JPH06510746A - 免疫抑制性および寛容原性修飾ルイスｘおよびルイスａ化合物 - Google Patents

免疫抑制性および寛容原性修飾ルイスｘおよびルイスａ化合物

Info

Publication number
JPH06510746A
JPH06510746A JP4511196A JP51119692A JPH06510746A JP H06510746 A JPH06510746 A JP H06510746A JP 4511196 A JP4511196 A JP 4511196A JP 51119692 A JP51119692 A JP 51119692A JP H06510746 A JPH06510746 A JP H06510746A
Authority
JP
Japan
Prior art keywords
compound
group
hydrogen
lewis
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4511196A
Other languages
English (en)
Japanese (ja)
Inventor
イッポリト，ロバート　エム．
ヘイク，ワシマル
ジアング，コング
ハンナ，リック
ヴェノ，アンドレ　ピー．
ニクラッド，パンデュラング　ブイ．
カシェム，モハメッド　エイ．
スミス，リチャード　エイチ．
Original Assignee
グライカムド　インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by グライカムド　インコーポレイテッド filed Critical グライカムド　インコーポレイテッド
Publication of JPH06510746A publication Critical patent/JPH06510746A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP4511196A 1991-06-10 1992-06-09 免疫抑制性および寛容原性修飾ルイスｘおよびルイスａ化合物 Pending JPH06510746A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US71416191A 1991-06-10 1991-06-10
US714,161 1991-06-10
US88901792A 1992-05-26 1992-05-26
US889,017 1992-05-26
PCT/CA1992/000245 WO1992022564A1 (en) 1991-06-10 1992-06-09 Immunosuppressive and tolerogenic modified lewisx and lewisa compounds

Publications (1)

Publication Number Publication Date
JPH06510746A true JPH06510746A (ja) 1994-12-01

Family

ID=27109107

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4511196A Pending JPH06510746A (ja) 1991-06-10 1992-06-09 免疫抑制性および寛容原性修飾ルイスｘおよびルイスａ化合物

Country Status (4)

Country Link
EP (1) EP0591254A1 (de)
JP (1) JPH06510746A (de)
CA (1) CA2110707A1 (de)
WO (1) WO1992022564A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8158763B2 (en) 2002-12-24 2012-04-17 Yasuhiro Kajihara Sugar chain asparagine derivatives, sugar chain asparagine, sugar chain and processes for producing these

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5559103A (en) * 1993-07-21 1996-09-24 Cytel Corporation Bivalent sialyl X saccharides
AU4364196A (en) * 1994-11-21 1996-06-17 Glycomed Incorporated Processes for the synthesis of 3'-substituted lewisxlewisx compounds
JPH0952902A (ja) * 1995-08-09 1997-02-25 Daikin Ind Ltd フッ素含有シアリルルイスｘ誘導体及びその合成中間体
AU1122897A (en) * 1995-11-13 1997-06-05 Glycomed Incorporated Novel oligosaccharide glycosides having mammalian immunosuppressive and tolerogenic properties
US5830871A (en) * 1996-10-28 1998-11-03 The Scripps Research Institute Inhibitors of E-, P- and L-selectin binding
US6756489B1 (en) * 1997-08-08 2004-06-29 Aventis Pharma Deutschland Gmbh Substituted tetrahydropyrane derivatives, method for producing same, their use as medicine or diagnostic agent, as well as medicine containing same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8158763B2 (en) 2002-12-24 2012-04-17 Yasuhiro Kajihara Sugar chain asparagine derivatives, sugar chain asparagine, sugar chain and processes for producing these

Also Published As

Publication number Publication date
CA2110707A1 (en) 1992-12-23
EP0591254A1 (de) 1994-04-13
WO1992022564A1 (en) 1992-12-23

Similar Documents

Publication Publication Date Title
US5580858A (en) Immunosuppressive and tolerogenic modified Lewisx compounds
US5550155A (en) Methods for the synthesis of monofucosylated oligosaccharides terminating in di-N-acetyllactosaminyl structures
US5646123A (en) Time dependent administration of oligosaccharide glycosides related to blood group determinants having a type I or type II core structure in reducing inflammation in a sensitized mammal arising form exposure to an antigen
CA2110386C (en) Method for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides
JP4553488B2 (ja) カルボキシメチルガラクトース誘導体
US6013779A (en) Process for preparation of glycosides of tumor-associated carbohydrate antigens
Koeller et al. Chemoenzymatic synthesis of sialyl‐trimeric‐Lewis x
JPH06510744A (ja) 変性されたシアリルルイスｘ化合物
CN111909910B (zh) 一种酶法模块和Sda糖抗原合成方法
JPH06510746A (ja) 免疫抑制性および寛容原性修飾ルイスｘおよびルイスａ化合物
JP2823358B2 (ja) 免疫抑制性および寛容原性修飾ルイス▲上ｃ▼およびＬａｃＮＡｃ化合物
CA2110495A1 (en) Immunosuppressive and tolerogenic oligosaccharide derivatives
CA2118522A1 (en) Time dependent administration of oligosaccharides glycosides related to blood group determinants having a type i or type ii core structure in reducing inflammation in a sensitized mammal arising from exposure to an antigen
Zhang et al. Synthesis of Double-Chain Bis-sulfone Neoglycolipids of the 2'-, 3'-, and 6'-Deoxyglobotrioses
JP2000507993A (ja) 合成多価ｓＬｅｘ含有ポリラクトサミンとその使用法
Cornil et al. Multigram synthesis of an orthogonally-protected pentasaccharide for use as a glycan precursor in a Shigella flexneri 3a conjugate vaccine: application to a ready-for-conjugation decasaccharide
EP3269385A1 (de) Pneumokokken-polysaccharid-proteinkonjugatzusammensetzung
Malleron et al. Chemoenzymatic synthesis of the 3-sulfated Lewisa pentasaccharide
WO1996040702A1 (en) Modified kojibiosides analogues
US5837830A (en) Stereodirected process for synthesis of α-N-acetylgalactosaminides
Sadraei Progress towards the Synthesis of Carbohydrate-Based Biomedical and Material-Science Relevant Molecules
EP0919563A2 (de) Synthetische- wie Kern-2 Abzweigstruktur als Liganden für Selectin
WO1996016071A1 (en) PROCESSES FOR THE SYNTHESIS OF 3'-SUBSTITUTED LEWISx COMPOUNDS
Liang A Short Synthetic Route to Derivatives of 2-acetamido-4-amino-2, 4, 6-trideoxy-D-galactose: A Component of the Cell Surface of Streptococcus Peneumoniae
JP2018030828A (ja) ガラクトオリゴ糖の製造方法及びその中間体