release sheets and the like. Used in the present invention Preferred polymer composites that can be dried have a non-tacky self-containing structure. It can be made into a supportive film and then re-humidified into an adhesive form. List of things that can be made into a state. Such materials should be In the film form, it is handled by 711, for example, in theaters and in cutting machines. be.

If the rubbery coprecipitate is sufficiently mobile at room temperature or higher, it It may not be necessary to dissolve the coprecipitate directly on the outer layer or as appropriate. It may be possible to cover it over a transfer surface. Forms polymer complexes and self- After application to the support layer, a sealed water vapor-containing bag (envelope), for example as described above, is used. lobes) to keep the polymer composite layer moist until use. It is preferable to

If it is desirable to add other additional ingredients such as plasticizers, colorants, drugs, etc. These are appropriately mixed into the coprecipitate or coprecipitate solution.

Thus, according to the invention, hydrophilic, water-soluble and solution (preferably aqueous) a polymer that can be co-precipitated from to form a wound-compatible polymer complex co-precipitate. need to be selected. The first polymer is a copolymer of acrylic acid (FAA), Polymers and copolymers of methacrylic acid (PMA), polymers of itaconic acid and Copolymers (PrA), polymers and copolymers of maleic acid (PMLA), and You can select from these combinations. The second hydrophilic polymer is vinyl Polymers or copolymers of lupyrrolidone, polymers or copolymers of ethylene oxide Polymers (propylene oxide and ethylene oxide (P (EO/PO)) ), chitosan, N,0-carbomethoxy chitosan, etc. You can choose from body, gelatin, and a combination of these.

When applied to a self-supporting layer and when packaged in bags, the polymer composite absorbs significant moisture. content, e.g. 20-70% by weight of the total, and the solid weight varies accordingly. Coalescing is 80-30% by weight. After applying to 119 sites, the water content of the polymer composite The bandage reaches equilibrium within minutes, but this is due to the loss of water vapor throughout the bandage. depends on the underlying wound as well as the rate of water vapor production in the skin. 20-70% Contact of the assembly of the water-containing polymeric composite and self-supporting layer with the wound site causes 1. It has a beneficial effect on wound healing as it prevents dryness of the area. ing. Occasionally antibiotics Appropriate drugs such as anti-infectives, analgesics, anti-pruritics, and growth factors can be included in the polymer complex. Additional benefits may be obtained by Such substances are particularly suitable for the present invention. Easy to include in polymer complexes. This is because after being formed by coprecipitation, heavy The conjugate is redissolved in an organic solvent, which generally dissolves the drug into a polymer conjugate. This is because it is a particularly good vehicle for adding to the body.

Thus, the adhesive dressing of the present invention relieves discomfort such as muscle pain, bruises, etc. A particularly useful skin-permeable drug delivery system (DR) for delivering drugs for It is useful as a delivery system. In addition to this Adhesive dressings have difficulty penetrating the skin and therefore require control of film rate. are particularly useful for drug delivery, but are not suitable for membrane-based skin-permeable drug delivery devices. be.

Once adhered to the treatment area, the polymer composite layer and self-supporting backing film form a combination. The steric space provides an effective barrier to microorganisms and other treatment-interfering foreign substances. adhesive assembly The body can withstand immersion in seawater or tap water or regular washing, and Withstands the application of skin creams and lotions.

The adhesive polymer composite layer can also be coated with a polymer composite to strengthen it and increase its bonding strength. A reinforcing mesh may be included disposed within the thickness of the coalescence. such reinforcement Mesh is essentially a tissue made of cellulose fibers and porous, similar to tea bags. It can be made into a non-woven fiber sheet made of fibers. Such materials are hydrogels. It is known for use in wound dressing materials.

Examples of such suitable materials available on the market include - The Dexter Corporation of Losox Dexter Gndes 785D and A special blend of hemp and other selected cellulose fibers sold as There is a high strength, low weight, porous tissue made from a blend.

Alternatively, polypropylene, high density polyethylene or polyethylene Strengthens thermoplastically welded fiber webs made of thermoplastic fibers such as Stell. It can be used as a chemical mesh. Such web appropriate and city An example of what is available on the market is Applied Exec in Middleton, P.O. Applied Extrusion Technology There are some products sold under the DaNET trademark by .

Such a reinforced mesh is created by applying a polymer in liquid form to a self-supporting outer layer. It can be incorporated into the polymer layer either before or after.

Particularly desirable for use as the second hydrophilic polymer is the polymerization of ethylene oxide. Polymers or copolymers of vinylpyrrolidone, especially polymers or copolymers of vinylpyrrolidone The other is polyethylene oxide or polyvinylpyrrolidone.

Acrylic acid type polymers or copolymers, especially polyacrylic acids, are suitable for the adhesive properties of the present invention. Selected as the first hydrophilic polymer to form the polymer composite adhesive layer of bandages It is particularly suitable for Using a wide range of grades and molecular weights of PAA The choice is within the skill of the art. Appropriate F　AA　A is 1 molecule or less at least 2,500, preferably from s,ooo to 450,000.

Particularly preferred for use in the present invention are polymers derived from FAA as the first polymer. The second polymer is PEO. A wide range of molecules is approximately PEO having a molecular weight of 6,000 to 600 can be used. 000 is particularly suitable.

As mentioned above, a plasticizer can be included in the polymer composite layer of the present invention; This allows the final softness of the layer to be adjusted. The preference of such plasticizers is Suitable ones include urea, polypylene glycol, low molecular weight polyhydroxylated compounds (such as glycerol), sorbitol, gluconola Chthone, triethanolamine and gluconic acid. triethanolamine Add an alkaline plasticizer such as the first hydrophilic polymer with a carboxylic acid group. It can be used to reduce the complexity of polymer complexes by neutralizing them. The viscosity M'/jE can thereby be increased by rehydration. If there is Traditional alkalis, such as caustic soda or ammonia, also serve the same purpose. It is advantageous for Furthermore, the polymer complex in contact with the wound inhibits microbial growth. Appropriate preservatives may be included to protect the product. Known to those skilled in the art and often used A number of preservatives are suitable for use for this purpose, including, for example, benzoic acid. Sodium and sorbic acid.

In the No. 1 real button 2j of the present invention, the polymer composite layer is applied to the outer film layer and then To a limited extent, the polymer is subjected to a cross-linking process to increase its strength and for sterilization purposes. It is possible to realize cross-coupling. This involves applying a polymer composite layer to a film layer. and then exposed to a controlled amount of appropriate radiation (e.g. 3-4 Mrad gamma rays). This can be conveniently achieved by applying Products that have actually been irradiated with radiation When applied to a wound site, it reduces bleeding much better than products that do not use radiation. was found to suppress

The outer layer of the assembly of the present invention is self-supporting and highly water vapor permeable. High water vapor permeability Permeability can be determined by the inherent high permeability of the material, by microporosity, or by openings. This can be obtained by providing . Furthermore, it has high oxygen permeability and the wound area It should have good foldability so that it is comfortable in position, and it should also have extensibility and elasticity. It is preferable to do so.

The combination of outer layer and polymer composite acts as a barrier to drying in one area. However, the wound area and adjacent skin may become edematous (swell), leading to To avoid detrimental effects on healing, or to prevent fluid build-up at the bandage and wound interface. Allow sufficient water vapor to pass through and exit the wound site to avoid loss of adhesion. It must also be something. For this purpose, the backing layer should be water vapor permeable. Suitably at least 100 gm/ar'/24 hours. Must Where necessary, water vapor permeability can be improved by drilling holes or introducing microporosity. It can be increased by The degree of aperture is not critical; The backing layer is determined by the requirements for protecting and retaining the polymer composite. It will be done. Therefore, the size and nature of such openings are determined by the backing sheet being made of a polymer composite. It should not interfere with the body's protective functions. Of course, it is a polymer composite. must be retained and the polymer must not diffuse through the backing sheet. must not.

For a discussion of water vapor permeability through wound dressings and how to measure it, see Marc el F Jonkman et al, “New Method to A s5ess the Water Vapor Permeanc■@of Wound Dressings”, Bicxrklterials, 19 88. Volume 9. May, page 263|267 You can refer to things.

In addition, the perforations provided in the outer layer are Increases adhesion to the outer layer of the composite and prevents the tendency of the lamination to peel It is also useful for In fact, the opening [1 is one of the physical connections between the outer layer and the conjugate complex. 1 to form two quibs, the shape of an open loft)) tear-resistant, It is advantageous to be in a state of

The physical linkage is the surface of the outer film layer that receives the polymer composite or adhesive. Emboss (embossed pattern), dots with pins), or rough finish It is also possible to realize the increase by fortune-telling.

The outer layer may be essentially any skin-compatible material exhibiting suitable permeability. It can be made according to quality. It is a self-supporting film, foam. Alternatively, it can be made of woven fabric. Suitable such materials are known in the prior art. The adhesive polarization covering bandages of the previous technology are generally based on the book. It is also useful in inventions. Examples include polyester polyurethane, polyether polyurethane, silicone, polyethylene, polypropylene, ethylene-vinyl Examples include acetate copolymer, polyvinyl chloride, and the like. it is , opaque items, genuine leather transparent items, colored items, transparent items, or designs or It can be printed with characters.

Ultra-thin polyurethane films semi-permeable to water vapor are available as wound dressings on the market. Agent 0P-5ITE is made of polyurethane foam coated with a pharmaceutical grade adhesive. (consisting of a film) can be cited as an example, and is particularly preferred. this Ultrathin polyurethane films often have adequate permeability even without apertures. , is there. Elastic silicone membranes are another preferred outer layer film. This is a good example.

This requires openings to provide adequate permeability.

Foam sheet (preferably open cell foam) m) or perforated closed self-ohm cell foam), natural, synthetic, or mixed fiber non-woven fabrics or A woven bandage may also be used as the outer layer of the assembly of the present invention. can.

Similarly, the non-polymer used as a skin-contacting layer in the assembly of embodiments of the invention Composite adhesives are used in conventional wound dressings fiIPfi, prior art known in the art or appropriate. Pressure-sensitive, skin-compatible adhesives are usually used There is.

Porous adhesive footings are particularly preferred10. stomach. These adhesives are acrylic acid Polymer or silicone (e.g., Dow Corning Pharmaceutical Adhesives) ninHMpAical adhesiva).

These are merely examples of suitable and available materials.

Referring again to the accompanying drawings, in particular FIGS. 4 and 5, the adhesive layer 46 The adhesion of the top release sheet 34 to the self-supporting outer layer 22 is controlled by the release of the bottom layer. The polymer composite must be strong enough to withstand removal of the sheet 30. Adhesion of body layer 24 to the wound site (in the embodiment of FIG. (reinforced by adhesion to). in addition The release sheet 34 can then be removed after applying the dressing to the wound area. . Adhesive 46 ensures that the adhesive bond to top release sheet 34 forms a self-supporting outer layer. It must be sufficiently stronger than the bond to 22. So, the material of adhesive 46 The choice of will be determined, in part, by the nature of the top surface of layer 22.

For PolJ'7 rethane film, adhesive 46 is weaker than adhesive 26. .

These weak adhesives are known in the industry as repository adhesives. nableadhesives) J. If the adhesive strength is weaker, is required, the adhesive may be applied to only a portion of the surface of the sheet 34, or ” 22 can be coated with a backside coating.

Another preferred embodiment of the invention is shown in FIG. Comparison with the example shown in Figure 5 In comparison, this embodiment lacks the adhesive layer 46 and the top release sheet 34 is attached to the bag. It is in direct adhesive contact with the upper surface of the king sheet 22. This is the backing Pour the solution in step 22 onto the appropriate side of the top release sheet and allow it to dry. This can be achieved by hardening if necessary. Or instead release sheet by hot melt process It can also be applied to. The final result is by direct contact and by intermediating the adhesive layer. Adhesion of the backing sheet to the release sheet without intervening.

The invention will now be further illustrated by way of illustrative, but non-limiting, examples. Ru.

Example ↓ Manufacture of double-merged composite layer using Nikari agent! 9■heheZ Tomoe BiΩ distilled water 600ml Medium polyethylene oxide (Union Carbide, Polyox WS 120 g of Aerysol A-3 (Ro ) un and Haas, 25% aqueous solution of polyacrylic acid) and quickly Stirred. After the addition was complete, the mixture was stirred for 25 minutes. Then cover , and left at room temperature for 6 weeks. At the end of that period, the mixture becomes a seven-colored, viscous liquid. It consisted of a translucent rubbery solid with no liquid. The liquid phase was discarded. rubbery The solid weighed 143g.

A total of 91 g of ethanol or by gentle warming ( (35-60°C warm bath) and knead/mix using a stiff stick with a ring on the bottom. It was added gradually. The following substances are then added to this mixture in order at room temperature. Added gradually by stirring: A mixture of 7 g of distilled water and 20 g of ethanol. A solution of 6 g of urea in a mixture; Z; A solution of 5 g of ruamine and 2.3 g of tartaric acid: Then, a total of 80g of distilled water and 267g of ethanol, each separately or a mixture. Added as. The mixture was allowed to stand for 2 days and finally mixed with a total of 58 g of distilled water and 14 g of distilled water. Diluted with 5g of ethanol. A hazy, viscous solution should be placed in a horizontally It was poured onto a sheet of low-density polyethylene attached to a lath board. poured in After the liquid was exposed to a laboratory environment (40% relative humidity) for 17 days, it The result was a transparent and somewhat elastic film. The top surface of the film is 31361 peeler. Approximately 0.17mm thick part of Tojima film covered with Inner (3 to 1 companies) or double layer scratches It was used as a polymer composite layer in a dressing. Polyethylene and #1361 foil It was cut into a desired shape with the release liner still attached.

Example λ double coalescence composite waste Q production 2 plastics simultaneously n-S f necessary upper Tomoe NΔ/E upper-Q distilled water 1050 g of polyethylene oxide (Union Carbide, Poly ox fSRN-750) 60g solution was diluted with 250g of distilled water. ysol A-1 (Rohm & Haas, 25% aqueous solution of PAA) at 5% Stir rapidly at room temperature while adding for minutes. After the addition is complete, let the mixture sit for an additional 5 minutes. It was stirred for a while and then allowed to stand for 22 hours.

At the end of this standing, it consists of a translucent rubber and a movable liquid suitable for genuine leather. was. The liquid is poured out and discarded, and the rubber is kneaded until the occluded liquid is squeezed out. It was. As a result, the amount of rubber was 282 g. Of this, 56.2g is taken as a share. The samples were placed in a covered container at room temperature for 4 months. Rubber is then treated with ethanol/ Add the water mixture in portions and then stir at room temperature. sting) in the form of a suitable solution. In total, ethanol 154.8 g and 82.3 g of distilled water were used. The solution is placed on a horizontally placed glass plate. It was poured onto a 7m11 high-density polyethylene plate. Realize the poured liquid After 4 days of exposure to laboratory conditions (30-37% relative humidity), the resulting film becomes transparent. It was bright and elastic. It can be heated up to 4°C to make it easier to remove from polyethylene. cooled down. Film is 3L-89-5P/P Peel Lychee on either side (MeadRelease Prcduct Health) and stored. film A section approximately 0.11 mm thick was used as the polymer composite layer of the 2m dressing.

It was cut into the desired shape with the release liner still attached.

Example 3 Yu≦141 Tamoto composite wound dressing! Insect α mouth 3 bubbles and two layers for this example A wound dressing was manufactured according to the FIG. 5 embodiment of the invention.

Adhesive layer 46 was provided as a weak film between two release sheets, but was self-adhesive. It was placed on a supporting top film 34. One release sheet can be removed A sandwich of adhesive placed between the release sheet and film 34 was left. next The assembly is then cut to the appropriate rectangular shape and size and the strips removed. It was written. Rectangular tab 44 was then attached to adhesive 46. The adhesive 26 The oval-shaped upper layer 22 has a release sheet that protects the adhesive 26, and One part of the film 34L is placed on top of the adhesive 46 71. ! , Tsukari and Brunossa You can decide the position! , :o The release sheet was removed. poured polymerization Remove one of the composite film or cut release sheet to the appropriate size and shape. After the polymer composite is removed, it is placed on top of the top layer 22 with the exposed side facing the top layer 22. It was done.

It is firmly pressed into position and the remaining release sheet is removed. It was. The assembly should not be exposed to high humidity; the polymer composite should not be exposed to moisture until it becomes viscous. I got it. A bottom release sheet 30 with removal tabs 32 is then installed. The rack assembly is completed. Then, it is made of laminated aluminum foil. It was placed in Carne 13 and heat-sealed.

By the procedure described above, a two-layer wound dressing was assembled from the following components ( (Reference numbers are given to match the drawings, especially Figure 5): Top layer release sheet 34 and adhesive layer 46 - 2 mm wide strip of reducible adhesive. 2ml polyester back coated at intervals. Glue strips are stored Parallel to the longitudinal direction of Kinsei: Tab 44-5ml covering a part of adhesive 46 of high density polyethylene; top layer 22 and adhesive coating 26 - porous pressure sensitive 1.5mil polyester polyurethane coated with adhesive (PSA) (Semex 1Iedica1, #KM1393-00); Polymer composite layer 24-Film obtained from IJ 2: Polymer composite release sheet 3ml with electron beam cured silicone coating High density polyethylene 0kad Re1ease Products, #-H ID-5233L-WHITE).

``-Hinbutsukotka interrogation ceremony The completed, assembled opening dressing should be removed from the hermetically sealed bag for human use. It was attached to the test site on the volunteer's second bowl. After 11 days, 95 of the polarization cover material % of the area was previously (7) adhered to the skin. During the entire test period, there was no discomfort at all. There was no evidence of skin damage. When the polarizing covering was removed on the 35th day, the floating Friendships were not recognized at all.

Small finger cut injury test A 47-year-old man in good health cut the tip of his left ring finger with a vapor cutter. Cut perpendicular to their plane. The incision was 5 mm long and estimated to be 2 mm deep.

There was considerable bleeding. Absorb the blood with a cosmetic tissue for about 60 seconds, then The complete, assembled polarization shroud was removed from the hermetically sealed bag and used. .

The plaster was left on the wound for 5 consecutive days. During this time, avoid immersing your hands in water. It was used for all normal activities except for the digits.

For 5 days, the deposit remained clear. Inflammation at the edges of the cut disappears within the first few days. Well, a thin reddish-brown line remained as evidence of the injury. Liquid under the cladding There was no accumulation at all. On the 5th day, Takanashi is still attached to the skin around the injury. However, by this time, the area around half of the area of the bandage had peeled off. was. Bond fit) IF was torn off. The injury appears to be completely healed , the adjacent skin that had been covered for 5 consecutive days appeared perfectly healthy.

□゛ni A 37-year-old man in good health sustained an abrasion on the ring finger of his right hand due to a routine household accident. Ta. The injury was located at the top of the finger, 1 cm from the middle joint of the finger. abrasion was 6 mm in diameter and extended well into the dermis.

The bleeding was absorbed and stopped with cosmetic tissue. Leave the wound exposed for about 4 hours. The complete, assembled polarization shroud is then removed from its hermetically sealed bag. It was taken out and used. There was no pain when using it. After putting it on, this bolan Tia was involved in active outdoor activities, including swimming, water skiing, and chopping wood. this During these activities, Kizuna fAI serum is applied to the wound and immediately adjacent healthy skin for 36 hours. It remained attached for a while, and then the surrounding area was slightly peeled off. Remove the bandage at that time. Ta.

The wound appeared healthy and was left exposed. I am very satisfied with the subsequent healing.\Kimono Met.

Example - Raw 7J11 joint qv taiba main injury first ao shoulder stand: 3 poor yofu cape stop example 3 outlines Assemble the two-layer cladding from the following components using the procedure described (Refer to the diagram for the components)・Jj peeling root 34 and adhesive 46- Same as 113; adhesive/tab 44 covering part of 16--JL! /II 3 and Same as above; - E layer 22 and M raw coating 26 → coated with porous pressure sensitive adhesive 0.7 mi I polyether polyurethane (Seaex) J edica1, #α1391-02); Film obtained with polymer composite layer 24-112; Polymer composite layer peeling sheet 1 Same as -30-1'13.

The polymer composite layer is exposed to 100% relative humidity for 3.5 hours to remove moisture. Gave. The complete, assembled polarization shroud is stored in a hermetically sealed bag for one day. The test site was used on the upper arm of a human patient. After 5 days, 88% of the area of the covering material It was still attached to the skin. There was no discomfort at all for 5 days, and there were no skin disorders. There was no evidence at all. When the polarizing covering was removed, no edema was observed and no A two-layer cladding was assembled from the following components using the procedure previously described in 3. Refer to the diagram: Polyurethane the outer corner of the upper layer release sheet T-34-2, 8 mil low density polyethylene. 0.5 mi due to the layer of acrylic acid adhesive! Laminate glued to polyester film Nate: Adhesive 46-, km 0.5 m1 of the above laminate forming the release sheet 34 1 Reducible adhesive on polyester component.

Tab 44 covering a part of adhesive 46 - Same as Jj 3; Upper layer 22 and adhesive Coating 26 - 1,5mi coated with porous pressure sensitive adhesive l Polyether polyurethane (Semex Medica 1, #Maki-139 3-02); Film of polymer composite layer 24-111; Polymer composite peeling zone 3 [)- Same as $13.

The polymer composite layer is moistened by exposure to a 100% relative humidity environment for 16.5 hours. Gave me energy. The complete, assembled polarization shroud is placed in a hermetically sealed bag. Saved for days. The bag was opened and the dressing was applied to the test site on the upper arm of a human patient.

After 18 days, 96% of the area of the polarized dressing was still attached to the skin. 18 days During this period, the test site was exposed to five warm showers. At the end of the 18th day, the dressing It was still transparent. There was no evidence of discomfort or skin damage.

Itashi U -Δ-Nii captive man in a basket! (and m2 type lniji;mi,);nikono A complete, assembled polarization shroud exactly as described in Example 5. was stored in a hermetically sealed bag for a total of 25 days. On the 13th day, there was still sea in the bag. For sterilization], gamma rays of 92 to 1 rad were irradiated. 2 On the fifth day, the bag was opened and the dressing was applied to the test site on the upper arm of a human patient. 6th day Afterwards, 94% of the area of the polarized dressing was still attached to the skin. For 6 days, no There was no evidence of pleasure or skin damage.

column Twenty-one renal dressings were assembled from the following components according to the procedure outlined in Example 3: i.e. referring to the figure: Upper release sheet 34 and adhesive layer 46 - same as Example 3; a portion of adhesive 46 Coating tab 44 - same as example 3.

Top layer 22 and adhesive coating 26 - coated with pressure sensitive adhesive 3ml partially transparent polyvinyl chloride with a yellowish tan color (“skin color”) (Betham Corporation, No. 1103-5); Polymer Composite layer 24 - film of Example 2; polymer composite release sheet 3 - same as Example 3 .

The polymer composite layer is moistened by exposing it to an environment of 100% relative humidity for 18 hours. I got it. Complete, assembled polarization shrouds were stored in hermetically sealed bags for 40 days. After that, it was pasted on the test site on the upper arm of a human. After 6 days, 9 of the area of polarization covering material 3% were still attached to the skin. Observe hair and veins through the dressing I was able to do something. When the polarizing dressing was removed on the 11th day, the skin that was attached to the dressing was much whiter than the surrounding skin. The whiteness can be reduced by exposing it to ambient air for 30 minutes. Disappeared. There was no discomfort and no evidence of skin damage during the entire study period. .

regular day A two-layer dressing was assembled from the following components using the procedure outlined in Example 3.

That is, with reference to fig.

Upper release sheet 34 and adhesive layer 46 - backcoat with reversible adhesive 1ml polyester processed: Tab 44 covering part of adhesive 46 - same as example 3; eleven layers 22 and adhesive Coating 26 - Porous, spa coated with porous pressure sensitive adhesive Lace polyester non-woven fabric (woven fabric weight is 12oz/sq, yd,) (S emex Medica 1, No. PA 1251-01); Polymer composite Body layer 24 - film of Example 2; polymer composite release sheet 3 - same as Example 3 character.

The polymer composite layer is moistened by exposing it to an environment with 100% relative humidity for 22 hours. I got it. After storing the complete, assembled polarization shroud in a hermetically sealed bag for one day. , a test between the first joint (the joint closest to the fingernail) and the second joint of the dorsum of a human patient's finger. pasted on the test site. After 35 days, 80% of the area of the polarized dressing is still attached to the skin. I was wearing it. The polarizing covering was then removed, but there was no evidence of edema or skin damage. was not recognized at all. Wash your hands with soap and warm water approximately 16 times during the test period. All normal activities took place, including:

Example 9- A two-layer dressing was assembled from the following components using the procedure outlined in Example 3.

i.e. with reference to the drawing: Upper release sheet 34 and adhesive layer A6 - same as Example 3; Overturning tab 44 - same as example 3; JJii22-1 ml microporous polypropy Ren (45% porosity, approximately 0.04 x 0.2 micrometer oblong pores), Ce1anese Corporation, Celgard 2500: Adhesive 26-] of polydimethylsiloxane coated on one side as follows. 6ml coating: i.e.)k+1ister 1cal Adhe sive (Holister Incorp+rated, No. 77 30) Aim the spray from the aerosol can into a small wide-mouth bottle and spray approximately 15 tr. I collected il. A portion of this liquid is applied to the upper layer, which is secured by taping the edges to a horizontal surface. spread out on one side. The solvent in the coating is allowed to evaporate in the laboratory environment. Ta. The sticky residue was then protected by applying 3ml polyester: Polymer composite layer 24 - film of Example 2; Polymer composite release sheet 1-3 nl Same as 3.

The polymer composite layer is moistened by exposing it to an environment of 100% relative humidity for 68 hours. I got it. After storing the complete, assembled polarization shroud in a hermetically sealed bag for one day. , applied to the test site on the upper arm of a human patient. After 4 days, 85% of the area of polarization covering material % was still attached to the skin. Approximately 8% of this attached area became transparent; This is probably due to the migration of low molecular weight silicone polymers to the upper layer. - days later , that is, on the fifth day, 65% of the area of the polarized covering is still attached to the skin. , 85% of the attached area was transparent. On the 6th day, the polarization covering will be removed. There was no edema and no evidence of skin damage.

Example - Lσ In this example, 〇 has little or no adhesion to the skin because it is not moisturized. If the polymer complex @24 or around the polarized wave 5 as shown in Figures 3-6, After applying the two-layer wound dressing, it is preferred if it has a protruding adhesive layer 26. Shows that it can become adhesive under certain conditions.

No moisture applied to the polymer composite layer, assembly or peeling of the polymer composite. Comes in a hermetically sealed package without being completed with the addition of sheets. Two-layer cladding using the procedure outlined in Example 3, except that it is not assembled.

The components used are as follows. In other words, referring to Figure 5, the upper layer peels off. Sea h34-2. 8mil low density polyethylene outer layer with adhesive layer 1 Laminate bonded to m1l polyester film.

Adhesive 46 - O,1m11 of the laminate forming the upper release sheet 34 above Reversible adhesive on polyester component; tab covering part of adhesive 46 44 - Same as example 3; Top layer 22 and adhesive coating 26 - Same as 13: Polymer composite layer 24 - Film of Example 2.

The assembly may be complete except for the addition of a polymeric composite release sheet 30, or the assembly may be kept at ambient temperature and relative humidity of 23% for only 30 minutes, then exposed the first finger of a human patient. It was pasted on the test site on the back of the joint and second joint. For the next 33 hours, the hand Other than avoiding contact with water, the patient performed normal hand activities. That 33 o'clock At the end of the interval, the entire area covered by the surrounding protrusion of the polarization covering was adhered. It remained as it was. The polymer composite layer adhered very well to the skin at the test site.

Example ↓↓ A two-layer dressing was assembled from the following components using the procedure outlined in Example 3.

That is, referring to the drawing: Upper layer release sheet 34--same as Example 9; tab 44 covering a portion of adhesive 46- Same as example 3; JJ22 and adhesive coating 26 - acrylic acid pressure sensitive adhesive 1/16 inch thick (41bs,) polyethylene foam coated with (Betham Corporation, No. 1117-W); Polymer Composite@24--Film of Example 2; same as polymer composite release sheet 30-613 character.

The polymer composite layer is moistened by exposing it to an environment with 100% relative humidity for 21 hours. I got it. After the complete, assembled polarization cover is stored in a hermetically sealed bag for one day , applied to the test site between the first and second joints of the dorsum of a human patient's finger. -day Afterwards, only 50% of the bilayer dressing remained on the skin. This exceptionally rapid adhesion The loss is due to the stiffness of the form and the size of the finger skewers. At this time, remove the covering material. removed. The area under the adhesive part of the polarization covering material was whitish.

Female 12 The two-layer wound dressing of this example includes a layer 22 and a polymer composite layer 24 as shown in FIG. manufactured according to the embodiment shown in FIG. 4, except that there is a layer 26 in between. It is something that Tab 42 in FIG. 4 is an extension of release sheet 34 and adhesive layer 46. It exists as. The protruding adhesive part of layer 46 is made of 5ml high density polyethylene. It is covered by The tabs 32 on the polymer composite release sheet 30 It exists as a folded extension of the sheet 30.

The general method of assembly is as described in Example 3, but with the following specific components: Use: Upper release sheet 34 and adhesive layer 46 - 2 mm wide and 1.5 mm apart. 2m1 back coated with strips of reversible adhesive placed in f Polyester: ] 22 and adhesive coating 26 - same as example 3; polymer composite layer 24 - example Film of No. 2: Polymer composite release sheet 3O-4PJ Same as No. 3.

The polymer composite layer is oval shaped with a maximum size of 27X16 an, but at a relative humidity of 100 % environment for 4 hours to moisten and apply approximately 25 m to the surface in the form of 2 drops from a syringe. g of distilled water and spread on the surface, followed by 2.5 hours in an environment with 100% relative humidity. exposed. The complete, assembled wound dressing can be stored in a hermetically sealed bag for 2 days. After application, it was applied between the first and second joints of the dorsum of a human patient's finger. 3 hours Afterwards, the test area with the wound dressing was immersed in a 5% solution of soap for 1 minute at 39°C and then I wiped it dry with a towel. Then avoid contact with water and do all other normal things We carried out various activities. Over the second and third days, we will continue to use two-handed stacked grip exercises. Because the movable crab tool was used for a long period of time, there was considerable creep or damage to the wound dressing. Ta.

After 4 days, 75% of the area of the wound dressing was still attached to the skin, with non-adhesive properties. Always turned out to be good and was. There was no evidence of skin damage.

39°C steam (rather than soap) placed on a similar test site on an adjacent finger. The performance of the same two-layer wound dressing soaked in standing water for 1 minute was comparable.

Example L1 Polymer 100g of Polymer 100g of Polymer Vinylpyrrolidone (PVP) (GAFC Corporation, Plasd oneK-29/32) was dissolved in 100 g of distilled water. 400g of Acrys PVP in ol A-1 (Rohm and Haas, 25% aqueous solution of FAA) The solution was stirred and added. When this was added, the rubber separated. Pour and discard the liquid phase. It was. The rubber was discarded until the stored liquid was squeezed out, and the liquid was thrown away. . Heat the rubber, stir and dissolve in 32g of ethanol, the solution will be 8g of ethanol. diluted with diluted water. The resulting solution was labeled 81-B. 50.2g of 81 ~While keeping B in the hot tub, 12. 0g of propylene glycol USP (Daminco Inc.), 9.0 g of urea (BDH Chemj, cals ), 8g of ethanol, and finally 8.4g of distilled water and 7g of ethanol. The mixture was added in stages with stirring. The warming solution (referred to as 97-C) was heated to 53 It was poured onto a polyethylene surface kept at ℃. After - days, the dried film becomes transparent. It was bright and flexible.

0.0 to 70 g of dry film in a small 3 ml polyethylene bag. 4 g of distilled water was added and the bag was sealed. After 2.5 days at room temperature, the bag was cut open and The stickiness of the film can be tested by pressing the edge of your finger against clean, dry skin for 3 seconds. It was evaluated based on the following. Its tack level was "very good".

Example 1401 joint venture" 1 vote for female lineage J review Warm 50.9g of 81-B in a hot tub, then add the following ingredients in order without stirring. Added: 5.5g propylene glycol; 4.0g trichloride in 7g ethanol. Reethanolamine (Fisher 5 Scientific); 16g ethanol Nord.

The resulting solution, while still warm, was poured onto a horizontal glass surface kept at room temperature. It was.

0.0 to 70 g of dry film in a small 3 ml polyethylene bag. 1 4g of distilled water was added and the bag was sealed. After 2.5 days at room temperature, cut the bag. Cut open the package and test the tackiness of the film by touching clean, dry skin with the tip of your finger for 3 seconds. Evaluation was made by pressing. Adhesiveness was judged to be "good".

Continuation of front page (81) Designated countries EP (AT, BE, CH, DE.

DK, ES, FR, GB, GR, IT, LU, NL, SE), 0A (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, SN, TD , TG), AU, BB, BG, BR, CA, FI, HU, JP, KP , K.R.

LK, MC, MG, M’v¥, NO, PL, R○, SD, S

Claims (24)

[Claims] 1. Contacts that contact the treatment area by adhesively adhering to the mammalian tissue. An adhesive coating material; a self-supporting and water vapor permeable outer layer of the film; an inner, treatment area contact layer consisting of an adhesive polymer composite; Consisting of The polymer composite layer composition is substantially wound- and skin-compatible and non-smooth to the skin. First and second hydrophilic polymers with sufficient moisture to be adhesive and capable of coprecipitation By co-precipitation as a result of mixing of body solutions and, if desired, further reducing their water content. Formed from a tacky, polymeric composite product manufactured in controlled quantities. Yes, adhesive covering material. 2. The polymer composite product was prepared by co-precipitation from a mixed aqueous solution. The adhesive coating material according to claim 1, characterized in that it is a material. 3. Further, a skin disposed between the self-supporting outer layer and the polymer composite layer. Adhesive coating according to claim 2, characterized in that it comprises an intermediate layer of compatible adhesive. . 4. the intermediate layer and the outer layer extend circumferentially beyond the edges of the polymer composite layer; Claim 3 characterized in that the dressing provides additional adhesion of the dressing to the wound location. Adhesive coating material as described in . 5. Additionally, a remover is applied to the surface of the polymer composite that may come into contact with scratches. A removable release sheet is included, and the removable sheet is used before applying the dressing to the wound site. The contact according to any one of the preceding items, characterized in that it is removable by peeling it off. Adhesive coating material. 6. Furthermore, an adhesive foil is attached to the outer surface of the supporting outer layer film. It has a release sheet, and the adhesive release sheet is used after the dressing is applied to the wound site. The adhesive covering material according to claim 1, which is removable by peeling. . 7. The polymer complex may have one or more drugs incorporated therein. The adhesive coating material according to any one of the preceding items, characterized in that: 8. The polymer composite layer is essentially a polymer or copolymer of acrylic acid. , consisting of a composite with a polymer or copolymer of ethylene oxide. The adhesive coating material according to any one of the above items. 9. The polymer composite layer consists essentially of polyacrylic acid and polyethylene oxide. The adhesive coating material according to claim 8, characterized in that it consists of: 10. The polymer composite layer is essentially a polymer or copolymer of acrylic acid. and a polymer or copolymer of vinylpyrrolidone. The adhesive coating material according to any one of claims 1 to 7. 11. The polymer composite layer consists essentially of polyacrylic acid and polyvinyl pyrolyte. The adhesive dressing according to claim 10, characterized in that it consists of a complex of lydones. 12. A sealable package containing an adhesive wound dressing suitable for application to a wound. Thus, the package protects the high water vapor-containing environment in which the wound dressing is stored. Consisting of a confining, sealing film envelope, the wound dressing is self-supporting. an outer layer of a transparent and moisture vapor permeable film, and a skin supported by the outer layer; Wound contact consists of a sticky polymer composite that contains enough water to be adhesive. an inner contact layer, the polymer composite layer being essentially wound and skin compatible. be, The adhesive coating material according to any one of the above items. 13. Remover affixed to surfaces that may come into contact with scratches in the polymer composite layer The sealable pad according to claim 12, characterized in that it has a removable sheet. cage. 14. It has an adhesive release sheet that is attached to the outer surface of the outer support film. The sealing property according to claim 12 or 13, characterized in that: package. 15. The sealable envelope is made of heat-sealable laminated aluminum Claim 12 or 13, characterized in that it is a foil. Sealed package included. 16. suitable for adhesively adhering to mammalian tissue and contacting its treatment area A process for producing an adhesive coating material; a solution of a coprecipitable hydrophilic polymer. to form a solid or semi-solid, wound-compatible polymeric composite. ; By applying the polymer composite to the surface of a self-supporting water vapor permeable film. forming a laminate of the polymer composite and the film; The polymer composite may be brought into contact with the skin before or after the polymer is applied to the film. adjusting the water content of the polymer composite necessary to make it adhesive; A method for producing a coating material, comprising: 17. The coprecipitated polymer complex is separated from the coprecipitation medium and dissolved in a water-miscible organic solvent. Dissolved, applied as a liquid-in-liquid to the self-supporting film, and dried thereon. 17. Process according to claim 16, characterized in that: 18. The coprecipitated polymer complex is separated from the coprecipitation medium and treated with a water-miscible organic solvent. The solution so formed is poured onto the transfer surface where it dries and forms the film. form a film and attach it as a film to the surface of a self-supporting film. 17. The process of claim 16. 19. The solutions of the coprecipitable and hydrophilic polymer are both aqueous solutions. 19. A process according to any one of claims 16, 17 and 18. 20. Claim characterized in that the polymer composite film is then rehydrated. 20. The process according to any one of 16 to 19. 21. The polymer may be a polymer or copolymer of acrylic acid and ethylene oxide. Claims 15 to 19, characterized in that it is a polymer or copolymer of sid. A process as described in any one of the preceding paragraphs. 22. Particularly, the polymer is polyacrylic acid and polyethylene oxide. 21. The process of claim 20. 23. The polymer may be a polymer or copolymer of acrylic acid, and vinyl pyrolyl. Claims 15 to 19, characterized in that it is a polymer or copolymer of DON. A process as described in any one of the preceding paragraphs. 24. Particularly, the polymer is polyacrylic acid and polyvinylpyrrolidone. 23. The process of claim 22, wherein: