JPH0690993A - Multicylinder type connecting mechanism for drug container and dissolving liquid container - Google Patents

Abstract

PURPOSE:To develop a connecting mechanism which can easily prepare diversified drug solns. from drugs and dissolving liquid in a nearly use stage. CONSTITUTION:A connecting outside cylinder 7 fitted to the outer side of a connecting inside cylinder 3 rising from the top plate of a crown cap 2 to an upstream side is engaged and mounted near the outer edge of a crown cap 1 and an injection cylinder 5 housing the dissolving liquid is mounted to the inner side of the connecting inside cylinder 3 and is engaged and mounted to and with the outside cylinder 7. A plug 6 in common use as a downstream side piston is mounted into an inside pipe 51 of the double pipe parts at the downstream end of the injection cylinder 5 and the upstream side part of a puncture needle member is internally fitted to the downstream side thereof. This puncture needle member is fitted onto a downstream end pointed puncture needle 41 and an upstream side part and is formed with a sleeve cylinder 42 fitted and mounted between the inside pipe 51 and the outside pipe 52 and further an expandable leg part 43 extending from the outer side thereof to the upstream side and fitted onto the outside pipe 52. A plug 8 in common use as an upstream side piston is fitted into the upstream end of the injection 5. Then, the liquid drugs of the combination most approximate to a request are rapidly and hygienically prepd. from the drugs and dissolving liquid of the available limited kinds and volume. The restrictions by commercially marketed kits are relieved.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention is a combination of a multi-cylinder type connecting mechanism and a coronal lid capable of connecting a medicine container and an injection cylinder while maintaining watertightness. Accordingly, the present invention relates to a coupling mechanism further incorporating an annular locking mechanism.

Another aspect of the present invention relates to a multi-cylinder type coupling mechanism in which a mounting member is used in place of the coronal lid, and an annular locking mechanism is further combined with the mounting member if necessary.

[0003]

2. Description of the Related Art Various kinds of so-called "treatment kits", in which a drug container and a solution container thereof are housed in a connecting mechanism and solution can be started if necessary, have already been provided, especially for drip use. However, these kits cannot already change the combination of the drug container and the solution container at a stage close to the site of use so as to meet the desired combination. The reason is that both are assembled in a state that they are already housed in the coupling mechanism. Therefore, there may be a situation in which the kit for the necessary combination is not present in the existing products, or even if it is not available on the side of the user, it may not be in time for use.

[0004]

SUMMARY OF THE INVENTION The present invention has been completed in order to solve the situation that remains in the above-mentioned conventional techniques.
The purpose is to select the optimum one from the drug containers containing the types and amounts of drugs that are in hand, and then select this from among the dissolution liquid containers that contain the types and amounts of solutions that are in hand. The purpose of the present invention is to provide a connecting mechanism that can be used for a wide range of purposes, particularly therapeutic purposes, by combining it with an optimum one and forming a drug solution at a stage close to the time of use.

[0005]

As a result of various studies on means for solving the above-mentioned problems, the inventors of the present invention have taken out only the connecting mechanism from the kit rather than the method of accommodating the drug container in the kit. While adopting a method that allows the drug container to be attached and detached to the outside, by combining a method that directly uses an injection cylinder as a contained solution container, it has been found that it can be used for a remarkably wide range of purposes, As a result of developing a mechanism adapted to this, the present invention has been completed.

That is, as a basic aspect of the present invention, in a multi-cylinder type coupling mechanism composed of an injection cylinder containing a solution, a connection inner cylinder, a connection outer cylinder, a puncture needle member and a drug container mounting member, a drug container is attached. A connecting outer cylinder engaged with the member, an injection cylinder fitted in from the upstream side of the connecting outer cylinder and engaged with the connecting outer cylinder,
A connection inner cylinder fitted between the injection cylinder and the connection outer cylinder from the downstream side and having a diameter expansion region on the inner wall of the downstream region, and a water-tight seal that is movable in the double pipe inner tube provided at the downstream end of the injection cylinder The upstream part of the puncture needle member is movably fitted to the stopper and the double tube inner tube fitted to the plug, and the expandable leg extending from the vicinity of the middle part of the member to the upstream side is connected to the inner wall of the inner tube. A multi-cylinder-type connecting mechanism for a drug container and a solution container, which are composed of a puncture needle member that slides in contact with the puncture needle member. It expands when it is accommodated in the expanded diameter part provided on the inner wall of the downstream area, and between the expandable leg inside and the outer side of the outer pipe in the double pipe part provided at the downstream end of the syringe barrel. A multi-cylinder type coupling mechanism in which a structure for releasing the retained lock is added to the basic mode. As a preferable mode 2 thereof, When the syringe barrel further descends in the connecting inner barrel after the locking in the suitable mode 1 is released, the convex portion near the inner middle stage of the expandable leg and the diameter reduction near the outer barrel outer wall middle stage of the double barrel of the syringe barrel. A multi-cylinder type coupling mechanism in which a configuration in which a step is engaged is added to the basic mode, and as a preferred mode 3 thereof, in the double pipe part at the downstream end of the injection cylinder, the shape of the inner wall near the inner pipe downstream end is the puncture needle upstream part. In addition to forming a watertight structure with the outer wall, the shape of the outer wall near the downstream end of the outer tube in the double pipe section forms an airtight structure with the inside near the downstream end of the expansive leg. In a multi-cylinder coupling mechanism, which is a cylindrical coupling mechanism, and as a fourth preferred embodiment thereof, a drug container mounting member, a coupling inner cylinder, a coupling outer cylinder, an injection cylinder containing a solution, a stopper, and a hollow puncture needle member. , Hakama formed by extending from the middle part of the puncture needle to the upstream side Part, a hollow puncture needle member in which one or more expandable legs extending upstream from the hakama part are connected annularly near the upstream end thereof, and an inner diameter capable of accommodating the expandable legs in its expanded state A multi-cylinder type coupling mechanism in which a configuration of a coupling inner cylinder provided with an enlarged portion on the inner wall near its upstream end is added to the basic mode, and the present invention, in another aspect, is a drug container mounting member, a coupling inner cylinder, a coupling. One or more expandable legs formed by extending from the vicinity of the middle stage of the puncture needle to the upstream side in a multi-cylinder type coupling mechanism including an outer cylinder, an injection cylinder containing a solution, a stopper and a hollow puncture needle member. Part is connected in an annular shape near its upstream end and is a double-ended pointed hollow puncture needle member having cusps at both ends, and a double pipe part provided at the downstream end of the syringe barrel is fitted watertightly and hard to move. The upstream end of the inner diameter enlarged portion capable of accommodating the stopper and the expandable leg portion in the expanded state. An injection multi-cylinder type coupling mechanism composed of a coupled inner cylinder provided on the inner wall in the vicinity can be adopted. [Description based on the drawings] Hereinafter, the present invention will be described in detail based on the drawings. In the following figures, the drug container side will be described as the downstream side and the syringe barrel side will be described as the upstream side, unless otherwise specified. It should be noted that the positional relationship between the drug container and the plunger is reversed (inverted) after (l) in FIG.

FIG. 1 shows a drug container A in which the multi-cylinder type coupling mechanism of the present invention further incorporates a coronal lid with an annular locking mechanism.
FIG. 4 is a schematic cross-sectional view showing a state in which the mouth portion is fitted over the mouth portion. In FIG. 1, A is a container (hereinafter, also referred to as “drug container”) containing a drug or the like used for treatment or the like,
A stopper A1 made of an elastic material is fitted and fixed inside the mouth. However, when the multi-cylinder coupling mechanism of the present invention further incorporates the annular locking mechanism, the mounting member is an integral structure of the coronal lid, that is, the coronal lid main body 11 (annular portion of the coronal lid) and the top plate 32. There is no need to do so, and of course, it does not matter if the mounting ring 11 and the septum plate (bottom plate) 32 that is a component of the connecting inner cylinder 3 are divided into two parts. However, here, for the sake of convenience, the case where the both are integrally structured will be described as a basic mode.

[Basic Mode] A coronary lid 1 is fitted on the mouth portion A2 of the medicine container A. A retaining projection (also known as "undercut") 11u is provided on the inner wall near the middle stage of the coronal lid 1, and a recess 11c is usually provided near the middle stage of the outer wall of the coronal lid 1. Neither the holding projection 11u nor the recess 11c needs to be continuous over the entire circumference. The one or more notches may be several ridges existing in at least one of the holding projection 11u and the recess 11c, or may be several scattered projections.

A tightening ring 2 is often fitted onto the outer wall of the coronal lid 1. The inner wall of the lower half of the tightening ring 2 exerts a tightening action on the coronal lid 1. The tightening ring 2 is usually substantially tubular and has a protrusion 2 for engagement with an outer wall near its upper end.
1 is usually provided. The cross-sectional shape of the convex portion 21 is formed on a slope that is open downward on the upstream side and on a rising surface that is substantially perpendicular to the ring surface on the downstream side (lower surface). In addition, the concave portion 11c on the inner wall surface of the coronal lid 1 is, on the contrary, a convex portion,
The convex portion 22 on the inner wall surface of the tightening ring 2 may be a concave portion which is engaged with each other. The tightening ring 2 may be omitted depending on the application of the multi-cylinder type coupling mechanism of the present invention.

In the basic mode, the connecting inner cylinder 3 includes a ceiling flat plate portion 32 (hereinafter sometimes referred to as "top plate") which constitutes the coronal lid 1, and a tubular portion 31 which rises from the upper surface of the top plate 32 toward the upstream side. It is essentially a part of the coronal lid. However, it will be explained using a different encoding system.

The inner diameter of the downstream portion of the tubular portion 31 constituting the connecting inner cylinder 3 is formed to be larger than the inner diameter of the upstream portion thereof, and the expandable sliding leg portion 43 of the puncture needle member 4 descending. Is set so that it can be accommodated in an expanded state. This requirement is necessary for the multi-cylinder coupling mechanism of the present invention to operate in a predetermined sequence and timing. The puncture needle member 4 and the injection cylinder 5 are fitted in the upstream region of the connection inner cylinder 3. A through hole 33 is provided at a substantially central portion of a top plate (septal plate) 32 that connects the connecting inner cylinder 3 and the coronal lid 1, and the through hole 33 is made of an elastic material for the puncture needle 41 of the puncture needle member 4. Provide a passage for piercing the stopper A1.

A portion 34 near the upstream end of the tubular portion 31 forming the connecting inner cylinder 3 extends at least partially further in the upstream direction and has a retaining projection (upward opening) 36 on the inner wall of the upstream end and a recess on the inner wall of the downstream side thereof. 35 are formed. These holding protrusions 36
And, when the connection inner cylinder 3 relatively rises between the connection outer cylinder 7 and the injection cylinder 5, the recess 35 finally becomes the projections 55 and the projections 56 provided on the outer wall near the upstream end of the injection cylinder 5. It has a shape to engage.

In the basic mode, the puncture needle member 4 comprises a hollow puncture needle 41 having a cusp on the downstream side, a support wall extending outward from a substantially middle stage of the puncture needle 41, and a sleeve 42 and a shoulder of the sleeve 42 which are turned to the upstream side. It is formed of a splayable sliding leg portion 43 that bulges outward from the vicinity and then turns to the upstream side.

A convex portion 45 is provided on the inner wall near the upstream end of the expandable sliding leg portion 43, and the convex portion 45 is the downstream end of the injection pipe 5 in which it is fitted and the downstream end of the outer pipe 52 in the double pipe portion. It abuts the inclined portion (upward opening) 57 provided on the outer wall in the vicinity to prevent the syringe barrel 5 from descending independently. That is, the shape of the convex portion 45 is a sawtooth shape and has an inclination that opens to the upstream side. The inclination of the convex portion 45 on the upstream side plays a role of prohibiting the descending of the injection barrel 5 as long as the inclined portion 57 can be kept in a state of being received from the downstream side. If the expandable sliding leg portion 43 expands, the convex portion 45 loses the inhibiting action, and the syringe barrel 5 is in a state where it can further descend in the connection inner barrel portion 3.

Usually, two or more expandable sliding leg portions 43 are provided side by side, but they may be cylindrical. However, it is important that the structure is expandable if it is cylindrical, for example, that two or more cuts are provided vertically.

The hakama 42 of the puncture needle member 4 need not be a perfect cylinder. Since its function is to guide the puncture needle 41, the puncture needle 41 is not limited to a single body and may be formed of two or more vertically divided parts, and a through hole or a cut-through is provided in the shoulder or the body. Good.

The puncture needle 41 has a flow passage 4 running in the axial direction.
6, the liquid passage hole 44 is opened in the vicinity of the downstream side shoulder of 41. Two liquid passage holes 44 are usually provided, but the number thereof can be selected as required. A downstream piston / stopper plug 6 is fitted in the upstream region of the inner pipe of the double pipe portion provided at the downstream end of the injection cylinder 5 into which the puncture needle 41 is fitted. The downstream piston / stopper plug 6 prevents the solution contained in the injection cylinder 5 from flowing out or leaking into the flow passage 46 in the puncture needle member 4.

An inner tube in a double-tube portion projecting at the downstream end of the injection cylinder 5 is provided in an annular gap formed between the inside of the hakama 42 which constitutes the puncture needle member 4 and the outside of the upstream part of the puncture needle 41. 51
Is fitted, and the inner wall of the expandable sliding leg portion 43 forming the puncture needle member 4 is in contact with the outer side of the outer tube 52.

The syringe barrel 5 is formed of the above-mentioned double pipe portions 51 and 52 and a main body portion 53 connected to the upstream end thereof. In the normal inner diameter region of the inner pipe 51 in the double pipe portion of the injection cylinder 5, as described above, the downstream piston and stopper 6 made of an elastic material is used.
Is fitted inside. In the upstream region 54 in the inner pipe 51, the inner diameter is enlarged.

The meaning of the expansion (expansion) of the inner diameter is such that when the downstream piston-cum-plug 6 moves to this area, the space is expanded to the extent that the liquid can flow through the outside (gap between 6 and the inner pipe wall). Especially. Securing this distribution space is of great significance for realizing the effects of the present invention.

On the other hand, in the upstream region of the injection cylinder 5, an upstream piston / combined plug 8 is fitted. The upstream piston / both stopper 8 has a function of preventing leakage of the solution contained in the syringe barrel, and also serves as a component of the syringe when the plunger 9 is mounted on the upstream side thereof. is there.

In order to ensure this function, the upstream piston / combined plug 8 is made of an elastic material, and the upstream piston / combined plug 8 is preferably provided in a locking groove provided substantially horizontally on the inner wall surface of the injection cylinder 5. The ridges provided on the outer peripheral surface of are engaged. A convex portion 55 is formed near the outer wall of the upstream end of the injection cylinder 5.
And a convex portion 56 are provided. Here, the convex portion 56 is formed to have a lower (lighter) protrusion degree than the convex portion 55. A connecting outer cylinder 7 is fitted on the outer side of the injection cylinder 5.

The connecting outer cylinder 7 is usually an upper half portion 72 (small diameter portion).
The larger diameter is formed in the lower half portion 71 (larger diameter portion). The large diameter portion 71 has a convex portion 21 provided on the upstream end edge portion of the tightening ring 2 by the convex portion 75 on the inner wall near the downstream end thereof.
To prevent it from pulling out in the upstream direction, and to provide gentle projections 73 and 74 on the inner wall near its upstream end, and the recess formed in the middle of both projections is the projection of the outer wall of the syringe barrel 5. Engage with section 55.

The length (height) of the large-diameter portion 71 of the connecting outer cylinder 7 is such that the connecting outer cylinder descends to the drug container side and the convex portion 1 at the downstream end of the coronal lid is formed.
f It is set so that the transition area from the large diameter portion 71 to the small diameter portion 72 does not contact the upstream end of the tightening ring 2 even when engaging with the outer edge. FIG. 1 shows a shape (as a paragraph) in which the transition from the large diameter portion 71 to the small diameter portion 72 is performed rapidly like a cliff, but it is not limited to this. The shape may be gradually changed as long as the above requirements are satisfied.

FIG. 2A is a vertical sectional view of the injection cylinder 5.
Inner cylinder 5 in the double pipe portion projecting at the downstream end of the injection cylinder 5.
A downstream piston / combined stopper 6 is fitted into the inside of 2. FIG. 2B shows a state in which the injection cylinder 5 is fitted in the connection outer cylinder 7. The concave portion sandwiched between the gentle convex portions 73 and 74 provided on the upstream end inner wall of the connecting outer cylinder 7 engages with the convex portion 55 provided on the outer wall near the upstream end of the injection cylinder 5. Figure 2 (c)
Is the upper half of the multi-cylinder type coupling mechanism in which the puncture needle member 4 is fitted to the inner tube 51 and the outer tube 52 of the double tube projecting at the downstream end of the injection cylinder 5 in FIG. Indicates a part.

On the other hand, FIG. 2D is a vertical sectional view of the medicine container A. As shown in FIG. 2 (e), a coronal lid 1 is placed on the mouth of A.
Is externally fitted, and the upstream slope of the holding convex portion (undercut) 11u provided on the inner wall of the coronal lid 1 is engaged with the mouth lower shoulder portion A2b of the medicine container A.

In FIG. 2 (e), the top plate 32 of the crown-shaped lid 1 fitted on the mouth of the medicine container A is a septum plate which also serves as the bottom plate of the connecting inner cylinder 3, and the tightening ring 2 is provided on the outer side thereof. Shows a state in which is loosely fitted.

A concave portion 12 is provided on the outer wall near the downstream end of the coronal lid body 11. The recess 12 may have a continuous groove shape, a series of discontinuous groove shapes, or a plurality of interstitial recesses. The fastening ring 2 rupturablely connected to the outer peripheral edge of the bottom plate (septal plate) 32 is usually a tubular member,
A convex portion 21 is provided on the outer wall near the upstream end. This convex portion 21 may be a continuous brim or a series of discontinuous protrusions,
It may be a plurality of scattered protrusions.

FIG. 2F shows a state in which the tightening ring 2 is externally fitted to the coronal lid 1 which is externally fitted to the mouth of the drug container A. The tightening ring 2 is slid toward the medicine container and is externally fitted until it abuts on a collar-shaped portion 1f provided at the downstream end of the coronal lid 1. As a result, the concave portion 12 provided on the middle outer wall of the coronal lid 1 and the convex portion 22 provided on the lower inner wall of the tightening ring 2 are provided.
Engage to prevent the tightening ring 2 from coming off. The protrusion 22 may be continuous with the entire circumference of the inner wall, may be a ridge having one or more notches, or may be a plurality of scattered protrusions.

Further, a convex portion 22 is usually provided on the inner wall of the downstream region of the tightening ring 2. Its role is to fix the tightening ring 2 to the mounting member 1 or the coronal lid 1. This convex portion 22 may be a continuous brim shape or a series of discontinuous protrusions.
It may be a plurality of scattered protrusions. However, the above concavo-convex relationship may be reversed, and other methods may be used.

[Other Embodiment] As another embodiment of the connecting mechanism of the present invention, the connecting member 1 and the bottom plate 3 which replace the coronal lid 1 are used instead of the structure of the connecting inner cylinder 3 in which the mechanism is integrated with the coronal lid 1.
2 (the top plate of the crown-shaped lid 1 in the basic mode) can be exemplified as a mode constituted by the connected inner cylinder 3. In this case, the tightening ring 2 is often additionally mounted. A convex portion 23 may be provided on the inner wall near the middle stage of the tightening ring 2. Its role is mainly to press and fix the outer peripheral edge of the bottom plate 32 to the top surface of the mounting ring 1. The convex portion 23 may be a ridge continuous over the entire circumference of the inner wall, a ridge divided into two or more pieces, or a plurality of scattered projections.

For example, both the convex portions 22 and 23 provided on the inner wall of the tightening ring 2 are concave portions, the outer peripheral edge of the bottom plate 32 of the connecting inner cylinder 3 further extends outward, and the concave portion 12 of the outer wall of the mounting ring 1 is formed. Even a convex portion may be used as long as it has the above-mentioned pressing and fixing functions.

[0033]

[Action]

[Basic mode] When the upstream part of the multi-cylinder coupling mechanism shown in FIG. 2 (c) is fitted to the downstream part of the multi-cylinder coupling mechanism shown in FIG. 2 (f), FIG. The pre-use assembled state shown in (g) is formed. When the product is shipped, a protective fixing means is usually attached to the outer shell. This is a measure to prevent an untimely start of operation.

In FIG. 3 (g), the concave portion 75 provided on the inner wall of the downstream end of the connecting outer cylinder 7 is fixed by engaging with the convex portion provided on the outer wall of the upstream end 21 of the tightening ring 2. ing. When the assembly in this state is pressed from above and the upper half of the multi-cylinder coupling mechanism is slid downward along the major axis,
To (h). During the sliding process, the puncture needle 41 located at the tip of the puncture needle member 4 pierces near the center of the stopper 1 of the drug container A.

When the flow port 44 located at the shoulder of the puncture needle 41 enters the container more than the inner wall surface of the stopper 1, the inside of the injection cylinder 5 and the inside of the drug container A communicate with each other. At the same time, the puncture needle member 4 is accommodated in the downstream region enlarged diameter portion 31e of the connecting inner cylinder 3, and as a result, the expandable sliding leg portion 43 of the same member is expanded and the lowering prohibition of the injection cylinder 5 is released.

When the injection cylinder 5 is pushed downward at the time when it reaches (h) in FIG. 3, the connection outer cylinder 7 is further lowered, and the connection outer cylinder 7
The recess 76 on the inner wall of the lower end is the collar-shaped overhang 1 at the downstream end of the coronal lid 1.
f It reaches (i) of FIG. 4 which engages with the outer edge. At this stage,
The puncture needle member 4 completely penetrates the stopper A1 of the drug container A.

At the time of reaching (i) of FIG. 4, a plunger 9 is attached to the upstream top surface of the upstream piston / combined plug 8 mounted in the injection cylinder 5 to obtain (j) of FIG. , 9 are pushed downward to move the dissolution liquid from the injection cylinder 5 into the medicine container A.
When the movement of the dissolution liquid is completed, the process reaches (k) in FIG.

In the process of reaching (k) in FIG. 5 or after the completion of the movement, the entire system, particularly the side of the drug container A, is effectively mechanically vibrated, rotated, etc., or physically heated, ultrasonically applied, etc. Means are used as necessary to sufficiently dissolve or disperse the drug. Next, when the system is inverted and the plunger 9 is moved in the direction of separating from the drug container A, the drug solution in the drug container A is accommodated in the syringe barrel 5, resulting in (l) of FIG.

When the connecting outer cylinder 7 is pushed and further moved in the direction of the medicine container A when reaching (l) of FIG. 6, the connecting inner cylinder 3 relatively enters into the connecting outer cylinder 7. The upstream end of the connecting inner cylinder 3 continues to enter while being expanded by the convex portion 57 of the outer wall of the injection cylinder 5. When the entry is further continued, the upstream end of the coupling inner cylinder 3 comes into contact with the convex portion 73 provided on the inner wall near the upper end of the coupling outer cylinder, and the coupling outer cylinder is further expanded. Therefore, the vicinity of the upper end of the connecting outer cylinder 7 is expanded and the locking projection 56 of the outer wall near the upper end of the injection cylinder 5 is formed.
And the concave portion between the convex portion 74 and the convex portion 73 on the inner wall near the tip of the connecting outer cylinder 7 are disengaged.

As a result, as shown in FIG. 6 (m), the injection cylinder 5 is ready to be pulled out from the connecting outer cylinder 7. Then, if the injection needle is attached to the puncture needle 41 after pulling out the injection cylinder 5, the state shown in FIG. 1C, that is, the preparation for injection is completed. [Other Embodiment] FIG. 7 shows another embodiment of the multi-cylinder type coupling mechanism of the present invention, which is provided with a coronal lid with an annular locking mechanism in many cases. The difference between the different mode and the basic mode is that a downstream side puncture needle having a pointed tip at the downstream side instead of the puncture needle member 4 having a pointed point at the downstream side, instead of the stopper 6 serving also as the downstream piston 6 is used. The point is that a double-ended pointed puncture needle member 4v composed of 41a and an upstream side puncture needle 41b having a pointed tip on the upstream side is used.

FIG. 7A is a schematic vertical sectional view showing a state in which a plunger is further attached to the embodiment. Of FIG.
(b) shows that the injection cylinder 5 of the multi-cylinder coupling mechanism, which is another embodiment of the present invention, moves to the drug container A side while engaging with the coupling outer cylinder 7,
Both-end pointed puncture needle member 4 attached to the tip of the injection cylinder 5
The downstream puncture needle 41a of v pierces the stopper A1 of the drug container A to open a flow passage, and the upstream puncture needle 41b pierces the fixed stopper 6a attached to the inner tube 51 of the syringe barrel to distribute the drug. In addition to opening the passage, the plunger 9
FIG. 3 is a schematic vertical cross-sectional view showing a state in which the bottom is pushed to the bottom. FIG. 7 (c) is a schematic vertical sectional view showing a state in which the injection cylinder 5 is extracted after the dissolution of the drug is completed and the downstream side puncture needle 41a is attached with the injection needle, which can be used for injection at any time. Is in a state.

[0042]

In the multi-cylinder type coupling mechanism of the present invention, all the various functions can be achieved by mounting the mounting member on the mouth of the drug container and performing necessary operations. .Interrelationship between each member, that is, the mounting member, the connecting inner cylinder, the injection cylinder and the connecting outer cylinder, and the retaining projections, collar-shaped portions, projections and recesses, etc., provided on them with the tightening rings that are added as necessary Can be reliably operated in a predetermined operation sequence and operation timing.-Since the injection tube also serves as a dissolution liquid container, a drug solution containing a desired kind of drug at a predetermined concentration can be obtained by a routine operation. That is, an injection cylinder containing a predetermined volume of a solution of a desired type and a drug container of a desired type are connected by a multi-cylinder type coupling mechanism of the present invention to form a kit, and if the drug is dissolved, the desired drug is brought to a predetermined concentration. An injectable solution that is dissolved or dispersed is obtained. -A combination that does not exist in existing commercial products-type and amount of drug and type and amount of solution-can be prepared. Combinations due to storage conditions, handling restrictions and other constraints in uncommercially available unions have the potential to be realized by the coupling mechanism of the present invention.

[Brief description of drawings]

FIG. 1 (a) is a schematic vertical cross-sectional view showing a state in which a plunger is attached to a basic mode in which a multi-cylinder type coupling mechanism of the present invention includes a crown-shaped lid with an annular locking mechanism, and FIG. ) Indicates that the syringe barrel of the multi-cylinder type coupling mechanism of the present invention moves to the drug container side, the puncture needle attached to the tip of the syringe barrel pierces the stopper of the drug container and opens the flow passage, and the plunger is the syringe barrel. A schematic vertical cross-sectional view of the state of being pushed to the bottom of FIG.
(c) is a schematic vertical cross-sectional view showing a state in which the injection cylinder is extracted after the dissolution of the drug is completed, and the injection needle is externally fitted to the puncture needle, which is ready for injection at any time.

2 (a) to 2 (c) illustrate the upstream side structure of the multi-cylinder portion of the basic mode in which the multi-cylinder coupling mechanism of the present invention is provided with a crown-shaped lid with an annular locking mechanism in the order of assembling. 2 (d) to 2 (f) are schematic vertical cross-sectional views for explaining the process of fitting the multi-cylinder portion into the mouth of the drug container in the order of assembling.

FIG. 3 (g) is a schematic vertical cross-sectional view showing a state in which the multi-cylinder coupling mechanism of the present invention is fitted in the mouth of a drug container, and FIG. 3 (h) shows the present invention. FIG. 6 is a schematic vertical cross-sectional view showing a state in which the multi-cylinder coupling mechanism of (1) moves to the drug container side and the puncture needle pierces the stopper of the drug container to open the flow passage.

FIG. 4 (i) shows that the multi-cylinder coupling mechanism of the present invention includes a crown-shaped lid with an annular locking mechanism, and the coupling outer cylinder and the injection cylinder of the multi-cylinder coupling mechanism are further moved to the drug container side. FIG. 4 (j) is a schematic vertical cross-sectional view showing a state in which the downstream end of the connecting outer cylinder fits into the protruding portion of the base of the coronal lid body and the puncture needle reaches the downstream end of the connecting inner cylinder. It is a typical longitudinal cross-sectional view which shows the state in which the plunger 9 was attached to the upstream side of the upstream piston and stopper 8 in i).

5 (k) is a schematic view showing a state in which the plunger 9 is pushed to the downstream end of the injection barrel 5 in the basic mode in which the multi-cylinder coupling mechanism of the present invention is provided with the coronal lid with the annular locking mechanism. FIG. FIG. This state is also shown in FIG. 1 (b). FIG. 5 (l) is a schematic vertical sectional view showing a state in which the system is changed to the inverted state and the plunger 9 is pulled out.

6 (m) is a view showing a basic mode in which the multi-cylinder type coupling mechanism of the present invention is provided with a coronal lid with an annular locking mechanism, in which the coupling inner barrel 3 is inserted between the coupling outer barrel 7 and the injection barrel 5. FIG. FIG. 7 is a schematic vertical sectional view showing a state in which the engagement between the two is released.
(N) is a schematic vertical cross-sectional view showing a state in which the injection needle is externally fitted and fixed to the puncture needle located at the tip of the injection cylinder 5 pulled out from the connecting outer cylinder 7 by releasing the engagement. This is
It matches the condition shown in (c).

FIG. 7 shows another embodiment in which the multi-cylinder coupling mechanism of the present invention is provided with a coronal lid with an annular locking mechanism. FIG. 7 (a) is a schematic vertical cross-sectional view showing a state in which a plunger is further attached to the embodiment, and FIG. 7 (b) shows that the syringe barrel of the mechanism moves to the drug container side and In addition to the fact that the downstream puncture needle of the attached double-ended pointed puncture needle member pierced the stopper of the drug container and the upstream puncture needle pierced the fixed stopper attached to the double-tube portion of the syringe barrel. FIG. 7 (c) is a schematic vertical cross-sectional view showing the state where the plunger is pushed to the bottom of the syringe barrel, and FIG. 7 (c) shows a state where the syringe barrel is pulled out after the dissolution of the drug is completed and the syringe needle is attached to the downstream side puncture needle. It is a schematic longitudinal cross-sectional view.

[Explanation of symbols]

1 Multi-cylinder type connection mechanism of the present invention 2 Tightening ring 3 Connection inner cylinder 4 Puncture needle member 5 Injection cylinder 6 Downstream piston combined stopper 7 Connection outer cylinder 8 Upstream piston combined stopper 9 Plunger A Drug container 11 Coronal lid body 12 Corrugated lid Main body outer wall concave portion 21 Tightening ring upstream end edge outer wall convex portion 22 Tightening ring downstream region inner wall convex portion 23 Tightening ring middle stage inner wall convex portion 31 Connected inner cylindrical portion downstream region expanded portion 32 Heaven forming the coronal lid Plate portion 33 Through hole near the center of the top plate portion 34 Upstream end region of the connecting inner cylinder 35 Upstream end region of the connecting inner cylinder Recessed portion provided on the inner wall 36 Upper opening holding convex portion provided at the upstream end of the connecting inner cylinder ( (Undercut) 41 Puncture needle of puncture needle member 42 Hack tube of puncture needle member 43 Expandable sliding leg portion of puncture needle member 44 Liquid passage hole (liquid passage port) of puncture needle shoulder portion 45 Expandable slide leg Projection located on the inner wall near the upstream end of the section 46 Flow Path in Puncture Needle Member 51 Inner Tube in Double Pipe at Downstream End of Injection Cylinder 52 Outer Tube in Double Pipe at Downstream of Injection Cylinder 53 Body of Injection Cylinder 54 Double Pipe at Downstream of Injection Cylinder Expanded part of the inner wall of the inner pipe 55 Strong protrusion of the outer wall near the upstream end of the syringe barrel 56 Mild convex part of the outer wall near the upstream end of the syringe barrel 57 Containing protrusion of the outer edge of the outer pipe downstream end of the double pipe portion at the downstream end of the syringe barrel Part (undercut) 4v Double-ended pointed puncture needle member 41a composed of an upstream puncture needle and a downstream puncture needle 41a Downstream puncture needle 41b Upstream puncture needle 44a Downstream puncture needle Fluid passage hole (liquid passage) Mouth) 44b Upstream puncture needle shoulder fluid passage hole (fluid passage) 6a Inner pipe mouth cap in the double pipe portion at the downstream end of the syringe barrel 71 Connection Expansion portion downstream of outer cylinder 72 Connection Outer cylinder main body 73 Gradient protrusion on the inner wall of the upstream area of the connected outer cylinder 74 Near the upstream end of the connected outer cylinder Convex part of wall A1 Plug fitted in mouth part of drug container A2 Mouth part of drug container 11c Concave part of outer wall of coronal lid body 11f Overhang of base part of coronal lid body 11u Retaining convex part of coronary lid body inner wall 31e Connection inner tube downstream region Expanded part of inner wall A2b Lower shoulder of drug container mouth

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Ken Doi Australia 7-25-11 Negishidai, Asaka-shi, Saitama Prefecture (72) Inhito Naoto Ito 6-6-6 Toro-cho, Omiya-shi, Saitama Omiya Toro Ekimae Heights 507

Claims (6)

[Claims] 1. A multi-cylinder type coupling mechanism comprising an injection barrel containing a solution, a coupling inner barrel, a coupling outer barrel, a puncture needle member and a drug container mounting member, the coupling engaged with a drug container tightening ring. An outer cylinder, an injection cylinder internally fitted from the upstream side of the connection outer cylinder and engaged with the connection outer cylinder, and fitted from the downstream side between the injection cylinder and the connection outer cylinder and having a diameter expansion area on the inner wall of the downstream area thereof. A connecting inner cylinder, a stopper that is movable in a double-tube inner tube provided at the downstream end of the injection tube and is watertightly fitted, and an upstream part of the puncture needle member that is movably fitted in the double-tube inner tube. A multi-cylinder type coupling mechanism of a drug container and a solution container, which is constituted by a puncture needle member in which expandable legs extending from the vicinity of the middle part of the member to the upstream side are in sliding contact with the inner wall of the coupling inner cylinder. 2. The expandable leg portion that constitutes the puncture needle member expands when it is accommodated in the expanded diameter portion provided on the inner wall of the downstream area of the connecting inner cylinder, and the expandable leg portion inside and The multi-cylinder type coupling mechanism according to claim 1, wherein the lock held between the outer side of the outer tube in the double tube section provided at the downstream end of the injection tube is released. 3. When the syringe barrel further descends inside the connecting inner barrel after the locking of claim 2 is released, the convex portion near the middle step of the inner side of the expandable leg and the outer barrel outer wall of the double barrel portion of the barrel. The multi-cylinder type coupling mechanism according to claim 1, wherein the reduced diameter stage near the middle stage is engaged. 4. In the double pipe portion at the downstream end of the syringe barrel, the shape of the inner wall near the downstream end of the inner pipe forms a watertight structure with the outer wall of the puncture needle upstream portion, and the outer wall near the downstream end of the outer pipe in the double pipe portion. 2. The multi-cylinder type coupling mechanism according to claim 1, wherein the shape forms an airtight structure with the inside of the downstream end of the expandable leg portion. 5. A multi-cylinder type connecting mechanism comprising a drug container mounting member, a connecting inner cylinder, a connecting outer cylinder, an injection cylinder containing a solution, a stopper and a hollow puncture needle member, from the vicinity of the middle stage of the puncture needle to the upstream. And a hollow puncture needle member in which one or more expandable legs extending upstream from the hakary part are annularly connected in the vicinity of the upstream end and expandable legs 2. The multi-cylinder type coupling mechanism according to claim 1, wherein the multi-cylinder type coupling mechanism is configured by a coupling inner cylinder having an inner diameter enlarging portion capable of accommodating in an expanded state on an inner wall near an upstream end thereof. 6. In a multi-cylinder type coupling mechanism composed of a drug container mounting member, a coupling inner cylinder, a coupling outer cylinder, an injection cylinder containing a solution, a stopper and a hollow puncture needle member, upstream from the middle stage of the puncture needle. One or more expandable legs formed by extending to the side are annularly connected near the upstream end thereof, and a double-ended pointed hollow puncture needle member having pointed ends is provided at the downstream end of the syringe barrel. It is composed of a plug which is watertightly fitted to the mouth of the double pipe portion and is hard to move, and a connecting inner cylinder having an inner diameter enlarged portion capable of accommodating the expandable leg portion in its expanded state on the inner wall near its upstream end. Multi-cylinder type coupling mechanism.